Projects per year
Personal profile
Biography
Kate received her PhD in 2017 from the University of Melbourne, Australia, where she studied interactions between mitochondrial biology, cell death and immune signalling. Her research employed advanced imaging techniques including live-cell lattice light-sheet microscopy (LLSM), live 3D-SIM, electron cryo-tomography and correlative light and electron microscopy to visualise – for the first time – the release of DNA from the mitochondria (mtDNA) during apoptosis.
This work was recognised by first prize in the 2018 Centenary Institute Medical Innovation Awards, and first prize in the 2019 Victorian Premier’s Excellence Awards. Kate has since become an NHMRC Early Career Fellow, a Group Leader within Monash University’s Biomedical Discovery Institute, and a mother (3 young kids), and is currently navigating the juggling act that the these positions demand.
Kate leads the Mitochondria, Cell Death & Immunity Group where she continues to use microscopy and biochemical assays to investigate mtDNA and its downstream signalling consequences in a range of human diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Visiting Scientist, Walter and Eliza Hall Institute of Medical Research (WEHI)
1 Jan 2018 → 31 Dec 2018
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigating mtDNA as a danger signal across the tree of life
McArthur, K. (Primary Chief Investigator (PCI))
Australian Research Council (ARC), Monash University – Internal Department Contribution
21/02/25 → 20/02/28
Project: Research
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The next great escape – how does mtDNA become extracellular?
McArthur, K. (Primary Chief Investigator (PCI)) & Ryan, M. (Chief Investigator (CI))
1/01/25 → 31/12/27
Project: Research
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Exploring the anti-apoptotic and apoptosis-unrelated functions of MCL-1 during embryonic and blood cell development to advance MCL-1 inhibitors in clinical trials for cancer
Brinkmann, K. (Primary Chief Investigator (PCI)) & McArthur, K. (Chief Investigator (CI))
1/01/23 → 31/12/25
Project: Research
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Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
McArthur, K. & Ryan, M. T., 20 Mar 2025, In: Nature. 639, 8055, p. 582-584 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy
Saunders, T. L., Windley, S. P., Gervinskas, G., Balka, K. R., Rowe, C., Lane, R., Tailler, M., Nguyen, T. N., Ramm, G., Lazarou, M., De Nardo, D., Kile, B. T. & McArthur, K., Mar 2024, In: Cell Death and Differentiation. 31, 3, p. 335-347 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Citations (Scopus) -
Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML
Salmon, J. M., Todorovski, I., Stanley, K. L., Bruedigam, C., Kearney, C. J., Martelotto, L. G., Rossello, F., Semple, T., Arnau, G. M., Zethoven, M., Bots, M., Bjelosevic, S., Cluse, L. A., Fraser, P. J., Litalien, V., Vidacs, E., McArthur, K., Matthews, A. Y., Gressier, E. & De Weerd, N. A. & 15 others, , Jun 2022, In: Cancer Discovery. 12, 6, p. 1560-1579 20 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access23 Citations (Scopus) -
Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death
Garciaz, S., Guirguis, A. A., Müller, S., Brown, F. C., Chan, Y.-C., Motazedian, A., Rowe, C. L., Kuzich, J. A., Chan, K. L., Tran, K., Smith, L., MacPherson, L., Liddicoat, B., Lam, E. Y. N., Cañeque, T., Burr, M. L., Litalien, V., Pomilio, G., Poplineau, M. & Duprez, E. & 9 others, , 1 Mar 2022, In: Cancer Discovery. 12, 3, p. 774-791 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access26 Citations (Scopus) -
Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells
Chappaz, S., McArthur, K., Kealy, L., Law, C. W., Tailler, M., Lane, R. M., Lieschke, A., Ritchie, M. E., Good-Jacobson, K. L., Strasser, A. & Kile, B. T., 20 Jul 2021, In: Cell Reports. 36, 3, 24 p., 109430.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)
Prizes
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Best Oral Presentation - AussieMit Conference
McArthur, Kate (Recipient), 2016
Prize: Prize (including medals and awards)
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Best Oral Presentation - Young Investigator Forum on Cell Death
McArthur, Kate (Recipient), 2016
Prize: Prize (including medals and awards)
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Discovery Award for Best Publication
McArthur, Kate (Recipient), 2018
Prize: Prize (including medals and awards)
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In Memory of Neil Lawrence Prize, 2018 Centenary Institute Medical Innovation Award
McArthur, K. (Recipient), 3 Oct 2018
Prize: Prize (including medals and awards)
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People's Choice Award for Best Oral Presentation - Invited Speaker 19th International Microscopy Congress
McArthur, Kate (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
- 1 Contribution to workshop, seminar, course
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AussieMit 2024
Kate McArthur (Organiser) & Luke Formosa (Organiser)
26 Nov 2024 → 1 Dec 2024Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
Press/Media
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Kile, B. T. & McArthur, K.
24/02/18 → 23/08/18
2 items of Media coverage, 1 Media contribution
Press/Media: Research