20062020
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Research Output 2006 2019

2019

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 6 Apr 2019, (Accepted/In press) In : Molecular Human Reproduction. 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Oocytes from stem cells

Sarma, U. C., Findlay, J. K. & Hutt, K. J., 1 Feb 2019, In : Best Practice & Research: Clinical Obstetrics & Gynaecology. 55, p. 14-22 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice

Winship, A. L., Carpenter, M., Griffiths, M. & Hutt, K. J., 1 May 2019, In : Toxicological sciences : an official journal of the Society of Toxicology. 169, 1, p. 43-53 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age

Winship, A. L., Bakai, M., Sarma, U., Liew, S. H. & Hutt, K. J., 25 Apr 2018, In : Scientific Reports. 8, 1, 13 p., 6516.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Examination of the ovotoxicity of 5-fluorouracil in mice

Lambouras, M., Liew, S. H., Horvay, K., Abud, H. E., Stringer, J. M. & Hutt, K. J., Jun 2018, In : Journal of Assisted Reproduction and Genetics. 35, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Nguyen, Q. N., Zerafa, N., Liew, S. H., Morgan, F. H., Strasser, A., Scott, C. L., Findlay, J. K., Hickey, M. & Hutt, K. J., 1 Jun 2018, In : Cell Death and Disease. 9, 6, 12 p., 633.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Maternal low-protein diet programmes low ovarian reserve in offspring

Winship, A. L., Gazzard, S. E., Cullen-McEwen, L. A., Bertram, J. F. & Hutt, K., 10 Jul 2018, In : Reproduction. 156, 4, p. 299-311 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Kondrashova, O., Topp, M., Nesic, K., Lieschke, E., Ho, G. Y., Harrell, M. I., Zapparoli, G. V., Hadley, A., Holian, R., Boehm, E., Heong, V., Sanij, E., Pearson, R. B., Krais, J. J., Johnson, N., McNally, O., Ananda, S., Alsop, K., Hutt, K. J., Kaufmann, S. H. & 11 othersLin, K. K., Harding, T. C., Traficante, N., Australian Ovarian Cancer Study (AOCS), deFazio, A., McNeish, I. A., Bowtell, D. D., Swisher, E. M., Dobrovic, A., Wakefield, M. J. & Scott, C. L., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 3970.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Multidose 5-Fluorouracil is Highly Toxic to Growing Ovarian Follicles in Mice

Stringer, J. M., Swindells, E. O. K., Zerafa, N., Liew, S. H. & Hutt, K. J., 1 Nov 2018, In : Toxicological sciences : an official journal of the Society of Toxicology. 166, 1, p. 97-107 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The capacity of oocytes for DNA repair

Stringer, J. M., Winship, A., Liew, S. H. & Hutt, K., Aug 2018, In : Cellular and Molecular Life Sciences. 75, 15, p. 2777-2792 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing

Winship, A. L., Stringer, J. M., Liew, S. H. & Hutt, K. J., 1 Mar 2018, In : Human Reproduction Update. 24, 2, p. 119-134 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-Apoptotic protein BMF

Liew, S. H., Nguyen, Q. N., Strasser, A., Findlay, J. K. & Hutt, K. J., 3 Aug 2017, In : Cell Death and Disease. 8, 8, e2971.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

BCL2-modifying factor promotes germ cell loss during murine oogenesis

Vaithiyanathan, K., Liew, S. H., Zerafa, N., Gamage, T., Cook, M., O'Reilly, L. A., Bouillet, P., Scott, C. L., Strasser, A., Findlay, J. K. & Hutt, K. J., 1 May 2016, In : Reproduction. 151, 5, p. 553-562 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Taking control of the female fertile lifespan: A key role for Bcl-2 family proteins

Liew, S. H., Vaithiyanathan, K. & Hutt, K. J., 2016, In : Reproduction, Fertility and Development. 28, 7, p. 864-871 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2015

How Is the number of primordial follicles in the ovarian reserve established?

Findlay, J. J. K., Hutt, K. J., Hickey, M. & Anderson, R. A., 2015, In : Biology of Reproduction. 93, 5 (Art. ID : 111), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Ovarian reserve screening: A scientific and ethical analysis

Findlay, J. K., Hutt, K. J., Hickey, M. & Anderson, R. A., 30 Sep 2015, In : Human Reproduction. 30, 4, p. 1000-1001 2 p.

Research output: Contribution to journalLetterOtherpeer-review

The role of BH3-only proteins in apoptosis within the ovary

Hutt, K. J., 2015, In : Reproduction. 149, 2, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

What is the "ovarian reserve"?

Findlay, J., Hutt, K. J., Hickey, M. & Anderson, R. A., 1 Mar 2015, In : Fertility and Sterility. 103, 3, p. 628-630 3 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

2014

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary

Best, S. A., Hutt, K. J., Fu, N. Y., Vaillant, F., Liew, S. H., Hartley, L., Scott, C. L., Lindeman, G. J. & Visvader, J., 2014, In : Development. 141, 16, p. 3159 - 3164 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

Liew, S. H., Vaithiyanathan, K., Cook, M., Bouillet, P., Scott, C. L., Kerr, J. B., Strasser, A., Findlay, J. J. K. & Hutt, K. J., 2014, In : Biology of Reproduction. 90, 4 (Art. ID: 77), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

Topp, M. D., Hartley, L., Cook, M., Heong, V., Boehm, E., McShane, L., Pyman, J. M., McNally, O. M., Ananda, S. S., Harrell, M., Etemadmoghadam, D., Galletta, L., Alsop, K., Mitchell, G. W. E., Fox, S. B., Kerr, J. B., Hutt, K. J., Kaufmann, S. H., Swisher, E. M., Bowtell, D. DL. & 2 othersWakefield, M. J. & Scott, C. L., 2014, In : Molecular Oncology. 8, 3, p. 656 - 668 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PUMA regulates germ cell loss and primordial follicle endowment in mice

Myers, M., Morgan, F. H., Liew, S. H., Zerafa, N., Gamage, T. U., Sarraj, M., Cook, M., Kuyznierewicz, I., Sutherland, A., Scott, C. L., Strasser, A., Findlay, J. J. K., Kerr, J. B. & Hutt, K. J., 2014, In : Reproduction. 148, 2, p. 211 - 219 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Damage control in the female germline: Protecting primordial follicles

Myers, M. & Hutt, K. J., 1 Jan 2013, Oogenesis. Coticchio, G., Albertini, D. F. & De Santis, L. (eds.). London: Springer-Verlag London Ltd., p. 39-47 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

How to best preserve oocytes in female cancer patients exposed to DNA damage inducing therapeutics

Hutt, K. J., Kerr, J. B., Scott, C. L., Findlay, J. K. & Strasser, A., 2013, In : Cell Death and Differentiation. 20, 8, p. 967 - 968 2 p.

Research output: Contribution to journalLetterOther

2012

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

Kerr, J. B., Hutt, K. J., Cook, M., Speed, T. P., Strasser, A., Findlay, J. K. & Scott, C. L., 2012, In : Nature Medicine. 18, 8, p. 1170 - 1172 3 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

Kerr, J. B., Hutt, K. J., Michalak, E. M., Cook, M., Vandenberg, C., Liew, S. H., Bouillet, P., Mills, A. A., Scott, C. L., Findlay, J. K. & Strasser, A., 2012, In : Molecular Cell. 48, 3, p. 343 - 352 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Paladin is an antiphosphatase that regulates neural crest cell formation and migration

Roffers-Agarwal, J., Hutt, K. J. & Gammill, L. S., 15 Nov 2012, In : Developmental Biology. 371, 2, p. 180-190 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The primordial follicle reserve is not renewed after chemical or gamma-irradiation mediated depletion

Kerr, J. B., Brogan, L., Myers, M., Hutt, K. J., Mladenovska, T., Ricardo, S. D., Hamza, K., Scott, C. L., Strasser, A. & Findlay, J. K., 2012, In : Reproduction. 143, 4, p. 469 - 476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Apoptosis in the germ line

Aitken, R. J., Findlay, J. K., Hutt, K. J. & Kerr, J. B., 2011, In : Reproduction. 141, 2, p. 139 - 150 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Morphogenesis of the rat pre-implantation embryo and environmental toxicant

Hutt, K. J., Shi, Z., Albertini, D. F. & Petroff, B. K., 1 Jan 2011, Environmental Chemistry: New Techniques and Data. Apple Academic Press, Inc., p. 150-162 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2010

Comparative analysis of the metaphase II spindle of human oocytes through polarized light and high-performance confocal microscopy

Coticchio, G., Sciajno, R., Hutt, K., Bromfield, J., Borini, A. & Albertini, D. F., Apr 2010, In : Fertility and Sterility. 93, 6, p. 2056-2064 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbs the establishment and maintenance of cell polarity in preimplantation rat embryos

Hutt, K. J., Shi, Z., Petroff, B. K. & Albertini, D. F., May 2010, In : Biology of Reproduction. 82, 5, p. 914-920 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Meiotic spindle dynamics in human oocytes following slow-cooling cryopreservation

Bromfield, J., Coticchio, G., Hutt, K., Sciajno, R., Borini, A. & Albertini, D. F., Sep 2009, In : Human Reproduction. 24, 9, p. 2114-2123 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo

Hutt, K. J., Shi, Z., Albertini, D. F. & Petroff, B. K., 6 Mar 2008, In : BMC Developmental Biology. 8, 1.

Research output: Contribution to journalArticleResearchpeer-review

2007

An oocentric view of folliculogenesis and embryogenesis

Hutt, K. J. & Albertini, D. F., 1 Jan 2007, In : Reproductive BioMedicine Online. 14, 6, p. 758-764 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Ferrichrome utilization in a mesorhizobial population: Microevolution of a three-locus system

Carlton, T. M., Sullivan, J. T., Stuart, G. S., Hutt, K., Lamont, I. L. & Ronson, C. W., 1 Dec 2007, In : Environmental Microbiology. 9, 12, p. 2923-2932 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Permeability of human oocytes to ethylene glycol and their survival and spindle configurations after slow cooling cryopreservation

De santis, L., Coticchio, G., Paynter, S., Albertini, D., Hutt, K., Cino, I., Iaccarino, M., Gambardella, A., Flamigni, C. & Borini, A., 1 Jan 2007, In : Human Reproduction. 22, 10, p. 2776-2783 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Clinical applications and limitations of current ovarian stem cell research: A review

Hutt, K. J. & Albertini, D. F., 27 Jul 2006, In : Journal of Experimental and Clinical Assisted Reproduction. 3, 6.

Research output: Contribution to journalReview ArticleResearchpeer-review

KIT/KIT ligand in mammalian oogenesis and folliculogenesis: roles in rabbit and murine ovarian follicle activation and oocyte growth

Hutt, K. J., McLaughlin, E. A. & Holland, M. K., 2006, In : Biology of Reproduction. 75, 3, p. 421 - 433 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis

Hutt, K. J., McLaughlin, E. A. & Holland, M. K., 2006, In : Molecular Human Reproduction. 12, 2, p. 61 - 69 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Primordial follicle activation and follicular development in the juvenile rabbit ovary

Hutt, K. J., McLaughlin, E. A. & Holland, M. K., 2006, In : Cell and Tissue Research. 326, 3, p. 809 - 822 14 p.

Research output: Contribution to journalArticleResearchpeer-review