If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Position

Principal Investigator, Class C GPCR Lab head
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Biography

I am co-lab head of the Class C G protein-coupled receptor (GPCR) laboratory, which is primarily interested in understanding the structure, function, physiology and therapeutic targeting of metabotropic glutamate receptors and the calcium sensing receptor. The Class C GPCR group is interested in the modulation of this protein family by endogenous and exogenous allosteric ligands that bind to sites distinct from that of the primary endogenous (orthosteric) agonist.

Supervision interests

Honours project supervision:

  1. Probing negative allosteric modulator binding sites in the human calcium sensing receptor. Current.
  2. Allosteric modulation of the calcium sensing receptor. H2 honours, 2015.
  3. Structure-function studies of the human calcium sensing receptor. H1 honours, 2010.
  4. Pharmacological characterisation of novel allosteric ligands acting at the M1 muscarinic acetylcholine receptor. H1 honours, 2009.
  5. Structure-function studies of the M4 muscarinic acetylcholine receptor. H1 honours, Dux of Year, 2008.
  6. Muscarinic M4 receptor interactions with GSK-3: possible targets for the treatment of schizophrenia. H2a honours, 2008.
  7. Pharmacological characterisation of a M4 muscarinic acetylcholine “Designer Receptor Exclusively Activated by Designer Drugs” (DREADD). H1 honours, Dux of Year, 2007.

Masters project supervision:

  1. Probing an allosteric binding site in the human calcium sensing receptor. Final year Pharmacy masters project, 2013-2014 – awarded M.Pharm with distinction
  2. Effects of two naturally occurring amino acid mutations on the pharmacoregulation of the human calcium sensing receptor. Second year Bioengineering masters project, 2010-2011 – awarded MSc. with distinction

PhD project supervision:

  1. Allosteric modulation and stimulus-bias at CB1 cannabinoid receptors.  PhD 2012-2015 – awarded PhD.
  2. Stimulus-bias at the calcium sensing receptor.  PhD 2009-2013 – awarded PhD.

Research area keywords

  • G protein-coupled receptors
  • calcium sensing receptor
  • allosterism
  • molecular pharmacology
  • structure-function
  • drug-receptor interactions
  • biased agonism
  • Class C GPCR

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2022

Research Output 2007 2020

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites

Gregory, K., Giraldo, J., Diao, J., Christopoulos, A. & Leach, K., 2020, In : Molecular Pharmacology. 97, 1, p. 35-45 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabotropic glutamate receptor 5 (mGlu5)-positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons

Hellyer, S. D., Albold, S., Sengmany, K., Singh, J., Leach, K. & Gregory, K. J., 1 Jan 2019, In : Journal of Neurochemistry. 151, 3, p. 301-315 15 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

Trinh, P. N. H., May, L. T., Leach, K. & Gregory, K. J., 15 Nov 2018, In : Clinical science (London, England : 1979). 132, 21, p. 2323-2338 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Activities 2011 2011

  • 1 Submissions to industry or govt committees, commissions and inquiries

Drug Discovery Biology

Katie Leach (Member)
29 Nov 2011

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries