Kelly Walton

Dr

20082021
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Research Output 2008 2019

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2019

Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

Walton, K. L., Chen, J. L., Arnold, Q., Kelly, E., La, M., Lu, L., Lovrecz, G., Hagg, A., Colgan, T. D., Qian, H., Gregorevic, P. & Harrison, C. A., 1 Oct 2019, In : Endocrinology. 160, 10, p. 2417-2426 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro

Richani, D., Constance, K., Lien, S., Agapiou, D., Stocker, W. A., Hedger, M. P., Ledger, W., Thompson, J. G., Robertson, D. M., Mottershead, D. G., Walton, K. L., Harrison, C. A. & Gilchrist, R., 1 Apr 2019, In : Endocrinology. 160, 4, p. 853-862 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum Concentrations of Oocyte-Secreted Factors BMP15 and GDF9 During IVF and in Women With Reproductive Pathologies

Riepsamen, A. H., Chan, K., Lien, S., Sweeten, P., Donoghoe, M. W., Walker, G., Fraison, E. H. J., Stocker, W. A., Walton, K. L., Harrison, C. A., Ledger, W. L., Robertson, D. M. & Gilchrist, R. B., 1 Oct 2019, In : Endocrinology. 160, 10, p. 2298-2313 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Molecular characterization of latent GDF8 reveals mechanisms of activation

Walker, R. G., McCoy, J. C., Czepnik, M., Mills, M. J., Hagg, A., Walton, K. L., Cotton, T. R., Hyvönen, M., Lee, R. T., Gregorevic, P., Harrison, C. A. & Thompson, T. B., 30 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 5, p. E866-E875 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with gdf9

Patino, L. C., Walton, K. L., Mueller, T. D., Johnson, K. E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R. B., Laissue, P. & Harrison, C. A., 1 Mar 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 3, p. 1009-1019 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple soluble TGF-β receptors in addition to soluble endoglin are elevated in preeclamptic serum and they synergistically inhibit TGF-β signaling

Wang, Y., Chen, Q., Zhao, M., Walton, K., Harrison, C. & Nie, G., 1 Aug 2017, In : Journal of Clinical Endocrinology and Metablism. 102, 8, p. 3065-3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Chen, J., Walton, K. L., Hagg, A. G., Colgan, T. D., Johnson, K. E., Qian, H., Gregorevic, P. & Harrison, C. A., 27 Jun 2017, In : Proceedings of the National Academy of Sciences. 114, 26, p. E5266-E5275 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for potency differences between GDF8 and GDF11

Walker, R. G., Czepnik, M., Goebel, E. J., McCoy, J. C., Vujic, A., Cho, M., Oh, J., Aykul, S., Walton, K. L., Schang, G., Bernard, D. J., Hinck, A. P., Harrison, C. A., Martinez-Hackert, E., Wagers, A. J., Lee, R. T. & Thompson, T. B., 3 Mar 2017, In : BMC Biology. 15, 1, 22 p., 19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma

Coulson, R., Liew, S. H., Connelly, A. A., Yee, N. S., Deb, S., Kumar, B., Vargas, A. C., O'Toole, S. A., Parslow, A. C., Poh, A., Putoczki, T., Morrow, R. J., Alorro, M., Lazarus, K. A., Yeap, E. F. W., Walton, K. L., Harrison, C. A., Hannan, N. J., George, A. J., Clyne, C. D. & 3 others, Ernst, M., Allen, A. M. & Chand, A. L., 20 Feb 2017, In : Oncotarget. 8, 12, p. 18640-18656 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

A novel, more efficient approach to generate bioactive inhibins

Walton, K. L., Kelly, E. K., Johnson, K. E., Robertson, D. M., Stanton, P. G. & Harrison, C. A., 1 Jul 2016, In : Endocrinology. 157, 7, p. 2799-2809 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Biological activity and in vivo half-life of pro-activin A in male rats

Johnson, K. E., Makanji, Y., Temple-Smith, P., Kelly, E. K., Barton, P. A., Al-Musawi, S. L., Mueller, T. D., Walton, K. L. & Harrison, C. A., 15 Feb 2016, In : Molecular and Cellular Endocrinology. 422, p. 84 - 92 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential effects of IL6 and activin A in the development of cancer-associated cachexia

Chen, J. L., Walton, K. L., Qian, H., Colgan, T. D., Hagg, A., Watt, M. J., Harrison, C. A. & Gregorevic, P., 15 Sep 2016, In : Cancer Research. 76, 18, p. 5372-5382 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, C. E., Murphy, K. T., Bernardo, B. C., Qian, H., Liu, Y., Sepulveda, P. V., Beyer, C., Hagg, A., Thomson, R. E., Chen, J. L., Walton, K. L., Loveland, K. L., McMullen, J. R., Rodgers, B. D., Harrison, C. A., Lynch, G. S. & Gregorevic, P., 20 Jul 2016, In : Science Translational Medicine. 8, 348, 12 p., 348ra98.

Research output: Contribution to journalArticleResearchpeer-review

2015

Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity

Heng, S., Dynon, K., Li, Y., Edgell, T. A., Walton, K., Rombauts, L., Vollenhoven, B. J. & Nie, G., 15 Apr 2015, In : Analytical Biochemistry. 475, p. 14 - 21 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of novel activin-targeted therapeutics

Chen, J., Walton, K., Al-Musawi, S., Kelly, E. M., Qian, H., La, M., Lu, L., Lovrecz, G. O., Ziemann, M., Lazarus, R., El-Osta, A., Gregorevic, P. & Harrison, C. A., 2015, In : Molecular Therapy. 23, 3, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibin biosynthesis and activity are limited by a prodomain-derived peptide

Walton, K., Kelly, E. M., Chan, K. L., Harrison, C. A. & Robertson, D., 2015, In : Endocrinology. 156, 8, p. 3047 - 3057 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Elevated expression of activins promotes muscle wasting and cachexia

Chen, J. L., Walton, K., Winbanks, C. E., Murphy, K. T., Thomson, R. E., Makanji, Y., Qian, H., Lynch, G. S., Harrison, C. A. & Gregorevic, P., 2014, In : FASEB Journal. 28, 4, p. 1711 - 1723 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Germline mutations of inhibins in early-onset ovarian epithelial tumors

Tournier, I., Marlin, R., Walton, K., Charbonnier, F., Coutant, S., Théry, J-C., Charbonnier, C., Spurrell, C., Vezain, M., Ippolito, L., Bougeard, G., Roman, H., Tinat, J., Sabourin, J-C., Stoppa-Lyonnet, D., Caron, O., Paillerets, B. B., Vaur, D., King, M-C., Harrison, C. & 1 others, Frebourg, T., Mar 2014, In : Human Mutation. 35, 3, p. 294-297 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013

Identification of protein binding partners of ALK-5 kinase inhibitors

Ciayadi, R., Kelso, G., Potdar, M. K., Harris, S. J., Walton, K., Harrison, C. A. & Hearn, M. T. W., 2013, In : Bioorganic & Medicinal Chemistry. 21, 21, p. 6496 - 6500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Species differences in the expression and activity of bone morphogenetic protein 15

Al-Musawi, S., Walton, K. L., Heath, D., Simpson, C. M. & Harrison, C. A., 2013, In : Endocrinology. 154, 2, p. 888 - 899 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Use of detergent-based buffers allows detection of precursor inhibin forms in an immunoassay format

Walton, K. L., Chan, K. L., Pruysers, E., Kelly, E. K., Harris, G., Harrison, C. A. & Robertson, D. M., 5 Dec 2013, In : Molecular and Cellular Endocrinology. 381, 1-2, p. 106-114 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Activation of latent human GDF9 by a single residue change (Gly 391 Arg) in the mature domain

Simpson, C., Stanton, P. G., Walton, K. L., Chan, K., Ritter, L. J., Gilchrist, R. B. & Harrison, C. A., 2012, In : Endocrinology. 153, 3, p. 1301 - 1310 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Activin signaling regulates sertoli cell differentiation and function

Nicholls, P. K., Stanton, P. G., Chen, J. L., Olcorn, J. S., Haverfield, J. T., Qian, H., Walton, K. L., Gregorevic, P. & Harrison, C. A., 2012, In : Endocrinology. 153, 12, p. 6065 - 6077 13 p.

Research output: Contribution to journalArticleResearchpeer-review

HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening

Dynon, K., Heng, S., Puryer, M. A., Li, Y., Walton, K. L., Endo, Y. & Nie, G., 2012, In : PLoS ONE. 7, 9, 14 p., e45956.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

Generation of a specific activin antagonist by modification of the activin A propeptide

Makanji, Y., Walton, K. L., Chan, K. L., Gregorevic, P., Robertson, D. M. & Harrison, C. A., Oct 2011, In : Endocrinology. 152, 10, p. 3758-3768 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hormonal regulation of sertoli cell micro-RNAs at spermiation

Nicholls, P. K., Harrison, C. A., Walton, K. L., McLachlan, R. I., O'Donnell, L. & Stanton, P., 2011, In : Endocrinology. 152, 4, p. 1670 - 1683 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands

Harrison, C. A., Al-Musawi, S. L. & Walton, K. L., Oct 2011, In : Growth Factors. 29, 5, p. 174-186 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex

Walton, K. L., Makanji, Y., Chen, J., Wilce, M. C. J., Chan, K. L., Robertson, D. M. & Harrison, C. A., 2010, In : Journal of Biological Chemistry. 285, 22, p. 17029 - 17037 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands

Walton, K., Makanji, Y., Wilce, M. C. J., Chan, K. L., Robertson, D. M. & Harrison, C. A., 2009, In : Journal of Biological Chemistry. 284, 14, p. 9311 - 9320 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibin B is a more potent suppressor of rat follicle-stimulating hormone release than inhibin a in vitro and in vivo

Makanji, Y., Temple-Smith, P. D. M., Walton, K. L., Harrison, C. A. & Robertson, D., 2009, In : Endocrinology. 150, 10, p. 4784 - 4793 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Suppression of inhibin A biological activity by alterations in the binding site for betaglycan

Makanji, Y., Walton, K., Wilce, M. C. J., Chan, K. L., Robertson, D. M. & Harrison, C. A., 2008, In : Journal of Biological Chemistry. 283, 24, p. 16743 - 16751 9 p.

Research output: Contribution to journalArticleResearchpeer-review