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Research Output 1998 2019

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2019

Active Micropump-Mixer for Rapid Antiplatelet Drug Screening in Whole Blood

Szydzik, C., Brazilek, R. J., Akbaridoust, F., De Silva, C., Moon, M., Marusic, I., Ooi, A. S. H., Nandurkar, H. H., Hamilton, J. R., Mitchell, A. & Nesbitt, W. S., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10830-10839 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Shared roles for Scl and Lyl1 in murine platelet production and function

Chiu, S. K., Orive, S. L., Moon, M. J., Saw, J., Ellis, S., Kile, B. T., Huang, Y., Chacon, D., Pimanda, J. E., Beck, D., Hamilton, J. R., Tremblay, C. S. & Curtis, D. J., 5 Sep 2019, In : Blood. 134, 10, p. 826-835 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The mode of anesthesia influences outcome in mouse models of arterial thrombosis

Sashindranath, M., Sturgeon, S., French, S. L., Craenmehr, D. D. D., Selan, C., Freddi, S., Johnson, C., Cody, S., Nesbitt, W., Hamilton, J., Cody, S. H., Nesbitt, W., Hamilton, J. & Nandurkar, H., Apr 2019, In : Thrombosis and Haemostasis. 3, 2, p. 197-206 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition

Selvadurai, M. V., Brazilek, R. J., Moon, M. J., Rinckel, J. Y., Eckly, A., Gachet, C., Meikle, P. J., Nandurkar, H. H., Nesbitt, W. S. & Hamilton, J. R., 1 Jan 2019, In : FEBS Letters. 593, 1, p. 88-96 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant

French, S. L., Thalmann, C., Bray, P. F., Macdonald, L. E., Murphy, A. J., Sleeman, M. W. & Hamilton, J. R., 12 Jun 2018, In : Blood Advances. 2, 11, p. 1283-1293 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Perinatal lethality of Par4–/– mice delivered by primiparous dams reveals spontaneous bleeding in mice without platelet thrombin receptor function

French, S. L. & Hamilton, J. R., 17 Feb 2018, In : Platelets. 29, 2, p. 196-198 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Class II phosphoinositide 3-kinases as novel drug targets

Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P., 12 Jan 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Green, T. N., Hamilton, J. R., Morel-Kopp, M. C., Zheng, Z., Chen, T. Y. T., Hearn, J. I., Sun, P. P., Flanagan, J. U., Young, D., Barber, P. A., During, M. J., Ward, C. M. & Kalev-Zylinska, M. L., 2017, In : Platelets. 28, 8, p. 799-811 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Saifuzzaman, M., Morrison, R., Zheng, Z., Orive, S., Hamilton, J., Thompson, P. E. & Al-Rawi, J. M. A., 15 Oct 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5531-5536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability

Petitjean, C., Setiabakti, N. M., Mountford, J. K., Arthur, J. F., Ellis, S. L. & Hamilton, J. R., 2016, In : Platelets. 27, 5, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Humanizing the protease-activated receptor (PAR) expression profile in mouse platelets by knocking Par1 into the Par3 locus reveals Par1 expression is not tolerated in mouse platelets

French, S. L., Paramitha, A. C., Moon, M. J., Dickins, R. A. & Hamilton, J. R., 1 Oct 2016, In : PLoS ONE. 11, 10, 14 p., e0165565.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French, S. L., Arthur, J. F., Lee, H., Nesbitt, W., Andrews, R. K., Gardiner, E. & Hamilton, J. R., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1642-1654 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Platelet and erythrocyte sources of S1P are redundant for vascular development and homeostasis, but both rendered essential after plasma S1P depletion in anaphylactic shock

Gazit, S. L., Mariko, B., Therond, P., Decouture, B., Xiong, Y., Couty, L., Bonnin, P., Baudrie, V., Le Gall, S. M., Dizier, B., Zoghdani, N., Ransinan, J., Hamilton, J. R., Gaussem, P., Tharaux, P. L., Chun, J., Coughlin, S. R., Bachelot-Loza, C., Hla, T., Ho-Tin-Noé, B. & 1 othersCamerer, E., 30 Sep 2016, In : Circulation Research. 119, 8, p. 110-126 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Protease-activated receptor 4: From structure to function and back again

French, S. L. & Hamilton, J. R., 2016, In : British Journal of Pharmacology. 173, 20, p. 2952 - 2965 14 p.

Research output: Contribution to journalArticleOtherpeer-review

2015

Approval of the first protease-activated receptor antagonist: rationale, development, significance, and considerations of a novel anti-platelet agent

French, S., Arthur, J. F., Tran, H. A. & Hamilton, J. R., 2015, In : Blood Reviews. 29, 3, p. 179 - 189 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The class II PI 3-kinase, PI3KC2{alpha}, links platelet internal membrane structure to shear-dependent adhesive function

Mountford, J. K., Petitjean, C., Kusuma Putra, H. W., McCafferty, J. A., Setiabakti, N. M., Lee, H., Tonnesen, L. L., McFadyen, J. D., Schoenwaelder, S. M., Eckly, A., Gachet, C., Ellis, S. L., Voss, A. K., Dickins, R. A., Hamilton, J. R. & Jackson, S., 2015, In : Nature Communications. 6, (Art. No: 6535), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIb{alpha}

Carrim, N., Arthur, J. F., Hamilton, J. R., Gardiner, E. E., Andrews, R. K., Moran, N., Berndt, M. & Metharom, P., 2015, In : Redox Biology. 6, p. 640 - 647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Differential signaling by protease-activated receptors: implications for therapeutic targeting

Sidhu, T., French, S. & Hamilton, J. R., 2014, In : International Journal of Molecular Sciences. 15, 4, p. 6169 - 6183 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

The PAR1 antagonist, SCH79797, alters platelet morphology and function independently of PARs

Lee, H. & Hamilton, J. R., 2013, In : Thrombosis and Haemostasis. 109, 1, p. 164 - 167 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Pathologic shear triggers shedding of vascular receptors: A novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

Al-Tamimi, M., Tan, C. W., Qiao, J. L., Pennings, G., Javadzadegan, A., Yong, A., Arthur, J. F., Davis, A., Jing, J., Mu, F-T., Hamilton, J. R., Jackson, S., Ludwig, A., Berndt, M. C., Ward, C., Kritharides, L., Andrews, R. K. & Gardiner, E. E., 2012, In : Blood. 119, 18, p. 4311 - 4320 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Physiology, pharmacology, and therapeutic potential of protease-activated receptors in vascular disease

Lee, H. & Hamilton, J. R., 2012, In : Pharmacology and Therapeutics. 134, 2, p. 246 - 259 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice

Lee, H., Sturgeon, S. A., Mountford, J. K., Jackson, S. & Hamilton, J. R., 2012, In : British Journal of Pharmacology. 166, 7, p. 2188 - 2197 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions

Lee, H., Sturgeon, S., Jackson, S. & Hamilton, J., 2012, In : Thrombosis and Haemostasis. 107, 2, p. 328 - 337 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Transgenic, inducible RNAi in megakaryocytes and platelets in mice

Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., Hamilton, J. R., Huang, D. CS., Kile, B. & Dickins, R. A., 2010, In : Journal of Thrombosis and Haemostasis. 8, 1538-7933, p. 2751 - 2756 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE-/- mice

Hamilton, J. R., Cornelissen, I., Mountford, J. K. & Coughlin, S. R., 2009, In : Atherosclerosis. 205, 2, p. 427 - 432 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Protease-activated receptors as targets for antiplatelet therapy

Hamilton, J. R., 2009, In : Blood Reviews. 23, 2, p. 61 - 65 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation

Busso, N., Chobaz-Peclat, V., Hamilton, J. R., Spee, P., Wagtmann, N. & So, A., 2008, In : Arthritis Research & Therapy. 10, 2, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth

Ono, A., Westein, E., Hsiao, S. T-F., Nesbitt, W. S., Hamilton, J. R., Schoenwaelder, S. M. & Jackson, S., 2008, In : Blood. 112, 1, p. 90 - 99 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Antiplatelet therapy: present status and future prospects

Hamilton, J. R., Kaplan, Z., Jackson, S. & Opat, S., 2007, In : Expert Opinion on Drug Discovery. 2, 8, p. 1035 - 1040 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of protease-activated receptor 2 in murine models of arthritis

Busso, N., Frasnelli, M., Feifel, R., Cenni, B., Steinhoff, M., Hamilton, J. R. & So, A., 2007, In : Arthritis and Rheumatism. 56, p. 101 - 107 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis

Vandendries, E. R., Hamilton, J. R., Coughlin, S. R., Furie, B. & Furie, B. C., 2007, In : Proceedings of the National Academy of Sciences. 104, 1, p. 288 - 292 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms

Su, X., Camerer, E., Hamilton, J. R., Coughlin, S. R. & Matthay, M. A., 2005, In : Journal of Immunology. 175, p. 2598 - 2605 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency

Camerer, E., Duong, D. N., Hamilton, J. R. & Coughlin, S. R., 2004, In : Blood. 103, 1, p. 152 - 154 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets

Hamilton, J. R., Cornelissen, I. & Coughlin, S. R., 2004, In : Journal of Thrombosis and Haemostasis. 2, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells

Kataoka, H., Hamilton, J. R., McKemy, D. D., Camerer, E., Zheng, Y-W., Cheng, A., Griffin, C. & Coughlin, S. R., 2003, In : Blood. 102, 9, p. 3224 - 3231 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Enzymatic activation of endothelial protease-activated receptors is dependent on artery diameter in human and porcine isolated coronary arteries.

Hamilton, J. R., Moffatt, J. D., Tatoulis, J. & Cocks, T. M., 2002, In : British Journal of Pharmacology. 136, p. 492 - 501 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Protection against thrombosis in mice lacking PAR3

Weiss, E. J., Hamilton, J. R., Lease, K. E. & Coughlin, S. R., 2002, In : Blood. 100, 9, p. 3240 - 3244 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries

Hamilton, J. R., Moffatt, J. D., Frauman, A. G. & Cocks, T. M., 2001, In : Journal of Cardiovascular Pharmacology. 38, p. 108 - 119 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

A protective role for protease-activated receptors in the airways

Cocks, T. M., Fong, B., Chow, J. M., Anderson, G. P., Frauman, A. G., Goldie, R. G., Henry, P. J., Carr, M. J., Hamilton, J. R. & Moffatt, J. D., 11 Mar 1999, In : Nature. 398, 6723, p. 156-160 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Protease-activated receptor-2 turnover stimulated independently of receptor activation in porcine coronary endothelial cells

Hamilton, J. R., Chow, J. M. & Cocks, T. M., 1999, In : British Journal of Pharmacology. 127, 3, p. 617-622 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries

Hamilton, J. R., Nguyen, P. & Cocks, T., 1998, In : Circulation Research. 82, 12, p. 1306 - 1311 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Degranulation enhances release of a stable contractile factor from rabbit polymorphonuclear leukocytes

Hamilton, J. R., Hart, J. L. & Woodman, O. L., May 1998, In : American Journal of Physiology - Heart and Circulatory Physiology. 43, 5 Pt 2, p. H1545 - H1551 7 p.

Research output: Contribution to journalArticleResearchpeer-review