Karen Alt

Senior Research Fellow, Aust Ctr for Blood Diseases

https://orcid.org/0000-0002-6252-1931

EmailKaren.Alt@monash.edu

Accepting PhD Students

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Personal profile

Biography

A central objective of my research is to develop imaging techniques to better understand the underlying mechanisms of different disease progression and the impact of therapy. My research is based on the combination of novel enzymatic and chemical modification techniques for recombinant antibodies. Using the bacterial transpeptidase sortase and click chemistry for imaging and drug delivery, I am progressing novel theranostic agents towards clinical use for the benefit of patients.

Keywords

PET/CT imaging
Bioconjugation
Antibody
Theranostic

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2019

1 Not started
1 Active

Novel targeted PEG nanoparticles for cancer treatment and monitoring

Alt, K. & Paterson, B.

National Health & Medical Research Council (NHMRC)

1/01/16 → 31/12/19

Project: Research

Novel targeted Onco-theranostic nanoparticles for personalised therapy and real-time monitoring

Alt, K.

Project: Research

Research Output 2008 2018

25 Article
2 Comment / Debate
1 Review Article

Magnetic fibrinolysis: putting the therapeutic wheels in a corkscrew motion

Medcalf, R. L., Hagemeyer, C. E. & Alt, K., 1 Apr 2018, In : Journal of Thrombosis and Haemostasis. 16, 4, p. 615-617 3 p.

Research output: Contribution to journal › Comment / Debate › Other › peer-review

The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma

Savvidou, I., Khong, T., Spencer, A. & Alt, K. M., Jul 2018, In : Archives of Medical Research. 6, 7, p. 1-15 15 p.

Research output: Contribution to journal › Review Article › Research › peer-review

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A., 11 Oct 2017, In : Science Translational Medicine. 9, 411, 10 p., eaam6084.

Research output: Contribution to journal › Article › Research › peer-review

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, H. T., Li, Z., Hagemeyer, C. E., Cowin, G., Zhang, S., Palasubramaniam, J., Alt, K., Wang, X., Peter, K. & Whittaker, A. K., 1 Jul 2017, In : Biomaterials. 134, p. 31-42 12 p.

Research output: Contribution to journal › Article › Research › peer-review