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Personal profile


Justin works in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Senior Research Fellow.

A/Prof Justin Hamilton is an ARC Future Fellow at the Australian Centre for Blood Diseases (Melbourne, Australia). His group studies the role of platelets, platelet thrombin receptors, and their signaling effectors, in haemostasis, thrombosis, and inflammatory conditions. Justin received his PhD from the Department of Pharmacology at The University of Melbourne, where he was awarded the Chancellor's Prize in Medicine for the best PhD thesis of 2001. He then performed post-doctoral studies as a NHMRC CJ Martin Fellow in Prof. Shaun Coughlin's laboratory at the University of California, San Francisco, before returning to Australia to start his own research group. His work has been published in numerous journals, including Nature, Nature CommunicationsPNAS, Blood, and Circulation Research, and is funded by the NHMRC and ARC.


  • Cardiovascular Diseases
  • Platelets
  • Protease-Activated Receptors
  • Thrombosis

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Projects 2001 2021

Research Output 1998 2018

A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant

French, S. L., Thalmann, C., Bray, P. F., Macdonald, L. E., Murphy, A. J., Sleeman, M. W. & Hamilton, J. R., 12 Jun 2018, In : Blood Advances. 2, 11, p. 1283-1293 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Perinatal lethality of Par4–/– mice delivered by primiparous dams reveals spontaneous bleeding in mice without platelet thrombin receptor function

French, S. L. & Hamilton, J. R., 17 Feb 2018, In : Platelets. 29, 2, p. 196-198 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and function of the open canalicular system–the platelet’s specialized internal membrane network

Selvadurai, M. V. & Hamilton, J. R., 19 May 2018, In : Platelets. 29, 4, p. 319-325 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition

Selvadurai, M. V., Brazilek, R. J., Moon, M. J., Rinckel, J. Y., Eckly, A., Gachet, C., Meikle, P. J., Nandurkar, H. H., Nesbitt, W. S. & Hamilton, J. R., 1 Jan 2018, (Accepted/In press) In : FEBS Letters. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Challenges and opportunities in protease-activated receptor drug development

Hamilton, J. R. & Trejo, J., 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 349-373 25 p.

Research output: Contribution to journalArticleOtherpeer-review