Projects per year
Personal profile
Biography
Dr Karla Hutt obtained her PhD from the Australian National University in 2006, where her studies focussed on the establishment and maintenance of the primordial follicle pool during ovarian development. She then undertook her postdoctoral studies at the University of Kansas Medical Center (USA), where she investigated the impact of environmental toxicants on oocyte and embryo quality. In 2008 she returned to Australia and to join Professor Jock Findlay's laboratory at Prince Henrys Institute (now the Hudson Institute of Medical Research). In 2015 she relocated to Monash University and leads the Ovarian Biology Laboratory. Her group investigates the role of DNA repair and apoptosis in determining oocyte number and quality, with the aim of i) improving women’s health and fertility during maternal aging and ii) developing new therapeutic strategies to protect female fertility during anti-cancer therapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- ovary
- oocyte
- follilce
- fertility
- apoptosis
- DNA repair
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Protecting fertility, healthy pregnancy and long-term endocrine function for cancer survivors after immunotherapy
Winship, A. (Primary Chief Investigator (PCI)), Cui, W. (Chief Investigator (CI)), Stern, C. (Chief Investigator (CI)), Rozen, G. (Chief Investigator (CI)), Hutt, K. (Associate Investigator (AI)), La Gruta, N. (Associate Investigator (AI)), Jarde, T. (Associate Investigator (AI)), Fitzgerald, H. (Associate Investigator (AI)) & Marshall, S. (Associate Investigator (AI))
1/01/25 → 31/12/28
Project: Research
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Defining the contribution of inflammatory cytokines to oocyte maturation and quality
Hutt, K. (Primary Chief Investigator (PCI)), Winship, A. (Chief Investigator (CI)), Stringer, J. (Chief Investigator (CI)), Green, M. (Associate Investigator (AI)), Vollenhoven, B. (Associate Investigator (AI)), Lliberos, C. (Associate Investigator (AI)) & Sarma, U. (Associate Investigator (AI))
20/09/24 → 31/12/27
Project: Research
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Characterization of the Germline Regulatory Landscape
Pocock, R. (Primary Chief Investigator (PCI)), Cao, W. (Chief Investigator (CI)), Fan, Q. (Chief Investigator (CI)), Hutt, K. (Associate Investigator (AI)), Gopal, S. (Associate Investigator (AI)), Schittenhelm, R. (Associate Investigator (AI)), Hobbs, R. (Associate Investigator (AI)), Archer, S. (Associate Investigator (AI)) & Coutts, S. (Associate Investigator (AI))
1/01/23 → 31/12/27
Project: Research
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Does Chlamydia infection damage the ovary and compromise fertility?
Hutt, K. (Primary Chief Investigator (PCI)), Beagley, K. (Chief Investigator (CI)), Homer, H. A. (Associate Investigator (AI)) & Carey, A. (Associate Investigator (AI))
1/01/22 → 31/12/26
Project: Research
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Survivorship Sequelae of Precision Breast Cancer Treatments: Defining the impacts of immunotherapy and PARP inhibitors on ovarian function and fertility
Hutt, K. (Primary Chief Investigator (PCI)), Phillips, K. A. (Chief Investigator (CI)), Loi, S. (Chief Investigator (CI)), Winship, A. (Chief Investigator (CI)) & Cui, W. (Chief Investigator (CI))
National Breast Cancer Foundation
23/03/22 → 31/12/24
Project: Research
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Conditional loss of Brca1 in oocytes causes reduced litter size, ovarian reserve depletion and impaired oocyte in vitro maturation with advanced reproductive age in mice
Winship, A., Alesi, L. R., Stringer, J., Cao, W., Lewis, Y., Tu, L., Swindells, E. O. K., Giridharan, S., Cai, X., Griffiths, M., Zerafa, N., Gilham, L., Hickey, M. & Hutt, K., Aug 2024, In: EBioMedicine. 106, 15 p., 105262.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Exome-informed formulations of food proteins enhance body growth and feed conversion efficiency in ad libitum-fed mice
Wu, T., Baatar, D., O' Connor, A. E., O'Bryan, M. K., Stringer, J. M., Hutt, K. J., Malimige Aponso, M., Monro, K., Luo, J., Zhu, Y., Ernst, A., Swindells, E. O. K., Alesi, L. R., Tho Tony Nguyen, N., Piper, M. D. W. & Bennett, L. E., Jan 2024, In: Food Research International. 176, 13 p., 113819.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life
Stringer, J. M., Alesi, L. R., Winship, A. L. & Hutt, K. J., 5 Jul 2023, In: Human Reproduction Update. 29, 4, p. 434-456 23 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access63 Citations (Scopus) -
Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals
Tsui, V., Lyu, R., Novakovic, S., Stringer, J. M., Dunleavy, J. E. M., Granger, E., Semple, T., Leichter, A., Martelotto, L. G., Merriner, D. J., Liu, R., McNeill, L., Zerafa, N., Hoffmann, E. R., O'Bryan, M. K., Hutt, K., Deans, A. J., Heierhorst, J., McCarthy, D. J. & Crismani, W., 9 Aug 2023, In: Cell Genomics. 3, 8, 27 p., 100349.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Impact of Chronic Multi-Generational Exposure to an Environmentally Relevant Atrazine Concentration on Testicular Development and Function in Mice
Kolaitis, N. D., Finger, B. J., Merriner, D. J., Nguyen, J., Houston, B. J., O’Bryan, M. K., Stringer, J. M., Zerafa, N., Nguyen, N., Hutt, K. J., Tarulli, G. A. & Green, M. P., Feb 2023, In: Cells. 12, 4, 18 p., 648.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)