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2019

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Koutsakos, M., McWilliam, H. E. G., Aktepe, T. E., Fritzlar, S., Illing, P. T., Mifsud, N. A., Purcell, A. W., Rockman, S., Reading, P. C., Vivian, J. P., Rossjohn, J., Brooks, A. G., Mackenzie, J. M., Mintern, J. D., Villadangos, J. A., Nguyen, T. H. O. & Kedzierska, K., 29 May 2019, In : Frontiers in Immunology. 10, 12 p., 1158.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)
2018

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Martin, M. P., Naranbhai, V., Shea, P. R., Qi, Y., Ramsuran, V., Vince, N., Gao, X., Thomas, R., Brumme, Z. L., Carlson, J. M., Wolinsky, S. M., Goedert, J. J., Walker, B. D., Segal, F. P., Deeks, S. G., Haas, D. W., Migueles, S. A., Connors, M., Michael, N., Fellay, J. & 12 others, Gostick, E., Llewellyn-Lacey, S., Price, D. A., Lafont, B. A., Pymm, P., Saunders, P. M., Widjaja, J., Wong, S. C., Vivian, J. P., Rossjohn, J., Brooks, A. G. & Carrington, M., 1 May 2018, In : Journal of Clinical Investigation. 128, 5, p. 1903-1912 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)
2017

A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling

de Weerd, N. A., Matthews, A. Y., Pattie, P. R., Bourke, N. M., Lim, S. S., Vivian, J. P., Rossjohn, J. & Hertzog, P. J., 5 May 2017, In : Journal of Biological Chemistry. 292, 18, p. 7554-7565 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Pymm, P., Illing, P. T., Ramarathinam, S. H., O'Connor, G. M., Hughes, V. A., Hitchen, C., Price, D. A., Ho, B. K., McVicar, D. W., Brooks, A. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., Apr 2017, In : Nature Structural & Molecular Biology. 24, 4, p. 387-394 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Structural and regulatory diversity shape HLA-C protein expression levels

Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortes, A., Barber, T., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., Carrington, M., McVean, G., Purcell, A. W., Rossjohn, J. & Fugger, L., 26 Jun 2017, In : Nature Communications. 8, 12 p., 15924.

Research output: Contribution to journalArticleResearchpeer-review

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32 Citations (Scopus)

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C∗06: 02 molecule

Mobbs, J. I., Illing, P. T., Dudek, N. L., Brooks, A. G., Baker, D. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., 20 Oct 2017, In : Journal of Biological Chemistry. 292, 42, p. 17203-17215 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2016

Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition

Saunders, P. M., Pymm, P., Pietra, G., Hughes, V. A., Hitchen, C., O'Connor, G. M., Loiacono, F., Widjaja, J., Price, D. A., Falco, M., Mingari, M. C., Moretta, L., McVicar, D. W., Rossjohn, J., Brooks, A. G. & Vivian, J. P., 4 Apr 2016, In : Journal of Experimental Medicine. 213, 5, p. 791-807 17 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2015

A bird's eye view of NK cell receptor interactions with their MHC class I ligands

Saunders, P. M., Vivian, J. P., O'Connor, G. M., Sullivan, L. C., Pymm, P. G., Rossjohn, J. & Brooks, A. G., 2015, In : Immunological Reviews. 267, 1, p. 148 - 166 19 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Peptide-dependent recognition of HLA-B*57:01 by KIR3DS1

O'Connor, G. M., Vivian, J. P., Gostick, E., Pymm, P. G., Lafont, B. A. P., Price, D. A., Rossjohn, J., Brooks, A. G. & McVicar, D. W., 2015, In : Journal of Virology. 89, 10, p. 5213 - 5221 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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44 Citations (Scopus)

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Beringer, D. X., Kleijwegt, F. S., Wiede, F., Van Der Slik, A. R., Loh, K. K. L., Petersen, J., Dudek, N. L., Duinkerken, G., Laban, S., Joosten, A. M., Vivian, J. P., Chen, Z., Uldrich, A. P., Godfrey, D. I., McCluskey, J., Price, D. A., Radford, K. J., Purcell, A. W., Nikolic, T., Reid, H. H. & 3 others, Tiganis, T., Roep, B. O. & Rossjohn, J., 2015, In : Nature Immunology. 16, 11, p. 1153 - 1161 9 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope

Saunders, P. M., Vivian, J. P., Baschuk, N., Beddoe, T. C., Widjaja, J. M. L., O'Connor, G. M., Hitchen, C. R., Pymm, P. G., Andrews, D. M. K., Gras, S., McVicar, D. W., Rossjohn, J. & Brooks, A. G., 2015, In : Journal of Immunology. 194, 2, p. 781 - 789 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4

Moradi, S., Berry, R., Pymm, P. G., Hitchen, C. R., Beckham, S. A., Wilce, M. C. J., Walpole, N. G., Clements, C. S., Reid, H. H., Perugini, M. A., Brooks, A. G., Rossjohn, J. & Vivian, J. P., 2015, In : Journal of Biological Chemistry. 290, 16, p. 10460 - 10471 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2014

HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

Heap, G. A., Weedon, M. N., Bewshea, C. M., Singh, A., Chen, M., Satchwell, J. B., Vivian, J., So, K., Dubois, P. C., Andrews, J. M., Annese, V., Bampton, P. A., Barnardo, M. C., Bell, S., Cole, A. T., Connor, S. J., Creed, T., Cummings, F. R., D'Amato, M., Daneshmend, T. K. & 36 others, Fedorak, R. N., Florin, T., Gaya, D. R., Greig, E., Halfvarson, J., Hart, A., Irving, P. M., Jones, G., Karban, A., Lawrance, I., Lee, J. C., Lees, C., Lev-Tzion, R., Lindsay, J. O., Mansfield, J., Mawdsley, J., Mazhar, Z., Parkes, M., Parnell, K., Orchard, T. R., Radford-Smith, G., Russell, R. K., Reffitt, D., Satsangi, J., Silverberg, M. S., Sturniolo, G. C., Tremelling, M., Tsianos, E. V., van Heel, D. A., Walsh, A., Watermeyer, G. A., Weersma, R. K., Zeissig, S., Rossjohn, J., Holden, A. L. & Ahmad, T., 2014, In : Nature Genetics. 46, 10, p. 1131 - 1134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)

Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity

O'Connor, G. M., Vivian, J. P., Widjaja, J. M. L., Bridgeman, J. S., Gostick, E., Lafont, B. A. P., Anderson, S. K., Price, D. A., Brooks, A. G., Rossjohn, J. & McVicar, D. W., 2014, In : Journal of Immunology. 192, 6, p. 2875 - 2884 10 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

The structure of the cytomegalovirus-encoded m04 glycoprotein, a prototypical member of the m02 family of immunoevasins

Berry, R., Vivian, J. P., Deuss, F. A., Balaji, G. R., Saunders, P. M., Lin, J., Littler, D., Brooks, A. G. & Rossjohn, J., 2014, In : Journal of Biological Chemistry. 289, 34, p. 23753 - 23763 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Human leukocyte antigen-associated drug hypersensitivity

Illing, P. T., Vivian, J. P., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2013, In : Current Opinion in Immunology. 25, 1, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1

De Weerd, N. A., Vivian, J., Nguyen, T. K., Mangan, N., Gould, J. A., Braniff, S-J., Zaker-Tabrizi, L., Fung, K. Y., Forster, S., Beddoe, T. C., Reid, H. H., Rossjohn, J. & Hertzog, P. J., 2013, In : Nature Immunology. 14, 9, p. 901 - 907 7 p.

Research output: Contribution to journalArticleResearchpeer-review

145 Citations (Scopus)

Targeting of a natural killer cell receptor family by a viral immunoevasin

Berry, R., Ng, N. M-Y., Saunders, P. M., Vivian, J., Lin, J., Deuss, F., Corbett, A., Forbes, C. A., Widjaja, J. ML., Sullivan, L. C., McAlister, A. D., Perugini, M. A., Call, M. J., Scalzo, A. A., Degli-Esposti, M., Coudert, J. D., Beddoe, T. C., Brooks, A. & Rossjohn, J., 2013, In : Nature Immunology. 14, 7, p. 699 - 707 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2012

A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b

Zeng, L., Sullivan, L. C., Vivian, J. P., Walpole, N. G., Harpur, C. M., Rossjohn, J., Clements, C. S. & Brooks, A. G., 2012, In : Journal of Immunology. 188, 1, p. 302 - 310 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by Macaque NK cells

Maloveste, S. M., Chen, D., Gostick, E., Vivian, J. P., Plishka, R. J., Iyengar, R., Kruthers, R. L., Buckler-White, A., Brooks, A. G., Rossjohn, J., Price, D. A. & Lafont, B. AP., 2012, In : Journal of Immunology. 189, 9, p. 4338 - 4348 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Illing, P. T., Vivian, J. P., Dudek, N. L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J. J., Kjer-Nielsen, L., Gras, S., Williamson, N. A., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 486, 7404, p. 554 - 558 5 p.

Research output: Contribution to journalArticleResearchpeer-review

413 Citations (Scopus)
2011

A molecular basis for NKT cell recognition of CD1d-self-antigen

Mallevaey, T., Clarke, A. J., Scott-Browne, J. P., Young, M. H., Roisman, L. C., Pellicci, D. G., Patel, O., Vivian, J. P., Matsuda, J. L., McCluskey, J., Godfrey, D. I., Marrack, P., Rossjohn, J. & Gapin, L., 2011, In : Immunity. 34, 3, p. 315 - 326 12 p.

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)

A semi-invariant V{alpha}10{+} T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

Uldrich, A., Patel, O., Cameron, G., Pellicci, D., Day, E. B., Sullivan, L., Kyparissoudis, K., Kjer-Nielsen, L., Vivian, J., Cao, B., Brooks, A., Williams, S., Illarionov, P., Besra, G., Turner, S., Porcelli, S., McCluskey, J., Smyth, M., Rossjohn, J. & Godfrey, D., 2011, In : Nature Immunology. 12, 7, p. 616 - 623 8 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

Vivian, J. P., Duncan, R. C., Berry, R., O'Connor, G. M., Reid, H. H., Beddoe, T. C., Gras, S., Saunders, P. M., Olshina, M. A., Widjaja, J. ML., Harpur, C. M., Lin, J., Maloveste, S. M., Price, D. A., Lafont, B. AP., McVicar, D. W., Clements, C. S., Brooks, A. G. & Rossjohn, J., 2011, In : Nature. 479, 7373, p. 401 - 405 5 p.

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)
2010

Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase

Scoble, J. A., McAlister, A. D., Fulton, Z. J., Troy, S. T., Byres, E., Vivian, J., Brammananth, R., Wilce, M. C. J., Le Nours, J., Zaker-Tabrizi, L., Coppel, R. L., Crellin, P., Rossjohn, J. & Beddoe, T. C., 2010, In : Journal of Molecular Biology. 398, 1, p. 26 - 39 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases

Vivian, J., Riedmaier, P., Ge, H., Le Nours, J., Sansom, F. M., Wilce, M. C. J., Byres, E., Dias, M., Schmidberger, J., Cowan, P. J., d'Apice, A. JF., Hartland, E. L., Rossjohn, J. & Beddoe, T. C., 2010, In : Structure. 18, 2, p. 228 - 238 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability

Crellin, P., Vivian, J., Scoble, J. A., Chow, F. M., West, N. P., Brammananth, R., Proellocks, N. I., Shahine, A. E., Le Nours, J., Wilce, M. CJ., Britton, W. J., Coppel, R. L., Rossjohn, J. & Beddoe, T. C., 2010, In : Journal of Biological Chemistry. 285, 39, p. 30050 - 30060 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2009

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Beddoe, T. C., Chen, Z., Clements, C. S., Ely, L. K., Bushell, S. R., Vivian, J. P., Kjer-Nielsen, L., Pang, S. S., Dunstone, M. A., Liu, Y. C., Macdonald, W. A., Perugini, M. A., Wilce, M. C. J., Burrows, S. R., Purcell, A. W., Tiganis, T., Bottomley, S. P., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 6, p. 777 - 788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Crystal structure of LipL32, the most abundant surface protein of pathogenic Leptospira spp.

Vivian, J., Beddoe, T. C., McAlister, A. D., Wilce, M. C. J., Zaker-Tabrizi, L., Troy, S. T., Byres, E., Hoke, D. E., Cullen, P. A., Lo, M., Murray, G. L., Adler, B. & Rossjohn, J., 2009, In : Journal of Molecular Biology. 387, 5, p. 1229 - 1238 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis

Vivian, J., Scoullar, J., Rimmer, K., Bushell, S. R., Beddoe, T. C., Wilce, M. C. J., Byres, E., Boyle, T. P., Doak, B. C., Simpson, J. S., Graham, B., Heras, B., Kahler, C. M., Rossjohn, J. & Scanlon, M., 2009, In : Journal of Molecular Biology. 394, 5, p. 931 - 943 13 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2008

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis

Vivian, J., Scoullar, J., Robertson, A. L., Bottomley, S. P., Horne, H. J., Chin, K-Y. Y., Wielens, J., Thompson, P., Velkov, T., Piek, S., Byres, E., Beddoe, T. C., Wilce, M. CJ., Kahler, C. M., Rossjohn, J. & Scanlon, M., 2008, In : Journal of Biological Chemistry. 283, 47, p. 32452 - 32461 10 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2007

An asymmetric structure of the bacillus subtilis replication terminator protein in complex with DNA

Vivian, J. P., Porter, C. J., Wilce, J. A. & Wilce, M. C. J., 2007, In : Journal of Molecular Biology. 370, 3, p. 481 - 491 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2005

Structure and RNA binding of the third KH domain of poly(C)-binding protein 1

Sidiqi, M., Wilce, J. A., Vivian, J. P., Porter, C. J., Barker, A., Leedman, P. J. & Wilce, M. C. J., 2005, In : Nucleic Acids Research. 33, 4, p. 1213 - 1221 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2003

The impact of single cysteine residue mutations on the replication terminator protein

Vivian, J. P., Hastings, A. F., Duggin, I. G., Wake, R. G., Wilce, M. C. J. & Wilce, J. A., 31 Oct 2003, In : Biochemical and Biophysical Research Communications. 310, 4, p. 1096-1103 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2002

Novel Binding of HuR and Poly(C)-binding Protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA

Yeap, B. B., Voon, D. C., Vivian, J. P., McCulloch, R. K., Thomson, A. M., Giles, K. M., Czyzyk-Krzeska, M. F., Furneaux, H., Wilce, M. C. J., Wilce, J. A. & Leedman, P., 2002, In : Journal of Biological Chemistry. 277, 30, p. 27183 - 27192 10 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)
2001

Crystallization of the Bacillus subtilis RTP-DNA complex prepared using NMR spectroscopy

Vivian, J. P., Wilce, J. A., Hastings, A. F. & Wilce, M. C. J., 21 Mar 2001, In : Acta Crystallographica Section D: Biological Crystallography. 57, 3, p. 421-424 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest

Wilce, J. A., Vivian, J. P., Hastings, A. F., Otting, G., Folmer, R. HA., Duggin, I. G., Wake, R. G. & Wilce, M. C. J., 2001, In : Nature Structural & Molecular Biology. 8, 3, p. 206 - 210 5 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)