20102022

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2018

Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress

Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance

Han, M-L., Velkov, T., Zhu, Y., Roberts, K. D., Le Brun, A. P., Chow, S. H., Gutu, A. D., Moskowitz, S. M., Shen, H-H. & Li, J., 19 Jan 2018, In : ACS Chemical Biology. 13, 1, p. 121-130 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

Schneider-Futschik, E. K., Paulin, O. K. A., Hoyer, D., Roberts, K. D., Ziogas, J., Baker, M. A., Karas, J., Li, J. & Velkov, T., 11 May 2018, In : ACS Infectious Diseases. 4, 5, p. 646-655 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 others, Owen, J., Li, J. & Cooper, M. A., 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)
2017

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Design and evaluation of novel polymyxin fluorescent probes

Yun, B., Roberts, K. D., Thompson, P. E., Nation, R. L., Velkov, T. & Li, J., 11 Nov 2017, In : Sensors. 17, 11, 8 p., 2598.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Functional characterization of the unique terminal thioesterase domain from polymyxin synthetase

Galea, C., Roberts, K. D., Zhu, Y., Thompson, P. E., Li, J. & Velkov, T., 31 Jan 2017, In : Biochemistry. 56, 4, p. 657-668 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

Han, M. L., Shen, H. H., Hansford, K. A., Schneider, E. K., Sivanesan, S., Roberts, K. D., Thompson, P. E., Le Brun, A. P., Zhu, Y., Sani, M-A., Separovic, F., Blaskovich, M. A. T., Baker, M. A., Moskowitz, S. M., Cooper, M. A., Li, J. & Velkov, T., 11 Aug 2017, In : ACS Infectious Diseases. 3, 8, p. 606-619 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Pharmacokinetics of the individual major components of polymyxin B and colistin in rats

Sivanesan, S., Roberts, K., Wang, J., Cheah, S-E., Thompson, P. E., Li, J., Nation, R. & Velkov, T., 27 Jan 2017, In : Journal of Natural Products. 80, 1, p. 225-229 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity

Mountford, S. J., Mohanty, B., Roberts, K. D., Yu, H. H., Scanlon, M. J., Nation, R. L., Velkov, T., Li, J. & Thompson, P. E., 2017, In : Organic and Biomolecular Chemistry. 15, 34, p. 7173-7180 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2016

A novel chemical biology approach for mapping of polymyxin lipopeptide antibody binding epitopes

Velkov, T., Yun, B., Schneider, E. K., Azad, M. A. K., Dolezal, O., Morris, F. C., Nation, R. L., Wang, J., Chen, K., Yu, H., Wang, L., Thompson, P. E., Roberts, K. D. & Li, J., 2016, In : ACS Infectious Diseases. 2, 5, p. 341-351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

Lu, X., Chan, F. T., Xu, C., Zhu, L., Zhou, Q. T., Roberts, K. D., Chan, H. K., Li, J. & Zhou, F., 1 Feb 2016, In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 403-412 10 p., dkv340.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Quantitation of polymyxin-lipopolysaccharide interactions using an image-based fluorescent probe

McInerney, M. P., Roberts, K. D., Thompson, P. E., Li, J., Nation, R. L., Velkov, T. & Nicolazzo, J. A., 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 1006-1010 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Transcriptomic analysis of the activity of a novel polymyxin against Staphylococcus aureus

Zhao, J., Cheah, S-E., Roberts, K. D., Nation, R. L., Thompson, P. E., Velkov, T., Du, Z., Johnson, M. D. & Li, J., 2016, In : mSphere. 1, 4, 13 p., e00119-16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes

Yun, B., Azad, M. A. K., Nowell, C. J., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7489-7496 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Imaging the distribution of polymyxins in the kidney

Yun, B., Azad, M. A. K., Wang, J., Nation, R. L., Thompson, P., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 3, p. 827 - 829 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
27 Citations (Scopus)

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

Azad, M. A. K., Roberts, K. D., Yu, H., Liu, B., Schofield, A. V., James, S. A., Howard, D. L., Nation, R. L., Rogers, K. L., de Jonge, M. D., Thompson, P., Fu, J., Velkov, T. & Li, J., 2015, In : Analytical Chemistry. 87, 3, p. 1590 - 1595 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)
2014

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Deris, Z. Z., Akter, J., Sivanesan, S., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2014, In : Journal of Antibiotics. 67, 2, p. 147 - 151 5 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria

Deris, Z. Z., Swarbrick, J. D., Roberts, K. D., Azad, M. A. K., Akter, J., Horne, A. S., Nation, R. L., Rogers, K. L., Thompson, P., Velkov, T. & Li, J., 2014, In : Bioconjugate Chemistry. 25, 4, p. 750 - 760 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
51 Citations (Scopus)

Teaching 'old' polymyxins new tricks: New-generation lipopeptides targeting gram-negative 'superbugs'

Velkov, T., Roberts, K. D., Nation, R. L., Wang, J., Thompson, P. & Li, J., 2014, In : ACS Chemical Biology. 9, 5, p. 1172 - 1177 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
62 Citations (Scopus)
2013

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A

Velkov, T., Soon, R. L-X., Huang, J. X., Cooper, M. A., Azad, M. A. K., Baker, M. A., Thompson, P., Roberts, K. D., Nation, R. L., Clements, A., Strugnell, R. A. & Li, J., 2013, In : Innate Immunity. 19, 3, p. 265 - 277 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats

He, H., Li, J. C., Nation, R. L., Jacob, J., Chen, G., Lee, H. J., Tsuji, B., Thompson, P., Roberts, K. D., Velkov, T. & Li, J., 2013, In : Journal of Antimicrobial Chemotherapy. 68, 10, p. 2311 - 2317 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
50 Citations (Scopus)

Pharmacology of polymyxins: New insights into an 'old' class of antibiotics

Velkov, T., Roberts, K. D., Nation, R. L., Thompson, P. & Li, J., 2013, In : Future Microbiology. 8, 6, p. 711 - 724 14 p.

Research output: Contribution to journalArticleResearchpeer-review

189 Citations (Scopus)

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro

McCoy, L. S., Roberts, K. D., Nation, R. L., Thompson, P., Velkov, T., Li, J. & Tor, Y., 2013, In : ChemBioChem. 14, 16, p. 2083 - 2086 4 p.

Research output: Contribution to journalArticleOtherpeer-review

17 Citations (Scopus)
2012

Structure-activity relationships for the binding of polymyxins with human alpha-1-acid glycoprotein

Azad, M. A. K., Huang, J. X., Cooper, M. A., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2012, In : Biochemical Pharmacology. 84, 3, p. 278 - 291 14 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2011

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

Soon, R., Velkov, T., Chiu, F., Thompson, P., Kancharla, R., Roberts, K., Larson, I., Nation, R. & Li, J., 2011, In : Analytical Biochemistry. 409, 2, p. 273 - 283 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
2010

Synthesis of "difficult" fluorescence quenched substrates of granzyme C

Northfield, S., Roberts, K., Mountford, S., Hughes, R., Kaiserman, D., Mangan, M., Pike, R., Bird, P. & Thompson, P., 2010, In : International Journal of Peptide Research and Therapeutics. 16, p. 159 - 165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)