20102024
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Research Output 2010 2019

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Article

Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15

Lam, M. M. C., Wyres, K. L., Wick, R. R., Judd, L. M., Fostervold, A., Holt, K. E. & Löhr, I. H., May 2019, In : Journal of Antimicrobial Chemotherapy. 74, 5, p. 1218-1222 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

Wyres, K. L., Wick, R. R., Judd, L. M., Froumine, R., Tokolyi, A., Gorrie, C. L., Lam, M. M. C., Duchêne, S., Jenney, A. & Holt, K. E., 1 Apr 2019, In : PLoS Genetics. 15, 4, 25 p., e1008114.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Wyres, K. L., Hawkey, J., Hetland, M. A. K., Fostervold, A., Wick, R. R., Judd, L. M., Hamidian, M., Howden, B. P., Löhr, I. H. & Holt, K. E., 1 Mar 2019, In : Journal of Antimicrobial Chemotherapy. 74, 3, p. 577-581 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Antimicrobial-resistant klebsiella pneumoniae carriage and infection in specialized geriatric care wards linked to acquisition in the referring hospital

Gorrie, C. L., Mirceta, M., Wick, R. R., Judd, L. M., Wyres, K. L., Thomson, N. R., Strugnell, R. A., Pratt, N. F., Garlick, J. S., Watson, K. M., Hunter, P. C., McGloughlin, S. A., Spelman, D. W., Jenney, A. W. J. & Holt, K. E., 2 Jul 2018, In : Clinical Infectious Diseases. 67, 2, p. 161-170 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Best practice data life cycle approaches for the life sciences

Griffin, P. C., Khadake, J., LeMay, K. S., Lewis, S. E., Orchard, S., Pask, A., Pope, B., Roessner, U., Russell, K., Seemann, T., Treloar, A., Tyagi, S., Christiansen, J. H., Dayalan, S., Gladman, S., Hangartner, S. B., Hayden, H. L., Ho, W. W. H., Keeble-Gagnère, G., Korhonen, P. K. & 7 othersNeish, P., Prestes, P. R., Richardson, M. F., Watson-Haigh, N. S., Wyres, K. L., Young, N. D. & Schneider, M. V., 4 Jun 2018, In : F1000Research. 6, 22 p., 1618.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations

Lam, M. MC., Wick, R. R., Wyres, K. L., Gorrie, C. L., Judd, L. M., Jenney, A. WJ., Brisse, S. & Holt, K. E., 1 Sep 2018, In : Microbial genomics. 4, 9, 14 p., 000196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Kaptive web: User-Friendly capsule and lipopolysaccharide serotype prediction for Klebsiella genomes

Wick, R. R., Heinz, E., Holt, K. E. & Wyres, K. L., 1 Jun 2018, In : Journal of Clinical Microbiology. 56, 6, 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination

Lam, M. M. C., Wyres, K. L., Duchêne, S., Wick, R. R., Judd, L. M., Gan, Y. H., Hoh, C. H., Archuleta, S., Molton, J. S., Kalimuddin, S., Koh, T. H., Passet, V., Brisse, S. & Holt, K. E., 1 Dec 2018, In : Nature Communications. 9, 1, 10 p., 2703.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae

Lam, M. M. C., Wyres, K. L., Judd, L. M., Wick, R. R., Jenney, A., Brisse, S. & Holt, K. E., 29 Oct 2018, In : Genome Medicine. 10, 1, 15 p., 77.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population

Lee, I. R., Molton, J. S., Wyres, K. L., Gorrie, C., Wong, J., Hoh, C. H., Teo, J., Kalimuddin, S., Lye, D. C., Archuleta, S., Holt, K. E. & Gan, Y. H., 13 Jul 2016, In : Scientific Reports. 6, 12 p., 29316.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of Klebsiella capsule synthesis loci from whole genome data

Wyres, K. L., Wick, R. R., Gorrie, C., Jenney, A., Follador, R., Thomson, N. R. & Holt, K. E., 1 Dec 2016, In : Microbial genomics. 2, 12, 15 p., e000102.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

Cohen, K. A., El-Hay, T., Wyres, K. L., Weissbrod, O., Munsamy, V., Yanover, C., Aharonov, R., Shaham, O., Conway, T. C., Goldschmidt, Y., Bishai, W. R. & Pym, A. S., 1 Jan 2016, In : EBioMedicine. 9, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The diversity of Klebsiella pneumoniae surface polysaccharides

Follador, R., Heinz, E., Wyres, K. L., Ellington, M. J., Kowarik, M., Holt, K. E. & Thomson, N. R., 1 Aug 2016, In : Microbial genomics. 2, 8, 15 p., e000073.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

A platform for leveraging next generation sequencing for routine microbiology and public health use

Rusu, L. I., Wyres, K. L., Reumann, M., Queiroz, C., Bojovschi, A., Conway, T., Garg, S. K., Edwards, D. J., Hogg, G. G. & Holt, K. E., Dec 2015, In : Health Information Science and Systems. 3, 1, 7 p., S7.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Extensive capsule locus variation and large-scale genomic recombination within the Klebsiella pneumoniae clonal group 258

Wyres, K. L., Gorrie, C., Edwards, D. J., Wertheim, H. F. L., Hsu, L. Y., Van Kinh, N., Zadoks, R., Baker, S. & Holt, K. E., 1 Jan 2015, In : Genome Biology and Evolution. 7, 5, p. 1267-1279 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Streptococcus pneumoniae carriage prevalence in Nepal: Evaluation of a method for delayed transport of samples from remote regions and implications for vaccine implementation

Hanieh, S., Hamaluba, M., Kelly, D. F., Metz, J. A., Wyres, K. L., Fisher, R., Pradhan, R., Shakya, D., Shrestha, L., Shrestha, A., Joshi, A., Habens, J., Maharjan, B. D., Thorson, S., Bohler, E., Yu, L. M., Kelly, S., Plested, E., John, T., Werno, A. M. & 4 othersAdhikari, N., Murdoch, D. R., Brueggemann, A. B. & Pollard, A. J., 6 Jun 2014, In : PLoS ONE. 9, 6, 9 p., e98739.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013

Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974

Wyres, K. L., van Tonder, A., Lambertsen, L. M., Hakenbeck, R., Parkhill, J., Bentley, S. D. & Brueggemann, A. B., 24 Jul 2013, In : BMC Genomics. 14, 1, 500.

Research output: Contribution to journalArticleResearchpeer-review

Pneumococcal capsular switching: A historical perspective

Wyres, K. L., Lambertsen, L. M., Croucher, N. J., McGee, L., Von Gottberg, A., Liñares, J., Jacobs, M. R., Kristinsson, K. G., Beall, B. W., Klugman, K. P., Parkhill, J., Hakenbeck, R., Bentley, S. D. & Brueggemann, A. B., 1 Feb 2013, In : Journal of Infectious Diseases. 207, 3, p. 439-449 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success

Wyres, K. L., Lambertsen, L. M., Croucher, N. J., McGee, L., von Gottberg, A., Liñares, J., Jacobs, M. R., Kristinsson, K. G., Beall, B. W., Klugman, K. P., Parkhill, J., Hakenbeck, R., Bentley, S. D. & Brueggemann, A. B., 16 Nov 2012, In : Genome Biology. 13, 11, R103.

Research output: Contribution to journalArticleResearchpeer-review

2010

Environmental factors determining the epidemiology and population genetic structure of the bacillus cereus group in the field

Raymond, B., Wyres, K. L., Sheppard, S. K., Ellis, R. J. & Bonsall, M. B., 1 May 2010, In : PLoS Pathogens. 6, 5, p. 1-13 13 p.

Research output: Contribution to journalArticleResearchpeer-review