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Personal profile

Biography

A central objective of my research is to develop imaging techniques to better understand the underlying mechanisms of different disease progression and the impact of therapy. My research is based on the combination of novel enzymatic and chemical modification techniques for recombinant antibodies. Using the bacterial transpeptidase sortase and click chemistry for imaging and drug delivery, I am progressing novel theranostic agents towards clinical use for the benefit of patients. I have established and currently head a NanoPET/CT preclinical imaging facility at AMREP.

Keywords

  • PET/CT imaging
  • Bioconjugation
  • Antibody
  • Theranostic

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Projects 2016 2019

Research Output 2008 2018

Magnetic fibrinolysis: putting the therapeutic wheels in a corkscrew motion

Medcalf, R. L., Hagemeyer, C. E. & Alt, K. 1 Apr 2018 In : Journal of Thrombosis and Haemostasis. 16, 4, p. 615-617 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A. 11 Oct 2017 In : Science Translational Medicine. 9, 411, 10 p., eaam6084

Research output: Contribution to journalArticleResearchpeer-review

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, H. T., Li, Z., Hagemeyer, C. E., Cowin, G., Zhang, S., Palasubramaniam, J., Alt, K., Wang, X., Peter, K. & Whittaker, A. K. 1 Jul 2017 In : Biomaterials. 134, p. 31-42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E. 3 Feb 2017 In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Dai, Y., Guo, J., Wang, T. Y., Ju, Y., Mitchell, A. J., Bonnard, T., Cui, J., Richardson, J. J., Hagemeyer, C. E., Alt, K. & Caruso, F. 23 Aug 2017 In : Advanced Healthcare Materials. 6, 16, 7 p., 1700467

Research output: Contribution to journalArticleResearchpeer-review