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Research Output 1985 2019

2019

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model

Klein, B., Pant, S., Bhushan, S., Kautz, J., Rudat, C., Kispert, A., Pilatz, A., Wijayarathna, R., Middendorff, R., Loveland, K., Hedger, M. & Meinhardt, A., 8 Jul 2019, In : Human Reproduction. 34, 7, p. 1195-1205 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamic paraspeckle component localization during spermatogenesis

Major, A. T., Hogarth, C. A., Young, J. C., Kurihara, Y., Jans, D. A. & Loveland, K., Jul 2019, (Accepted/In press) In : Reproduction.

Research output: Contribution to journalArticleResearchpeer-review

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Lepletier, A., Hun, M. L., Hammett, M. V., Wong, K., Naeem, H., Hedger, M., Loveland, K. & Chidgey, A. P., 25 Jun 2019, In : Cell Reports. 27, 13, p. 3887–3901–e4 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis

Kauerhof, A. C., Nicolas, N., Bhushan, S., Wahle, E., Loveland, K. A., Fietz, D., Bergmann, M., Groome, N. P., Kliesch, S., Schuppe, H-C., Pilatz, A., Meinhardt, A., Hedger, M. P. & Fijak, M., 24 Jul 2019, (Accepted/In press) In : Human Reproduction. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Activins in male reproduction

Loveland, K. A. L., 27 Jul 2018, Encyclopedia of Reproduction: Volume 1: Male Reproduction. Skinner, M. K. (ed.). 2nd ed. Oxford UK: Academic Press, Vol. 1. p. 208-214 7 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens

Wijayarathna, R., de Kretser, D. M., Sreenivasan, R., Ludlow, H., Middendorff, R., Meinhardt, A., Loveland, K. L. & Hedger, M. P., 1 Jan 2018, In : Reproduction. 155, 1, p. 15-23 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential expression profiles of conserved Snail transcription factors in the mouse testis

Micati, D. J., Hime, G. R., McLaughlin, E. A., Abud, H. E. & Loveland, K. L., 1 Mar 2018, In : Andrology. 6, 2, p. 362-373 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Testicular Cancer in Relation to Testicular Dysgenesis Syndrome

Loveland, K. L., Rajpert-De Meyts, E. & Veeramachaneni, D. N. R., 2018, Comprehensive Toxicology. McQueen, C. A. (ed.). 3rd ed. Netherlands: Elsevier, Vol. 4. p. 147-164 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress

Miyamoto, Y., Whiley, P. A. F., Goh, H., Wong, C. L., Tachibana, T., McMenamin, P. G., Mayne, L. & Loveland, K. A. L., 1 Jan 2018, In : Biology Open. 7, 8, 12 p., bio032631.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., Loveland, K. L., Meinhardt, A., de Kretser, D. M. & Hedger, M. P., May 2017, In : Andrology. 5, 3, p. 578-588 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract

Wijayarathna, R., de Kretser, D. M., Meinhardt, A., Middendorff, R., Ludlow, H., Groome, N. P., Loveland, K. A. & Hedger, M. P., 15 Jul 2017, In : Molecular and Cellular Endocrinology. 470, p. 188-198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

An in vitro model demonstrates the potential of neoplastic human germ cells to influence the tumour microenvironment

Klein, B., Schuppe, H. -C., Bergmann, M., Hedger, M. P., Loveland, B. E. & Loveland, K. L., Jul 2017, In : Andrology. 5, 4, p. 763-770 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytokines in male fertility and reproductive pathologies: Immunoregulation and beyond

Loveland, K. L., Klein, B., Pueschl, D., Indumathy, S., Bergmann, M., Loveland, B. E., Hedger, M. P. & Schuppe, H-C., 20 Nov 2017, In : Frontiers in Endocrinology. 8, NOV, 16 p., 307.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins

Major, A. T., Miyamoto, Y., Lo, C. Y., Jans, D. A. & Loveland, K. L., 27 Feb 2017, In : Scientific Reports. 7, 18 p., 43323.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Induction of EAO in mice: responses to 2 elevated circulating levels of the activin-binding protein, follistatin

Nicholas, N., Muir, J. A., Hayward, S., Chen, J. L., Stanton, P. G., Gregorevic, P., de Kretser, D. M., Loveland, K. L., Bhushan, S., Meinhardt, A., Fijak, M. & Hedger, M. P., 1 Sep 2017, In : Reproduction. 154, 3, p. 293-305 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Interactome of the inhibitory isoform of the nuclear transporter Importin 13

Fatima, S., Wagstaff, K. M., Lieu, K. G., Davies, R. G., Tanaka, S. S., Yamaguchi, Y. L., Loveland, K. L., Tam, P. P. L. & Jans, D. A., 1 Mar 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 3, p. 546-561 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Signaling by TGF-betas in tubule cultures of adult rat testis

Chan, K. H., Galuska, S. P., Kudipudi, P. K., Riaz, M. A., Loveland, K. L. & Konrad, L., 2017, In : American Journal of Translational Research. 9, 3, p. 1173-1182 10 p., AJTR0034593.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice

Haverfield, J. T., Stanton, P. G., Loveland, K. L., Zahid, H., Nicholls, P. K., Olcorn, J. S., Makanji, Y., Itman, C. M., Simpson, E. R. & Meachem, S. J., 2017, In : Reproduction, Fertility and Development. 29, 3, p. 609-620 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice

Nicolas, N., Michel, V., Bhushan, S., Wahle, E., Hayward, S., Ludlow, H., De Kretser, D. M., Loveland, K., Schuppe, H. C., Meinhardt, A., Hedger, M. P. & Fijak, M., 13 Feb 2017, In : Scientific Reports. 7, 42391.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

In the shadow of fibrosis: Innate immune suppression mediated by transforming growth factor-β

Thomas, B. J., Kan-o, K., Loveland, K., Elias, J. A. & Bardin, P. G., 1 Dec 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 6, p. 759-766 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Prepubertal Di-n-Butyl phthalate exposure alters Sertoli and Leydig cell function and lowers bone density in adult male mice

Bielanowicz, A., Johnson, R. W., Goh, H., Moody, S. C., Poulton, I. J., Croce, N., Loveland, K. L., Hedger, M. P., Sims, N. A. & Itman, C., Jul 2016, In : Endocrinology. 157, 7, p. 2595-2603 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, C. E., Murphy, K. T., Bernardo, B. C., Qian, H., Liu, Y., Sepulveda, P. V., Beyer, C., Hagg, A., Thomson, R. E., Chen, J. L., Walton, K. L., Loveland, K. L., McMullen, J. R., Rodgers, B. D., Harrison, C. A., Lynch, G. S. & Gregorevic, P., 20 Jul 2016, In : Science Translational Medicine. 8, 348, 12 p., 348ra98.

Research output: Contribution to journalArticleResearchpeer-review

Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia

Klein, B., Haggeney, T., Fietz, D., Indumathy, S., Loveland, K. L., Hedger, M., Kliesch, S., Weidner, W., Bergmann, M. & Schuppe, H-C., 1 Oct 2016, In : Human Reproduction. 31, 10, p. 2192-2202 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Spermatogenesis

de Kretser, D. M., Loveland, K. A. L. & O'Bryan, M. K., 2016, Endocrinology: Adult & Pediatric. Jameson, J. L., De Groot, L. J., de Kretser, D. M., Giudice, L. C., Grossman, A. B., Melmed, S., Potts Jr, J. T. & Weir, G. C. (eds.). 7th ed. Philadelphia PA USA: Elsevier, Vol. 1 and 2. p. 2325 - 2353 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis

Michel, V., Duan, Y., Stoschek, E., Bhushan, S., Middendorff, R., Young, J. M., Loveland, K. L., Kretser, D. M. D., Hedger, M. P. & Meinhardt, A., 1 Sep 2016, In : Journal of Pathology. 240, 1, p. 15-24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Activins and inhibins in Sertoli cell biology: implications for testis development and function

Loveland, K. L. & Hedger, M. P., 2015, Sertoli Cell Biology. Griswold, M. D. (ed.). 2nd ed. Amsterdam The Netherlands: Elsevier, p. 201-232 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Changing expression and subcellular distribution of karyopherins during murine oogenesis

Mihalas, B. P., Western, P. S., Loveland, K. A. L., McLaughlin, E. A. & Holt, J., 2015, In : Reproduction. 150, 6, p. 485 - 496 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2

Fatima, S., Wagstaff, K. M., Loveland, K. A. L. & Jans, D. A., 2015, In : Scientific Reports. 5, 9 p., 9459.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Murine inhibin alpha-subunit haploinsufficiency causes transient abnormalities in prepubertal testis development followed by adult testicular decline

Itman, C. M., Bielanowicz, A., Goh, H., Lee, Q. C. Y., Fulcher, A. J., Moody, S. C., Doery, J. C. G., Martin, J., Eyre, S., Hedger, M. P. & Loveland, K. A. L., 2015, In : Endocrinology. 156, 6, p. 2254 - 2268 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis

Loveland, K. A. L., Major, A. T., Butler, R. L. M., Young, J. C., Jans, D. A. & Miyamoto, Y., 2015, In : Asian Journal of Andrology. 17, 4, p. 537 - 544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Specific interaction with the nuclear transporter importin alpha2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles

Major, A. T., Hogarth, C. A., Miyamoto, Y., Sarraj, M., Smith, C. L., Koopman, P. A., Kurihara, Y., Jans, D. A. & Loveland, K. A. L., 2015, In : Molecular Biology of the Cell. 26, 8, p. 1543 - 1558 16 p.

Research output: Contribution to journalArticleResearchpeer-review

TGF-beta superfamily signaling in testis formation and early male germline development

Young, J. C., Wakitani, S. & Loveland, K. L., 2015, In : Seminars in Cell and Developmental Biology. 45, p. 94 - 103 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2014

Dynamic Hedgehog signalling pathway activity in germline stem cells

Sahin, Z., Szczepny, A., McLaughlin, E. A., Meistrich, M. L., Zhou, W., Ustunel, I. & Loveland, K. A. L., 2014, In : Andrology. 2, 2, p. 267 - 274 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche

Jorgensen, A., Young, J. C., Nielsen, J., Joensen, U. N., Toft, B. G., Rajpert-De Meyts, E. & Loveland, K. A. L., 2014, In : British Journal of Cancer. 110, 10, p. 2604 - 2614 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Overlapping binding sites for importin b1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization

Szczepny, A., Wagstaff, K. M., Dias, M., Gajewska, K. A., Wang, C., Davies, R. G., Kaur, G., Ly Huynh, J. D., Loveland, K. A. L. & Jans, D. A., 2014, In : Biochemical Journal. 461, 3, p. 469 - 476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulated Wnt/beta-catenin signaling sustains adult spermatogenesis in mice

Kerr, G. E., Young, J. C., Horvay, K., Abud, H. E. & Loveland, K. A. L., 2014, In : Biology of Reproduction. 90, 1 (Art. No.:3), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development

Bryant, S. L., Francis, J. C., Lokody, I. B., Wang, H., Risbridger, G. P., Loveland, K. A. L. & Swain, A., 2014, In : Developmental Biology. 395, 2, p. 209 - 217 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The alpha-importome of mammalian germ cell maturation provides novel insights for importin biology

Arjomand, A., Baker, M. A., Li, C., Buckle, A. M., Jans, D. A., Loveland, K. A. L. & Miyamoto, Y., 2014, In : FASEB Journal. 28, 8, p. 3480 - 3493 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A survey of Sertoli cell differentiation in men after gonadotropin suppression and in testicular cancer

Tarulli, G. A., Stanton, P. G., Loveland, K. A. L., Rajpert-De Meyts, E., McLachlan, R. I. & Meachem, S. J., 2013, In : Spermatogenesis. 3, 1 (e24014), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Hidden gems in the niche: a new approach to the study of spermatogonial stem cells

Loveland, K. A. L. & McLaughlin, E. A., 2013, In : Asian Journal of Andrology. 15, 2, p. 214 - 215 2 p.

Research output: Contribution to journalArticleOther

Prepubertal mouse testis growth and maturation and androgen production are acutely sensitive to di-n-butyl phthalate

Moody, S., Goh, H., Bielanowicz, A., Rippon, P., Loveland, K. A. L. & Itman, C. M., 2013, In : Endocrinology. 154, 9, p. 3460 - 3475 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Smads and cell fate: distinct roles in specification, development, and tumorigenesis in the testis

Itman, C. M. & Loveland, K. A. L., 2013, In : IUBMB Life. 65, 2, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The activin A antagonist follistatin inhibits asthmatic airway remodelling

Hardy, C. L., Nguyen, H-A. T., Mohamud, R., Yao, J. J., Oh, D. Y., Plebanski, M., Loveland, K. A. L., Harrison, C., Rolland, J. M. & O'Hehir, R. E., 2013, In : Thorax. 68, 1, p. 9 - 18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins

Davies, R., Wagstaff, K. M., McLaughlin, E. A., Loveland, K. A. L. & Jans, D. A., 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 12, p. 3436 - 3444 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis

McIver, S. C., Loveland, K. A. L., Roman, S. D., Nixon, B., Kitazawa, R. & McLaughlin, E. A., 2013, In : Andrology. 1, 3, p. 517 - 529 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The nuclear import factor importin a4 can protect against oxidative stress

Young, J. C., Ly Huynh, J. D., Lescesen, H. E., Miyamoto, Y., Browne, C. M., Yoneda, Y., Koopman, P. A., Loveland, K. A. L. & Jans, D. A., 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 10, p. 2348 - 2356 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets

McIver, S. C., Roman, S. D., Nixon, B., Loveland, K. A. L. & McLaughlin, E. A., 2013, In : F1000Research. 2, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Towards delineation of a developmental α-importome in the mammalian male germline

Miyamoto, Y., Baker, M. A., Whiley, P. A. F., Arjomand, A., Ludeman, J. P., Wong, C. L., Jans, D. A. & Loveland, K. A. L., 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 3, p. 731-742 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Activins and inhibins in mammalian testis development: new models, new insights

Barakat, B. M., Itman, C. M., Mendis, S. & Loveland, K. A. L., 2012, In : Molecular and Cellular Endocrinology. 359, 1-2, p. 66 - 77 12 p.

Research output: Contribution to journalArticleResearchpeer-review