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Personal profile


My work is principally focused on events central to infection and immunity. Specifically I work on deducing the structural arrangement of Killer-Cell Immunoglobulin-like Receptors (KIR) and their ligands and detail the molecular mode of interaction generating their complexes. This has important implications in disease and transplant outcomes. I also investigate immune reactions to specific drugs. This work is intended to lead to the better design and screening of new therapeutics.


  • Structural Biology
  • Immunology
  • Innate Immunity
  • Receptors and Signal Transduction
  • Drug hypersensitivity

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Research Output 2001 2018

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Martin, M. P., Naranbhai, V., Shea, P. R., Qi, Y., Ramsuran, V., Vince, N., Gao, X., Thomas, R., Brumme, Z. L., Carlson, J. M., Wolinsky, S. M., Goedert, J. J., Walker, B. D., Segal, F. P., Deeks, S. G., Haas, D. W., Migueles, S. A., Connors, M., Michael, N., Fellay, J. & 12 othersGostick, E., Llewellyn-Lacey, S., Price, D. A., Lafont, B. A., Pymm, P., Saunders, P. M., Widjaja, J., Wong, S. C., Vivian, J. P., Rossjohn, J., Brooks, A. G. & Carrington, M., 1 May 2018, In : Journal of Clinical Investigation. 128, 5, p. 1903-1912 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Production of recombinant killer immunoglobulin-like receptors for crystallography and luminex-based assays

Pymm, P. & Vivian, J. P., 11 Jan 2018, Methods in Molecular Biology. Humana Press, p. 281-299 19 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling

de Weerd, N. A., Matthews, A. Y., Pattie, P. R., Bourke, N. M., Lim, S. S., Vivian, J. P., Rossjohn, J. & Hertzog, P. J., 5 May 2017, In : Journal of Biological Chemistry. 292, 18, p. 7554-7565 13 p.

Research output: Contribution to journalArticleResearchpeer-review