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Research Output 1991 2019

2019
3 Citations (Scopus)

Diabetes and hypertension differentially affect renal catecholamines and renal reactive oxygen species

Watson, A. M. D., Gould, E. A. M., Penfold, S. A., Lambert, G. W., Pratama, P. R., Dai, A., Gray, S. P., Head, G. A. & Jandeleit-Dahm, K. A., Apr 2019, In : Frontiers in Physiology. 10, MAR, 16 p., 309.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Dipeptidyl peptidase-4 inhibitors and cardiovascular and renal disease in type 2 diabetes: What have we learned from the CARMELINA trial?

Hanssen, N. M. J. & Jandeleit-Dahm, K. A. M., 1 Jul 2019, In : Diabetes and Vascular Disease Research. 16, 4, p. 303-309 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse

Jha, J. C., Dai, A., Holterman, C. E., Cooper, M. E., Touyz, R. M., Kennedy, C. R. & Jandeleit-Dahm, K. A. M., 1 Sep 2019, In : Diabetologia. 62, 9, p. 1712-1726 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of Oxidative Stress in Cardiovascular Diseases

Jha, J. C., Bose, M. & Jandeleit-Dahm, K. A. M., 2019, Modulation of Oxidative Stress in Cardiovascular diseases. Chakraborti, S., Dhalla, N. S., Dikshit, M. & Ganguly, N. K. (eds.). Singapore, Singapore: Springer, p. 237-253 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage

Elbatreek, M. H., Pachado, M. P., Cuadrado, A., Jandeleit-Dahm, K. & Schmidt, H. H. H. W., 1 May 2019, In : Trends in Endocrinology and Metabolism. 30, 5, p. 312-327 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

SGLT-2 Inhibition: Novel therapeutics for reno-and cardioprotection in diabetes mellitus

Gill, A., Gray, S. P., Jandeleit-Dahm, K. A. & Watson, A. M. D., 1 Jan 2019, In : Current Diabetes Reviews. 15, 5, p. 349-356 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

Pickering, R. J., Tikellis, C., Rosado, C. J., Tsorotes, D., Dimitropoulos, A., Smith, M., Huet, O., Seeber, R. M., Abhayawardana, R., Johnstone, E. K. M., Golledge, J., Wang, Y., Jandeleit-Dahm, K. A., Cooper, M. E., Pfleger, K. D. G. & Thomas, M. C., 2 Jan 2019, In : Journal of Clinical Investigation. 129, 1, p. 406-421 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018
18 Citations (Scopus)

A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

Jha, J. C., Ho, F., Dan, C. & Jandeleit-Dahm, K., 1 Aug 2018, In : Clinical Science. 132, 16, p. 1811-1836 26 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation

Mathew, G., Sharma, A., Pickering, R. J., Rosado, C. J., Lemarie, J., Mudgal, J., Thambi, M., Sebastian, S., Jandeleit-Dahm, K. A., de Haan, J. B. & Unnikrishnan, M. K., 3 Oct 2018, In : Free Radical Research. 52, 10, p. 1140-1157 18 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Cardiovascular Disease and Diabetic Kidney Disease

Maqbool, M., Cooper, M. E. & Jandeleit-Dahm, K. A. M., 1 May 2018, In : Seminars in Nephrology. 38, 3, p. 217-232 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Lipoxins protect against inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Mohan, M., McClelland, A., De Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., Gray, S. P., Pickering, R., Tan, S. M., Godson-Treacy, M., Sheehan, S., Dowdall, J. F., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P. J. & 4 others, Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Dec 2018, In : Diabetes. 67, 12, p. 2657-2667 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease

Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Tasadaque Ali-Shah, S., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1437-1448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Metabolic karma-the atherogenic legacy of diabetes: The 2017 edwin bierman award lecture

Cooper, M. E., El-Osta, A., Allen, T. J., Watson, A. M. D., Thomas, M. C. & Jandeleit-Dahm, K., 1 May 2018, In : Diabetes. 67, 5, p. 785-790 6 p.

Research output: Contribution to journalArticleOther

2017
30 Citations (Scopus)

Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Gray, S. P., Jha, J. C., Kennedy, K., Bommel, E. V., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E. & Jandeleit-Dahm, K. A. M., May 2017, In : Diabetologia. 60, 5, p. 927-937 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes

Ying, Y. L., Chen, Y. C., Jandeleit-Dahm, K. & Peter, K., 1 Oct 2017, In : Atherosclerosis. 265, p. 250-252 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

35 Citations (Scopus)

NADPH oxidase Nox5 accelerates renal injury in diabetic nephropathy

Jha, J. C., Banal, C., Okabe, J., Gray, S. P., Hettige, T., Chow, B. S. M., Thallas-Bonke, V., Vos, L. D., Holterman, C. E., Coughlan, M. T., Power, D. A., Skene, A., Ekinci, E. I., Cooper, M. E., Touyz, R. M., Kennedy, C. R. & Jandeleit-Dahm, K., 1 Oct 2017, In : Diabetes. 66, 10, p. 2691-2703 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathogenesis of Macrovascular Complications in Diabetes

Gray, S. P., Di Marco, E., Candido, R., Cooper, M. E. & Jandeleit-Dahm, K. A. M., 2017, Textbook of Diabetes. Holt, R. I. G., Cockram, C. S., Flyvbjerg, A. & Goldstein, B. J. (eds.). Wiley-Blackwell, p. 611-628 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

7 Citations (Scopus)

Platelet hyperreactivity in diabetes: Focus on GPVI signaling-are useful drugs already available?

Arthur, J. F., Jandeleit-Dahm, K. & Andrews, R. K., 1 Jan 2017, In : Diabetes. 66, 1, p. 7-13 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

40 Citations (Scopus)

Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Wang, B., McClelland, A., Mohan, M., Marai, M., Beuscart, O., Derouiche, S., Gray, S., Pickering, R., Tikellis, C., De Gaetano, M., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P., Jandeleit-Dahm, K. A. M., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Aug 2017, In : Diabetes. 66, 8, p. 2266-2277 12 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The emerging role of NADPH oxidase NOX5 in vascular disease

Jha, J. C., Watson, A. M. D., Mathew, G., de Vos, L. C. & Jandeleit-Dahm, K., 2017, In : Clinical Science. 131, 10, p. 981-990 10 p.

Research output: Contribution to journalEditorialOtherpeer-review

2016
84 Citations (Scopus)

Diabetes and kidney disease: Role of oxidative stress

Jha, J. C., Banal, C., Chow, B. S. M., Cooper, M. E. & Jandeleit-Dahm, K., 20 Oct 2016, In : Antioxidants and Redox Signaling. 25, 12, p. 657-684 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE−/− mice

Di Marco, E., Gray, S. P., Chew, P., Kennedy, K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K., Aug 2016, In : Clinical Science. 130, 15, p. 1363-1374 12 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

Di Marco, E., Gray, S. P., Kennedy, K., Szyndralewiez, C., Griendling, K. K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K., 1 Aug 2016, In : Free Radical Biology and Medicine. 97, p. 556-567 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathogenese, praeinterventionelle Patientenevaluation sowie Indikationsstellung zur Angioplastie: Pathogenesis, pre-patient evaluation of patients and indication of angioplasty

Jandeleit-Dahm, K., 2016, Vaskuläre Interventionen. Chavan, A. (ed.). Stuttgart Germany: Thieme, p. 192-197 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

48 Citations (Scopus)

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

Jha, J. C., Thallas-Bonke, V., Banal, C., Gray, S. P., Chow, B. S. M., Ramm, G., Quaggin, S. E., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., 1 Feb 2016, In : Diabetologia. 59, 2, p. 379-389 11 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., 1 Feb 2016, In : Arteriosclerosis, Thrombosis and Vascular Biology. 36, 2, p. 295-307 13 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis

Chow, B. S. M., Koulis, C., Krishnaswamy, P., Steckelings, U. M., Unger, T., Cooper, M. E., Jandeleit-Dahm, K. A. & Allen, T. J., 1 Aug 2016, In : Diabetologia. 59, 8, p. 1778-1790 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
35 Citations (Scopus)

Are reactive oxygen species still the basis for diabetic complications?

Di Marco, E., Jha, J. C., Sharma, A., Wilkinson-Berka, J. L., Jandeleit-Dahm, K. A. & De Haan, J., 2015, In : Clinical Science. 129, 2, p. 199-216 18 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

35 Citations (Scopus)

AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy

Koulis, C., Chow, B. SM., Mckelvey, M., Steckelings, U. M., Unger, T., Thallas-Bonke, V., Thomas, M. C., Cooper, M. E., Jandeleit-Dahm, K. A. M. & Allen, T. J., 2015, In : Hypertension. 65, 5, p. 1073 - 1081 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

CXCR4 antagonism attenuates the development of diabetic cardiac fibrosis

Chu, P. Y., Walder, K., Horlock, D., Williams, D., Nelson, E. M., Byrne, M., Jandeleit-Dahm, K., Zimmet, P. & Kaye, D. M., 27 Jul 2015, In : PLoS ONE. 10, 7, e0133616.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
72 Citations (Scopus)

Diabetic kidney disease

Thomas, M. C., Brownlee, M., Susztak, K., Sharma, S. K., Jandeleit-Dahm, K. A. M., Zoungas, S., Rossing, P., Groop, P-H. & Cooper, M. E., 30 Jul 2015, In : Nature Reviews Disease Primers. 1, 15018.

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

Ahrens, I., Chen, Y-C., Topcic, D., Bode, M., Haenel, D., Hagemeyer, C. E., Seeba, H., Duerschmied, D., Bassler, N., Jandeleit-Dahm, K., Sweet, M. J., Agrotis, A., Bobik, A. & Peter, K., 2015, In : Thrombosis and Haemostasis. 114, 5, p. 994 - 1003 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Linking RAGE and Nox in diabetic micro- and macrovascular complications

Koulis, C., Watson, A. M. D., Gray, S. P. & Jandeleit-Dahm, K. A., 1 Sep 2015, In : Diabetes and Metabolism. 41, 4, p. 272-281 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Nox-4 and progressive kidney disease

Thallas-Bonke, V., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2015, In : Current Opinion in Nephrology and Hypertension. 24, 1, p. 74-80 7 p.

Research output: Contribution to journalArticleResearchpeer-review

RAGE against the ABCs

Allen, T. J., Murphy, A. J. & Jandeleit-Dahm, K. A., 1 Dec 2015, In : Diabetes. 64, 12, p. 3981-3983 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

23 Citations (Scopus)

The role of NADPH oxidase in vascular disease – Hypertension, atherosclerosis & stroke

Gray, S. P. & Jandeleit-Dahm, K. A. M., 1 Jan 2015, In : Current Pharmaceutical Design. 21, 41, p. 5933-5944 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2014
16 Citations (Scopus)

Auditory neuropathy in individuals with Type 1 diabetes

Rance, G., Chisari, D., O'Hare, F., Roberts, L., Shaw, J., Jandeleit-Dahm, K. & Szmulewicz, D., 2014, In : Journal of Neurology. 261, 8, p. 1531-1536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Beyond Glycosuria: Exploring the intrarenal effects of SGLT-2 inhibition in diabetes

Thomas, M. C., Jandeleit-Dahm, K. & Bonnet, F., 1 Dec 2014, In : Diabetes and Metabolism. 40, 6, p. S17-S22 6 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)
161 Citations (Scopus)

Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in longterm diabetic nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., Touyz, R. M., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2014, In : Journal of the American Society of Nephrology. 25, 6, p. 1237-1254 18 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?

Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K. A. M. & Kammoun, H. L., 2014, In : Frontiers in Immunology. 5, Art. No.: 470, p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications

Gray, S. P., Jha, J. C., Di Marco, E. & Jandeleit-Dahm, K. A., Mar 2014, In : Expert Review of Endocrinology and Metabolism. 9, 2, p. 111-122 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

55 Citations (Scopus)

NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy

Wilkinson-Berka, J., Deliyanti, D., Rana, I., Miller, A. G., Agrotis, A., Armani, R., Szyndralewiez, C., Wingler, K., Touyz, R. M., Cooper, M. E., Jandeleit-Dahm, K. A. M. & Schmidt, H., 2014, In : Antioxidants and Redox Signaling. 20, 17, p. 2726-2740 15 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

New insights into the use of biomarkers of diabetic nephropathy

Jha, J., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2014, In : Advances in Chronic Kidney Disease. 21, 3, p. 318-326 9 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy

Thallas-Bonke, V., Jha, J. C., Gray, S. P., Barit, D., Haller, H., Schmidt, H. H. H. W., Coughlan, M. T., Cooper, M. E., Forbes, J. M. & Jandeleit-Dahm, K. A. M., 2014, In : Physiological Reports. 2, 11, 13 p., e12192.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
30 Citations (Scopus)

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe −/− mice

Di Marco, E., Gray, S. P., Chew, P., Koulis, C., Ziegler, A. I., Szyndralewiez, C., Touyz, R. M., Schmidt, H., Cooper, M. E., Slattery, R. M. & Jandeleit-Dahm, K. A. M., 2014, In : Diabetologia. 57, 3, p. 633 - 642 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice

Koulis, C., Chen, Y-C., Hausding, C., Ahrens, I., Kyaw, T. S., Tay, C., Allen, T. J., Jandeleit-Dahm, K. A. M., Sweet, M. J., Akira, S., Bobik, A., Peter, K. & Agrotis, A., 2014, In : Arteriosclerosis, Thrombosis and Vascular Biology. 34, 3, p. 516 - 525 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice

Watson, A. M. D., Li, J., Samijono, D., Bierhaus, A., Thomas, M. C., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2014, In : Atherosclerosis. 235, 2, p. 444 - 448 5 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

Koulis, C., Kanellakis, P., Pickering, R. J., Tsorotes, D., Murphy, A. J., Gray, S. P., Thomas, M. C., Jandeleit-Dahm, K. A. M., Cooper, M. E. & Allen, T. J., 2014, In : Clinical Science. 127, 7, p. 485-497 13 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

The pathobiology of diabetic vascular complications-cardiovascular and kidney disease

Gray, S. P. & Jandeleit-Dahm, K., 2014, In : Journal of Molecular Medicine. 92, 5, p. 441-452 12 p.

Research output: Contribution to journalReview ArticleOtherpeer-review