20042018
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Personal profile

Biography

My research is focused on developing a "designer" stem cell therapy for stroke using a non-human primate model. Our approach combines cell therapy with gene therapy to create designer cells for transplantation. Specifically, my work involves genetically engineering stem cells to ensure their safety and enhance their therapeutic function. We hope this research will accelerate the translation of cell therapies into human clinical trials.

 

I also have a long-standing interest in understanding the intrinsic and extrinsic factors that govern cell fate. In particular, I am interested in understanding how stem cells are regulated and behave in various native and artificially induced states of pluripotency. My previous work with Wnt/beta-catenin signaling sparked this interest, since Wnt signaling can act as both a positive or negative regulator of stem cell self-renewal, depending on the pluripotent state. Greater knowledge of the process of cell state change may enable us to generate alternative cell types with therapeutic relevance.

Keywords

  • Stem cells
  • Reprogramming
  • Pluripotent stem cells
  • Neuroplasticity
  • Regenerative medicine
  • Cell therapies
  • Wnt signal transduction
  • Stem cell differentiation
  • Non-human primates
  • Neurodegeneration
  • Developmental biology

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Projects 2004 2004

Research Output 2007 2018

Fine tuning of canonical Wnt stimulation enhances differentiation of pluripotent stem cells independent of β-catenin-mediated T-cell factor signalling

Chen, J., Nefzger, C. M., Rossello, F., Sun, Y. B. Y., Lim, S. M., Liu, X., De Boer, S., Knaupp, A. S., Li, J., Davidson, K. C., Polo, J. M. & Barberi, T., Jun 2018, In : Stem Cells. 36, 6, p. 822-833 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Defined Medium Conditions for the Induction and Expansion of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

Lidgerwood, G. E., Lim, S. Y., Crombie, D. E., Ali, R., Gill, K. P., Hernández, D., Kie, J., Conquest, A., Waugh, H. S., Wong, R. C. B., Liang, H. H., Hewitt, A. W., Davidson, K. C. & Pébay, A., 1 Apr 2016, In : Stem Cell Reviews. 12, 2, p. 179-188 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Stem cell surface marker expression defines late stages of reprogramming to pluripotency in human fibroblasts

Pomeroy, J. E., Hough, S. R., Davidson, K. C., Quaas, A. M., Rees, J. A. & Pera, M. F., Jul 2016, In : Stem Cells Translational Medicine. 5, 7, p. 870-882 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells

Xu, Z., Robitaille, A. M., Berndt, J. D., Davidson, K. C., Fischer, K. A., Mathieu, J., Potter, J. C., Ruohola-Baker, H. & Moon, R. T., 18 Oct 2016, In : Proceedings of the National Academy of Sciences. 113, 42, p. E6382-E6390 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Characterization of the retinal pigment epithelium in Friedreich ataxia

Crombie, D. E., Van Bergen, N. J., Davidson, K. C., Anjomani-Virmouni, S., McKelvie, P. A., Chrysostomou, V., Conquest, A., Corben, L. A., Pook, M. A., Kulkarni, T., Trounce, I. A., Pera, M. F., Delatycki, M. & Pebay, A., 2015, In : Biochemistry and Biophysics Reports. 4, p. 141 - 147 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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