Karen Gregory

Dr

20052021
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Personal profile

Biography

NHMRC Overseas Biomedical Research Fellow 2011-2015

NARSAD-Maltz Young Investigator 2010

Related Links:

Keywords

  • allosteric
  • G protein-coupled receptor
  • molecular modeling
  • drug discovery
  • bitopic
  • metabotropic glutamate receptor
  • muscarinic receptor
  • signaling bias

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Projects 2007 2021

Research Output 2005 2019

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of global and ligand-specific calcium sensing receptor activation mechanisms S

Keller, A., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T-V., Conigrave, A. D., Christopoulos, A., Gregory, K. J. & Leach, K., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 619-630 12 p.

Research output: Contribution to journalArticleResearchpeer-review

“Selective” class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands

Hellyer, S. D., Albold, S., Wang, T., Chen, A. N. Y., May, L. T., Leach, K. & Gregory, K. J., 1 May 2018, In : Molecular Pharmacology. 93, 5, p. 504-514 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: implications for optimizing preclinical neuroscience drug discovery

Sengmany, K., Singh, J., Stewart, G. D., Conn, P. J., Christopoulos, A. & Gregory, K. J., 15 Mar 2017, In : Neuropharmacology. 115, p. 60-72 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Dean's Honours List in B.Sc. (Honours)

Karen Gregory (Recipient), 2014

Prize: Prize (including medals and awards)

Dux - Honours Class, 2004

Karen Gregory (Recipient), 2014

Prize: Prize (including medals and awards)

Graduate Student Travel Award

Karen Gregory (Recipient), 2007

Prize: National/international honour

Runner-Up

Karen Gregory (Recipient), 2007

Prize: National/international honour

Activities 2014 2014

  • 1 Submissions to industry or govt committees, commissions and inquiries

7-11 December 2014

Karen Gregory (Member)
1 Jan 201431 Dec 2014

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries