Projects per year
Personal profile
Biography
A central objective of my research is to develop imaging techniques to better understand the underlying mechanisms of different disease progression and the impact of therapy. My research is based on the combination of novel enzymatic and chemical modification techniques for recombinant antibodies. Using the bacterial transpeptidase sortase and click chemistry for imaging and drug delivery, I am progressing novel theranostic agents towards clinical use for the benefit of patients.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- PET/CT imaging
- Bioconjugation
- Antibody
- Theranostic
- Metal-Organic Framework
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Molecular Imaging of Cardiac Fibrosis in Atrial Fibrillation, Heart Failure and Myocardial Infarction
Niego, B., Alt, K. & Hagemeyer, C.
1/01/23 → 31/12/24
Project: Research
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Clinical imaging of CXCR4 in the development of an i-body therapy for idiopathic pulmonary fibrosis
Foley, M., Hagemeyer, C., Egan, G., Scott, A., Westall, G., Donnelly, P. S. & Alt, K.
1/02/20 → 31/12/21
Project: Research
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Novel targeted Onco-theranostic nanoparticles for personalised therapy and real-time monitoring
1/01/18 → 31/12/21
Project: Research
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Novel targeted PEG nanoparticles for cancer treatment and monitoring
Alt, K. & Paterson, B.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/19
Project: Research
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Chemoselective Methionine Labelling of Recombinant Trastuzumab Shows High In Vitro and In Vivo Tumour Targeting
Hashad, R., Jap, E., Casey, J. L., Ho, Y. T. C., Wright, A., Thalmann, C., Sleeman, M., Lupton, D. W., Hagemeyer, C. E., Cryle, M. J., Robert, R. & Alt, K., 21 Feb 2023, In: Chemistry - A European Journal. 29, 11, 7 p., e202202491.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
18F Site‐Specific Labelling of a Single‐Chain Antibody against Activated Platelets for the Detection of Acute Thrombosis in Positron Emission Tomography
Ardipradja, K. S., Wichmann, C. W., Hickson, K., Rigopoulos, A., Alt, K. M., Pearce, H. A., Wang, X., O’keefe, G., Scott, A. M., Peter, K., Hagemeyer, C. E. & Ackermann, U., 1 Jul 2022, In: International Journal of Molecular Sciences. 23, 13, 16 p., 6886.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Chemoenzymatic surface decoration of Nisin-shelled nanoemulsions: Novel targeted drug-nanocarriers for cancer applications
Hashad, R. A., Singla, R., Kaur Bhangu, S., Jap, E., Zhu, H., Peleg, A. Y., Blakeway, L., Hagemeyer, C. E., Cavalieri, F., Ashokkumar, M. & Alt, K., Nov 2022, In: Ultrasonics Sonochemistry. 90, 8 p., 106183.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Self-Assembly of Oriented Antibody-Decorated Metal–Organic Framework Nanocrystals for Active-Targeting Applications
Alt, K., Carraro, F., Jap, E., Linares-Moreau, M., Riccò, R., Righetto, M., Bogar, M., Amenitsch, H., Hashad, R. A., Doonan, C., Hagemeyer, C. E. & Falcaro, P., 26 May 2022, In: Advanced Materials. 34, 21, 7 p., 2106607.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Template-Assisted Antibody Assembly: A Versatile Approach for Engineering Functional Antibody Nanoparticles
Hu, Y., Li, J., Ju, Y., Houston, Z. H., Fletcher, N. L., De Rose, R., Fernandes, S., Hagemeyer, C. E., Alt, K., Thurecht, K. J., Cortez-Jugo, C. & Caruso, F., 26 Apr 2022, In: Chemistry of Materials. 34, 8, p. 3694-3704 11 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)
Prizes
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2022 Dept Collaborative Seed grant
Antonic-Baker, Ana (Recipient), Jupp, Bianca (Recipient) & Alt, Karen (Recipient), 17 Feb 2022
Prize: Prize (including medals and awards)
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AMREP Collaborative Seed Grant
Alt, Karen (Recipient), 2016
Prize: Prize (including medals and awards)
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Central Clinical School Travel Grant
Alt, Karen (Recipient), 2016
Prize: Prize (including medals and awards)
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Central Clinical School Travel Grant
Alt, Karen (Recipient), 2015
Prize: Prize (including medals and awards)
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DFG (German Research Foundation) Fellowship
Alt, Karen (Recipient), 2012
Prize: Prize (including medals and awards)