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Research Output 1983 2019

2019

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats

Walton, S. L., Tjongue, M., Tare, M., Kwok, E., Probyn, M., Parkington, H. C., Bertram, J. F., Moritz, K. M. & Denton, K. M., 22 Apr 2019, In : Biology of Sex Differences. 10, 1, 14 p., 21.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Sustained Decrease in Blood Pressure and Reduced Anatomical and Functional Reinnervation of Renal Nerves in Hypertensive Sheep 30 Months After Catheter-Based Renal Denervation

Singh, R. R., McArdle, Z. M., Iudica, M., Easton, L. K., Booth, L. C., May, C. N., Parkington, H. C., Lombardo, P., Head, G. A., Lambert, G., Moritz, K. M., Schlaich, M. P. & Denton, K. M., 1 Mar 2019, In : Hypertension. 73, 3, p. 718-727 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Adenosine Receptors: A Tantalizing Target for the Treatment of Salt-Sensitive Hypertension

Denton, K. M., 1 Aug 2018, In : Hypertension. 72, 2, p. 283-284 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Perinatal programming of arterial pressure

Singh, R. R., Denton, K. M. & Bertram, J. F., 1 Jan 2018, Pediatric Hypertension. Flynn, J. T., Ingelfinger, J. R. & Redwine, K. M. (eds.). Springer, p. 135-158 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

4 Citations (Scopus)

Renal Denervation: A Treatment for Hypertension and Chronic Kidney Disease

Singh, R. R. & Denton, K. M., 1 Sep 2018, In : Hypertension. 72, 3, p. 528-536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Role of the sympathetic nervous system and its modulation in renal hypertension

Sata, Y., Head, G. A., Denton, K., May, C. N. & Schlaich, M. P., 29 Mar 2018, In : Frontiers in Medicine. 5, 10 p., 82.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Sex-specific differences in hypertension and associated cardiovascular disease

Mirabito Colafella, K. M. & Denton, K. M., 1 Mar 2018, In : Nature Reviews Nephrology. 14, 3, p. 185-201 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017
27 Citations (Scopus)

Anti-fibrotic actions of relaxin

Samuel, C. S., Royce, S. G., Hewitson, T. D., Denton, K. M., Cooney, T. E. & Bennett, R. G., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 962-976 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In : Frontiers in Pharmacology. 8, 7 p., 564.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

Catheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage

Singh, R. R., Sajeesh, V., Booth, L. C., McArdle, Z., May, C. N., Head, G. A., Moritz, K. M., Schlaich, M. P. & Denton, K. M., 28 Feb 2017, In : Journal of the American College of Cardiology. 69, 8, p. 951-964 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Editorial: Editorial: Function of renal sympathetic nerves

Wang, Y., Lim, K. & Denton, K. M., 28 Aug 2017, In : Frontiers in Physiology. 8, 642.

Research output: Contribution to journalEditorialOtherpeer-review

11 Citations (Scopus)

Effect of renal denervation on kidney function in patients with chronic kidney disease

Hering, D., Marusic, P., Duval, J., Sata, Y., Head, G. A., Denton, K. M., Burrows, S., Walton, A. S., Esler, M. D. & Schlaich, M. P., 1 Apr 2017, In : International Journal of Cardiology. 232, p. 93-97 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Relaxin contributes to the regulation of arterial pressure in adult female mice

Colafella, K. M. M., Samuel, C. S. & Denton, K. M., 28 Nov 2017, In : Clinical Science. 131, 23, p. 2795-2805 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Renal denervation promotes atherosclerosis in hypertensive apolipoprotein E-Deficient mice infused with angiotensin II

Wang, Y., Dinh, T. N., Nield, A., Krishna, S. M., Denton, K. & Golledge, J., 13 Apr 2017, In : Frontiers in Physiology. 8, 9 p., 215.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016
18 Citations (Scopus)

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thone-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlof, B., Hallberg, A., Unger, T. & Steckelings, U. M., Aug 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
Open Access
File
10 Citations (Scopus)

Epochs in the depressor/pressor balance of the renin-angiotensin system

Mirabito Colafella, K. M., Hilliard, L. M. & Denton, K. M., May 2016, In : Clinical Science. 130, 10, p. 761-771 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Placental Growth Factor: A Step Forward in the Search for a Treatment for Preeclampsia

Hilliard, L. M. & Denton, K. M., 2016, In : Hypertension. 67, 6, p. 1114 - 1116 3 p.

Research output: Contribution to journalLetterOther

6 Citations (Scopus)

Renal nitric oxide deficiency and chronic kidney disease in young sheep born with a solitary functioning kidney

Singh, R. R., Easton, L. K., Booth, L. C., Schlaich, M. P., Head, G. A., Moritz, K. M. & Denton, K. M., 26 May 2016, In : Scientific Reports. 6, 11 p., 26777.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Sex- and age-related differences in arterial pressure and albuminuria in mice

Barsha, G., Denton, K. M. & Mirabito Colafella, K. M., 14 Nov 2016, In : Biology of Sex Differences. 7, 1, 15 p., 57.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
Open Access
File
2015
17 Citations (Scopus)

Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction

Black, M. J., Lim, K. J., Zimanyi, M. A., Sampson, A. K., Bubb, K. J., Flower, R. L., Parkington, H. C., Tare, M. & Denton, K. M., 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309, 9, p. 1153 - 1161 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin Type 2 Receptor: Hidden Partner

Denton, K. M., 2015, In : Hypertension. 66, 2, p. 273 - 274 2 p.

Research output: Contribution to journalLetterOther

1 Citation (Scopus)

Angiotensis-based peptides as AT2R agonists

Jones, E. S., Wang, Y., Del Borgo, M. P., Denton, K. M., Aguilar, M-I. I. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 141 - 147 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

AT2R, vascular effects, and blood pressure

Dias Baraldi, D., Jones, E. S., Hilliard, L. M., Del Borgo, M. P., Gaspari, T. A., McCarthy, C. A., Vinh, A., Weungoda, I., Aguilar, M-I. I., Denton, K. M. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 49 - 55 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Erratum: Reduced sensitivity of the renal vasculature to angiotensin II in young rats: The role of the angiotensin type 2 receptor (Pediatric Research (2014) 76 (448-452) DOI: 10.1038/pr.2014.121)

Brown, R. D., Hilliard, L. M., Mirabito, K. M., Wirth, L. C., Moritz, K. M., Evans, R. G. & Denton, K. M., 19 Apr 2015, In : Pediatric Research. 77, 4, p. 606 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2 Citations (Scopus)

High-dose estradiol-replacement therapy enhances the renal vascular response to angiotensin II via an AT2-receptor dependent mechanism

Safari, T., Nematbakhsh, M., Evans, R. G. & Denton, K. M., 2015, In : Advances in Pharmacological Sciences. 2015, 7 p., 682745.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)

Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

Lankadeva, Y. R., Singh, R. R., Moritz, K. M., Parkington, H. C., Denton, K. M. & Tare, M., 2015, In : Circulation. 131, 3, p. 280 - 288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Role of the kidney in the fetal programming of adult cardiovascular disease: an update

Singh, R. R. & Denton, K. M., 2015, In : Current Opinion in Pharmacology. 21, p. 53 - 59 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex differences in AT2R expression and action

Hilliard, L. M., Mirabito, K. M., Widdop, R. E. & Denton, K. M., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 125 - 130 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

14 Citations (Scopus)

β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

Del Borgo, M. P., Wang, Y., Bosnyak, S., Walters, P. E., Spizzo, I., Perlmutter, P., Hilliard, L. M., Denton, K. M., Aguilar, M-I. M., Widdop, R. E. & Jones, E. S., 2015, In : Clinical Science. 129, 6, p. 505 - 513 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
27 Citations (Scopus)

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats

Hilliard, L. M., Chow, C. L. E., Mirabito, K. M., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2014, In : Hypertension. 64, 2, p. 378 - 383 6 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Compensatory responses to nephron deficiency: adaptive or maladaptive?

Fong, D. S. Y., Denton, K. M., Moritz, K. M., Evans, R. G. & Singh, R. R., 2014, In : Nephrology. 19, 3, p. 119 - 128 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Impaired ability to modulate glomerular filtration rate in aged female sheep following fetal uninephrectomy

Lankadeva, Y. R., Singh, R. R., Hilliard, L. M., Moritz, K. M. & Denton, K. M., 2014, In : Physiological Reports. 2, 1 (Art. No.: e00208), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)

Loss of a kidney during fetal life: long-term consequences and lessons learned

Lankadeva, Y. R., Singh, R. R., Tare, M., Moritz, K. M. & Denton, K. M., 2014, In : American Journal of Physiology - Renal Physiology. 306, 8, p. 791 - 800 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
Open Access
File
6 Citations (Scopus)

Reduced sensitivity of the renal vasculature to angiotensin II in young rats: the role of the angiotensin type 2 receptor

Brown, R. D., Hilliard, L. M., Mirabito, K. M., Firth, L. C., Moritz, K. M., Evans, R. G. & Denton, K. M., 2014, In : Pediatric Research. 76, 5, p. 448 - 452 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
28 Citations (Scopus)

Sex-and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor

Mirabito, K. M., Hilliard, L. M., Kett, M. M., Brown, R. D., Booth, S. C., Widdop, R. E., Moritz, K. M., Evans, R. G. & Denton, K. M., 2014, In : American Journal of Physiology - Renal Physiology. 307, 8, p. 901 - 907 7 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats

Gallo, L. A., Tran, M., Cullen-McEwen, L. A., Denton, K. M., Jefferies, A. J., Moritz, K. M. & Wlodek, M. E., 2014, In : Reproduction, Fertility and Development. 26, 7, p. 1032 - 1043 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Using stimulation of the diving reflex in humans to teach integrative physiology

Choate, J., Denton, K. M., Evans, R. G. & Hodgson, Y. M., 2014, In : Advances in Physiology Education. 38, 4, p. 355 - 365 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
2 Citations (Scopus)

Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation

Wang, Y., Denton, K. M. & Golledge, J., Nov 2013, In : Hypertension Research. 36, 11, p. 1006-1007 2 p.

Research output: Contribution to journalLetterOtherpeer-review

9 Citations (Scopus)

Improvement in renal hemodynamics following combined angiotensin II infusion and AT1R blockade in aged female sheep following fetal unilateral nephrectomy

Singh, R. R., Lankadeva, Y. R., Denton, K. M. & Moritz, K. M., 2013, In : PLoS ONE. 8, 7, 10 p., e68036.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Maternal Obesity: Bad for Baby's Future

Kett, M. M. & Denton, K. M., 2013, In : Hypertension. 62, 3, p. 457 - 458 2 p.

Research output: Contribution to journalLetterOther

25 Citations (Scopus)

Sex-related differences in hypertension: seek and ye shall find.

Denton, K. M., Hilliard, L. M. & Tare, M., Oct 2013, In : Hypertension. 62, 4, p. 674-677 4 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

The "his and hers" of the renin-angiotensin system

Hilliard, L. M., Sampson, A. K., Brown, R. D. & Denton, K. M., 2013, In : Current Hypertension Reports. 15, 1, p. 71 - 79 9 p.

Research output: Contribution to journalArticleResearchpeer-review