Projects per year
Personal profile
Biography
A central objective of my research is to develop imaging techniques to better understand the underlying mechanisms of different disease progression and the impact of therapy. My research is based on the combination of novel enzymatic and chemical modification techniques for recombinant antibodies. Using the bacterial transpeptidase sortase and click chemistry for imaging and drug delivery, I am progressing novel theranostic agents towards clinical use for the benefit of patients.
Research area keywords
- PET/CT imaging
- Bioconjugation
- Antibody
- Theranostic
- Metal-Organic Framework
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
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Clinical imaging of CXCR4 in the development of an i-body therapy for idiopathic pulmonary fibrosis
Foley, M., Hagemeyer, C., Egan, G., Scott, A., Westall, G., Donnelly, P. & Alt, K.
1/02/20 → 31/12/21
Project: Research
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Novel targeted Onco-theranostic nanoparticles for personalised therapy and real-time monitoring
1/01/18 → 31/12/21
Project: Research
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Novel targeted PEG nanoparticles for cancer treatment and monitoring
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/19
Project: Research
Research output
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A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls
McMahon, J. H., Zerbato, J. M., Lau, J. S. Y., Lange, J. L., Roche, M., Tumpach, C., Dantanarayana, A., Rhodes, A., Chang, J., Rasmussen, T. A., Mackenzie, C. A., Alt, K., Hagenauer, M., Roney, J., O‘Bryan, J., Carey, A., McIntyre, R., Beech, P., O'Keefe, G. J., Wichmann, C. W. & 11 others, , Mar 2021, In : EBioMedicine. 65, 10 p., 103252.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Collagen-Targeted Theranostic Nanosponges for Delivery of the Matrix Metalloproteinase 14 Inhibitor Naphthofluorescein
Wang, T-Y., Kendrick-Williams, L. L., Choy, M. Y., Gilmore, K. A., Bonnard, T., Pearce, H. A., Law, L. S., Carmichael, I., Cody, S., Alt, K., Hagemeyer, C. & Harth, E., 12 May 2020, In : Chemistry of Materials. 32, 9, p. 3707-3714 8 p.Research output: Contribution to journal › Article › Research › peer-review
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Carbohydrates@MOFs
Astria, E., Thonhofer, M., Ricco, R., Liang, W., Chemelli, A., Tarzia, A., Alt, K., Hagemeyer, C. E., Rattenberger, J., Schroettner, H., Wrodnigg, T., Amenitsch, H., Huang, D. M., Doonan, C. J. & Falcaro, P., 1 Jun 2019, In : Materials Horizons. 6, 5, p. 969-977 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile13 Citations (Scopus) -
Development of a novel peptide tracer for detection of cardiac fibrosis and atrial fibrillation using mouse models of cardiomyopathies
Niego, B., Alt, K., Noor, A., How, O. J., Du, X-J., Donnelly, P. S., McMullen, J. & Hagemeyer, C., 9 Jul 2019.Research output: Contribution to conference › Abstract
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Engineering Antibodies with C-Terminal Sortase-Mediated Modification for Targeted Nanomedicine
Hashad, R. A., Lange, J. L., Tan, N. C. W., Alt, K. & Hagemeyer, C. E., 2019, Bioconjugation : Methods in Molecular Biology. Massa, S. & Devoogdt, N. (eds.). New York, NY: Humana Press, p. 67-80 14 p. (Methods in Molecular Biology; vol. 2033).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
1 Citation (Scopus)
Prizes
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AMREP Collaborative Seed Grant
Alt, Karen (Recipient), 2016
Prize: Prize (including medals and awards)
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Central Clinical School Travel Grant
Alt, Karen (Recipient), 2015
Prize: Prize (including medals and awards)
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Central Clinical School Travel Grant
Alt, Karen (Recipient), 2016
Prize: Prize (including medals and awards)
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DFG (German Research Foundation) Fellowship
Alt, Karen (Recipient), 2012
Prize: Prize (including medals and awards)
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ECS Harold Mitchell Travelling Fellowship
Alt, Karen (Recipient), 2014
Prize: Prize (including medals and awards)