Accepting PhD Students

20082019
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Personal profile

Biography

A central objective of my research is to develop imaging techniques to better understand the underlying mechanisms of different disease progression and the impact of therapy. My research is based on the combination of novel enzymatic and chemical modification techniques for recombinant antibodies. Using the bacterial transpeptidase sortase and click chemistry for imaging and drug delivery, I am progressing novel theranostic agents towards clinical use for the benefit of patients.

Keywords

  • PET/CT imaging
  • Bioconjugation
  • Antibody
  • Theranostic

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Projects 2016 2019

Research Output 2008 2018

Magnetic fibrinolysis: putting the therapeutic wheels in a corkscrew motion

Medcalf, R. L., Hagemeyer, C. E. & Alt, K., 1 Apr 2018, In : Journal of Thrombosis and Haemostasis. 16, 4, p. 615-617 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma

Savvidou, I., Khong, T., Spencer, A. & Alt, K. M., Jul 2018, In : Archives of Medical Research. 6, 7, p. 1-15 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A., 11 Oct 2017, In : Science Translational Medicine. 9, 411, 10 p., eaam6084.

Research output: Contribution to journalArticleResearchpeer-review

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, H. T., Li, Z., Hagemeyer, C. E., Cowin, G., Zhang, S., Palasubramaniam, J., Alt, K., Wang, X., Peter, K. & Whittaker, A. K., 1 Jul 2017, In : Biomaterials. 134, p. 31-42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 3 Feb 2017, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Prizes

AMREP Collaborative Seed Grant

Karen Alt (Recipient), 2016

Prize: Prize (including medals and awards)

Central Clinical School Travel Grant

Karen Alt (Recipient), 2015

Prize: Prize (including medals and awards)

Central Clinical School Travel Grant

Karen Alt (Recipient), 2016

Prize: Prize (including medals and awards)

DFG (German Research Foundation) Fellowship

Karen Alt (Recipient), 2012

Prize: Prize (including medals and awards)

ECS Harold Mitchell Travelling Fellowship

Karen Alt (Recipient), 2014

Prize: Prize (including medals and awards)