Projects per year
Personal profile
Biography
Dr Kelly Crossley is a perinatal physiologist focussed on improving the fetal to neonatal transition in all infants requiring assistance at birth. Her research is particularly focussed on understanding how the respiratory and cardiovascular systems interact causing brain injury.
Dr Crossley is a leading expert in the development and use of the most advanced animal models in perinatal research. With over 19 years’ experience, she has developed a unique skill set using a multi-pronged approach investigating newborn physiology and biomedical imaging in collaboration with physiologists, clinicians and physicists. Her research utilises both the Australian and Japanese synchrotrons as well as sophisticated pre-clinical models in rabbits and sheep.
More recently, Dr Crossley has been involved in biomedical imaging experiments that provide evidence of fundamental mechanisms regulating the transition from fetal to newborn life. Specifically, identifying interventions to improve spontaneous breathing in premature newborns. This pre-clinical evidence has led to a current clinical trial focussed on the effect of oxygenation during resuscitation on promoting spontaneous breathing in premature newborns. Her current involvement in projects focussed on improving respiratory and cardiovascular outcomes for newborns with a congenital diaphragmatic hernia and transient tachypnoea of the newborn have uncovered previously unrealised mechanisms underpinning complications at birth and identifying interventions that can be translated into future clinical trials to improve outcomes for these newborns.
Senior Reserch Fellow
Fetal and Neonatal Health Research Group, The Ritchie centre, Hudson Institute of Medical Research.
Adjunct Senior Resaerch Fellow, Department of Obstetrics and Gynaecology, Monash University.
Education/Academic qualification
Bachelor of Science Honours, The role of progesterone in the regulation of fetal behavioural states, MONASH UNIVERSITY
1991 → 1995
Research area keywords
- Preterm birth
- lung development
- Brain development
- Respiratory Physiology
- Cardiovascular Physiology
- preterm infant
- congenital diaphragmatic hernia
- transition at birth
- Imaging studies
- Mechanical ventilation
- Fetal & Neonatal Physiology
- fetal and neonatal circulation and brain injury
- Neonatal resuscitation
- Synchrotron Imaging
Collaborations and top research areas from the last five years
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Reducing the burden of respiratory distress after caesarean delivery.
Crossley, K., Hooper, S., Kitchen, M., te Pas, A. B., Wallace, M., Tran, N., Polglase, G. & Thio, M.
1/01/23 → 31/12/26
Project: Research
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Phase-Contrast Neuroimaging for Early Detection of Brain Injury at Birth
Kitchen, M., Croton, L., Hooper, S., Cheong, J. L. Y., Miller, S., Polglase, G., Crossley, K., Morgan, K. & Galinsky, R.
1/01/22 → 31/12/26
Project: Research
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Improving the neonatal transition in infants with a congenital diaphragmatic hernia
Hodges, R., Crossley, K., Hooper, S., DeKoninck, P. & Kashyap, A.
Congenital Diaphragmatic Hernia Australia
19/03/20 → 19/03/21
Project: Research
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Reducing the risk of pulmonary hypertension in infants with a congenital diaphragmatic hernia.
Crossley, K., DeKoninck, P., Hodges, R. & Thio, M.
1/01/20 → 31/12/23
Project: Research
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Identifying mechanisms to improve newborn respiratory function using phase contrast X-ray imaging
Hooper, S., Kitchen, M., McGillick, E., Wallace, M., Crossley, K., te Pas, A. B., Pearson, J., Robert, L., Yagi, N. & Uesugi, K.
14/02/18 → 14/02/20
Project: Research
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Assessing the influence of abdominal compression on time to return of circulation during resuscitation of asphyxiated newborn lambs: a randomised preclinical study
Polglase, G. R., Hwang, C., Blank, D. A., Badurdeen, S., Crossley, K. J., Kluckow, M., Gill, A. W., Camm, E., Galinsky, R., Brian, Y., Hooper, S. B. & Roberts, C. T., 19 Jun 2024, In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 109, 4, p. 405-411 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Endotracheal epinephrine at standard versus high dose for resuscitation of asystolic newborn lambs
Polglase, G. R., Brian, Y., Tantanis, D., Blank, D. A., Badurdeen, S., Crossley, K. J., Kluckow, M., Gill, A. W., Camm, E., Galinsky, R., Thomas Songstad, N., Klingenberg, C., Hooper, S. B. & Roberts, C. T., May 2024, In: Resuscitation. 198, 9 p., 110191.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Extended period of ventilation before umbilical cord clamping at birth: A study that mis-interprets and mis-represents the physiology
Hooper, S. B., Crossley, K. J., Blank, D. A., Davies, I. M., Polglase, G. R. & te Pas, A. B., 1 Sept 2024, In: The Journal of Physiology. 602, 17, p. 4327-4328 2 p.Research output: Contribution to journal › Letter › Other › peer-review
2 Citations (Scopus) -
Multicentre, randomised controlled trial of physiological-based cord clamping versus immediate cord clamping in infants with a congenital diaphragmatic hernia (PinC): statistical analysis plan
Horn-Oudshoorn, E. J. J., Vermeulen, M. J., Knol, R., Bout-Rebel, R., te Pas, A. B., Hooper, S. B., Otter, S. C. M. C. D., Wijnen, R. M. H., Crossley, K. J., Rafat, N., Schaible, T., de Boode, W. P., Debeer, A., Urlesberger, B., Roberts, C. T., Kipfmueller, F., Capolupo, I., Burgos, C. M., Hansen, B. E., Reiss, I. K. M., & 1 others , Dec 2024, In: Trials. 25, 1, 12 p., 198.Research output: Contribution to journal › Article › Other › peer-review
Open Access -
Assessing lung aeration using ultrasound after birth in near-term lambs at risk of respiratory distress
Pryor, E. J., Davies, I. M., Crossley, K. J., Thiel, A. M., McGillick, E. V., Rodgers, K., Nitsos, I., Kitchen, M. J., Blank, D. A. & Hooper, S. B., 2023, In: Frontiers in Pediatrics. 11, p. 1-10 10 p., 1148443.Research output: Contribution to journal › Article › Research › peer-review
Open Access