• 19 Innovation Walk

    3800 Clayton

20062020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Do cancer therapies damage the uterus and compromise fertility?

Griffiths, M. J., Winship, A. L. & Hutt, K. J., Mar 2020, In : Human Reproduction Update. 26, 2, p. 161-173 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Moderate episodic prenatal alcohol does not impact female offspring fertility in rats

McReight, E. K., Liew, S. H., Steane, S. E., Hutt, K. J., Moritz, K. M. & Akison, L. K., May 2020, In : Reproduction. 159, 5, p. 615-626 12 p.

Research output: Contribution to journalArticleResearchpeer-review

NMN does not protect the ovarian reserve from cancer treatments

Stringer, J., Groenewegen, E., Liew, S. H. & Hutt, K., Feb 2020, In : Reproduction. 159, 2, p. 105-113 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health

Stringer, J. M., Winship, A., Zerafa, N., Wakefield, M. & Hutt, K., 26 May 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 21, p. 11513–11522 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation

Winship, A. L., Griffiths, M., Lliberos Requesens, C., Sarma, U., Phillips, K-A. & Hutt, K. J., 30 Jun 2020, (Accepted/In press) In : Human Reproduction. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 1 Aug 2019, In : Molecular Human Reproduction. 25, 8, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study

Winship, A. L., Willson, C., Hansen, K. R., Hutt, K. J. & Hickey, M., 25 Nov 2019, In : BMJ Open. 9, 11, 7 p., e033810.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Evaluation of mitochondria in oocytes following γ-irradiation

Wang, Q., Stringer, J. M., Liu, J. & Hutt, K. J., 27 Dec 2019, In : Scientific Reports. 9, 1, 9 p., 19941.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Oocytes from stem cells

Sarma, U. C., Findlay, J. K. & Hutt, K. J., 1 Feb 2019, In : Best Practice & Research: Clinical Obstetrics & Gynaecology. 55, p. 14-22 9 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice

Winship, A. L., Carpenter, M., Griffiths, M. & Hutt, K. J., 1 May 2019, In : Toxicological Sciences. 169, 1, p. 43-53 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age

Winship, A. L., Bakai, M., Sarma, U., Liew, S. H. & Hutt, K. J., 25 Apr 2018, In : Scientific Reports. 8, 1, 13 p., 6516.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Examination of the ovotoxicity of 5-fluorouracil in mice

Lambouras, M., Liew, S. H., Horvay, K., Abud, H. E., Stringer, J. M. & Hutt, K. J., Jun 2018, In : Journal of Assisted Reproduction and Genetics. 35, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Nguyen, Q. N., Zerafa, N., Liew, S. H., Morgan, F. H., Strasser, A., Scott, C. L., Findlay, J. K., Hickey, M. & Hutt, K. J., 1 Jun 2018, In : Cell Death and Disease. 9, 6, 12 p., 633.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Maternal low-protein diet programmes low ovarian reserve in offspring

Winship, A. L., Gazzard, S. E., Cullen-McEwen, L. A., Bertram, J. F. & Hutt, K., 10 Jul 2018, In : Reproduction. 156, 4, p. 299-311 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Kondrashova, O., Topp, M., Nesic, K., Lieschke, E., Ho, G. Y., Harrell, M. I., Zapparoli, G. V., Hadley, A., Holian, R., Boehm, E., Heong, V., Sanij, E., Pearson, R. B., Krais, J. J., Johnson, N., McNally, O., Ananda, S., Alsop, K., Hutt, K. J., Kaufmann, S. H. & 11 others, Lin, K. K., Harding, T. C., Traficante, N., Australian Ovarian Cancer Study (AOCS), deFazio, A., McNeish, I. A., Bowtell, D. D., Swisher, E. M., Dobrovic, A., Wakefield, M. J. & Scott, C. L., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 3970.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
37 Citations (Scopus)

Multidose 5-Fluorouracil is Highly Toxic to Growing Ovarian Follicles in Mice

Stringer, J. M., Swindells, E. O. K., Zerafa, N., Liew, S. H. & Hutt, K. J., 1 Nov 2018, In : Toxicological sciences : an official journal of the Society of Toxicology. 166, 1, p. 97-107 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2017

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-Apoptotic protein BMF

Liew, S. H., Nguyen, Q. N., Strasser, A., Findlay, J. K. & Hutt, K. J., 3 Aug 2017, In : Cell Death and Disease. 8, 8, e2971.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)
2016

BCL2-modifying factor promotes germ cell loss during murine oogenesis

Vaithiyanathan, K., Liew, S. H., Zerafa, N., Gamage, T., Cook, M., O'Reilly, L. A., Bouillet, P., Scott, C. L., Strasser, A., Findlay, J. K. & Hutt, K. J., 1 May 2016, In : Reproduction. 151, 5, p. 553-562 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2015

How Is the number of primordial follicles in the ovarian reserve established?

Findlay, J. J. K., Hutt, K. J., Hickey, M. & Anderson, R. A., 2015, In : Biology of Reproduction. 93, 5 (Art. ID : 111), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

The role of BH3-only proteins in apoptosis within the ovary

Hutt, K. J., 2015, In : Reproduction. 149, 2, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
2014

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary

Best, S. A., Hutt, K. J., Fu, N. Y., Vaillant, F., Liew, S. H., Hartley, L., Scott, C. L., Lindeman, G. J. & Visvader, J., 2014, In : Development (Cambridge). 141, 16, p. 3159 - 3164 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

Liew, S. H., Vaithiyanathan, K., Cook, M., Bouillet, P., Scott, C. L., Kerr, J. B., Strasser, A., Findlay, J. J. K. & Hutt, K. J., 2014, In : Biology of Reproduction. 90, 4 (Art. ID: 77), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

Topp, M. D., Hartley, L., Cook, M., Heong, V., Boehm, E., McShane, L., Pyman, J. M., McNally, O. M., Ananda, S. S., Harrell, M., Etemadmoghadam, D., Galletta, L., Alsop, K., Mitchell, G. W. E., Fox, S. B., Kerr, J. B., Hutt, K. J., Kaufmann, S. H., Swisher, E. M., Bowtell, D. DL. & 2 others, Wakefield, M. J. & Scott, C. L., 2014, In : Molecular Oncology. 8, 3, p. 656 - 668 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
58 Citations (Scopus)

PUMA regulates germ cell loss and primordial follicle endowment in mice

Myers, M., Morgan, F. H., Liew, S. H., Zerafa, N., Gamage, T. U., Sarraj, M., Cook, M., Kuyznierewicz, I., Sutherland, A., Scott, C. L., Strasser, A., Findlay, J. J. K., Kerr, J. B. & Hutt, K. J., 2014, In : Reproduction. 148, 2, p. 211 - 219 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2012

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

Kerr, J. B., Hutt, K. J., Cook, M., Speed, T. P., Strasser, A., Findlay, J. K. & Scott, C. L., 2012, In : Nature Medicine. 18, 8, p. 1170 - 1172 3 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

Kerr, J. B., Hutt, K. J., Michalak, E. M., Cook, M., Vandenberg, C., Liew, S. H., Bouillet, P., Mills, A. A., Scott, C. L., Findlay, J. K. & Strasser, A., 2012, In : Molecular Cell. 48, 3, p. 343 - 352 10 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)

Paladin is an antiphosphatase that regulates neural crest cell formation and migration

Roffers-Agarwal, J., Hutt, K. J. & Gammill, L. S., 15 Nov 2012, In : Developmental Biology. 371, 2, p. 180-190 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The primordial follicle reserve is not renewed after chemical or gamma-irradiation mediated depletion

Kerr, J. B., Brogan, L., Myers, M., Hutt, K. J., Mladenovska, T., Ricardo, S. D., Hamza, K., Scott, C. L., Strasser, A. & Findlay, J. K., 2012, In : Reproduction. 143, 4, p. 469 - 476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)
2011

Apoptosis in the germ line

Aitken, R. J., Findlay, J. K., Hutt, K. J. & Kerr, J. B., 2011, In : Reproduction. 141, 2, p. 139 - 150 12 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)
2010

Comparative analysis of the metaphase II spindle of human oocytes through polarized light and high-performance confocal microscopy

Coticchio, G., Sciajno, R., Hutt, K., Bromfield, J., Borini, A. & Albertini, D. F., Apr 2010, In : Fertility and Sterility. 93, 6, p. 2056-2064 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbs the establishment and maintenance of cell polarity in preimplantation rat embryos

Hutt, K. J., Shi, Z., Petroff, B. K. & Albertini, D. F., May 2010, In : Biology of Reproduction. 82, 5, p. 914-920 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2009

Meiotic spindle dynamics in human oocytes following slow-cooling cryopreservation

Bromfield, J., Coticchio, G., Hutt, K., Sciajno, R., Borini, A. & Albertini, D. F., Sep 2009, In : Human Reproduction. 24, 9, p. 2114-2123 10 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)
2008

The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo

Hutt, K. J., Shi, Z., Albertini, D. F. & Petroff, B. K., 6 Mar 2008, In : BMC Developmental Biology. 8, 1.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2007

Ferrichrome utilization in a mesorhizobial population: Microevolution of a three-locus system

Carlton, T. M., Sullivan, J. T., Stuart, G. S., Hutt, K., Lamont, I. L. & Ronson, C. W., 1 Dec 2007, In : Environmental Microbiology. 9, 12, p. 2923-2932 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Permeability of human oocytes to ethylene glycol and their survival and spindle configurations after slow cooling cryopreservation

De santis, L., Coticchio, G., Paynter, S., Albertini, D., Hutt, K., Cino, I., Iaccarino, M., Gambardella, A., Flamigni, C. & Borini, A., 1 Jan 2007, In : Human Reproduction. 22, 10, p. 2776-2783 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2006

KIT/KIT ligand in mammalian oogenesis and folliculogenesis: roles in rabbit and murine ovarian follicle activation and oocyte growth

Hutt, K. J., McLaughlin, E. A. & Holland, M. K., 2006, In : Biology of Reproduction. 75, 3, p. 421 - 433 13 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis

Hutt, K. J., McLaughlin, E. A. & Holland, M. K., 2006, In : Molecular Human Reproduction. 12, 2, p. 61 - 69 9 p.

Research output: Contribution to journalArticleResearchpeer-review

127 Citations (Scopus)

Primordial follicle activation and follicular development in the juvenile rabbit ovary

Hutt, K. J., McLaughlin, E. A. & Holland, M. K., 2006, In : Cell and Tissue Research. 326, 3, p. 809 - 822 14 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)