Accepting PhD Students

20082019
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Research Output 2008 2019

2019

Functional Brush Poly(2-ethyl-2-oxazine)s: Synthesis by CROP and RAFT, Thermoresponsiveness and Grafting onto Iron Oxide Nanoparticles

Klein, T., Parkin, J., de Jongh, P. A. J. M., Esser, L., Sepehrizadeh, T., Zheng, G., De Veer, M., Alt, K., Hagemeyer, C. E., Haddleton, D. M., Davis, T. P., Thelakkat, M. & Kempe, K., May 2019, In : Macromolecular Rapid Communications. 40, 10, 6 p., 1800911.

Research output: Contribution to journalArticleResearchpeer-review

2018

Magnetic fibrinolysis: putting the therapeutic wheels in a corkscrew motion

Medcalf, R. L., Hagemeyer, C. E. & Alt, K., 1 Apr 2018, In : Journal of Thrombosis and Haemostasis. 16, 4, p. 615-617 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma

Savvidou, I., Khong, T., Spencer, A. & Alt, K. M., Jul 2018, In : Archives of Medical Research. 6, 7, p. 1-15 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A., 11 Oct 2017, In : Science Translational Medicine. 9, 411, 10 p., eaam6084.

Research output: Contribution to journalArticleResearchpeer-review

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, H. T., Li, Z., Hagemeyer, C. E., Cowin, G., Zhang, S., Palasubramaniam, J., Alt, K., Wang, X., Peter, K. & Whittaker, A. K., 1 Jul 2017, In : Biomaterials. 134, p. 31-42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 3 Feb 2017, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Dai, Y., Guo, J., Wang, T. Y., Ju, Y., Mitchell, A. J., Bonnard, T., Cui, J., Richardson, J. J., Hagemeyer, C. E., Alt, K. & Caruso, F., 23 Aug 2017, In : Advanced Healthcare Materials. 6, 16, 7 p., 1700467.

Research output: Contribution to journalArticleResearchpeer-review

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., May 2017, In : Journal of Thrombosis and Haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets

Ziegler, M., Alt, K., Paterson, B. M., Kanellakis, P., Bobik, A., Donnelly, P. S., Hagemeyer, C. E. & Peter, K., 2 Dec 2016, In : Scientific Reports. 6, p. 1-10 10 p., 38161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Polymer capsules for plaque-targeted in vivo delivery

Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., Cui, J., Law, L. S., Hagemeyer, C. E. & Caruso, F., 21 Sep 2016, In : Advanced Materials. 28, 35, p. 7703-7707 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymer capsules for plaque-targeted in vivo delivery (Adv. Mater, (2016), 28, (7703-7707), 10.1002/adma.201601754): Erratum

Richardson, J. J., Choy, M. Y., Guo, J., Liang, K., Alt, K., Ping, Y., Cui, J., Law, L. S., Hagemeyer, C. E. & Caruso, F., 28 Sep 2016, In : Advanced Materials. 28, 36, p. 7820 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2015

A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry

Alt, K. M., Paterson, B. M., Westein, E., Rudd, S., Poniger, S., Jagdale, S., Ardipradja, K., Connell, T. U., Krippner, G. Y., Nair, A. K. N., Wang, X., Tochon-Danguy, H., Donnelly, P. S., Peter, K. & Hagemeyer, C. E., 2015, In : Angewandte Chemie - International Edition. 54, 26, p. 7515 - 7519 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols

Guo, J., Alt, K. M., Sun, H., Tardy, B. L., Richardson, J. J., Suma, T., Ejima, H., Cui, J., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Healthcare Materials. 4, 12, p. 1796 - 1801 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering poly(ethylene glycol) particles for improved biodistribution

Cui, J., De Rose, R., Alt, K. M., Alcantara, S., Paterson, B. M., Liang, K., Hu, M., Richardson, J. J., Yan, Y., Jeffery, C. M., Price, R. I., Peter, K., Hagemeyer, C. E., Donnelly, P. S., Kent, S. J. & Caruso, F., 2015, In : ACS Nano. 9, 2, p. 1571 - 1580 10 p.

Research output: Contribution to journalArticleResearchpeer-review

High affinity binders to EphA2 isolated from Abdurin Scaffold libraries; Characterization, binding and tumor targeting

Ullman, C., Mathonet, P., Oleksy, A., Diamamdakis, A., Tomei, L., Demartis, A., Nardi, M. C., Sambucini, S., Missineo, A., Alt, K. M., Hagemeyer, C. E., Harris, M., Hedt, A., Weis, R. & Gehlsen, K. R., 2015, In : PLoS ONE. 10, 8, 25 p., e0135278.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Gunawan, S. T., Kempe, K., Bonnard, T. M. E., Cui, J., Alt, K. M., Law, L. S., Wang, X., Westein, E., Such, G. K., Peter, K., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Materials. 27, 35, p. 5153-5157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Particle generation, functionalization and sortase A-mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use

Hagemeyer, C. E., Alt, K. M., Johnston, A., Such, G. K., Ta, H. T., Leung, M. K. M., Prabhu, S., Wang, X., Caruso, F. & Peter, K., 2015, In : Nature Protocols. 10, 1, p. 90 - 105 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Detection of activated platelets in a mouse model of carotid artery thrombosis with {18} F-labeled single-chain antibodies

Ardipradja, K., Yeoh, S. D., Alt, K., O'Keefe, G. J., Rigopoulos, A., Howells, D. W., Scott, A. M., Peter, K., Ackermann, U. & Hagemeyer, C. E., 2014, In : Nuclear Medicine and Biology. 41, 3, p. 229 - 237 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering multifunctional capsules through the assembly of metal-phenolic networks

Guo, J., Ejima, H., Alt, K. M., Meissner, M. V., Richardson, J. J., Yan, Y., Peter, K., von Elverfeldt, D., Hagemeyer, C. E. & Caruso, F., 2014, In : Angewandte Chemie - International Edition. 53, 22, p. 5546 - 5551 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody

Paterson, B. M., Alt, K. M., Jeffery, C. M., Price, R. I., Jagdale, S., Williams, C. C., Rigby, S., Peter, K., Hagemeyer, C. E. & Donnelly, P. S., 2014, In : Angewandte Chemie - International Edition. 53, 24, p. 6115-6119 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets

Alt, K. M., Paterson, B. M., Ardipradja, K., Schieber, C., Buncic, G., Lim, B., Poniger, S., Jakoby, B., Wang, X., O'Keefe, G. J., Tochon-Danguy, H., Scott, A. M., Ackermann, U., Peter, K., Donnelly, P. S. & Hagemeyer, C. E., 2014, In : Molecular Pharmaceutics. 11, 8, p. 2855-2863 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets

Wang, X., Palasubramaniam, J., Gkanatsas, Y., Hohmann, J. D., Westein, E., Kanojia, R., Alt, K., Huang, D., Jia, F., Ahrens, I., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 2014, In : Circulation Research. 114, 7, p. 1083 - 1093 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Effective targeting of prostate cancer by lymphocytes redirected by a PSMA×CD3 bispecific single-chain diabody

Fortmüller, K., Alt, K., Gierschner, D., Wolf, P., Baum, V., Freudenberg, N., Wetterauer, U., Elsässer-Beile, U. & Bühler, P., May 2011, In : Prostate. 71, 6, p. 588-596 9 p.

Research output: Contribution to journalArticleResearchpeer-review

In vivo testing of 177Lu-labelled anti-PSMA antibody as a new radioimmunotherapeutic agent against prostate cancer

Behe, M., Alt, K., Deininger, F., Bühler, P., Wetterauer, U., Weber, W. A., Elsässer-Beile, U. & Wolf, P., Jan 2011, In : In Vivo. 25, 1, p. 55-59 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

High-resolution animal PET imaging of prostate cancer xenografts with three different 64Cu-labeled antibodies against native cell-adherent PSMA

Alt, K., Wiehr, S., Ehrlichmann, W., Reischl, G., Wolf, P., Pichler, B. J., Elsässer-Beile, U. & Bühler, P., 15 Sep 2010, In : Prostate. 70, 13, p. 1413-1421 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Preclinical evaluation of a recombinant anti-prostate specific membrane antigen single-chain immunotoxin against prostate cancer

Wolf, P., Alt, K., Wetterauer, D., Bühler, P., Gierschner, D., Katzenwadel, A., Wetterauer, U. & Elsässer-Beile, U., Apr 2010, In : Journal of immunotherapy (Hagerstown, Md. : 1997). 33, 3, p. 262-271 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Three conformational antibodies specific for different PSMA epitopes are promising diagnostic and therapeutic tools for prostate cancer

Wolf, P., Freudenberg, N., Bühler, P., Alt, K., Schultze-Seemann, W., Wetterauer, U. & Elsässer-Beile, U., 1 Apr 2010, In : Prostate. 70, 5, p. 562-569 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

PET imaging of prostate cancer xenografts with a highly specific antibody against the prostate-specific membrane antigen

Elsässer-Beile, U., Reischl, G., Wiehr, S., Bühler, P., Wolf, P., Alt, K., Shively, J., Judenhofer, M. S., Machulla, H. J. & Pichler, B. J., 1 Apr 2009, In : Journal of Nuclear Medicine. 50, 4, p. 606-611 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Anti-PSMA immunotoxin as novel treatment for prostate cancer? High and specific antitumor activity on human prostate xenograft tumors in SCID mice

Wolf, P., Alt, K., Bühler, P., Katzenwadel, A., Wetterauer, U., Tacke, M. & Elsässer-Beile, U., 1 Feb 2008, In : Prostate. 68, 2, p. 129-138 10 p.

Research output: Contribution to journalArticleResearchpeer-review