Personal profile


Justin works in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Senior Research Fellow.

Dr Justin Hamilton is an ARC Future Fellow at the Australian Centre for Blood Diseases (Melbourne, Australia). His group studies the role of platelets, platelet thrombin receptors, and their signaling effectors, in haemostasis, thrombosis, and inflammatory conditions. Justin received his PhD from the Department of Pharmacology at The University of Melbourne, where he was awarded the Chancellor's Prize in Medicine for the best PhD thesis of 2001. He then performed post-doctoral studies as a NHMRC CJ Martin Fellow in Prof. Shaun Coughlin's laboratory at the University of California, San Francisco, before returning to Australia to start his own research group. His work has been published in numerous journals, including Nature, Nature CommunicationsPNAS, Blood, and Circulation Research, and is funded by the NHMRC and ARC.


  • Cardiovascular Diseases
  • Platelets
  • Protease-Activated Receptors
  • Thrombosis

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Projects 2001 2021

Research Output 1998 2017

Challenges and opportunities in protease-activated receptor drug development

Hamilton, J. R. & Trejo, J. 2017 In : Annual Review of Pharmacology and Toxicology. 57, p. 349-373 25 p.

Research output: Other - peer-reviewArticle

Class II phosphoinositide 3-kinases as novel drug targets

Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P. 12 Jan 2017 In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.

Research output: Research - peer-reviewArticle

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Green, T. N., Hamilton, J. R., Morel-Kopp, M. C., Zheng, Z., Chen, T. Y. T., Hearn, J. I., Sun, P. P., Flanagan, J. U., Young, D., Barber, P. A., During, M. J., Ward, C. M. & Kalev-Zylinska, M. L. 2017 In : Platelets. 28, 8, p. 799-811 13 p.

Research output: Research - peer-reviewArticle

Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability

Petitjean, C., Setiabakti, N. M., Mountford, J. K., Arthur, J. F., Ellis, S. L. & Hamilton, J. R. 2016 In : Platelets. 27, 5, p. 402 - 409 8 p.

Research output: Research - peer-reviewArticle

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E. 21 Oct 2016 In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Research - peer-reviewArticle