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Personal profile

Biography

Justin works in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Senior Research Fellow.

A/Prof Justin Hamilton is an ARC Future Fellow at the Australian Centre for Blood Diseases (Melbourne, Australia). His group studies the role of platelets, platelet thrombin receptors, and their signaling effectors, in haemostasis, thrombosis, and inflammatory conditions. Justin received his PhD from the Department of Pharmacology at The University of Melbourne, where he was awarded the Chancellor's Prize in Medicine for the best PhD thesis of 2001. He then performed post-doctoral studies as a NHMRC CJ Martin Fellow in Prof. Shaun Coughlin's laboratory at the University of California, San Francisco, before returning to Australia to start his own research group. His work has been published in numerous journals, including Nature, Nature CommunicationsPNAS, Blood, and Circulation Research, and is funded by the NHMRC and ARC.

Keywords

  • Cardiovascular Diseases
  • Platelets
  • Protease-Activated Receptors
  • Thrombosis

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Projects 2001 2021

Research Output 1998 2018

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition

Selvadurai, M. V., Brazilek, R. J., Moon, M. J., Rinckel, J. Y., Eckly, A., Gachet, C., Meikle, P. J., Nandurkar, H. H., Nesbitt, W. S. & Hamilton, J. R., 1 Jan 2018, (Accepted/In press) In : FEBS Letters. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Challenges and opportunities in protease-activated receptor drug development

Hamilton, J. R. & Trejo, J., 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 349-373 25 p.

Research output: Contribution to journalArticleOtherpeer-review

Class II phosphoinositide 3-kinases as novel drug targets

Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P., 12 Jan 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Green, T. N., Hamilton, J. R., Morel-Kopp, M. C., Zheng, Z., Chen, T. Y. T., Hearn, J. I., Sun, P. P., Flanagan, J. U., Young, D., Barber, P. A., During, M. J., Ward, C. M. & Kalev-Zylinska, M. L., 2017, In : Platelets. 28, 8, p. 799-811 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Saifuzzaman, M., Morrison, R., Zheng, Z., Orive, S., Hamilton, J., Thompson, P. E. & Al-Rawi, J. M. A., 15 Oct 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5531-5536 6 p.

Research output: Contribution to journalArticleResearchpeer-review