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2020

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations

Reutens, A. T., Jandeleit-Dahm, K., Thomas, M., Salim, A., De Livera, A. M., Bach, L. A., Colman, P. G., Davis, T. M. E., Ekinci, E. I., Fulcher, G., Hamblin, P. S., Kotowicz, M. A., MacIsaac, R. J., Morbey, C., Simmons, D., Soldatos, G., Wittert, G., Wu, T., Cooper, M. E. & Shaw, J. E., Mar 2020, In : Contemporary Clinical Trials. 90, 8 p., 105892.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes

Gueguen, C., Burke, S. L., Barzel, B., Eikelis, N., Watson, A. M. D., Jha, J. C., Jackson, K. L., Sata, Y., Lim, K., Lambert, G. W., Jandeleit-Dahm, K. A. M., Cooper, M. E., Thomas, M. C. & Head, G. A., Jul 2020, In : Diabetologia. 63, 7, p. 1424–1434 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

Deliyanti, D., Alrashdi, S. F., Touyz, R. M., Kennedy, C. R., Jha, J. C., Cooper, M. E., Jandeleit-Dahm, K. A. & Wilkinson-Berka, J. L., 1 Apr 2020, In : Hypertension. 75, 4, p. 1091-1101 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Nox4-mediated ROS production is involved, but not essential for TGFβ-induced lens EMT leading to cataract

Das, S. J., Wishart, T. F. L., Jandeleit-Dahm, K. & Lovicu, F. J., Mar 2020, In : Experimental Eye Research. 192, 15 p., 107918.

Research output: Contribution to journalArticleResearchpeer-review

2019

Diabetes and hypertension differentially affect renal catecholamines and renal reactive oxygen species

Watson, A. M. D., Gould, E. A. M., Penfold, S. A., Lambert, G. W., Pratama, P. R., Dai, A., Gray, S. P., Head, G. A. & Jandeleit-Dahm, K. A., Apr 2019, In : Frontiers in Physiology. 10, MAR, 16 p., 309.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse

Jha, J. C., Dai, A., Holterman, C. E., Cooper, M. E., Touyz, R. M., Kennedy, C. R. & Jandeleit-Dahm, K. A. M., 1 Sep 2019, In : Diabetologia. 62, 9, p. 1712-1726 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

Pickering, R. J., Tikellis, C., Rosado, C. J., Tsorotes, D., Dimitropoulos, A., Smith, M., Huet, O., Seeber, R. M., Abhayawardana, R., Johnstone, E. K. M., Golledge, J., Wang, Y., Jandeleit-Dahm, K. A., Cooper, M. E., Pfleger, K. D. G. & Thomas, M. C., 2 Jan 2019, In : Journal of Clinical Investigation. 129, 1, p. 406-421 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)
2018

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation

Mathew, G., Sharma, A., Pickering, R. J., Rosado, C. J., Lemarie, J., Mudgal, J., Thambi, M., Sebastian, S., Jandeleit-Dahm, K. A., de Haan, J. B. & Unnikrishnan, M. K., 3 Oct 2018, In : Free Radical Research. 52, 10, p. 1140-1157 18 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Lipoxins protect against inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Mohan, M., McClelland, A., De Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., Gray, S. P., Pickering, R., Tan, S. M., Godson-Treacy, M., Sheehan, S., Dowdall, J. F., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P. J. & 4 others, Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Dec 2018, In : Diabetes. 67, 12, p. 2657-2667 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease

Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Tasadaque Ali-Shah, S., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1437-1448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
9 Citations (Scopus)
2017

Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Gray, S. P., Jha, J. C., Kennedy, K., Bommel, E. V., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E. & Jandeleit-Dahm, K. A. M., May 2017, In : Diabetologia. 60, 5, p. 927-937 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

NADPH oxidase Nox5 accelerates renal injury in diabetic nephropathy

Jha, J. C., Banal, C., Okabe, J., Gray, S. P., Hettige, T., Chow, B. S. M., Thallas-Bonke, V., Vos, L. D., Holterman, C. E., Coughlan, M. T., Power, D. A., Skene, A., Ekinci, E. I., Cooper, M. E., Touyz, R. M., Kennedy, C. R. & Jandeleit-Dahm, K., 1 Oct 2017, In : Diabetes. 66, 10, p. 2691-2703 13 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Wang, B., McClelland, A., Mohan, M., Marai, M., Beuscart, O., Derouiche, S., Gray, S., Pickering, R., Tikellis, C., De Gaetano, M., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P., Jandeleit-Dahm, K. A. M., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Aug 2017, In : Diabetes. 66, 8, p. 2266-2277 12 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)
2016

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE−/− mice

Di Marco, E., Gray, S. P., Chew, P., Kennedy, K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K., Aug 2016, In : Clinical Science. 130, 15, p. 1363-1374 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

Di Marco, E., Gray, S. P., Kennedy, K., Szyndralewiez, C., Griendling, K. K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K., 1 Aug 2016, In : Free Radical Biology and Medicine. 97, p. 556-567 12 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

Jha, J. C., Thallas-Bonke, V., Banal, C., Gray, S. P., Chow, B. S. M., Ramm, G., Quaggin, S. E., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., 1 Feb 2016, In : Diabetologia. 59, 2, p. 379-389 11 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., 1 Feb 2016, In : Arteriosclerosis, Thrombosis and Vascular Biology. 36, 2, p. 295-307 13 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis

Chow, B. S. M., Koulis, C., Krishnaswamy, P., Steckelings, U. M., Unger, T., Cooper, M. E., Jandeleit-Dahm, K. A. & Allen, T. J., 1 Aug 2016, In : Diabetologia. 59, 8, p. 1778-1790 13 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2015

AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy

Koulis, C., Chow, B. SM., Mckelvey, M., Steckelings, U. M., Unger, T., Thallas-Bonke, V., Thomas, M. C., Cooper, M. E., Jandeleit-Dahm, K. A. M. & Allen, T. J., 2015, In : Hypertension. 65, 5, p. 1073 - 1081 9 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

CXCR4 antagonism attenuates the development of diabetic cardiac fibrosis

Chu, P. Y., Walder, K., Horlock, D., Williams, D., Nelson, E. M., Byrne, M., Jandeleit-Dahm, K., Zimmet, P. & Kaye, D. M., 27 Jul 2015, In : PLoS ONE. 10, 7, e0133616.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

Ahrens, I., Chen, Y-C., Topcic, D., Bode, M., Haenel, D., Hagemeyer, C. E., Seeba, H., Duerschmied, D., Bassler, N., Jandeleit-Dahm, K., Sweet, M. J., Agrotis, A., Bobik, A. & Peter, K., 2015, In : Thrombosis and Haemostasis. 114, 5, p. 994 - 1003 10 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Nox-4 and progressive kidney disease

Thallas-Bonke, V., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2015, In : Current Opinion in Nephrology and Hypertension. 24, 1, p. 74-80 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2014

Auditory neuropathy in individuals with Type 1 diabetes

Rance, G., Chisari, D., O'Hare, F., Roberts, L., Shaw, J., Jandeleit-Dahm, K. & Szmulewicz, D., 2014, In : Journal of Neurology. 261, 8, p. 1531-1536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Beyond Glycosuria: Exploring the intrarenal effects of SGLT-2 inhibition in diabetes

Thomas, M. C., Jandeleit-Dahm, K. & Bonnet, F., 1 Dec 2014, In : Diabetes and Metabolism. 40, 6, p. S17-S22 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
49 Citations (Scopus)

Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in longterm diabetic nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., Touyz, R. M., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2014, In : Journal of the American Society of Nephrology. 25, 6, p. 1237-1254 18 p.

Research output: Contribution to journalArticleResearchpeer-review

182 Citations (Scopus)

Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?

Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K. A. M. & Kammoun, H. L., 2014, In : Frontiers in Immunology. 5, Art. No.: 470, p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
125 Citations (Scopus)

NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy

Wilkinson-Berka, J., Deliyanti, D., Rana, I., Miller, A. G., Agrotis, A., Armani, R., Szyndralewiez, C., Wingler, K., Touyz, R. M., Cooper, M. E., Jandeleit-Dahm, K. A. M. & Schmidt, H., 2014, In : Antioxidants and Redox Signaling. 20, 17, p. 2726-2740 15 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

New insights into the use of biomarkers of diabetic nephropathy

Jha, J., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2014, In : Advances in Chronic Kidney Disease. 21, 3, p. 318-326 9 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy

Thallas-Bonke, V., Jha, J. C., Gray, S. P., Barit, D., Haller, H., Schmidt, H. H. H. W., Coughlan, M. T., Cooper, M. E., Forbes, J. M. & Jandeleit-Dahm, K. A. M., 2014, In : Physiological Reports. 2, 11, 13 p., e12192.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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60 Citations (Scopus)

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe −/− mice

Di Marco, E., Gray, S. P., Chew, P., Koulis, C., Ziegler, A. I., Szyndralewiez, C., Touyz, R. M., Schmidt, H., Cooper, M. E., Slattery, R. M. & Jandeleit-Dahm, K. A. M., 2014, In : Diabetologia. 57, 3, p. 633 - 642 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice

Koulis, C., Chen, Y-C., Hausding, C., Ahrens, I., Kyaw, T. S., Tay, C., Allen, T. J., Jandeleit-Dahm, K. A. M., Sweet, M. J., Akira, S., Bobik, A., Peter, K. & Agrotis, A., 2014, In : Arteriosclerosis, Thrombosis and Vascular Biology. 34, 3, p. 516 - 525 10 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice

Watson, A. M. D., Li, J., Samijono, D., Bierhaus, A., Thomas, M. C., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2014, In : Atherosclerosis. 235, 2, p. 444 - 448 5 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b

Wang, B., Jha, J. C., Hagiwara, S., Mcclelland, A. D., Jandeleit-Dahm, K., Thomas, M. C., Cooper, M. E. & Kantharidis, P., Feb 2014, In : Kidney International. 85, 2, p. 352-361 10 p.

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)
2013

Improvement in albuminuria in patients with type 2 diabetes after laparoscopic adjustable gastric banding

Stephenson, D. T., Jandeleit-Dahm, K. A. M., Balkau, B. & Cohen, N., 2013, In : Diabetes and Vascular Disease Research. 10, 6, p. 514 - 519 6 p.

Research output: Contribution to journalArticleOther

13 Citations (Scopus)

NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., De Haan-Klein, J. B., Koulis, C., El-Osta, A., Andrews, K. L., Chin-Dusting, J. PF., Touyz, R. M., Wingler, K., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2013, In : Circulation. 127, 18, p. 1888 - 1902 15 p.

Research output: Contribution to journalArticleResearchpeer-review

224 Citations (Scopus)

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of type 2 diabetes

Sedeek, M., Gutsol, A., Montezano, A. C., Burger, D., Nguyen Dinh Cat, A., Kennedy, C. R. J., Burns, K. D., Cooper, M. E., Jandeleit-Dahm, K., Page, P., Szyndralewiez, C., Heitz, F., Hebert, R. L. & Touyz, R. M., 1 Feb 2013, In : Clinical Science. 124, 3, p. 191-202 12 p.

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)

Role of Nox2 in diabetic kidney disease

You, Y. H., Okada, S., Ly, S., Jandeleit-Dahm, K., Barit, D., Namikoshi, T. & Sharma, S. K., 2013, In : American Journal of Physiology-Renal Physiology. 304, 7, p. F840-F848 9 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Gray, S. P., Jandeleit-Dahm, K. A. M., McMullen, J. R. & Ritchie, R. H., 2013, In : Free Radical Biology and Medicine. 60, p. 307 - 317 11 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: Studies in humans and in a mouse model of diabetes

Watson, A., Olukman, M., Koulis, C., Tu, Y., Samijono, D., Yuen, D. Y. C., Lee, C., Behm, D., Cooper, M., Jandeleit-Dahm, K. A. M., Calkin, A. C. & Allen, T. J., 2013, In : Diabetologia. 56, 5, p. 1155 - 1165 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
2012

Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice

Watson, A. M. D., Gray, S. P., Jiaze, L., Soro-Paavonen, A., Wong, B., Cooper, M. E., Bierhaus, A., Pickering, R., Tikellis, C., Tsorotes, D., Thomas, M. C. & Jandeleit-Dahm, K. A. M., Aug 2012, In : Diabetes. 61, 8, p. 2105-2113 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Coenzyme Q{10} attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Jandeleit-Dahm, K. A. M., Forbes, J., McMullen, J. R. & Ritchie, R. H., 2012, In : Diabetologia. 55, 5, p. 1544 - 1553 10 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

Ritchie, R. H., Love, J. E., Huynh, K., Bernardo, B. C., Henstridge, D. C., Kiriazis, H., Tham, Y. K., Sapra, G., Qin, C., Cemerlang, N., Boey, E. J. H., Jandeleit-Dahm, K., Du, X. J. & McMullen, J. R., Dec 2012, In : Diabetologia. 55, 12, p. 3369-3381 13 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Insulin and cardiovascular disease: Biomarker or association?

Jandeleit-Dahm, K. A. M. & Gray, S. P., Dec 2012, In : Diabetologia. 55, 12, p. 3145-3151 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Oxidative stress, nox isoforms and complications of diabetes-potential targets for novel therapies

Sedeek, M., Montezano, A. C., Hebert, R. L., Gray, S. P., Di Marco, E., Jha, J. C., Cooper, M., Jandeleit-Dahm, K. A. M., Schiffrin, E. L., Wilkinson-Berka, J. & Touyz, R. M., 2012, In : Journal of Cardiovascular Translational Research. 5, 4, p. 509 - 518 10 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis

Wang, B., Komers, R., Carew, R., Winbanks, C. E., Xu, B., Herman-Edelstein, M., Koh, P., Thomas, M., Jandeleit-Dahm, K., Gregorevic, P., Cooper, M. E. & Kantharidis, P., Feb 2012, In : Journal of the American Society of Nephrology. 23, 2, p. 252-265 14 p.

Research output: Contribution to journalArticleResearchpeer-review

324 Citations (Scopus)

The endothelin system and endothelin receptor antagonists

Jandeleit-Dahm, K. A. M. & Watson, A., 2012, In : Current Opinion in Nephrology and Hypertension. 21, 1, p. 66 - 71 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2011

Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice

Watson, A., Soro-Paavonen, A., Sheehy, K., Li, J., Calkin, A. C., Koitka, A., Rajan, S. N., Brasacchio, D., Allen, T. J., Cooper, M. E., Thomas, M. C. & Jandeleit-Dahm, K. J. A., Mar 2011, In : Diabetologia. 54, 3, p. 681-689 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)