Karlheinz Peter

Professor

20032019

Research output per year

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Research Output

2003

Improving selection of αIIbβ3-binding phage antibodies with increased reactivity derived from immunized donors

Jacobin, M. J., Robert, R., Pouns, O., Laroche-Traineau, J., Nurden, A., Peter, K., Little, M. & Clofent-Sanchez, G., 1 Sep 2003, In : Clinical Immunology. 108, 3, p. 199-210 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2004

Construction and characterization of a recombinant plasminogen activator composed of an anti-fibrin single-chain antibody and low-molecular-weight urokinase

Hagemeyer, C. E., Tomic, I., Weirich, U., Graeber, J., Nordt, T. K., Runge, M. S., Bode, C. & Peter, K., 2004, In : Journal of Thrombosis and Haemostasis. 2, 5, p. 797 - 803 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Fibrin-targeted direct factor Xa inhibition: Construction and characterization of a recombinant factor Xa inhibitor composed of an anti-fibrin single-chain antibody and tick anticoagulant peptide

Hagemeyer, C. E., Tomic, I., Jaminet, P., Weirich, U., Bassler, N., Schwarz, M., Runge, M. S., Bode, C. & Peter, K., 2004, In : Thrombosis and Haemostasis. 92, 1, p. 47 - 53 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2006

Conformation-specific blockade of the integrin GPIIb/IIIa: A novel antiplatelet strategy that selectively targets activated platelets

Schwarz, M., Meade, G., Stoll, P., Ylanne, J., Bassler, N., Chen, Y. C., Hagemeyer, C. E., Ahrens, I., Moran, N., Kenny, D., Fitzgerald, D. J., Bode, C. & Peter, K., 6 Jul 2006, In : Circulation Research. 99, 1, p. 25 - 33 9 p.

Research output: Contribution to journalArticleResearchpeer-review

119 Citations (Scopus)
2007

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIbbeta3 (GPIIb/IIIa) antagonists

Bassler, N., Loeffler, C., Mangin, P., Yuan, Y-P., Schwarz, M., Hagemeyer, C. E., Eisenhardt, S. U., Ahrens, I., Bode, C., Jackson, S. & Peter, K., 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 3, p. 9 - 15 7 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Antibodies as helpers: Targeted antithrombotic and fibrinolytic therapy

Schwarz, M., Hagemeyer, C. E., Peter, K. & Bode, C., 2007, In : Hamostaseologie. 27, 5, p. 360 - 362 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Single-chain antibodies as new antithrombotic drugs

Hagemeyer, C. E., Schwarz, M. & Peter, K., Mar 2007, In : Seminars in Thrombosis and Hemostasis. 33, 2, p. 185-195 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

13 Citations (Scopus)

Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation

Stoll, P., Bassler, N., Hagemeyer, C. E., Eisenhardt, S. U., Chen, Y-C., Schmidt, R., Schwarz, M., Ahrens, I., Katagiri, Y., Pannen, B., Bode, C. & Peter, K., 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 5, p. 1206 - 1212 7 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)
2008

Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis

Von Zur Muhlen, C., von Elverfeldt, D., Moeller, J. A., Choudhury, R. P., Paul, D., Hagemeyer, C. E., Olschewski, M., Becker, A-K., Neudorfer, I., Bassler, N., Schwarz, M., Bode, C. & Peter, K., 2008, In : Circulation. 118, 3, p. 258 - 267 10 p.

Research output: Contribution to journalArticleResearchpeer-review

115 Citations (Scopus)

Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation

Woollard, K., Suhartoyo, A., Harris, E. E., Eisenhardt, S. U., Jackson, S., Peter, K., Dart, A. M., Hickey, M. J. & Chin-Dusting, J. PF., 2008, In : Circulation Research. 103, 10, p. 1128 - 1138 11 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation

Straub, A., Wendel, H. P., Dietz, K., Schiebold, D., Peter, K., Schoenwaelder, S. M. & Ziemer, G., 2008, In : Thrombosis and Haemostasis. 99, 3, p. 609 - 615 7 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2009

2nd combined working group and management committee meeting of urine and kidney proteomics COST action 29-30 March 2009, Nafplio, Greece

Vlahou, A., Allmaier, G., Attwood, T., Bongcam-Rudloff, E., Charonis, A., Frokiaer, J., Mischak, H., Schanstra, J., Spasovski, G., Aasberg, A., Allory, Y., Arthur, J., Attwood, T., Banks, R. W., Baumann, M., Benigni, A., Bezerianos, A., Campistol, J. M., Candiano, G., Capasso, G. & 81 others, Carpentier, S., Dadlez, M., Deltas, C., Dijilianov, D., de Zeeuw, D., Decramer, S., Dihazi, H., Domon, B., Endlich, N., d'Alche-Buc, F., D'Haese, P., Edelman, A., Egido, J., El Nahas, M., Farinazzo, A., Fernandez-Llama, P., Feldt-Rasmussen, B., Frokiaer, J., Gansevoort, R. T., Garbis, S., Garin, J., Ghiggeri, G. M., Gimenez, I., Granier, C., Goumenos, D., Haylor, J. L., Hilario, M., Holthofer, H., Kalousis, A., Kaski, S., Knepper, M., Korneti, P., Kossida, S., Langham, R., Loftheim, H., Lopez-Novoa, J., Luider, T., Magni, F., Malats, N., Martin, J. L., Mayrhofer, C., Monsarrat, B., Mueller, G., Nielsen, S., Norling, M., O'Connell, S., Ortiz, J. P. A., Perunicic-Pekovic, G., Planelles, G., Polenakovic, M., Promponas, V., Rasic-Milutinovic, Z., Rehulka, P., Peter, K., Righetti, P. G., Ronco, P., Ryan, M., Sánchez-Carbayo, M., Schanstra, J., Semmes, J., Sheehan, D., Stenman, U. H., Stodkilde-Jorgensen, L., Tasic, V., Theodorescu, D., Thongboonkerd, V., Toncheva, D., Tsillibari, E., Tsiotis, G., Unwin, R., Vanholder, R., Vassilev, D., Vickers, M. E., Verhulst, A., Vilasi, A., Vlahakos, D., Vonk, R., Wright, P. C., Yamamoto, T., Yutaka, Y. & Zielenkiewicz, P., 2009, In : Proteomics - Clinical Applications. 3, 9, p. 1017-1022 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques

Eisenhardt, S. U., Habersberger, J., Murphy, A., Chen, Y-C., Woollard, K. J., Bassler, N., Qian, H., von zur Muhlen, C., Hagemeyer, C. E., Ahrens, I., Chin-Dusting, J., Bobik, A. & Peter, K., 17 Jul 2009, In : Circulation Research. 105, 2, p. 128-137 10 p.

Research output: Contribution to journalArticleResearchpeer-review

160 Citations (Scopus)
5 Citations (Scopus)

Recent advances in vascular biology: Selected highlights from IVBM 2008

Khachigian, L. M., Peter, K. & Berndt, M. C., 2009, In : Thrombosis and Haemostasis. 101, 6, p. 997-998 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Single-chain antibodies as diagnostic tools and therapeutic agents

Hagemeyer, C. E., Von Zur Muhlen, C., von Elverfeldt, D. & Peter, K., 2009, In : Thrombosis and Haemostasis. 101, 6, p. 1012 - 1019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)
2010

Genetic transfer of fusion proteins effectively inhibits VCAM-1-mediated cell adhesion and transmigration via inhibition of cytoskeletal anchorage

Hagemeyer, C. E., Ahrens, I., Bassler, N., Dschachutaschwili, N., Chen, Y-C., Eisenhardt, S. U., Bode, C. & Peter, K., 2010, In : Journal of Cellular and Molecular Medicine. 14, 1-2, p. 290 - 302 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Targeting the platelet integrin GPIIb/IIIa

Hagemeyer, C. E. & Peter, K., 2010, In : Current Pharmaceutical Design. 16, 37, p. 4119 - 4133 15 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
2011

Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody

Heidt, T., Braun, F., Peter, K., Goldschmidt, J., Pethe, A., Hagemeyer, C. E., Neudorfer, I., Zirlik, A., Weber, W. A., Bode, C., Meyer, P. T., Behe, M. & Von Zur Muhlen, C., 2011, In : PLoS ONE. 6, 3, 9 p., e18446.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)

An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia

Topcic, D., Kim, W., Holien, J. K., Jia, F., Armstrong, P., Hohmann, J. D., Straub, A., Krippner, G. Y., Haller, C. A., Domeij, H., Hagemeyer, C. E., Parker, M. W., Chaikof, E. L. & Peter, K., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 9, p. 2015 - 2023 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Enzymatic single-chain antibody tagging: A universal approach to targeted molecular imaging and cell homing in cardiovascular disease

Ta, H. T., Prabhu, S., Leitner, E., Jia, F., von Elverfeldt, D., Jackson, K. E., Heidt, T., Nair, A. K. N., Pearce, H., Von Zur Muhlen, C., Wang, X., Peter, K. & Hagemeyer, C. E., 2011, In : Circulation Research. 109, 4, p. 365 - 373 9 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target

Straub, A., Krajewski, S., Hohmann, J. D., Westein, E., Jia, F., Bassler, N., Selan, C., Kurz, J., Wendel, H., Dezfouli, S., Yuan, Y-P., Nandurkar, H., Jackson, S., Hickey, M. & Peter, K., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 7, p. 1607 - 1616 10 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

GPVI and GPIb alpha mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors

Hu, H., Armstrong, P., Khalil, E., Chen, Y-C., Straub, A., Li, M., Soosairajah, J., Hagemeyer, C., Bassler, N., Huang, D., Ahrens, I., Krippner, G., Gardiner, E. & Peter, K., 2011, In : PLoS ONE. 6, 4, 9 p., e19190.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

High-Mobility Group Box Protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein E-deficient mice

Kanellakis, P., Agrotis, A., Kyaw, T. S., Koulis, C., Ahrens, I., Mori, S., Takahashi, H. K., Liu, K., Peter, K., Nishibori, M. & Bobik, A., Feb 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 2, p. 313-319 7 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC

Ahrens, I., Habersberger, J., Baumlin, N., Qian, H., Smith, B., Stasch, J-P., Bode, C., Schmidt, H. & Peter, K., 2011, In : Atherosclerosis. 218, 2, p. 431 - 434 4 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Perioperative antiplatelet therapy: A knife-edged choice between thrombosis and bleeding still based on consensus rather than evidence

Peter, K. & Myles, P. S., May 2011, In : Thrombosis and Haemostasis. 105, 5, p. 750-751 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

8 Citations (Scopus)

Proton pump inhibitors, genetic polymorphisms and response to clopidogrel therapy

Fernando, H., Dart, A. M., Peter, K. & Shaw, J. A., Jun 2011, In : Thrombosis and Haemostasis. 105, 6, p. 933-944 12 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

38 Citations (Scopus)

Randomized double-blind placebo-controlled crossover study to determine the effects of esomeprazole on inhibition of platelet function by clopidogrel

Fernando, H., Bassler, N., Habersberger, J., Sheffield, L. J., Sharma, R., Dart, A. M., Peter, K. H. & Shaw, J. A., Aug 2011, In : Journal of Thrombosis and Haemostasis. 9, 8, p. 1582-1589 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression

Ahrens, I., Domeij, H., Topcic, D., Haviv, I., Merivirta, R-M., Agrotis, A., Leitner, E., Jowett, J. B., Bode, C., Lappas, M. & Peter, K., 2011, In : PLoS ONE. 6, 8, 12 p., e23210.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
39 Citations (Scopus)
2012

Amyloid plaques dissociate pentameric to monomeric C-reactive protein: a novel pathomechanism driving cortical inflammation in Alzheimer's disease?

Strang, F., Scheichl, A., Chen, Y-C., Wang, X., Htun, N-M., Bassler, N., Eisenhardt, S. U., Habersberger, J. P. & Peter, K., 2012, In : Brain Pathology. 22, 3, p. 337 - 346 10 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Bio-click chemistry: enzymatic functionalization of PEGylated capsules for targeting applications

Leung, M. K. M., Hagemeyer, C. E., Johnston, A. P. R., Gonzales, C., Kamphuis, M. MJ., Ardipradja, K., Such, G. K., Peter, K. & Caruso, F., 2012, In : Angewandte Chemie - International Edition. 51, 29, p. 7132 - 7136 5 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies

Wolf, D., Jehle, F., Rodriguez, A. O., Dufner, B., Hoppe, N., Colberg, C., Lozhkin, A., Bassler, N., Rupprecht, B., Wiedemann, A., Hilgendorf, I., Stachon, P., Willecke, F., Febbraio, M., Binder, C. J., Bode, C., Zirlik, A. & Peter, K., 8 Mar 2012, In : PLoS ONE. 7, 3, e33026.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction

Habersberger, J. P., Strang, F., Scheichl, A., Htun, N., Bassler, N., Merivirta, R-M., Diehl, P., Krippner, G. Y., Meikle, P. J., Eisenhardt, S. U., Meredith, I. T. & Peter, K., 2012, In : Cardiovascular Research. 96, 1, p. 64 - 72 9 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Development and clinical applications of novel oral anticoagulants. Part I. Clinically approved drugs.

Ahrens, I., Peter, K., Lip, G. Y. H. & Bode, C., Jun 2012, In : Discovery Medicine. 13, 73, p. 433-443 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

12 Citations (Scopus)

Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation.

Ahrens, I., Peter, K., Lip, G. Y. H. & Bode, C., Jun 2012, In : Discovery Medicine. 13, 73, p. 445-450 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

27 Citations (Scopus)

Enzymatic antibody tagging: Toward a universal biocompatible targeting tool

Ta, H. T., Peter, K. & Hagemeyer, C. E., May 2012, In : Trends in Cardiovascular Medicine. 22, 4, p. 105-111 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

18 Citations (Scopus)

HMGB1 signals danger in acute coronary syndrome: Emergence of a new risk marker for cardiovascular death?

Peter, K. & Bobik, A., Apr 2012, In : Atherosclerosis. 221, 2, p. 317-318 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

12 Citations (Scopus)

Microparticles: major transport vehicles for distinct microRNAs in circulation

Diehl, P., Fricke, A., Sander, L., Stamm, J., Bassler, N., Htun, N., Ziemann, M., Helbing, T., El-Osta, A., Jowett, J. B. & Peter, K., 2012, In : Cardiovascular Research. 93, 4, p. 633-644 12 p.

Research output: Contribution to journalArticleResearchpeer-review

305 Citations (Scopus)

Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: Validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice

Wang, X., Hagemeyer, C. E., Hohmann, J. D., Leitner, E., Armstrong, P. CJ., Jia, F., Olschewski, M., Needles, A., Peter, K. & Ahrens, I., 2012, In : Circulation. 125, 25, p. 3117 - 3126 10 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL-monocyte interactions

Eisenhardt, S. U., Starke, J., Thiele, J. R., Murphy, A., Björn Stark, G., Bassler, N., Sviridov, D., Winkler, K. & Peter, K., Oct 2012, In : Atherosclerosis. 224, 2, p. 384-393 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Staphylococcal superantigen-like protein 5 induces thrombotic and bleeding complications in vivo: inhibition by an anti-SSL5 antibody and the glycan Bimosiamose

Armstrong, P. CJ., Hu, H., Rivera, J., Rigby, S., Chen, Y. C., Howden, B. P., Gardiner, E. E. & Peter, K., 2012, In : Journal of Thrombosis and Haemostasis. 10, 12, p. 2607 - 2609 3 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Urine proteome analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows the discovery of new candidate biomarkers in mouse and human atherosclerosis.

von zur Muhlen, C., Schiffer, E., Sackmann, C., Zürbig, P., Neudorfer, I., Zirlik, A., Htun, N., Iphöfer, A., Jänsch, L., Mischak, H., Bode, C., Chen, Y. C. & Peter, K., Jul 2012, In : Molecular & cellular proteomics : MCP. 11, 7, p. 1-13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Chen, Y-C., Bui, A. V., Diesch, J., Manasseh, R., Hausding, C., Rivera, J., Haviv, I., Agrotis, A., Htun, N. M., Jowett, J. B. M., Hagemeyer, C. E., Hannan, R. D., Bobik, A. & Peter, K., 2013, In : Circulation Research. 113, 3, p. 252 - 265 14 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Coagulation disorders and aortic stenosis: A chicken and egg question?

Htun, N. M. & Peter, K., Apr 2013, In : Journal of Thrombosis and Haemostasis. 11, 4, p. 731-732 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

Hohmann, J. D., Wang, X., Krajewski, S., Selan, C., Haller, C. A., Straub, A., Chaikof, E. L., Nandurkar, H. H., Hagemeyer, C. E. & Peter, K., 2013, In : Blood. 121, 16, p. 3067 - 3075 9 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Destination known: Targeted drug delivery in atherosclerosis and thrombosis

Westein, E., Flierl, U., Hagemeyer, C. E. & Peter, K., 2013, In : Drug Development Research. 74, 7, p. 460-471 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)
2014

Biomarkers for AAA: Encouraging steps but clinical relevance still to be delivered

Htun, N. M. & Peter, K., 1 Oct 2014, In : Proteomics - Clinical Applications. 8, 10, p. 732-734 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

4 Citations (Scopus)

Coinhibitory suppression of t cell activation by CD40 protects against obesity and adipose tissue inflammation in mice

Wolf, D., Jehle, F., Michel, N. A., Bukosza, E. N., Rivera, J., Chen, Y. C., Hoppe, N., Dufner, B., Rodriguez, A. O., Colberg, C., Nieto, L., Rupprecht, B., Wiedemann, A., Schulte, L., Peikert, A., Bassler, N., Lozhkin, A., Hergeth, S. P., Stachon, P., Hilgendorf, I. & 11 others, Willecke, F., Von Zur Mühlen, C., von Elverfeldt, D., Binder, C. J., Aichele, P., Varo, N., Febbraio, M. A., Libby, P., Bode, C., Peter, K. & Zirlik, A., 10 Jun 2014, In : Circulation. 129, 23, p. 2414-2425 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Detection of activated platelets in a mouse model of carotid artery thrombosis with {18} F-labeled single-chain antibodies

Ardipradja, K., Yeoh, S. D., Alt, K., O'Keefe, G. J., Rigopoulos, A., Howells, D. W., Scott, A. M., Peter, K., Ackermann, U. & Hagemeyer, C. E., 2014, In : Nuclear Medicine and Biology. 41, 3, p. 229 - 237 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)