Projects per year
Personal profile
Biography
Dr. Kasthuri Bai earned her PhD in Medical and Health Sciences, with a specialization in molecular neuroscience, in 2020. Following this, she joined Monash University Malaysia in 2021 as a post-doctoral scientist. Due to her significant contributions and expertise, she was promoted to the position of lecturer in 2023. Her academic background and training span a variety of fields, including molecular neuroscience, gene expression, proteomics, and epigenetics. Throughout her career, she has published numerous research articles in prestigious international journals.
Currently, Dr. Kasthuri's research focuses on understanding the impact of climate change on disease mechanisms, particularly in the context of neurodegenerative diseases like Parkinson’s disease and Alzheimer's disease. She is also engaged in therapeutic drug discovery, working on proof-of-concept studies aimed at identifying potential treatments for these conditions.
Research interests
Kasthuri is a researcher in the field of neuroscience, particularly understanding the Parkinson's disease mechanism and identification of natural bioactive compounds that delay the neurodegenerative process. She has reported that natural palm phytonutrients, such as vitamin E isoforms and palm mixed carotenes, exhibited significant neuroprotective effects on human dopaminergic-like neurons in in vitro experiments. Moreover, numerous fascinating molecular changes have been discovered following exposure of neurons to tocotrienols compounds, including biochemical, protein expression, gene expression and DNA methylation. She has employed bioinformatic tool such R bioconductor and databases (KEGG, STRING, METASCAPE, PANTHER) to analyse genome-wide association studies (GWAS) and proteomics data. These findings have been successfully published in high impact Q1 journals. Furthermore, she is also involved in a proof of concept randomised controlled trial on dry skin patients in collaboration with PPUKM and pharmaceutical company.
Areas of Interests:
- Neurodegeneration
- Oxidative stress
- Molecular biology and Disease Mechanism
- Neuroimmunology
- Neuroprotection pathways
Internal Research Grant
JCSMHS Seed Grant 2025 - Untangling the heat paradox in Parkinson's disease - An in vivo Approach/RM 30,000 (Principal Investigator), Status: On-going
Industry Grant (PhytoGaia M Sdn Bhd) 2024 - Alterations in skin hydration, moisture and genomic in patient with dry skin conditions following daily oral palm tocotrienol and squalene (STGAIA) supplementation/ RM 88,000 (Principal Investigator) : Status: On-going
JCSMHS Seed Grant 2024 - Developing a Cellular model of Ethanol-Induced psychosis using differentiated SH-SY5Y human neural cells/RM30, 000 (Principal Investigator). Status : On-Going
JCSMHS Seed Grants 2023 - Neuroprotective effects of Beta-carotene on 6-OHDA-induced toxicity in differentiated SH-SY5Y neuroblastoma cells: A comparison study between natural and synthetic beta-carotenes/ RM30,000 (Principal Investigator). Status: Completed
Monash teaching commitment
MED 1100 - Advocates in Indigenous Health, Health Enhancement Program (HEP)
MED 1200 - Problem-Based Learning (PBL), Physiology
MED 2100 - Health Promotion (HP), Advovates in Indigenous Health, Student Project Case (SPC)
MED 2200 - Inter-Professional Education (IPE), Physiology
NUT 1022 - Fundamentals in Biomedical Sciences
NUT 1023 - Nutritional Biochemistry and Nutrigenomics
MED 5101 - Applied Studies in Medical Research and Professional Practice/ Scholarly Intensive Placement
BRM 5011 - Foundations in Medical Biotechnology and its Applications
Supervision interests
Dr. Kasthuri Bai is currently leading research that explores the impact of climate change on the pathogenesis of Parkinson’s disease, using animal models to better understand the underlying mechanisms. Her work aims to uncover how environmental changes may contribute to the development or progression of neurodegenerative disorders. In addition, Dr. Bai is actively seeking a qualified postgraduate student to join her research team and contribute to this critical study, offering an opportunity for an aspiring researcher to be part of groundbreaking work in the field of neuroscience and environmental health.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Neuroscience, PhD Medical and Health Sciences, Neuroprotective Role of Tocotrienols Against 6-hydroxydopamine (6-OHDA) Induced Cytotoxic Damage in SH-SY5Y Neuroblastoma Cells, Universiti Perubatan Antarabangsa (International Medical University)
1 Jun 2016 → 22 Dec 2020
Award Date: 22 Dec 2020
Oxidative Stress and Neurodegeneration, Msc Medical and Health Sciences, Antioxidant Effects of Quercetin Glycoside Derivatives Against 6-Hydroxydopamine (6-Ohda) Induced Cytotoxic Damage In PC-12 Neuronal Cells, Universiti Perubatan Antarabangsa (International Medical University)
1 Oct 2010 → 14 Jun 2014
Award Date: 14 Jun 2014
Biomedical Sciences, BSc (Hons), Effects of Trace Elements and Flavonoids on the Proliferation of Mouse T-lymphocytes. , Universiti Malaya (University of Malaya)
1 Aug 1997 → 16 Sept 2000
Award Date: 16 Sept 2000
Research area keywords
- Neurodegeneration
- SH-SY5Y Neuroblastoma
- Cellular model of Parkinson's disease
- Natural phytonutrients
- DNA methylation
- Gene expression
- Immune modulation in Parkinson's Disease
- Oxidant stress
- Protein expression
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Alterations in skin hydration, moisture and genomic in patients with dry skin conditions following daily oral palm tocotrienol and squalene (STGAIA) supplementation
Bai, K. (Primary Chief Investigator (PCI)), Radhakrishnan, A. (Chief Investigator (CI)), Pillai, B. S. B. (Chief Investigator (CI)), Arumugam, M. (Chief Investigator (CI)), Jamil, A. (Chief Investigator (CI)) & See, B. (Partner Investigator (PI))
15/05/24 → 30/06/25
Project: Research
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Insights into the Anticancer Mechanisms Modulated by Gamma and Delta Tocotrienols in Colorectal Cancers
Khalid, A. Q., Zaidan, T. N., Pillai, B. S. B., Magalingam, K. B., Mohamed Musa Mohamedahmed, S., Ramdas, P. & Radhakrishnan, A. K. C., Mar 2025, In: Nutrition Reviews. 83, 3, p. e1295-e1310 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Carotenoids modulate antioxidant pathways in In vitro models of Parkinson's disease: A comprehensive scoping review
Guo, H. T., Lee, Z. X., Magalingam, K. B., Radhakrishnan, A. K. & Bhuvanendran, S., Nov 2024, In: Neurochemistry International. 180, 12 p., 105857.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Explicating the multifunctional roles of tocotrienol and squalene in promoting skin health
Morgan, N. R., Magalingam, K. B., Radhakrishnan, A. K., Arumugam, M., Jamil, A. & Bhuvanendran, S., Oct 2024, In: Skin Health and Disease. 4, 5, 12 p., e448.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
A Glimpse into the Genome-wide DNA Methylation Changes in 6-hydroxydopamine-induced In Vitro Model of Parkinson’s Disease
Magalingam, K. B., Somanath, S. D. & Radhakrishnan, A. K., Jun 2023, In: Experimental Neurobiology. 32, 3, p. 119-132 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile3 Citations (Scopus) -
Tocotrienol-Rich Fraction Regulates Proteomic Changes That Induce Cellular Response to Stress Associated Pathways in Resistant Glioblastoma Cell Line
Osman, D.E.-R., Magalingam, K. B., Kamarudin, M. N. A., Abidin, S. A. Z., Radhakrishnan, A. K. & Bhuvanendran, S., Jun 2023, In: Molecular Oncology. 17, S1, p. 141-142 2 p.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access
Activities
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National Cancer Congress Malaysia
Lee, J. S. Y. (Speaker), Bai, K. (Speaker), Palanisamy, U. (Speaker), Farghadani, R. (Organiser) & Radhakrishnan, A. (Speaker)
21 Jun 2024 → 23 Jun 2024Activity: Participating in or organising an event types › Contribution to conference
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International Conference of the Asian Society Against Dementia (ASAD) 2024
Bai, K. (Speaker) & Radhakrishnan, A. (Speaker)
16 Aug 2024Activity: Participating in or organising an event types › Contribution to conference
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Annals of Medicine (Journal)
Magalingam, K. B. (Peer reviewer)
19 Jan 2024Activity: Publication peer-review and editorial work types › Peer review responsibility
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3rd Virtual International Conference on Carotenoids
Bai, K. (Speaker) & Radhakrishnan, A. (Speaker)
24 Jul 2024Activity: Participating in or organising an event types › Contribution to conference
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Campus Community Engagement Program
Bai, K. (Contributor)
3 Dec 2024 → 15 Feb 2025Activity: Community Talks, Presentations, Exhibitions and Events › Public outreach