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Personal profile


I am interested in understanding the evolution of bacteria through exploring their DNA. I use comparative genomics techniques to investigate the diversity and evolution of Klebsiella pneumoniae, a bacterium that causes large numbers of hospital-associated infections with high rates of drug resistance. I am particularly interested in the features and evolution of closely related groups of K. pneumoniae, called ‘clones,’ that seem to be associated with distinct behanviours e.g. some are particularly good at becoming drug-resistant while others are particularly virulent.

I have been a Reserach Fellow in the Holt Pathogen Genmics Lab since September 2015. Prior to this I spent 2 ½ years as a Staff Researcher at IBM Research - Australia. I was a founding member of the IBM Research – Australia Genomics Team and later became the Team Lead. My team was interested in exploring the use of computing for clinical and public health genomics. We collaborated with colleagues around the world and contributed to a number of applied and pure research projects, including an evolutionary exploration of drug-resistant Mycobacterium tuberculosis, the bacterium that causes TB.

Before moving to Australia and joining IBM I completed my Bachelor’s and Doctoral degrees at the University of Oxford, UK. During my doctoral degree, I studied the genomic evolution of another important disease-causing bacterium, Streptococcus pneumoniae. I focused on the evolution of penicillin resistance and capsule switching, which is important for vaccine design.

Education/Academic qualification

Zoology, DPhil, University of Oxford

Jan 2009Sep 2012

University of Oxford

Oct 2004Jun 2007

External positions

Post-Doctoral Research Fellow, The University of Melbourne

Sep 2015Dec 2018

Staff Researcher & Genomics Team Lead, IBM Research - Australia

Jan 2015Sep 2015

Staff Researcher, IBM Research - Australia

Feb 2013Dec 2014

DPhil Candidate, University of Oxford

Jan 2009Sep 2012

Laboratory Technician, University of Oxford

Oct 2007Dec 2008

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2019 2020

Research Output 2010 2019

Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15

Lam, M. M. C., Wyres, K. L., Wick, R. R., Judd, L. M., Fostervold, A., Holt, K. E. & Löhr, I. H., 15 Feb 2019, (Accepted/In press) In : Journal of Antimicrobial Chemotherapy. 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Wyres, K. L., Hawkey, J., Hetland, M. A. K., Fostervold, A., Wick, R. R., Judd, L. M., Hamidian, M., Howden, B. P., Löhr, I. H. & Holt, K. E., 1 Mar 2019, In : Journal of Antimicrobial Chemotherapy. 74, 3, p. 577-581 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Small IncQ1 and col-like plasmids harboring bla KPC-2 and non-Tn4401 elements (NTE KPC -IId) in high-risk lineages of Klebsiella pneumoniae CG258

Cerdeira, L. T., Lam, M. M. C., Wyres, K. L., Wick, R. R., Judd, L. M., Lopes, R., Ribas, R. M., Morais, M. M., Holt, K. E. & Lincopan, N., 1 Mar 2019, In : Antimicrobial Agents and Chemotherapy. 63, 3, 4 p., e02140-18.

Research output: Contribution to journalLetterResearchpeer-review

Antimicrobial-resistant klebsiella pneumoniae carriage and infection in specialized geriatric care wards linked to acquisition in the referring hospital

Gorrie, C. L., Mirceta, M., Wick, R. R., Judd, L. M., Wyres, K. L., Thomson, N. R., Strugnell, R. A., Pratt, N. F., Garlick, J. S., Watson, K. M., Hunter, P. C., McGloughlin, S. A., Spelman, D. W., Jenney, A. W. J. & Holt, K. E., 2 Jul 2018, In : Clinical Infectious Diseases. 67, 2, p. 161-170 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access