20082019
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Personal profile

Biography

A central objective of my research is to develop imaging techniques to better understand the underlying mechanisms of different disease progression and the impact of therapy. My research is based on the combination of novel enzymatic and chemical modification techniques for recombinant antibodies. Using the bacterial transpeptidase sortase and click chemistry for imaging and drug delivery, I am progressing novel theranostic agents towards clinical use for the benefit of patients.

Research area keywords

  • PET/CT imaging
  • Bioconjugation
  • Antibody
  • Theranostic

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Projects 2016 2019

Research Output 2008 2019

3 Citations (Scopus)

Carbohydrates@MOFs

Astria, E., Thonhofer, M., Ricco, R., Liang, W., Chemelli, A., Tarzia, A., Alt, K., Hagemeyer, C. E., Rattenberger, J., Schroettner, H., Wrodnigg, T., Amenitsch, H., Huang, D. M., Doonan, C. J. & Falcaro, P., 1 Jun 2019, In : Materials Horizons. 6, 5, p. 969-977 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Development of a novel peptide tracer for detection of cardiac fibrosis and atrial fibrillation using mouse models of cardiomyopathies

Niego, B., Alt, K., Noor, A., How, O. J., Du, X-J., Donnelly, P. S., McMullen, J. & Hagemeyer, C., 9 Jul 2019.

Research output: Contribution to conferenceAbstractOtherpeer-review

Engineering Antibodies with C-Terminal Sortase-Mediated Modification for Targeted Nanomedicine

Hashad, R. A., Lange, J. L., Tan, N. C. W., Alt, K. & Hagemeyer, C. E., 2019, Bioconjugation : Methods in Molecular Biology. Massa, S. & Devoogdt, N. (eds.). New York, NY: Humana Press, p. 67-80 14 p. (Methods in Molecular Biology; vol. 2033).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

Functional Brush Poly(2-ethyl-2-oxazine)s: Synthesis by CROP and RAFT, Thermoresponsiveness and Grafting onto Iron Oxide Nanoparticles

Klein, T., Parkin, J., de Jongh, P. A. J. M., Esser, L., Sepehrizadeh, T., Zheng, G., De Veer, M., Alt, K., Hagemeyer, C. E., Haddleton, D. M., Davis, T. P., Thelakkat, M. & Kempe, K., May 2019, In : Macromolecular Rapid Communications. 40, 10, 6 p., 1800911.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake

Cui, J., Alt, K., Ju, Y., Gunawan, S. T., Braunger, J. A., Wang, T. Y., Dai, Y., Dai, Q., Richardson, J. J., Guo, J., Björnmalm, M., Hagemeyer, C. E. & Caruso, F., 9 Sep 2019, In : Biomacromolecules. 20, 9, p. 3592-3600 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

AMREP Collaborative Seed Grant

Karen Alt (Recipient), 2016

Prize: Prize (including medals and awards)

Central Clinical School Travel Grant

Karen Alt (Recipient), 2016

Prize: Prize (including medals and awards)

Central Clinical School Travel Grant

Karen Alt (Recipient), 2015

Prize: Prize (including medals and awards)

DFG (German Research Foundation) Fellowship

Karen Alt (Recipient), 2012

Prize: Prize (including medals and awards)

ECS Harold Mitchell Travelling Fellowship

Karen Alt (Recipient), 2014

Prize: Prize (including medals and awards)