• 19 Innovation Walk, 76

    3800 Clayton

Accepting PhD Students

19972021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Somatic hypermutation of the YAP oncogene in a human cutaneous melanoma

Zhang, X., Tang, J. Z., Vergara, I. A., Zhang, Y., Szeto, P., Yang, L., Mintoff, C., Colebatch, A., McIntosh, L., Mitchell, K. A., Shaw, E., Rizos, H., Long, G. V., Hayward, N., McArthur, G. A., Papenfuss, A. T., Harvey, K. F. & Shackleton, M., 1 Jul 2019, In : Molecular Cancer Research. 17, 7, p. 1435-1449 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development

Dent, L. G., Manning, S. A., Kroeger, B., Williams, A. M., Saiful Hilmi, A. J., Crea, L., Kondo, S., Horne-Badovinac, S. & Harvey, K. F., 22 May 2019, In : PLoS Genetics. 15, 5, 31 p., e1008083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster

Poon, C. L. C., Liu, W., Song, Y., Gomez, M., Kulaberoglu, Y., Zhang, X., Xu, W., Veraksa, A., Hergovich, A., Ghabrial, A. & Harvey, K. F., 3 Dec 2018, In : Developmental Cell. 47, 5, p. 564-575 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo

Manning, S. A., Dent, L. G., Kondo, S., Zhao, Z. W., Plachta, N. & Harvey, K. F., 21 May 2018, In : Current Biology. 28, 10, p. 1651-1660 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate

Vissers, J. H. A., Froldi, F., Schroder, J., Papenfuss, A. T., Cheng, L. Y. & Harvey, K. F., 6 Nov 2018, In : Cell Reports. 25, 6, p. 1561-1576 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
2017

Regulation of tissue growth by the mammalian Hippo signaling pathway

Watt, K., Harvey, K. F. & Gregorevic, P., 24 Nov 2017, In : Frontiers in Physiology. 8, 12 p., 942.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)
2016

A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth

Vissers, J. H. A., Manning, S. A., Kulkarni, A. & Harvey, K. F., 13 Jan 2016, In : Nature Communications. 7, 6 p., 10368.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
24 Citations (Scopus)

Hippo Wades into Cancer Immunology

Gebhardt, T. & Harvey, K. F., 19 Dec 2016, In : Developmental Cell. 39, 6, p. 635-637 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File
4 Citations (Scopus)

Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua

Yang, L., Paul, S., Trieu, K. G., Dent, L. G., Froldi, F., Forés, M., Webster, K., Siegfried, K. R., Kondo, S., Harvey, K., Cheng, L., Jiménez, G., Shvartsman, S. Y. & Veraksa, A., 20 Sep 2016, In : Proceedings of the National Academy of Sciences. 113, 38, p. 10583-10588 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

The Hippo Pathway Regulates Neuroblasts and Brain Size in Drosophila melanogaster

Poon, C. L. C., Mitchell, K. A., Kondo, S., Cheng, L. Y. & Harvey, K. F., 25 Apr 2016, In : Current Biology. 26, 8, p. 1034-1042 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
38 Citations (Scopus)
2015

Control of organ growth by patterning and Hippo signaling in Drosophila

Irvine, K. D. & Harvey, K. F., 1 Jan 2015, In : Cold Spring Harbor Perspectives in Biology. 7, 6, 16 p., a019224.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
59 Citations (Scopus)

Growth control: Re-examining zyxin's role in the hippo pathway

Harvey, K. F., 1 Jan 2015, In : Current Biology. 25, 6, p. R230-R231 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File
2 Citations (Scopus)

The GTPase regulatory proteins pix and git control tissue growth via the hippo pathway

Dent, L. G., Poon, C. L. C., Zhang, X., Degoutin, J. L., Tipping, M., Veraksa, A. & Harvey, K. F., 5 Jan 2015, In : Current Biology. 25, 1, p. 124-130 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F. & Gregorevic, P., 12 Jan 2015, In : Nature Communications. 6, 13 p., 6048.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
45 Citations (Scopus)

Warts Opens Up for Activation

Manning, S. A. & Harvey, K. F., 21 Dec 2015, In : Developmental Cell. 35, 6, p. 666-668 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File
3 Citations (Scopus)
2014

The hippo pathway regulates hematopoiesis in Drosophila melanogaster

Milton, C. C., Grusche, F. A., Degoutin, J. L., Yu, E., Dai, Q., Lai, E. C. & Harvey, K. F., 17 Nov 2014, In : Current Biology. 24, 22, p. 2673-2680 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
24 Citations (Scopus)
2013

Riquiqui and minibrain are regulators of the Hippo pathway downstream of Dachsous

Degoutin, J. L., Milton, C. C., Yu, E., Tipping, M., Bosveld, F., Yang, L., Bellaiche, Y., Veraksa, A. & Harvey, K. F., 1 Oct 2013, In : Nature Cell Biology. 15, 10, p. 1176-1185 10 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

The Hippo pathway and human cancer

Harvey, K. F., Zhang, X. & Thomas, D. M., 1 Apr 2013, In : Nature Reviews Cancer. 13, 4, p. 246-257 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

810 Citations (Scopus)

The Hippo size control pathway - Ever expanding

Lin, J. I., Poon, C. L. C. & Harvey, K. F., 22 Jan 2013, In : Science Signaling. 6, 259, pe4.

Research output: Contribution to journalReview ArticleResearchpeer-review

22 Citations (Scopus)

Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis

Beverdam, A., Claxton, C., Zhang, X., James, G., Harvey, K. F. & Key, B., 1 Jun 2013, In : Journal of Investigative Dermatology. 133, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2012

Control of tissue growth and cell transformation by the Salvador/Warts/Hippo pathway

Zhang, X., Grusche, F. A. & Harvey, K. F., 16 Feb 2012, In : PLoS ONE. 7, 2, 9 p., e31994.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth

Poon, C. L. C., Zhang, X., Lin, J. I., Manning, S. A. & Harvey, K. F., 11 Sep 2012, In : Current Biology. 22, 17, p. 1587-1594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

The Hippo pathway

Harvey, K. F. & Hariharan, I. K., 1 Aug 2012, In : Cold Spring Harbor Perspectives in Biology. 4, 8

Research output: Contribution to journalShort ReviewOtherpeer-review

51 Citations (Scopus)

The Hippo pathway-From top to bottom and everything in between

Tapon, N. & Harvey, K. F., 1 Jan 2012, In : Seminars in Cell and Developmental Biology. 23, 7, p. 768-769 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

13 Citations (Scopus)

Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP

Angus, L., Moleirinho, S., Herron, L., Sinha, A., Zhang, X., Niestrata, M., Dholakia, K., Prystowsky, M. B., Harvey, K. F., Reynolds, P. A. & Gunn-Moore, F. J., 12 Jan 2012, In : Oncogene. 31, 2, p. 238-250 13 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)
2011

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

Bowtell, D. D. L., Harvey, K. F. & AOCS Study Group, 23 Jun 2011, In : Oncogene. 30, 25, p. 2810-2822 13 p.

Research output: Contribution to journalArticleResearchpeer-review

182 Citations (Scopus)

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

Grusche, F. A., Degoutin, J. L., Richardson, H. E. & Harvey, K. F., 15 Feb 2011, In : Developmental Biology. 350, 2, p. 255-266 12 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway

Poon, C. L. C., Lin, J. I., Zhang, X. & Harvey, K. F., 15 Nov 2011, In : Developmental Cell. 21, 5, p. 896-906 11 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway

Zhang, X., Milton, C. C., Poon, C. L. C., Hong, W. & Harvey, K. F., 1 Aug 2011, In : Cell Death and Differentiation. 18, 8, p. 1346-1355 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ

Chan, S. W., Lim, C. J., Huang, C., Chong, Y. F., Gunaratne, H. J., Hogue, K. A., Blackstock, W. P., Harvey, K. F. & Hong, W., 3 Feb 2011, In : Oncogene. 30, 5, p. 600-610 11 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)
2010

Bunched and Madm: A novel growth-regulatory complex?

Harvey, K. F., 26 Feb 2010, In : Journal of Biology. 9, 1, 8.

Research output: Contribution to journalShort SurveyOtherpeer-review

1 Citation (Scopus)

Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster

Milton, C. C., Zhang, X., Albanese, N. O. & Harvey, K. F., 1 Mar 2010, In : Development. 137, 5, p. 735-743 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F. & Richardson, H. E., 13 Apr 2010, In : Current Biology. 20, 7, p. 573-581 9 p.

Research output: Contribution to journalArticleResearchpeer-review

250 Citations (Scopus)

Modularity in the Hippo signaling pathway

Sudol, M. & Harvey, K. F., 1 Nov 2010, In : Trends in Biochemical Sciences. 35, 11, p. 627-633 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

114 Citations (Scopus)

Upstream regulation of the Hippo size control pathway

Grusche, F. A., Richardson, H. E. & Harvey, K. F., 13 Jul 2010, In : Current Biology. 20, 13, p. 574-582 9 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)
2009

A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling

Classen, A. K., Bunker, B. D., Harvey, K. F., Vaccari, T. & Bilder, D., 1 Oct 2009, In : Nature Genetics. 41, 10, p. 1150-1155 6 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Making brundlefly, one gene at a time

Zhang, X., Richardson, H. E. & Harvey, K. F., 1 Jan 2009, In : Cell Research. 19, 1, p. 5-7 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcriptional output of the Salvador/Warts/Hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines

Zhang, X., Milton, C. C., Humbert, P. O. & Harvey, K. F., 1 Aug 2009, In : Cancer Research. 69, 15, p. 6033-6041 9 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)
2008

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs

Harvey, K. F., Mattila, J., Sofer, A., Bennett, F. C., Ramsey, M. R., Ellisen, L. W., Puig, O. & Hariharan, I. K., 25 Feb 2008, In : Journal of Cell Biology. 180, 4, p. 691-696 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2007

Mutation of the gene encoding the ubiquitin activating enzyme uba1 causes tissue overgrowth in Drosophila

Pfleger, C. M., Harvey, K. F., Yan, H. & Hariharan, I. K., 1 Jan 2007, In : Fly. 1, 2, p. 95-105 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The Salvador-Warts-Hippo pathway - An emerging tumour-suppressor network

Harvey, K. & Tapon, N., 1 Mar 2007, In : Nature Reviews Cancer. 7, 3, p. 182-191 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

455 Citations (Scopus)
2006

Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway

Bennett, F. C. & Harvey, K. F., 7 Nov 2006, In : Current Biology. 16, 21, p. 2101-2110 10 p.

Research output: Contribution to journalArticleResearchpeer-review

222 Citations (Scopus)

The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death

Mills, K., Daish, T., Harvey, K. F., Pfleger, C. M., Hariharan, I. K. & Kumar, S., 13 Mar 2006, In : Journal of Cell Biology. 172, 6, p. 809-815 7 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)
2003

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

Harvey, K. F., Pfleger, C. M. & Hariharan, I. K., 22 Aug 2003, In : Cell. 114, 4, p. 457-467 11 p.

Research output: Contribution to journalArticleResearchpeer-review

569 Citations (Scopus)
2002

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein

Harvey, K. F., Shearwin-Whyatt, L. M., Fotia, A., Parton, R. G. & Kumar, S., 15 Mar 2002, In : Journal of Biological Chemistry. 277, 11, p. 9307-9317 11 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

Tapon, N., Harvey, K. F., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Haber, D. A. & Hariharan, I. K., 23 Aug 2002, In : Cell. 110, 4, p. 467-478 12 p.

Research output: Contribution to journalArticleResearchpeer-review

547 Citations (Scopus)
2001

Roles of the C Termini of α-, β-, and γ-Subunits of Epithelial Na+ Channels (ENaC) in Regulating ENaC and Mediating Its Inhibition by Cytosolic Na+

Dinudom, A., Harvey, K. F., Komwatana, P., Jolliffe, C. N., Young, J. A., Kumar, S. & Cook, D. I., 27 Apr 2001, In : Journal of Biological Chemistry. 276, 17, p. 13744-13749 6 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The Nedd4-like Protein KIAA0439 is a Potential Regulator of the Epithelial Sodium Channel

Harvey, K. F., Dinudom, A., Cook, D. I. & Kumar, S., 16 Mar 2001, In : Journal of Biological Chemistry. 276, 11, p. 8597-8601 5 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)
2000

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

Jolliffe, C. N., Harvey, K. F., Haines, B. P., Parasivam, G. & Kumar, S., 1 Nov 2000, In : Biochemical Journal. 351, 3, p. 557-565 9 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)
1999

All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+

Harvey, K. F., Dinudom, A., Komwatana, P., Jolliffe, C. N., Day, M. L., Parasivam, G., Cook, D. I. & Kumar, S., 30 Apr 1999, In : Journal of Biological Chemistry. 274, 18, p. 12525-12530 6 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)