Kara Britt

Dr

Accepting PhD Students

PhD projects

PhD projects available

20002020

Research output per year

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Research Output

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Article
2020

Sex-specific adipose tissue imprinting of regulatory T cells

Vasanthakumar, A., Chisanga, D., Blume, J., Gloury, R., Britt, K., Henstridge, D. C., Zhan, Y., Torres, S. V., Liene, S., Collins, N., Cao, E., Sidwell, T., Li, C., Spallanzani, R. G., Liao, Y., Beavis, P. A., Gebhardt, T., Trevaskis, N., Nutt, S. L., Zajac, J. D. & 5 others, Davey, R. A., Febbraio, M. A., Mathis, D., Shi, W. & Kallies, A., 26 Mar 2020, In : Nature. 579, 7800, p. 581–585+ 29 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

Au, C. M. C., Furness, J. B., Britt, K., Oshchepkova, S., Ladumor, H., Soo, K. Y., Callaghan, B., Gerard, C., Inghirami, G., Mittal, V., Wang, Y., Huang, X. Y., Spector, J. A., Andreopoulou, E., Zumbo, P., Betel, D., Dow, L. & Brown, K. A., 15 Jul 2020, In : eLife. 9, 27 p., e56913.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Estrogen receptor subtypes dictate the proliferative nature of the mammary gland

Dall, G. V., Hawthorne, S., Seyed-Razavi, Y., Vieusseux, J., Wu, W., Gustafsson, J. A., Byrne, D., Murphy, L., Risbridger, G. P. & Britt, K. L., 1 Jun 2018, In : Journal of Endocrinology. 237, 3, p. 323-336 14 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

High mammographic density in women is associated with protumor inflammation

Huo, C. W., Hill, P., Chew, G., Neeson, P. J., Halse, H., Williams, E. D., Henderson, M. A., Thompson, E. W. & Britt, K. L., 9 Aug 2018, In : Breast Cancer Research. 20, 1, 16 p., 92.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

InforMD: A new initiative to raise public awareness about breast density

Hugo, H. J., Zysk, A., Dasari, P., Britt, K., Hopper, J. L., Stone, J., Thompson, E. W. & Ingman, W. V., 6 Feb 2018, In : ecancermedicalscience. 12, 5 p., 807.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model

Sun, X., Glynn, D. J., Hodson, L. J., Huo, C., Britt, K., Thompson, E. W., Woolford, L., Evdokiou, A., Pollard, J. W., Robertson, S. A. & Ingman, W. V., 11 Jan 2017, In : Breast Cancer Research. 19, 1, 15 p., 4.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
20 Citations (Scopus)

Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors

Chai, R. C., Vieusseux, J. L., Lang, B. J., Nguyen, C. H., Kouspou, M. M., Britt, K. L. & Price, J. T., May 2017, In : Molecular Oncology. 11, 5, p. 567-583 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion

Duivenvoorden, H. M., Rautela, J., Edgington-Mitchell, L. E., Spurling, A., Greening, D. W., Nowell, C. J., Molloy, T. J., Robbins, E., Brockwell, N. K., Lee, C. S., Chen, M., Holliday, A., Selinger, C. I., Hu, M., Britt, K. L., Stroud, D. A., Bogyo, M., Möller, A., Polyak, K., Sloane, B. F. & 2 others, O'Toole, S. A. & Parker, B. S., 1 Dec 2017, In : Journal of Pathology. 243, 4, p. 496-509 14 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

SCA-1 labels a subset of estrogen-responsive bipotential repopulating cells within the CD24+ CD49fhi mammary stem cell-enriched compartment

Dall, G. V., Vieusseux, J. L., Korach, K. S., Arao, Y., Hewitt, S. C., Hamilton, K. J., Dzierzak, E., Boon, W. C., Simpson, E. R., Ramsay, R. G., Stein, T., Morris, J. S., Anderson, R. L., Risbridger, G. P. & Britt, K. L., 14 Feb 2017, In : Stem Cell Reports. 8, 2, p. 417-431 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)
2016

Human glandular organoid formation in murine engineering chambers after collagenase digestion and flow cytometry isolation of normal human breast tissue single cells

Huo, C. W., Huang, D., Chew, G. L., Hill, P., Vohora, A., Ingman, W. V., Glynn, D. J., Godde, N., Henderson, M. A., Thompson, E. W. & Britt, K. L., Nov 2016, In : Cell Biology International. 40, 11, p. 1212-1223 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis

Huo, C. W., Waltham, M., Khoo, C., Fox, S. B., Hill, P., Chen, S., Chew, G. L., Price, J. T., Nguyen, C. H., Williams, E. D., Henderson, M., Thompson, E. W. & Britt, K. L., 25 Oct 2016, In : Breast Cancer Research. 18, 1, 106.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

OMIP-032: Two multi-color immunophenotyping panels for assessing the innate and adaptive immune cells in the mouse mammary gland

Unsworth, A., Anderson, R., Haynes, N. & Britt, K., Jun 2016, In : Cytometry Part A. 89, 6, p. 527-530 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2015

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer

Johnstone, C. N., Smith, Y. E., Cao, Y., Burrows, A. D., Cross, R. S. N., Ling, X., Redvers, R. P., Doherty, J. P., Eckhardt, B. L., Natoli, A. L., Restall, C. M., Lucas, E., Pearson, H. B., Deb, S., Britt, K. L., Rizzitelli, A., Li, J., Harmey, J. H., Pouliot, N. & Anderson, R. L., 1 Mar 2015, In : Disease Models and Mechanisms. 8, 3, p. 237-251 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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53 Citations (Scopus)

High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium

Huo, C. W., Chew, G., Hill, P. A., Huang, D., Ingman, W. V., Hodson, L., Brown, K. A., Magenau, A., Allam, A. H., McGhee, E. J., Timpson, P., Henderson, M. A., Thompson, E. W. & Britt, K. L., 2015, In : Breast Cancer Research. 17, 1, 20 p., 79.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
59 Citations (Scopus)

Low dose, low cost estradiol pellets can support MCF-7 tumour growth in nude mice without bladder symptoms

Dall, G. V., Vieusseux, J. L., Unsworth, A. S., Anderson, R. & Britt, K. L., 2015, In : Journal of Cancer. 6, 12, p. 1331 - 1336 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2014

Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

Godde, N. J., Sheridan, J. M., Smith, L. K., Pearson, H. B., Britt, K. L., Galea, R. C., Yates, L. L., Visvader, J. E. & Humbert, P. O., May 2014, In : PLoS Genetics. 10, 5, 18 p., e1004323.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
36 Citations (Scopus)
2013

Next-generation sequence analysis of cancer xenograft models

Rossello, F. J., Tothill, R., Britt, K. L., Marini, K. D., Falzon, J., Thomas, D. M., Peacock, C. D., Marchionni, L., Li, J., Bennett, S., Tantoso, E., Brown, T. J., Chan, P., Martelotto, L. G. & Watkins, D. N., 2013, In : PLoS ONE. 8, 9, 12 p., e7443.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
20 Citations (Scopus)
2011

Generation of human female reproductive tract epithelium from human embryonic stem cells

Ye, P., Mayberry, R., Lo, C., Britt, K., Stanley, E., Elefanty, A. & Gargett, C., 2011, In : PLoS ONE. 6, 6, 11 p., e21136.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)
2010

Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation

Vafaizadeh, V., Klemmt, P., Brendel, C., Weber, K., Doebele, C., Britt, K. L., Grez, M., Fehse, B., Desrivieres, S. & Groner, B., 2010, In : Stem Cells. 28, 5, p. 928 - 938 11 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)
2009

Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers

Taylor, R. A., Wang, H., Wilkinson, S., Richards, M. G., Britt, K. L., Vaillant, F., Lindeman, G. J., Visvader, J. E., Cunha, G. R., St John, J. C. & Risbridger, G. P., 2009, In : Stem Cells. 27, 12, p. 3032 - 3042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells

Britt, K. L., Kendrick, H., Regan, J. L., Molyneux, G., Magnay, F-A., Ashworth, A. & Smalley, M. J., 2009, In : Breast Cancer Research. 11, 2, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2007

Pregnancy and the risk of breast cancer

Britt, K. L., Ashworth, A. & Smalley, M. J., 2007, In : Endocrine-Related Cancer. 14, 4, p. 907 - 933 27 p.

Research output: Contribution to journalArticleResearchpeer-review

161 Citations (Scopus)

Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers.

Smalley, M. J., Iravani, M., Leao, M., Grogoriadis, A., Kendrick, H., Dexter, T., Fenwick, K., Regan, J. L., Britt, K. L., McDonald, S., Lord, C. J., MacKay, A. & Ashworth, A., 2007, In : Breast Cancer Research. 9, 6 (R85), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2006

Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply

Kerr, J. B., Duckett, R., Myers, M. A., Britt, K. L., Mladenovska, T. & Findlay, J. K., 2006, In : Reproduction. 132, 1, p. 95 - 109 15 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)
2005

Effects of phytoestrogens on the ovarian and pituitary phenotypes of estrogen-deficient female aromatase knockout mice

Britt, K. L., Simpson, E. R. & Findlay, J. K., 2005, In : Menopause. 12, 2, p. 174 - 185 12 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2004

Estrogen actions on follicle formation and early follicle development

Britt, K. L., Saunders, P. K., McPherson, S. J., Misso, M. L., Simpson, E. R. & Findlay, J. K., 2004, In : Biology of Reproduction. 71, 5, p. 1712 - 1723 12 p.

Research output: Contribution to journalArticleResearchpeer-review

119 Citations (Scopus)

Methods for quantifying follicular numbers within the mouse ovary

Myers, M., Britt, K. L., Wreford, N. G. M., Ebling, F. J. P. & Kerr, J. B., 2004, In : Reproduction. 127, 5, p. 569 - 580 12 p.

Research output: Contribution to journalArticleResearchpeer-review

304 Citations (Scopus)

The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad

Britt, K. L., Stanton, P. G., Misso, M. L., Simpson, E. R. & Findlay, J. K., 2004, In : Endocrinology. 145, 8, p. 3950 - 3960 11 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)
2003

Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse

Misso, M. L., Murata, Y., Boon, W. C., Jones, M. E. E., Britt, K. L. & Simpson, E. R., 2003, In : Endocrinology. 144, 4, p. 1474 - 1480 7 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Estrogen is not directly required for oocyte developmental competence

Huynh, K., Jones, G. M., Thouas, G. A., Britt, K. L., Simpson, E. R. & Jones, M. E. E., 2003, In : Biology of Reproduction. 70, 5, p. 1263 - 1269 7 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Regulation of the phenotype of ovarian somatic cells by estrogen

Britt, K. L. & Findlay, J. K., 2003, In : Molecular and Cellular Endocrinology. 202, 1-2, p. 11 - 17 7 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)
2002

Aromatase--a brief overview

Simpson, E. R., Clyne, C., Rubin, G., Boon, W. C., Robertson, K. M., Britt, K. L., Speed, C. J. & Jones, M., 2002, In : Annual Review of Physiology. 64, p. 93 - 127 35 p.

Research output: Contribution to journalArticleResearchpeer-review

518 Citations (Scopus)

Estrogen regulates development of the somatic cell phenotype in the eutherian ovary

Britt, K. L., Kerr, J. B., O'Donnell, L., Jones, M. E. E., Drummond, A. E., Davis, S. R., Simpson, E. R. & Findlay, J. K., 2002, In : The FASEB Journal. 16, 11, p. 1389 - 1397 9 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Ovarian steroid receptors and their role in ovarian function

Drummond, A. E., Britt, K. L., Dyson, M., Jones, M. E., Kerr, J. B., O'Donnell, L., Simpson, E. R. & Findlay, J. K., 2002, In : Molecular and Cellular Endocrinology. 191, p. 27 - 33 7 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)
2001

Aromatase-deficient (ArKO) mice accumulate excess adipose tissue

Jones, M. E. E., Thorburn, A. W., Britt, K. L., Hewitt, K. N., Misso, M. L., Wreford, N. G., Proietto, J., Oz, O. K., Leury, B. J., Robertson, K. M., Yao, S. & Simpson, E. R., 1 Dec 2001, In : Journal of Steroid Biochemistry and Molecular Biology. 79, 1-5, p. 3-9 7 p.

Research output: Contribution to journalArticleResearchpeer-review

99 Citations (Scopus)

The ovarian phenotype of the aromatase knockout (ArKO) mouse

Britt, K. L., Drummond, A. E., Dyson, M., Wreford, N. G., Jones, M. E. E., Simpson, E. R. & Findlay, J. K., 2001, In : Journal of Steroid Biochemistry and Molecular Biology. 79, 1-5, p. 181-185 5 p.

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)

The road to ovulation: The role of oestrogens

Findlay, J. K., Britt, K., Kerr, J. B., O'Donnell, L., Jones, M. E., Drummond, A. E. & Simpson, E. R., 2001, In : Reproduction, Fertility and Development. 13, 7-8, p. 543-547 5 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2000

An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene

Britt, K. L., Drummond, A. E., Cox, V. A., Dyson, M., Wreford, N. G., Jones, M. E. E., Simpson, E. R. & Findlay, J. K., 2000, In : Endocrinology. p. 2614 - 2623 10 p.

Research output: Contribution to journalArticleResearchpeer-review

178 Citations (Scopus)

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity

Jones, M. E. E., Thorburn, A. W., Britt, K. L., Hewitt, K. N., Wreford, N. G., Proietto, J., Oz, O. K., Leury, B. J., Robertson, K. M., Yao, S. & Simpson, E. R., 2000, In : Proceedings of the National Academy of Sciences of the United States of America. p. 12735 - 12740 6 p.

Research output: Contribution to journalArticleResearchpeer-review

558 Citations (Scopus)

The roles of activins, inhibins and estrogen in early committed follicles

Findlay, J. K., Drummond, A. E., Britt, K. L., Dyson, M., Wreford, N. G., Robertson, D. M., Groome, N. P., Jones, M. E. E. & Simpson, E. R., 2000, In : Molecular and Cellular Endocrinology. p. 81 - 87 7 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)