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Research Output 2002 2019

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Article
2019
3 Citations (Scopus)

The transgenerational effects of oocyte mitochondrial supplementation

St. John, J. C., Makanji, Y., Johnson, J. L., Tsai, T. S., Lagondar, S., Rodda, F., Sun, X., Pangestu, M., Chen, P. & Temple-Smith, P., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6694.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018
5 Citations (Scopus)

The association of mitochondrial DNA haplotypes and phenotypic traits in pigs

St John, J. C. & Tsai, T. S., 6 Jul 2018, In : BMC Genetics. 19, 1, 12 p., 41.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma

Sun, X., Vaghjiani, V., Jayasekara, W. S. N., Cain, J. E. & St John, J. C., 17 Dec 2018, In : Clinical Epigenetics. 10, 1, 17 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)
1 Citation (Scopus)

The mitochondrial genome: How it drives fertility

St John, J. C., Srirattana, K., Tsai, T. S. & Sun, X., 1 Jan 2018, In : Reproduction, Fertility and Development. 30, 1, p. 118-139 22 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The molecular characterisation of mitochondrial DNA deficient oocytes using a pig model

Tsai, T. S., Tyagi, S. & St John, J. C., 1 May 2018, In : Human Reproduction. 33, 5, p. 942-953 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017
9 Citations (Scopus)

Cattle phenotypes can disguise their maternal ancestry

Srirattana, K., McCosker, K., Schatz, T. & St. John, J. C., 26 Jun 2017, In : BMC Genetics. 18, 1, 59.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Manipulating the mitochondrial genome to enhance cattle embryo development

Srirattana, K. & St. John, J. C., 1 Jul 2017, In : G3: Genes, Genomes, Genetics. 7, 7, p. 2065-2080 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns

Lee, W. T., Sun, X., Tsai, T-S., Johnson, J. L., Gould, J. A., Garama, D. J., Gough, D. J., McKenzie, M., Trounce, I. A. & St John, J. C., 1 Jan 2017, In : Cell Death Discovery. 3, 11 p., 17062.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Modulation of mitochondrial DNA copy number to induce hepatocytic differentiation of human Amniotic Epithelial cells

Vaghjiani, V., Cain, J. E., Lee, W., Vaithilingam, V., Tuch, B. E. & St John, J. C., 15 Oct 2017, In : Stem Cells and Development. 26, 20, p. 1505-1519 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The molecular characterization of porcine egg precursor cells

Tsai, T-S., Johnson, J., White, Y. & St John, J. C., 2017, In : Oncotarget. 8, 38, p. 63484-63505 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
5 Citations (Scopus)

Deletion of the Complex I subunit NDUFS4 adversely modulates cellular differentiation

Johnson, J., Lee, W., Frazier, A. E., Vaghjiani, V., Laskowski, A., Rodriguez, A. L., Cagnone, G. L., McKenzie, M., White, S. J., Nisbet, D. R., Thorburn, D. R. & St. John, J. C., 2016, In : Stem Cells and Development. 25, 3, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee, WTY., Cain, JE., Cuddihy, AR., Dickinson, A., Yeung, K-Y., Kumar, B., Johns, TG., Watkins, DN., Spencer, A., St John, JC. & Johnson, J., 2016, In : Cell Death Discovery. 2, p. 1 - 11 11 p., 16016.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Mitochondrial DNA supplementation as an enhancer of female reproductive capacity

St John, J. C., Tsai, T-S. & Cagnone, G. L. M., 2016, In : Current Opinion in Obstetrics and Gynecology. 28, 3, p. 211 - 216 6 p.

Research output: Contribution to journalArticleOtherpeer-review

35 Citations (Scopus)

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency

Cagnone, G., Tsai, T-S., Makanji, Y., Matthews, P. M., Gould, J. A., Bonkowski, M. S., Elgass, K., Wong, A. S. A., Wu, L. E., McKenzie, M., Sinclair, D. A. & St John, J. C., 2016, In : Scientific Reports. 6, p. 1 - 15 15 p., 23229.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)

Segregation of naturally occurring mitochondrial DNA variants in a mini-pig model

Cagnone, G., Tsai, T-S., Srirattana, K., Rossello, F., Powell, D. R., Rohrer, G., Cree, L., Trounce, I. A. & St John, J. C., Mar 2016, In : Genetics. 202, 3, p. 931 - 944 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The relationship between mitochondrial DNA haplotype and the reproductive capacity of domestic pigs (Sus scrofa domesticus)

Tsai, T-S., Rajasekar, S. & St. John, J. C., 18 May 2016, In : BMC Genetics. 17, 1, 17 p., 67.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
6 Citations (Scopus)

Differences in mitochondrial DNA inheritance and function align with body conformation in genetically lean and fat sheep

Henry, B. A., Loughnan, R., Hickford, J., Young, I. R., St John, J. C. & Clarke, I., 1 May 2015, In : Journal of Animal Science. 93, 5, p. 2083-2093 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

Lee, W., Johnson, J. L., Gough, D. J., Donoghue, J. F., Cagnone, G., Vaghjiani, V., Brown, K. A., Johns, T. G. & St John, J. C., 2015, In : Cell Death and Disease. 6, 2 (Art. No: e1664), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
96 Citations (Scopus)

Mitochondrial dysfunction in oocytes of obese mothers: Transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

Wu, L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T-S., St John, J. C., Norman, R. J., Febbraio, M. A., Carroll, J. G. & Robker, R., 2015, In : Development. 142, 4, p. 681 - 691 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
23 Citations (Scopus)

The control of mitochondrial DNA replication during development and tumorigenesis

Lee, W. T. Y. & St John, J. C., 2015, In : Annals of the New York Academy of Sciences. 1350, 1, p. 95-106 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
7 Citations (Scopus)

Capture of somatic mtDNA point mutations with severe effects on oxidative phosphorylation in synaptosome cybrid clones from human brain

McKenzie, M., Chiotis, M., Hroudova, J., Lopez Sanchez, M. I. G., Lim, S. C., Cook, M. J., McKelvie, P. A., Cotton, R. G. H., Murphy, M. A., St John, J. C. & Trounce, I. A., 2014, In : Human Mutation. 35, 12, p. 1476 - 1484 9 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility

Sobinoff, A. P., Sutherland, J., Beckett, E. L., Stanger, S. J., Johnson, R., Jarnicki, A. G., McCluskey, A., St John, J. C., Hansbro, P. M. & McLaughlin, E. A., 2014, In : Human Reproduction. 29, 12, p. 2719 - 2735 17 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

High cortisol responses identify propensity for obesity that is linked to thermogenesis in skeletal muscle

Lee, T-K. K., Clarke, I. J., St John, J. C., Young, I. R., Leury, B., Rao, A., Andrews, Z. B. & Henry, B. A., 2014, In : FASEB Journal. 28, 1, p. 35 - 44 10 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

The control of mtDNA replication during differentiation and development

St John, J. C., 2014, In : Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1840, 4, p. 1345 - 1354 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

The identification of mitochondrial DNA variants in glioblastoma multiforme

Yeung, K. Y. V., Dickinson, A., Donoghue, J. F., Polekhina, G., White, S., Grammatopoulos, D. K., McKenzie, M., Johns, T. G. & St John, J. C., 2014, In : Acta neuropathologica communications. 2, p. 1 - 21 21 p., 1.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013
49 Citations (Scopus)

Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells

Kelly, R. D. W., Rodda, A. E., Dickinson, A., Mahmud, A., Nefzger, C., Lee, W., Forsythe, J. S., Polo, J. M., Trounce, I. A., McKenzie, M., Nisbet, D. R. & St John, J. C., 2013, In : Stem Cells. 31, 4, p. 703 - 716 14 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

The effects of nuclear reprogramming on mitochondrial DNA replication

Kelly, R. D. W., Sumer, H., McKenzie, M., Facucho-Oliveira, J. M., Trounce, I. A., Verma, P. J. & St John, J. C., 2013, In : Stem Cell Reviews. 9, 1, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

The regulation of mitochondrial DNA copy number in glioblastoma cells

Dickinson, A., Yeung, V. K. Y., Donoghue, J. F., Baker, M. J., Kelly, R. D. W., McKenzie, M., Johns, T. G. & St John, J. C., 2013, In : Cell Death and Differentiation. 20, 12, p. 1644 - 1653 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
94 Citations (Scopus)

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

Kelly, R. D. W., Mahmud, A., McKenzie, M., Trounce, I. & St John, J. C., 2012, In : Nucleic Acids Research. 40, 20, p. 10124 - 10138 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Transmission, inheritance and replication of mitochondrial DNA in mammals: implications for reproductive processes and infertility

St John, J. C., 2012, In : Cell and Tissue Research. 349, 3, p. 795 - 808 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
26 Citations (Scopus)

Angiogenic potential of endothelial progenitor cells and embryonic stem cells

Rae, P., Kelly, R., Egginton, S. & St John, J., 2011, In : Vascular Cell. 3, Art. No: 11, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors

Jiang, Y., Kelly, R., Peters, A., Fulka, H., Dickinson, A., Mitchell, D. & St John, J., 2011, In : PLoS ONE. 6, 4, 12 p., e14805.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

The generation of live offspring from vitrified oocytes

Sanchez-Partida, L., Kelly, R., Sumer, H., Lo, C., Aharon, R., Holland, M., O'Bryan, M. & St John, J., 2011, In : PLoS ONE. 6, 6, 11 p., e21597.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010
22 Citations (Scopus)

Generation of mtDNA homoplasmic cloned lambs

Lee, J-H., Peters, A., Fisher, P., Bowles, E., St John, J. & Campbell, K., 2010, In : Cellular Reprogramming. 12, 3, p. 347 - 355 9 p.

Research output: Contribution to journalArticleResearchpeer-review

138 Citations (Scopus)

Mitochondrial DNA transmission, replication and inheritance: A journey from the gamete through the embryo and into offspring and embryonic stem cells

St John, J. C., Facucho-Oliveira, J., Jiang, Y., Kelly, R. & Salah, R., 2010, In : Human Reproduction Update. 16, 5, p. 488 - 509 22 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Role of mitochondrial DNA replication during differentiation of reprogrammed stem cells

Kelly, R. D. W. & St John, J. C., 2010, In : International Journal of Developmental Biology. 54, 11-12, p. 1659 - 1670 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
21 Citations (Scopus)

Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers

Taylor, R. A., Wang, H., Wilkinson, S., Richards, M. G., Britt, K. L., Vaillant, F., Lindeman, G. J., Visvader, J. E., Cunha, G. R., St John, J. C. & Risbridger, G. P., 2009, In : Stem Cells. 27, 12, p. 3032 - 3042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

mtDNA and sperm function

St. John, J. C., Feb 2009, In : Systems Biology in Reproductive Medicine. 55, 1, p. 17-18 2 p.

Research output: Contribution to journalArticleResearchpeer-review

161 Citations (Scopus)

The relationship between pluripotency and mitochondrial DNA proliferation during early embryo development and embryonic stem cell differentiation

Facucho-Oliveira, J. & St John, J., 2009, In : Stem Cell Reviews. 5, 2, p. 140 - 158 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
45 Citations (Scopus)

Chromatin in early mammalian embryos: achieving the pluripotent state

Fulka, H., St John, J., Fulka, Jnr, J. & Hozak, P., 2008, In : Differentiation. 76, 1, p. 3 - 14 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Mitochondrial DNA transmission and transcription after somatic cell fusion to one or more cytoplasts

Bowles, E. J., Tecirlioglu, R. T., French, A. J., Holland, M. K. & St John, J. C., 2008, In : Stem Cells. 26, 3, p. 775 - 782 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
47 Citations (Scopus)

Contrasting effects of in vitro fertilization and nuclear transfer on the expression of mtDNA replication factors

Bowles, E., Lee, J-H., Alberio, R., Lloyd, R., Stekel, D., Campbell, K. & St John, J., 2007, In : Genetics. 176, 3, p. 1511 - 1526 16 p.

Research output: Contribution to journalArticleResearchpeer-review

199 Citations (Scopus)

Mitochondrial DNA replication during differentiation of murine embryonic stem cells

Facucho-Oliveira, J., Alderson, J., Spikings, E., Egginton, S. & St John, J., 2007, In : Journal of Cell Science. 120, 22, p. 4025 - 4034 10 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Nuclear transfer: Preservation of a nuclear genome at the expense of its associated mtDNA genome(s)

Bowles, E., Campbell, K. & St John, J., 2007, In : Current Topics in Developmental Biology. 77, Art. No: 10, p. 251 - 290 40 p.

Research output: Contribution to journalArticleResearchpeer-review

160 Citations (Scopus)

Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development

Spikings, E., Alderson, J. & St John, J., 2007, In : Biology of Reproduction. 76, 2, p. 327 - 335 9 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm

Amaral, A., Ramalho-Santos, J. & St John, J., 2007, In : Human Reproduction. 22, 6, p. 1585 - 1596 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
53 Citations (Scopus)

Aberrant nucleo-cytoplasmic cross-talk results in donor cell mtDNA persistence in cloned embryos

Lloyd, R., Lee, J-H., Alberio, R., Bowles, E., Ramalho-Santos, J., Campbell, K. & St John, J., 2006, In : Genetics. 172, 4, p. 2515 - 2527 13 p.

Research output: Contribution to journalArticleResearchpeer-review

222 Citations (Scopus)

Mitochondria directly influence fertilisation outcome in the pig

El Shourbagy, S., Spikings, E., Freitas, M. & St John, J., 2006, In : Reproduction. 131, 2, p. 233 - 245 13 p.

Research output: Contribution to journalArticleResearchpeer-review

198 Citations (Scopus)

Mitochondrial content reflects oocyte variability and fertilization outcome

Santos, T., El Shourbagy, S. & St John, J., 2006, In : Fertility and Sterility. 85, 3, p. 584 - 591 8 p.

Research output: Contribution to journalArticleResearchpeer-review