Projects per year
Personal profile
Biography
NHMRC Overseas Biomedical Research Fellow 2011-2015
NARSAD-Maltz Young Investigator 2010
Related Links:
Keywords
- allosteric
- G protein-coupled receptor
- molecular modeling
- drug discovery
- bitopic
- metabotropic glutamate receptor
- muscarinic receptor
- signaling bias
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2021
Towards the rational design of calcium sensing receptor allosteric modulators for the treatment of osteoporosis and calcium handling disorders
Leach, K., Gregory, K., Conigrave, A., Capuano, B., Kufareva, I., Thakker, R. & Hannan, F.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
Exploring metabotropic glutamate receptor 5 bias, allostery and heteromers
1/07/17 → 30/06/21
Project: Research
Stabilising biased allosteric G protein-coupled receptor conformations
Leach, K., Gregory, K., Capuano, B. & Kufareva, I.
Australian Research Council (ARC), Monash University, University of California
1/01/17 → 31/12/19
Project: Research
Research Output 2005 2019
Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5
Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.Research output: Contribution to journal › Article › Research › peer-review
Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.Research output: Contribution to journal › Article › Research › peer-review
Identification of global and ligand-specific calcium sensing receptor activation mechanisms S
Keller, A., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T-V., Conigrave, A. D., Christopoulos, A., Gregory, K. J. & Leach, K., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 619-630 12 p.Research output: Contribution to journal › Article › Research › peer-review
“Selective” class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands
Hellyer, S. D., Albold, S., Wang, T., Chen, A. N. Y., May, L. T., Leach, K. & Gregory, K. J., 1 May 2018, In : Molecular Pharmacology. 93, 5, p. 504-514 11 p.Research output: Contribution to journal › Article › Research › peer-review
Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: implications for optimizing preclinical neuroscience drug discovery
Sengmany, K., Singh, J., Stewart, G. D., Conn, P. J., Christopoulos, A. & Gregory, K. J., 15 Mar 2017, In : Neuropharmacology. 115, p. 60-72 13 p.Research output: Contribution to journal › Article › Research › peer-review
Prizes
Dean's Honours List in B.Sc. (Honours)
Karen Gregory (Recipient), 2014
Prize: Prize (including medals and awards)
Graduate Student Best Abstract Award - Molecular Pharmacology division
Karen Gregory (Recipient), 2008
Prize: National/international honour
Activities 2014 2014
- 1 Submissions to industry or govt committees, commissions and inquiries
7-11 December 2014
Karen Gregory (Member)1 Jan 2014 → 31 Dec 2014
Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries