Projects per year
Personal profile
Biography
Dr Lawlor received her PhD in Medical Biology in 2004 at the Walter and Eliza Hall Institute of Medical Research and The University of Melbourne. After being awarded an NHMRC CJ Martin Overseas Biomedical Fellowship, she completed postdoctoral research at the Cambridge Institute for Medical Research, University of Cambridge, UK and the Walter and Eliza Hall Institute, most recently in the laboratory of Dr James Vince. During this time she established expertise in the molecular and cellular dissection of inflammatory signalling pathways, and the translation of these findings in vivo using models of autoimmune, inflammatory and infectious diseases. In 2018, she was recruited to head the Cell Death and Inflammatory Signalling group within the Centre for Innate Immunity and Infectious Diseases at the Hudson Institute.
Research interests
The Cell Death and Inflammatory Signalling group aims to identify new molecules that regulate cell death and inflammatory signalling. We also seek to establish whether cell death signalling can be inhibited therapeutically to treat inflammatory disease, or triggered to promote antimicrobial responses.
Dr Lawlor and her team investigate the cross-talk between programmed cell death and inflammatory signalling pathways in disease. In particular, the laboratory studies how cell death induces activation of innate immune cell pattern recognition receptors (PRRs), including the inflammasomes. Inflammasomes are now known to activate pro-inflammatory protein Interleukin-1β (IL-1β) to induce a lytic form of cell death, called pyroptosis. This activity is critical for clearance of microbial organisms by the immune system. However, excess IL-1β activity can exacerbate rare hereditary autoinflammatory syndromes and common diseases, such as rheumatoid arthritis, type 2 diabetes and cancer.
External positions
Honorary Fellow, Walter and Eliza Hall Institute of Medical Research (WEHI)
Research area keywords
- innate immunity
- Inflammasomes
- Cell death
- Inflammatory diseases
- Signalling pathways
- Infection and immunity
- Autoimmune Diseases
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
- 5 Active
Role of A1 in repressing mitochondrial apoptosis to limit pathogen clearance
1/01/20 → 31/12/22
Project: Research
Investigating the roles of non-coding RNAs in inflammatory signalling and cancer
Conos, S. & Lawlor, K.
5/08/19 → 28/02/22
Project: Research
Role of programmed cell death in NLRP3 inflammasome activation and Metabolic Syndrome
1/01/19 → 31/12/21
Project: Research
Unconventional mechanisms for activating the NLRP3 inflammasome
Vince, J., Murphy, J. M., Lawlor, K. & Lindqvist, L. M.
1/01/18 → 31/12/20
Project: Research
Research Output
Editorial: Immunomodulation of innate immune cells
Almeida, C. R., Bottazzi, B., De Nardo, D. & Lawlor, K. E., 11 Feb 2020, In : Frontiers in Immunology. 3 p., 101.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access
File
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Lalaoui, N., Boyden, S. E., Oda, H., Wood, G. M., Stone, D. L., Chau, D., Liu, L., Stoffels, M., Kratina, T., Lawlor, K. E., Zaal, K. J. M., Hoffmann, P. M., Etemadi, N., Shield-Artin, K., Biben, C., Tsai, W. L., Blake, M. D., Kuehn, H. S., Yang, D., Anderton, H. & 34 others, , 2 Jan 2020, In : Nature. 577, 7788, p. 103-108 6 p.Research output: Contribution to journal › Article › Research › peer-review
11
Citations
(Scopus)
Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
Speir, M., Nowell, C. J., Chen, A. A., O’Donnell, J. A., Shamie, I. S., Lakin, P. R., D’Cruz, A. A., Braun, R. O., Babon, J. J., Lewis, R. S., Bliss-Moreau, M., Shlomovitz, I., Wang, S., Cengia, L. H., Stoica, A. I., Hakem, R., Kelliher, M. A., O’Reilly, L. A., Patsiouras, H., Lawlor, K. E. & 5 others, , 1 Jan 2020, In : Nature Immunology. 21, 1, p. 54-64 11 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Balka, K. R., Louis, C., Saunders, T. L., Smith, A. M., Calleja, D. J., D'Silva, D. B., Moghaddas, F., Tailler, M., Lawlor, K. E., Zhan, Y., Burns, C. J., Wicks, I. P., Miner, J. J., Kile, B. T., Masters, S. L. & De Nardo, D., 7 Apr 2020, In : Cell Reports. 31, 1, 22 p., 107492.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling
Liu, X., D'Cruz, A. A., Hansen, J., Croker, B. A., Lawlor, K. E., Sims, N. A. & Wicks, I. P., Oct 2019, In : Osteoarthritis and Cartilage. 27, 10, p. 1557-1563 7 p.Research output: Contribution to journal › Article › Research › peer-review
1
Citation
(Scopus)