Julie McMullen

Adj Assoc Prof

20082020

Research output per year

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Research Output

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Article
2020

Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes

Prakoso, D., De Blasio, M. J., Tate, M., Kiriazis, H., Donner, D. G., Qian, H., Nash, D., Deo, M., Weeks, K. L., Parry, L. J., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., Apr 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H840-H852 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling

Nguyen, M-N., Ziemann, M., Kiriazis, H., Su, Y., Thomas, Z., Lu, Q., Donner, D. G., Zhao, W-B., Rafehi, H., Sadoshima, J., McMullen, J. R., El-Osta, A. & Du, X-J., Jan 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H45-H60 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development

Goodall, K. J., Nguyen, A., Matsumoto, A., McMullen, J. R., Eckle, S. B., Bertolino, P., Sullivan, L. C. & Andrews, D. M., 1 Mar 2019, In : Immunology and Cell Biology. 97, 3, p. 326-339 14 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2018

Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure

Nguyen, M. N., Su, Y., Vizi, D., Fang, L., Ellims, A. H., Zhao, W. B., Kiriazis, H., Gao, X. M., Sadoshima, J., Taylor, A. J., McMullen, J. R., Dart, A. M., Kaye, D. M. & Du, X. J., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 8213.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)
2017

Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases

Ooi, J. Y. Y., Bernardo, B. C., Singla, S., Patterson, N. L., Lin, R. C. Y. & McMullen, J. R., 4 May 2017, In : RNA Biology. 14, 5, p. 500-513 14 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Prakoso, D., De Blasio, M. J., Qin, C., Rosli, S., Kiriazis, H., Qian, H., Du, X-J., Weeks, K. L., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., 7 Jun 2017, In : Clinical Science. 131, 12, p. 1345-1360 16 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2016

Inhibition of miR-154 protects against cardiac dysfunction and fibrosis in a mouse model of pressure overload

Bernardo, B. C., Nguyen, S. S., Gao, X-M., Tham, Y. K., Ooi, J. Y. Y., Patterson, N. L., Kiriazis, H., Su, Y., Thomas, C. J., Lin, R. C. Y., Du, X-J. & McMullen, J. R., 1 Mar 2016, In : Scientific Reports. 6, 12 p., 22442.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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24 Citations (Scopus)

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, C. E., Murphy, K. T., Bernardo, B. C., Qian, H., Liu, Y., Sepulveda, P. V., Beyer, C., Hagg, A., Thomson, R. E., Chen, J. L., Walton, K. L., Loveland, K. L., McMullen, J. R., Rodgers, B. D., Harrison, C. A., Lynch, G. S. & Gregorevic, P., 20 Jul 2016, In : Science Translational Medicine. 8, 348, 12 p., 348ra98.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2015

Long-term overexpression of Hsp70 does not protect against cardiac dysfunction and adverse remodeling in a murc transgenic mouse model with chronic heart failure and atrial fibrillation

Bernardo, B. C., Sapra, G., Patterson, N. L., Cemerlang, N., Kiriazis, H., Ueyama, T., Febbraio, M. A. & McMullen, J. R., 14 Dec 2015, In : PLoS ONE. 10, 12, 17 p., 0145173.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart

Bernardo, B. C., Ooi, J., Lin, R. C. Y. & McMullen, J. R., 2015, In : Future Medicinal Chemistry. 7, 13, p. 1771 - 1792 22 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

Tham, Y. K., Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L. & McMullen, J. R., 2015, In : Archives of Toxicology. 89, 9, p. 1401 - 1438 38 p.

Research output: Contribution to journalArticleResearchpeer-review

173 Citations (Scopus)

Spontaneous ventricular tachyarrhythmias in beta2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis

Nguyen, M-N., Kiriazis, H., Ruggiero, D., Gao, X-M., Su, Y., Jian, A., Han, L-P., McMullen, J. R. & Du, X-J., 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 5, p. 946 - 957 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110alpha) signaling

De Blasio, M. J., Huynh, K. N. N., Qin, C. H., Rosli, S., Kiriazis, H., Ayer, A., Cemerlang, N., Stocker, R., Du, X-J., McMullen, J. R. & Ritchie, R. H., 2015, In : Free Radical Biology and Medicine. 87, (Art. No:12407), p. 137 - 147 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2014

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

Huynh, K., Bernardo, B. C., McMullen, J. R. & Ritchie, R. H., 2014, In : Pharmacology and Therapeutics. 142, 3, p. 375 - 415 41 p.

Research output: Contribution to journalArticleResearchpeer-review

251 Citations (Scopus)

he therapeutic potential of miRNAs regulated in settings of physiological cardiac hypertrophy

Ooi, J. Y. Y., Bernardo, B. C. & McMullen, J. R., 2014, In : Future Medicinal Chemistry. 6, 2, p. 205 - 222 18 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: potential drug targets?

Winbanks, C. E., Ooi, J. Y. Y., Nguyen, S. S., McMullen, J. R. & Bernardo, B. C., 2014, In : Clinical and Experimental Pharmacology and Physiology. 41, 9, p. 727 - 737 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy

Bernardo, B. C., Gao, X-M., Tham, Y. K., Kiriazis, H., Winbanks, C. E., Ooi, J. Y. Y., Boey, E. J. H., Obad, S., Kauppinen, S., Gregorevic, P., Du, X-J., Lin, R. C. Y. & McMullen, J. R., 2014, In : PLoS ONE. 9, 2, 13 p., e90337.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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51 Citations (Scopus)

Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

Bernardo, B. C., Nguyen, S. S., Winbanks, C. E., Gao, X-M., Boey, E. J. H., Tham, Y. K., Kiriazis, H., Ooi, J. Y. Y., Porrello, E. R., Igoor, S., Thomas, C. J., Gregorevic, P., Lin, R. C. Y., Du, X. J. & McMullen, J. R., 1 Dec 2014, In : The FASEB Journal. 28, 12, p. 5097-5110 14 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Sapra, G., Tham, Y. K., Cemerlang, N., Matsumoto, A., Kiriazis, H., Bernardo, B. C., Henstridge, D. C., Ooi, J. Y. Y., Pretorius, L., Boey, E. J. H., Lim, L., Sadoshima, J., Meikle, P. J., Mellett, N. A., Woodcock, E. A., Marasco, S., Ueyama, T., Du, X-J., Febbraio, M. A. & McMullen, J. R., 2014, In : Nature Communications. 5, p. 1 - 16 16 p., 5705.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)
2013

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Gray, S. P., Jandeleit-Dahm, K. A. M., McMullen, J. R. & Ritchie, R. H., 2013, In : Free Radical Biology and Medicine. 60, p. 307 - 317 11 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Winbanks, C. E., Chen, J., Qian, H., Liu, Y., Bernardo, B. C., Beyer, C., Watt, K. I., Thomson, R. E., Connor, T., Turner, B. J., McMullen, J. R., Larsson, L., McGee, S. L., Harrison, C. A. & Gregorevic, P., 2013, In : Journal of Cell Biology. 203, 2, p. 345 - 357 13 p.

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)
2012

Coenzyme Q{10} attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Jandeleit-Dahm, K. A. M., Forbes, J., McMullen, J. R. & Ritchie, R. H., 2012, In : Diabetologia. 55, 5, p. 1544 - 1553 10 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

Ritchie, R. H., Love, J. E., Huynh, K., Bernardo, B. C., Henstridge, D. C., Kiriazis, H., Tham, Y. K., Sapra, G., Qin, C., Cemerlang, N., Boey, E. J. H., Jandeleit-Dahm, K., Du, X. J. & McMullen, J. R., Dec 2012, In : Diabetologia. 55, 12, p. 3369-3381 13 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

Winbanks, C. E., Weeks, K. L., Thomson, R. E., Sepulveda, P. V., Beyer, C., Qian, H., Chen, J. L., Allen, J. M., Lancaster, G. I., Febbraio, M. A., Harrison, C. A., McMullen, J. R., Chamberlain, J. S. & Gregorevic, P., 28 Jun 2012, In : Journal of Cell Biology. 197, 7, p. 997-1008 12 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation

Lin, E., Irvine, J. C., Cao, A. H., Alexander, A. E., Love, J. E., Patel, R., McMullen, J. R., Kaye, D. M., Kemp-Harper, B. K. & Ritchie, R. H., 2012, In : PLoS ONE. 7, 4, 11 p., e34892.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

Phosphoinositide 3-kinase p110{alpha} is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction

Weeks, K. L., Gao, X-M., Du, X-J., Boey, E. JH., Matsumoto, A., Bernardo, B. C., Kiriazis, H., Cemerlang, N., Tan, J. W., Tham, Y. K., Franke, T. F., Qian, H., Bogoyevitch, M. A., Woodcock, E. A., Febbraio, M. A., Gregorevic, P. & McMullen, J. R., 2012, In : Circulation: Heart Failure. 5, 4, p. 523 - 534 12 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

Bernardo, B. C., Gao, X. M., Winbanks, C. E., Boey, E. J. H., Tham, Y. K., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., Du, X. J., Lin, R. C. Y. & McMullen, J. R., 23 Oct 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17615-17620 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
254 Citations (Scopus)
2010

Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy

Huynh, K., McMullen, J. R., Julius, T. L., Tan, J. W., Love, J. E., Cemerlang, N., Kiriazis, H., Du, X. J. & Ritchie, R. H., 1 Jun 2010, In : Diabetes. 59, 6, p. 1512-1520 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
95 Citations (Scopus)

Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies

Bernardo, B. C., Weeks, K. L., Pretorius, L. & McMullen, J. R., 2010, In : Pharmacology and Therapeutics. 128, 1, p. 191 - 227 37 p.

Research output: Contribution to journalArticleResearchpeer-review

446 Citations (Scopus)

PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA

Lin, R. CY., Weeks, K. L., Gao, X-M., Williams, R. BH., Bernardo, B. C., Kiriazis, H., Matthews, V., Woodcock, E. A., Bouwman, R., Mollica, J., Speirs, H. J., Dawes, I. W., Daly, R. J., Shioi, T., Izumo, S., Febbraio, M. A., Du, X-J. & McMullen, J. R., 2010, In : Arteriosclerosis, Thrombosis and Vascular Biology. 30, 4, p. 724 - 732 9 p.

Research output: Contribution to journalArticleResearchpeer-review

115 Citations (Scopus)
2009

Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction

Porrello, E. R., Bell, J. R., Schertzer, J. D., Curl, C. L., McMullen, J. R., Mellor, K. M., Ritchie, R. H., Lynch, G. S., Harrap, S. B., Thomas, W. G. & Delbridge, L. M. D., 1 Mar 2009, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 296, 3

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation

Pretorius, L., Du, X-J., Woodcock, E. A., Kiriazis, H., Lin, R. C. Y., Marasco, S. F., Medcalf, R. L., Ming, Z., Head, G. A., Tan, J. W., Cemerlang, N., Sadoshima, J., Shioi, T., Izumo, S., Lukoshkova, E. V., Dart, A. M., Jennings, G. L. R. & McMullen, J. R., 2009, In : American Journal of Pathology. 175, 3, p. 998 - 1009 12 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Role of phosphoinositide 3-kinases in regulating cardiac function

Pretorius, L., Owen, K. L. & McMullen, J. R., 2009, In : Frontiers in Bioscience. 14, 6, p. 2221 - 2229 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Selective activation of the "b" splice variant of phospholipase Cβ1 in chronically dilated human and mouse atria

Woodcock, E. A., Grubb, D. R., Filtz, T. M., Marasco, S., Luo, J., McLeod-Dryden, T. J., Kaye, D. M., Sadoshima, J., Du, X. J., Wong, C., McMullen, J. R. & Dart, A. M., Nov 2009, In : Journal of Molecular and Cellular Cardiology. 47, 5, p. 676-683 8 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

The protective effects of exercise and phosphoinositide 3-kinase (p110alpha) in the failing heart

Owen, K. L., Pretorius, L. & McMullen, J. R., 2009, In : Clinical Science. 116, 5, p. 365 - 375 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
2008

Promoting physiological hypertrophy in the failing heart

Pretorius, L., Owen, K. L., Jennings, G. L. R. & McMullen, J. R., 2008, In : Clinical and Experimental Pharmacology and Physiology. 35, 4, p. 438 - 441 4 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)