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Research Output 1983 2019

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2019

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats

Walton, S. L., Tjongue, M., Tare, M., Kwok, E., Probyn, M., Parkington, H. C., Bertram, J. F., Moritz, K. M. & Denton, K. M., 22 Apr 2019, In : Biology of Sex Differences. 10, 1, 14 p., 21.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Sustained Decrease in Blood Pressure and Reduced Anatomical and Functional Reinnervation of Renal Nerves in Hypertensive Sheep 30 Months After Catheter-Based Renal Denervation

Singh, R. R., McArdle, Z. M., Iudica, M., Easton, L. K., Booth, L. C., May, C. N., Parkington, H. C., Lombardo, P., Head, G. A., Lambert, G., Moritz, K. M., Schlaich, M. P. & Denton, K. M., 1 Mar 2019, In : Hypertension. 73, 3, p. 718-727 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
4 Citations (Scopus)

Renal Denervation: A Treatment for Hypertension and Chronic Kidney Disease

Singh, R. R. & Denton, K. M., 1 Sep 2018, In : Hypertension. 72, 3, p. 528-536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2017
12 Citations (Scopus)

Catheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage

Singh, R. R., Sajeesh, V., Booth, L. C., McArdle, Z., May, C. N., Head, G. A., Moritz, K. M., Schlaich, M. P. & Denton, K. M., 28 Feb 2017, In : Journal of the American College of Cardiology. 69, 8, p. 951-964 14 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Effect of renal denervation on kidney function in patients with chronic kidney disease

Hering, D., Marusic, P., Duval, J., Sata, Y., Head, G. A., Denton, K. M., Burrows, S., Walton, A. S., Esler, M. D. & Schlaich, M. P., 1 Apr 2017, In : International Journal of Cardiology. 232, p. 93-97 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Relaxin contributes to the regulation of arterial pressure in adult female mice

Colafella, K. M. M., Samuel, C. S. & Denton, K. M., 28 Nov 2017, In : Clinical Science. 131, 23, p. 2795-2805 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Renal denervation promotes atherosclerosis in hypertensive apolipoprotein E-Deficient mice infused with angiotensin II

Wang, Y., Dinh, T. N., Nield, A., Krishna, S. M., Denton, K. & Golledge, J., 13 Apr 2017, In : Frontiers in Physiology. 8, 9 p., 215.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
18 Citations (Scopus)

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thone-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlof, B., Hallberg, A., Unger, T. & Steckelings, U. M., Aug 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
Open Access
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6 Citations (Scopus)

Renal nitric oxide deficiency and chronic kidney disease in young sheep born with a solitary functioning kidney

Singh, R. R., Easton, L. K., Booth, L. C., Schlaich, M. P., Head, G. A., Moritz, K. M. & Denton, K. M., 26 May 2016, In : Scientific Reports. 6, 11 p., 26777.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Sex- and age-related differences in arterial pressure and albuminuria in mice

Barsha, G., Denton, K. M. & Mirabito Colafella, K. M., 14 Nov 2016, In : Biology of Sex Differences. 7, 1, 15 p., 57.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
Open Access
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2015
17 Citations (Scopus)

Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

Black, M. J., Lim, K. J., Zimanyi, M. A., Sampson, A. K., Bubb, K. J., Flower, R. L., Parkington, H. C., Tare, M. & Denton, K. M., 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309, 9, p. 1153 - 1161 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

High-dose estradiol-replacement therapy enhances the renal vascular response to angiotensin II via an AT2-receptor dependent mechanism

Safari, T., Nematbakhsh, M., Evans, R. G. & Denton, K. M., 2015, In : Advances in Pharmacological Sciences. 2015, 7 p., 682745.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)

Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

Lankadeva, Y. R., Singh, R. R., Moritz, K. M., Parkington, H. C., Denton, K. M. & Tare, M., 2015, In : Circulation. 131, 3, p. 280 - 288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Role of the kidney in the fetal programming of adult cardiovascular disease: an update

Singh, R. R. & Denton, K. M., 2015, In : Current Opinion in Pharmacology. 21, p. 53 - 59 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

Del Borgo, M. P., Wang, Y., Bosnyak, S., Walters, P. E., Spizzo, I., Perlmutter, P., Hilliard, L. M., Denton, K. M., Aguilar, M-I. M., Widdop, R. E. & Jones, E. S., 2015, In : Clinical Science. 129, 6, p. 505 - 513 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
27 Citations (Scopus)

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats

Hilliard, L. M., Chow, C. L. E., Mirabito, K. M., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2014, In : Hypertension. 64, 2, p. 378 - 383 6 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Compensatory responses to nephron deficiency: adaptive or maladaptive?

Fong, D. S. Y., Denton, K. M., Moritz, K. M., Evans, R. G. & Singh, R. R., 2014, In : Nephrology. 19, 3, p. 119 - 128 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Impaired ability to modulate glomerular filtration rate in aged female sheep following fetal uninephrectomy

Lankadeva, Y. R., Singh, R. R., Hilliard, L. M., Moritz, K. M. & Denton, K. M., 2014, In : Physiological Reports. 2, 1 (Art. No.: e00208), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)

Loss of a kidney during fetal life: long-term consequences and lessons learned

Lankadeva, Y. R., Singh, R. R., Tare, M., Moritz, K. M. & Denton, K. M., 2014, In : American Journal of Physiology - Renal Physiology. 306, 8, p. 791 - 800 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
Open Access
File
6 Citations (Scopus)

Reduced sensitivity of the renal vasculature to angiotensin II in young rats: the role of the angiotensin type 2 receptor

Brown, R. D., Hilliard, L. M., Mirabito, K. M., Firth, L. C., Moritz, K. M., Evans, R. G. & Denton, K. M., 2014, In : Pediatric Research. 76, 5, p. 448 - 452 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
28 Citations (Scopus)

Sex-and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor

Mirabito, K. M., Hilliard, L. M., Kett, M. M., Brown, R. D., Booth, S. C., Widdop, R. E., Moritz, K. M., Evans, R. G. & Denton, K. M., 2014, In : American Journal of Physiology - Renal Physiology. 307, 8, p. 901 - 907 7 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats

Gallo, L. A., Tran, M., Cullen-McEwen, L. A., Denton, K. M., Jefferies, A. J., Moritz, K. M. & Wlodek, M. E., 2014, In : Reproduction, Fertility and Development. 26, 7, p. 1032 - 1043 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Using stimulation of the diving reflex in humans to teach integrative physiology

Choate, J., Denton, K. M., Evans, R. G. & Hodgson, Y. M., 2014, In : Advances in Physiology Education. 38, 4, p. 355 - 365 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
9 Citations (Scopus)

Improvement in renal hemodynamics following combined angiotensin II infusion and AT1R blockade in aged female sheep following fetal unilateral nephrectomy

Singh, R. R., Lankadeva, Y. R., Denton, K. M. & Moritz, K. M., 2013, In : PLoS ONE. 8, 7, 10 p., e68036.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Sex-related differences in hypertension: seek and ye shall find.

Denton, K. M., Hilliard, L. M. & Tare, M., Oct 2013, In : Hypertension. 62, 4, p. 674-677 4 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

The "his and hers" of the renin-angiotensin system

Hilliard, L. M., Sampson, A. K., Brown, R. D. & Denton, K. M., 2013, In : Current Hypertension Reports. 15, 1, p. 71 - 79 9 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Update on the angiotensin AT(2) receptor

McCarthy, C. A., Widdop, R. E., Denton, K. M. & Jones, E. S., 2013, In : Current Hypertension Reports. 15, 1, p. 25 - 30 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
7 Citations (Scopus)

Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy

Lankadeva, Y. R., Singh, R. R., Hilliard, L. M., Moritz, K. M. & Denton, K. M., 2012, In : PLoS ONE. 7, 10, 10 p., e47528.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)

Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats

Bosnyak, S., Widdop, R. E., Denton, K. M. & Jones, E. S., 2012, In : International Journal of Hypertension. 2012, Art. No.192567, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Effects of tempol and candesartan on neural control of the kidney

Eppel, G. A., Head, G. A., Denton, K. M. & Evans, R. G., 2012, In : Autonomic Neuroscience: Basic and Clinical. 168, 1-2, p. 48 - 57 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Increased cardiovascular and renal risk is associated with low nephron endowment in aged females: an ovine model of fetal unilateral nephrectomy

Singh, R. R., Jefferies, A. J., Lankadeva, Y. R., Lombardo, P. P., Schneider-Kolsky, M. E., Hilliard, L. M., Denton, K. M. & Moritz, K. M., 2012, In : PLoS ONE. 7, 8, 11 p., e42400.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)

Long-term alteration in maternal blood pressure and renal function after pregnancy in normal and growth-restricted rats

Gallo, L. A., Denton, K. M., Moritz, K. M., Tare, M., Parkington, H. C., Davies, M. M., Tran, M., Jefferies, A. J. & Wlodek, M. E., 2012, In : Hypertension. 60, 1, p. 206 - 213 8 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Postnatal ontogeny of angiotensin receptors and ACE2 in male and female rats

Sampson, A. K., Moritz, K. M. & Denton, K. M., 2012, In : Gender Medicine. 9, 1, p. 21 - 32 12 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II

Brown, R. D., Hilliard, L. M., Head, G. A., Jones, E. S., Widdop, R. E. & Denton, K. M., 2012, In : Hypertension. 59, 1, p. 129 - 135 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Sex differences in the renal vascular response to angiotensin II involves the Mas receptor

Safari, T., Nematbakhsh, M., Hilliard, L. M., Evans, R. G. & Denton, K. M., 2012, In : Acta Physiologica. 206, 2, p. 150 - 156 7 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension

Hilliard, L. M., Jones, E. S., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2012, In : Hypertension. 59, 2, p. 409 - 414 6 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
2011
11 Citations (Scopus)

Fetal uninephrectomy in male sheep alters the systemic and renal responses to angiotensin II infusion and AT1R blockade

Singh, R., Moritz, K., Wintour-Coghlan, M., Jefferies, A., Iqbal, J., Bertram, J. & Denton, K., 2011, In : American Journal of Physiology - Renal Physiology. 301, 2, p. F319 - F326 8 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Gender differences in pressure-natriuresis and renal autoregulation: Role of the Angiotensin type 2 receptor

Hilliard, L. M., Nematbakhsh, M., Kett, M. M., Teichman, E., Sampson, A. K., Widdop, R. E., Evans, R. G. & Denton, K. M., 2011, In : Hypertension. 57, 2, p. 275 - 282 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
71 Citations (Scopus)

Renal programming: Cause for concern?

Kett, M. M. & Denton, K. M., 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300, p. 1 - 38 38 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Urine-concentrating defects exacerbate with age in male offspring with a low-nephron endowment

Singh, R., Denton, K., Bertram, J., Dowling, J. & Moritz, K., 2011, In : American Journal of Physiology - Renal Physiology. 301, 6, p. F1168 - F1176 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
7 Citations (Scopus)

Chronic maternal hypertension affects placental gene expression and differentiation in rabbits

McArdle, A. M., Maduwegedera, D. WK., Moritz, K. M., Flower, R. L., Denton, K. M. & Roberts, C. T., 2010, In : Journal of Hypertension. 28, 5, p. 959 - 968 10 p.

Research output: Contribution to journalArticleResearchpeer-review