Projects per year
To understand how the vascular complications of diabetes develop and progress and how we can target specific pathways to delay, stop or reverse diabetic micro-and macrovascular complications including heart and kidney disease.
I am Deputy Head of the Diabetes Departmnet at Monash University, Central Clinical School and lead the research program Diabetes and Kidney disease. I am Professor of Medicine at Monash University, the University of Hannover, Germany and have an honory affiliation with Maastricht University, the Netherlands. I hold the prestigeous Leibniz Chair for Diabetes Research at the University of Dusseldorf,Germany where I also lead a Research group in diabetic nephropathy.
My research program is considered one of the leading groups in diabetic compliactions, nephropathy and cardiovascular disease in the world.
My team was the first to describe the role of NADPH oxidases in diabetic complications. This has resulted in 6 papers in nephropathy (JASN 2014; Diabetes 2017-on front cover, and Diabetologia 2017). Furthermore, the group has published 7 papers in atherosclerosis (Circulation 2013, ATVB 2016 and Diabetologia 2014) as well as in retinopathy. Overall I have published > 170 publications in the top journals of nephrology, cardiovascular research and diabetes. My h-index is 56 and I have >10,000 citations.
I am increasingly invited to write expert reviews and editorials (> 20) and am invited to present at the major meetings in diabetes, nephrology and cardiovascular research (> 40 international invitations in the last 5 years), often as plenary or keynote lecturer.
I am currently Chief investigator on 2 NHMRC project grants and in my role as a clinician/scientist lead a clinical trial on a novel Nox inhibitor in diabetic kidney disease in type 1 diabetes. Inded, I have secrured a multimillion dollar grant from JDRF and ARC for this investigator initiated trial which is currently recruiting at 15 sites in Australia, NZ, Denmark and in Germany.
I have established many international high level collaborations (Prof R Touyz, Glasgow University, Prof H Schmidt, University of Maastricht, and Prof C Godson, University of Dublin.
I am a past president of the Australian Athersclerosis Society and serve on editorial boards for several journal: Diabetologia> 8 years, Clinical Science, PlosOne, Journal Molecular Medicine and the Australian RACP endorsed Internal Mediccine Journal.
Furthermore, I am co-chair of the BmedSc program at CCS, Monash University and have supervised > 20 Honours students and 5 PhD students to completion.
Currently we work on several programs on the role of Nox5 in diabetic complications, the role of epigenetic mechanisms in diabetic complications specifically atherosclerosis and on inflammasome inhibition in diabetic kidney disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Diabetic complications
- diabetic nephropathy
- cardiovascular disease
- oxidative stress
- reactive oxygen species
- unstable plaque
- novel targets
- clinical translation
Dive into details
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1/01/22 → 31/12/22
NOX5 in circulating peripheral blood mononuclear cells as a new biomarkerfor unstable diabetic cardiovascular disease
1/01/22 → 31/12/22
Australia-Germany Joint Research Cooperation Scheme: Targeting oxidative stress in diabetic nephropathy
1/01/21 → 31/12/22
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney diseaseØstergaard, J. A., Jha, J. C., Sharma, A., Dai, A., Choi, J. S. Y., de Haan, J. B., Cooper, M. E. & Jandeleit-Dahm, K., Jan 2022, In: Clinical science (London, England : 1979). 136, 2, p. 167-180 14 p.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access
Khan, A. W., Paneni, F. & Jandeleit-Dahm, K. A. M., May 2021, In: Clinical Science. 135, 9, p. 1165-1187 23 p.
Research output: Contribution to journal › Review Article › Other › peer-review
Diabetische Nephropathie bei den neuen Diabetessubphänotypen: Diabetische Nephropathie und Insulinresistenz
Jandeleit-Dahm, K. & Urner, S., Jan 2021, In: Der Diabetologe. 17, 1, p. 3-10 8 p. Translated title of the contribution: Diabetic nephropathy in novel diabetes subphenotypes: Diabetic nephropathy and insulin resistance
Research output: Contribution to journal › Review Article › Research › peer-review
Jandeleit-Dahm, K., 21 Mar 2021, In: Cardiovascular Research. 117, 4, p. 987-989 3 p.
Research output: Contribution to journal › Article › Other › peer-review
Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1Ouerd, S., Idris-Khodja, N., Trindade, M., Ferreira, N. S., Berillo, O., Coelho, S. C., Neves, M. F., Jandeleit-Dahm, K. A., Paradis, P. & Schiffrin, E. L., 1 Apr 2021, In: Cardiovascular Research. 117, 4, p. 1144-1153 10 p.
Research output: Contribution to journal › Article › Research › peer-review
Jandeleit-Dahm, Karin (Recipient), Oct 2018
Prize: National/international honour
Leibniz Chair, German Diabetes Centre and Leibniz Centre for Diabetes Research at the Heinrich Heine University, Dusseldorf, Germany
Jandeleit-Dahm, Karin (Recipient), Dec 2019
Prize: National/international honour