Personal profile
Biography
Dr Kelly Crossley is a perinatal physiologist focussed on improving the fetal to neonatal transition in all infants requiring assistance at birth. Her research is particularly focussed on understanding how the respiratory and cardiovascular systems interact causing brain injury.
Dr Crossley is a leading expert in the development and use of the most advanced animal models in perinatal research. With over 19 years’ experience, she has developed a unique skill set using a multi-pronged approach investigating newborn physiology and biomedical imaging in collaboration with physiologists, clinicians and physicists. Her research utilises both the Australian and Japanese synchrotrons as well as sophisticated pre-clinical models in rabbits and sheep.
More recently, Dr Crossley has been involved in biomedical imaging experiments that provide evidence of fundamental mechanisms regulating the transition from fetal to newborn life. Specifically, identifying interventions to improve spontaneous breathing in premature newborns. This pre-clinical evidence has led to a current clinical trial focussed on the effect of oxygenation during resuscitation on promoting spontaneous breathing in premature newborns. Her current involvement in projects focussed on improving respiratory and cardiovascular outcomes for newborns with a congenital diaphragmatic hernia and transient tachypnoea of the newborn have uncovered previously unrealised mechanisms underpinning complications at birth and identifying interventions that can be translated into future clinical trials to improve outcomes for these newborns.
Senior Reserch Fellow
Fetal and Neonatal Health Research Group, The Ritchie centre, Hudson Institute of Medical Research.
Adjunct Senior Resaerch Fellow, Department of Obstetrics and Gynaecology, Monash University.
Education/Academic qualification
Bachelor of Science Honours, The role of progesterone in the regulation of fetal behavioural states, MONASH UNIVERSITY
1991 → 1995
Research area keywords
- Preterm birth
- lung development
- Brain development
- Respiratory Physiology
- Cardiovascular Physiology
- preterm infant
- congenital diaphragmatic hernia
- transition at birth
- Imaging studies
- Mechanical ventilation
- Fetal & Neonatal Physiology
- fetal and neonatal circulation and brain injury
- Neonatal resuscitation
- Synchrotron Imaging
Collaborations and top research areas from the last five years
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Reducing the burden of respiratory distress after caesarean delivery.
Crossley, K. (Primary Chief Investigator (PCI)), Hooper, S. (Chief Investigator (CI)), Kitchen, M. (Chief Investigator (CI)), te Pas, A. B. (Chief Investigator (CI)), Wallace, M. (Associate Investigator (AI)), Tran, N. (Associate Investigator (AI)), Polglase, G. (Associate Investigator (AI)) & Thió-Lluch, M. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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Phase-Contrast Neuroimaging for Early Detection of Brain Injury at Birth
Kitchen, M. (Primary Chief Investigator (PCI)), Croton, L. (Chief Investigator (CI)), Hooper, S. (Associate Investigator (AI)), Cheong, J. L. Y. (Associate Investigator (AI)), Miller, S. (Associate Investigator (AI)), Polglase, G. (Associate Investigator (AI)), Crossley, K. (Associate Investigator (AI)), Morgan, K. (Associate Investigator (AI)) & Galinsky, R. (Associate Investigator (AI))
1/01/22 → 31/12/26
Project: Research
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Improving the neonatal transition in infants with a congenital diaphragmatic hernia
Hodges, R. (Primary Chief Investigator (PCI)), Crossley, K. (Chief Investigator (CI)), Hooper, S. (Chief Investigator (CI)), DeKoninck, P. (Chief Investigator (CI)) & Kashyap, A. (Chief Investigator (CI))
Congenital Diaphragmatic Hernia Australia
19/03/20 → 19/03/21
Project: Research
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Reducing the risk of pulmonary hypertension in infants with a congenital diaphragmatic hernia.
Crossley, K. (Primary Chief Investigator (PCI)), DeKoninck, P. (Chief Investigator (CI)), Hodges, R. (Chief Investigator (CI)) & Thió-Lluch, M. (Chief Investigator (CI))
1/01/20 → 31/12/23
Project: Research
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Identifying mechanisms to improve newborn respiratory function using phase contrast X-ray imaging
Hooper, S. (Primary Chief Investigator (PCI)), Kitchen, M. (Chief Investigator (CI)), McGillick, E. (Chief Investigator (CI)), Wallace, M. (Chief Investigator (CI)), Crossley, K. (Chief Investigator (CI)), te Pas, A. B. (Chief Investigator (CI)), Pearson, J. (Chief Investigator (CI)), Robert, L. (Chief Investigator (CI)), Yagi, N. (Chief Investigator (CI)) & Uesugi, K. (Chief Investigator (CI))
14/02/18 → 14/02/20
Project: Research
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Optimising CPAP and oxygen levels to support spontaneous breathing in preterm rabbits
Cannata, E. R., Crossley, K. J., McGillick, E. V., Wallace, M. J., Croughan, M. K., Jurkschat, D., Cramer, S. J. E., te Pas, A. B., Hooper, S. B. (Leading Author) & Kitchen, M. J., Mar 2026, In: Pediatric Research. 99, 4, p. 1583–1590 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
3DMPR – a robust morphological approach for applying phase retrieval in proximity to highly attenuating objects in computed tomography
Pollock, J. A., Croton, L. C. P., Morgan, K., Crossley, K. J., Wallace, M. J., Buckley, G. A., Hooper, S. B. & Kitchen, M. J., Sept 2025, In: Journal of Synchrotron Radiation. 32, 5, p. 1319-1327 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A small constant external negative pressure improves lung aeration at birth in rabbit kittens with a diaphragmatic hernia
Riddington, P. J. (Leading Author), DeKoninck, P. L. J., Davies, I. M., Jurkschat, D., Wallace, M. J., Dekker, J., te Pas, A. B., Kitchen, M. J., Hooper, S. B. & Crossley, K. J. (Leading Author), Aug 2025, In: Journal of Applied Physiology. 139, 2, p. 582-593 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology
Stainsby, A. V., DeKoninck, P. L. J., Crossley, K. J., Thiel, A., Wallace, M. J., Pearson, J. T., Kashyap, A. J., Croughan, M. K., Allison, B. A., Hodges, R., Thio, M., Flemmer, A. W., McGillick, E. V., te Pas, A. B., Hooper, S. B. & Kitchen, M. J., Apr 2025, In: Anatomical Record. 308, 4, p. 1082-1093 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Link opens in a new tab Citations (Scopus) -
Erratum: Correction: Multicentre, randomised controlled trial of physiological-based cord clamping versus immediate cord clamping in infants with a congenital diaphragmatic hernia (PinC): statistical analysis plan (Trials (2024) 25 1 DOI: 10.1186/s13063-024-08027-7.)
Horn-Oudshoorn, E. J. J., Vermeulen, M. J., Knol, R., Bout-Rebel, R., Pas, A. B. T., Hooper, S. B., Otter, S. C. M. C. D., Wijnen, R. M. H., Crossley, K. J., Rafat, N., Schaible, T., de Boode, W. P., Debeer, A., Urlesberger, B., Roberts, C. T., Kipfmueller, F., Capolupo, I., Burgos, C. M., Hansen, B. E. & Reiss, I. K. M. & 1 others, , 3 Jul 2025, In: Trials. 26, 1, p. 235 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access