If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Activin A determines steroid levels and composition in the fetal testis

Whiley, P. A. F., O'Donnell, L., Moody, S. C., Handelsman, D. J., Young, J. C., Richards, E. A., Almstrup, K., Western, P. S. & Loveland, K. L., 10 Apr 2020, (Accepted/In press) In : Endocrinology. 41 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse

Klein, B., Bhushan, S., Gunther, S., Middendorff, R., Loveland, K. L., Hedger, M. P. & Meinhardt, A., 24 Apr 2020, In : Molecular Human Reproduction. 26, 4, p. 215-227 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2019

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model

Klein, B., Pant, S., Bhushan, S., Kautz, J., Rudat, C., Kispert, A., Pilatz, A., Wijayarathna, R., Middendorff, R., Loveland, K., Hedger, M. & Meinhardt, A., 8 Jul 2019, In : Human Reproduction. 34, 7, p. 1195-1205 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamic paraspeckle component localisation during spermatogenesis

Major, A. T., Hogarth, C. A., Young, J. C., Kurihara, Y., Jans, D. A. & Loveland, K. L., 1 Sep 2019, In : Reproduction. 158, 3, p. 267-280 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Lepletier, A., Hun, M. L., Hammett, M. V., Wong, K., Naeem, H., Hedger, M., Loveland, K. & Chidgey, A. P., 25 Jun 2019, In : Cell Reports. 27, 13, p. 3887–3901–e4 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis

Kauerhof, A. C., Nicolas, N., Bhushan, S., Wahle, E., Loveland, K. A., Fietz, D., Bergmann, M., Groome, N. P., Kliesch, S., Schuppe, H-C., Pilatz, A., Meinhardt, A., Hedger, M. P. & Fijak, M., 1 Aug 2019, In : Human Reproduction. 34, 8, p. 1536-1550 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens

Wijayarathna, R., de Kretser, D. M., Sreenivasan, R., Ludlow, H., Middendorff, R., Meinhardt, A., Loveland, K. L. & Hedger, M. P., 1 Jan 2018, In : Reproduction. 155, 1, p. 15-23 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Differential expression profiles of conserved Snail transcription factors in the mouse testis

Micati, D. J., Hime, G. R., McLaughlin, E. A., Abud, H. E. & Loveland, K. L., 1 Mar 2018, In : Andrology. 6, 2, p. 362-373 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress

Miyamoto, Y., Whiley, P. A. F., Goh, H., Wong, C. L., Tachibana, T., McMenamin, P. G., Mayne, L. & Loveland, K. A. L., 1 Jan 2018, In : Biology Open. 7, 8, 12 p., bio032631.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., Loveland, K. L., Meinhardt, A., de Kretser, D. M. & Hedger, M. P., May 2017, In : Andrology. 5, 3, p. 578-588 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract

Wijayarathna, R., de Kretser, D. M., Meinhardt, A., Middendorff, R., Ludlow, H., Groome, N. P., Loveland, K. A. & Hedger, M. P., 15 Jul 2017, In : Molecular and Cellular Endocrinology. 470, p. 188-198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

An in vitro model demonstrates the potential of neoplastic human germ cells to influence the tumour microenvironment

Klein, B., Schuppe, H. -C., Bergmann, M., Hedger, M. P., Loveland, B. E. & Loveland, K. L., Jul 2017, In : Andrology. 5, 4, p. 763-770 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins

Major, A. T., Miyamoto, Y., Lo, C. Y., Jans, D. A. & Loveland, K. L., 27 Feb 2017, In : Scientific Reports. 7, 18 p., 43323.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Induction of EAO in mice: responses to 2 elevated circulating levels of the activin-binding protein, follistatin

Nicholas, N., Muir, J. A., Hayward, S., Chen, J. L., Stanton, P. G., Gregorevic, P., de Kretser, D. M., Loveland, K. L., Bhushan, S., Meinhardt, A., Fijak, M. & Hedger, M. P., 1 Sep 2017, In : Reproduction. 154, 3, p. 293-305 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Interactome of the inhibitory isoform of the nuclear transporter Importin 13

Fatima, S., Wagstaff, K. M., Lieu, K. G., Davies, R. G., Tanaka, S. S., Yamaguchi, Y. L., Loveland, K. L., Tam, P. P. L. & Jans, D. A., 1 Mar 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 3, p. 546-561 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Signaling by TGF-betas in tubule cultures of adult rat testis

Chan, K. H., Galuska, S. P., Kudipudi, P. K., Riaz, M. A., Loveland, K. L. & Konrad, L., 2017, In : American Journal of Translational Research. 9, 3, p. 1173-1182 10 p., AJTR0034593.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice

Haverfield, J. T., Stanton, P. G., Loveland, K. L., Zahid, H., Nicholls, P. K., Olcorn, J. S., Makanji, Y., Itman, C. M., Simpson, E. R. & Meachem, S. J., 2017, In : Reproduction, Fertility and Development. 29, 3, p. 609-620 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice

Nicolas, N., Michel, V., Bhushan, S., Wahle, E., Hayward, S., Ludlow, H., De Kretser, D. M., Loveland, K., Schuppe, H. C., Meinhardt, A., Hedger, M. P. & Fijak, M., 13 Feb 2017, In : Scientific Reports. 7, 42391.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)
2016

Prepubertal Di-n-Butyl phthalate exposure alters Sertoli and Leydig cell function and lowers bone density in adult male mice

Bielanowicz, A., Johnson, R. W., Goh, H., Moody, S. C., Poulton, I. J., Croce, N., Loveland, K. L., Hedger, M. P., Sims, N. A. & Itman, C., Jul 2016, In : Endocrinology. 157, 7, p. 2595-2603 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, C. E., Murphy, K. T., Bernardo, B. C., Qian, H., Liu, Y., Sepulveda, P. V., Beyer, C., Hagg, A., Thomson, R. E., Chen, J. L., Walton, K. L., Loveland, K. L., McMullen, J. R., Rodgers, B. D., Harrison, C. A., Lynch, G. S. & Gregorevic, P., 20 Jul 2016, In : Science Translational Medicine. 8, 348, 12 p., 348ra98.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia

Klein, B., Haggeney, T., Fietz, D., Indumathy, S., Loveland, K. L., Hedger, M., Kliesch, S., Weidner, W., Bergmann, M. & Schuppe, H-C., 1 Oct 2016, In : Human Reproduction. 31, 10, p. 2192-2202 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis

Michel, V., Duan, Y., Stoschek, E., Bhushan, S., Middendorff, R., Young, J. M., Loveland, K. L., Kretser, D. M. D., Hedger, M. P. & Meinhardt, A., 1 Sep 2016, In : Journal of Pathology. 240, 1, p. 15-24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2015

Changing expression and subcellular distribution of karyopherins during murine oogenesis

Mihalas, B. P., Western, P. S., Loveland, K. A. L., McLaughlin, E. A. & Holt, J., 2015, In : Reproduction. 150, 6, p. 485 - 496 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2

Fatima, S., Wagstaff, K. M., Loveland, K. A. L. & Jans, D. A., 2015, In : Scientific Reports. 5, 9 p., 9459.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Murine inhibin alpha-subunit haploinsufficiency causes transient abnormalities in prepubertal testis development followed by adult testicular decline

Itman, C. M., Bielanowicz, A., Goh, H., Lee, Q. C. Y., Fulcher, A. J., Moody, S. C., Doery, J. C. G., Martin, J., Eyre, S., Hedger, M. P. & Loveland, K. A. L., 2015, In : Endocrinology. 156, 6, p. 2254 - 2268 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis

Loveland, K. A. L., Major, A. T., Butler, R. L. M., Young, J. C., Jans, D. A. & Miyamoto, Y., 2015, In : Asian Journal of Andrology. 17, 4, p. 537 - 544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

Specific interaction with the nuclear transporter importin alpha2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles

Major, A. T., Hogarth, C. A., Miyamoto, Y., Sarraj, M., Smith, C. L., Koopman, P. A., Kurihara, Y., Jans, D. A. & Loveland, K. A. L., 2015, In : Molecular Biology of the Cell. 26, 8, p. 1543 - 1558 16 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2014

Dynamic Hedgehog signalling pathway activity in germline stem cells

Sahin, Z., Szczepny, A., McLaughlin, E. A., Meistrich, M. L., Zhou, W., Ustunel, I. & Loveland, K. A. L., 2014, In : Andrology. 2, 2, p. 267 - 274 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche

Jorgensen, A., Young, J. C., Nielsen, J., Joensen, U. N., Toft, B. G., Rajpert-De Meyts, E. & Loveland, K. A. L., 2014, In : British Journal of Cancer. 110, 10, p. 2604 - 2614 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Overlapping binding sites for importin b1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization

Szczepny, A., Wagstaff, K. M., Dias, M., Gajewska, K. A., Wang, C., Davies, R. G., Kaur, G., Ly Huynh, J. D., Loveland, K. A. L. & Jans, D. A., 2014, In : Biochemical Journal. 461, 3, p. 469 - 476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Regulated Wnt/beta-catenin signaling sustains adult spermatogenesis in mice

Kerr, G. E., Young, J. C., Horvay, K., Abud, H. E. & Loveland, K. A. L., 2014, In : Biology of Reproduction. 90, 1 (Art. No.:3), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development

Bryant, S. L., Francis, J. C., Lokody, I. B., Wang, H., Risbridger, G. P., Loveland, K. A. L. & Swain, A., 2014, In : Developmental Biology. 395, 2, p. 209 - 217 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The alpha-importome of mammalian germ cell maturation provides novel insights for importin biology

Arjomand, A., Baker, M. A., Li, C., Buckle, A. M., Jans, D. A., Loveland, K. A. L. & Miyamoto, Y., 2014, In : The FASEB Journal. 28, 8, p. 3480 - 3493 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2013

A survey of Sertoli cell differentiation in men after gonadotropin suppression and in testicular cancer

Tarulli, G. A., Stanton, P. G., Loveland, K. A. L., Rajpert-De Meyts, E., McLachlan, R. I. & Meachem, S. J., 2013, In : Spermatogenesis. 3, 1 (e24014), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Hidden gems in the niche: a new approach to the study of spermatogonial stem cells

Loveland, K. A. L. & McLaughlin, E. A., 2013, In : Asian Journal of Andrology. 15, 2, p. 214 - 215 2 p.

Research output: Contribution to journalArticleOther

Prepubertal mouse testis growth and maturation and androgen production are acutely sensitive to di-n-butyl phthalate

Moody, S., Goh, H., Bielanowicz, A., Rippon, P., Loveland, K. A. L. & Itman, C. M., 2013, In : Endocrinology. 154, 9, p. 3460 - 3475 16 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Smads and cell fate: distinct roles in specification, development, and tumorigenesis in the testis

Itman, C. M. & Loveland, K. A. L., 2013, In : IUBMB Life. 65, 2, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The activin A antagonist follistatin inhibits asthmatic airway remodelling

Hardy, C. L., Nguyen, H-A. T., Mohamud, R., Yao, J. J., Oh, D. Y., Plebanski, M., Loveland, K. A. L., Harrison, C., Rolland, J. M. & O'Hehir, R. E., 2013, In : Thorax. 68, 1, p. 9 - 18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins

Davies, R., Wagstaff, K. M., McLaughlin, E. A., Loveland, K. A. L. & Jans, D. A., 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 12, p. 3436 - 3444 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis

McIver, S. C., Loveland, K. A. L., Roman, S. D., Nixon, B., Kitazawa, R. & McLaughlin, E. A., 2013, In : Andrology. 1, 3, p. 517 - 529 13 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

The nuclear import factor importin a4 can protect against oxidative stress

Young, J. C., Ly Huynh, J. D., Lescesen, H. E., Miyamoto, Y., Browne, C. M., Yoneda, Y., Koopman, P. A., Loveland, K. A. L. & Jans, D. A., 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 10, p. 2348 - 2356 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets

McIver, S. C., Roman, S. D., Nixon, B., Loveland, K. A. L. & McLaughlin, E. A., 2013, In : F1000Research. 2, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Towards delineation of a developmental α-importome in the mammalian male germline

Miyamoto, Y., Baker, M. A., Whiley, P. A. F., Arjomand, A., Ludeman, J. P., Wong, C. L., Jans, D. A. & Loveland, K. A. L., 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 3, p. 731-742 12 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2012

Activins and inhibins in mammalian testis development: new models, new insights

Barakat, B. M., Itman, C. M., Mendis, S. & Loveland, K. A. L., 2012, In : Molecular and Cellular Endocrinology. 359, 1-2, p. 66 - 77 12 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Changing subcellular localization of nuclear transport factors during human spermatogenesis

Whiley, P. A. F., Miyamoto, Y., McLachlan, R. I., Jans, D. & Loveland, K., 2012, In : International Journal of Andrology. 35, 2, p. 158 - 169 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Nuclear importin alpha and its physiological importance

Miyamoto, Y., Loveland, K. A. L. & Yoneda, Y., 2012, In : Communicative and Integrative Biology. 5, 2, p. 220 - 222 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

Nuclear retention of importin alpha coordinates cell fate through changes in gene expression

Yasuda, Y., Miyamoto, Y., Yamashiro, T., Asally, M., Masui, A., Wong, C., Loveland, K. A. L. & Yoneda, Y., 2012, In : The EMBO Journal. 31, 1, p. 83 - 94 12 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Regulated nucleocytoplasmic transport during gametogenesis

Miyamoto, Y., Boag, P., Hime, G. R. & Loveland, K. A. L., 2012, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1819, 6, p. 616 - 630 15 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2011

Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis

Mendis, S., Meachem, S. J., Sarraj, M. & Loveland, K., 2011, In : Biology of Reproduction. 84, 2, p. 379 - 391 13 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)