1974 …2020

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2020

The EngCP endo α-N-acetylgalactosaminidase is a virulence factor involved in Clostridium perfringens gas gangrene infections

Cheung, J. K., Adams, V., D'Souza, D., James, M., Day, C. J., Jennings, M. P., Lyras, D. & Rood, J. I., Feb 2020, In : International Journal of Medical Microbiology. 310, 2, 12 p., 151398.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Tcp plasmids of Clostridium perfringens require the resP gene to ensure stable inheritance

Revitt-Mills, S., Lao, C., Archambault, M., Lyras, D., Rood, J. I. & Adams, V., Jan 2020, In : Plasmid. 107, 11 p., 102461.

Research output: Contribution to journalArticleResearchpeer-review

Two putative zinc metalloproteases contribute to the virulence of Clostridium perfringens strains that cause avian necrotic enteritis

Wade, B., Keyburn, A. L., Haring, V., Ford, M., Rood, J. I. & Moore, R. J., Mar 2020, In : Journal of Veterinary Diagnostic Investigation. 32, 2, p. 259-267 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)
2019

Clostridial genetics: Genetic manipulation of the pathogenic Clostridia

Kuehne, S., Rood, J. I. & Lyras, D., Jun 2019, In : Microbiology spectrum. 7, 3, 16 p., GPP3-0040-2018.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Histotoxic clostridial infections

Nagahama, M., Takehara, M. & Rood, J. I., Jul 2019, In : Microbiology spectrum. 7, 4, 17 p., GPP3-0024-2018.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

pCP13, a representative of a new family of conjugative toxin plasmids in Clostridium perfringens

Watts, T. D., Vidor, C. J., Awad, M. M., Lyras, D., Rood, J. I. & Adams, V., 1 Mar 2019, In : Plasmid. 102, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Virulence Plasmids of the Pathogenic Clostridia

Revitt-Mills, S. A., Vidor, C. J., Watts, T. D., Lyras, D., Rood, J. I. & Adams, V., 17 May 2019, In : Microbiology spectrum. 7, 3, 28 p., GPP3-0034-2018.

Research output: Contribution to journalArticleResearchpeer-review

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2018

Clostridium sordellii pathogenicity locus plasmid pCS1-1 encodes a novel clostridial conjugation locus

Vidor, C. J., Watts, T. D., Adams, V., Bulach, D., Couchman, E., Rood, J. I., Fairweather, N. F., Awad, M. & Lyras, D., 16 Jan 2018, In : mBio. 9, 1, 14 p., e01761-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Concurrent host-pathogen transcriptional responses in a clostridium perfringens murine myonecrosis infection

Low, L-Y., Harrison, P. F., Gould, J., Powell, D. R., Choo, J. M., Forster, S. C., Chapman, R., Gearing, L. J., Cheung, J. K., Hertzog, P. & Rood, J. I., 1 Mar 2018, In : mBio. 9, 2, 15 p., e00473-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Expansion of the Clostridium perfringens toxin-based typing scheme

Rood, J. I., Adams, V., Lacey, J. A., Lyras, D., McClane, B. A., Melville, S. B., Moore, R. J., Popoff, M. R., Sarker, M. R., Songer, J. G., Uzal, F. A. & Van Immerseel, F., 1 Oct 2018, In : Anaerobe. 53, p. 5-10 6 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

The incidence of Clostridioides difficile and Clostridium perfringens netF-positive strains in diarrheic dogs

Diniz, A. N., Coura, F. M., Rupnik, M., Adams, V., Stent, T. L., Rood, J. I., de Oliveira, C. A., Lobato, F. C. F. & Silva, R. O. S., 1 Feb 2018, In : Anaerobe. 49, p. 58-62 5 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Vibrational spectroscopy combined with transcriptomic analysis for investigation of bacterial responses towards acid stress

Hlaing, M. M., Wood, B. R., McNaughton, D., Rood, J. I., Fox, E. M. & Augustin, M. A., 1 Jan 2018, In : Applied Microbiology and Biotechnology. 102, 1, p. 333-343 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Whole genome analysis reveals the diversity and evolutionary relationships between necrotic enteritis-causing strains of Clostridium perfringens

Lacey, J. A., Allnutt, T. R., Vezina, B., Van, T. T. H., Stent, T., Han, X., Rood, J. I., Wade, B., Keyburn, A. L., Seemann, T., Chen, H., Haring, V., Johanesen, P. A., Lyras, D. & Moore, R. J., 22 May 2018, In : BMC Genomics. 19, 1, 22 p., 379.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)
2017

Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative

Hutton, M. L., Cunningham, B. A., Mackin, K. E., Lyon, S. A., James, M. L., Rood, J. I. & Lyras, D., 16 Jun 2017, In : Scientific Reports. 7, 1, 13 p., 3665.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)
6 Citations (Scopus)
2016

Analysis of the virulence-associated RevSR two-component signal transduction system of Clostridium perfringens

Cheung, J. K., Wisniewski, J. A., Adams, V. M., Quinsey, N. S. & Rood, J. I., Sep 2016, In : International Journal of Medical Microbiology. 306, 6, p. 429-442 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

CdtR regulates TcdA and TcdB production in Clostridium difficile

Lyon, S. A., Hutton, M. L., Rood, J. I., Cheung, J. K. & Lyras, D., 14 Jul 2016, In : PLoS Pathogens. 12, 7, 19 p., e1005758.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

Functional analysis of an feoB mutant in Clostridium perfringens strain 13

Awad, M. M., Cheung, J. K., Tan, J. E., McEwan, A. G., Lyras, D. & Rood, J. I., Oct 2016, In : Anaerobe. 41, p. 10-17 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

RNA-seq analysis of virR and revR mutants of Clostridium perfringens

Low, L-Y., Harrison, P. F., Lin, Y-H., Boyce, J. D., Rood, J. I. & Cheung, J. K., 23 May 2016, In : BMC Genomics. 17, 14 p., 391.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

Wisniewski, J. A., Traore, D. A. K., Bannam, T. L., Lyras, D., Whisstock, J. C. & Rood, J. I., 1 Mar 2016, In : Molecular Microbiology. 99, 5, p. 884-896 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The adherent abilities of Clostridium perfringens strains are critical for the pathogenesis of avian necrotic enteritis

Wade, B., Keyburn, A. L., Haring, V., Ford, M., Rood, J. I. & Moore, R. J., 25 Dec 2016, In : Veterinary Microbiology. 197, p. 53-61 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The NEAT domain-containing proteins of Clostridium perfringens bind heme

Choo, J. M., Cheung, J. K., Wisniewski, J. A., Steer, D. L., Bulach, D. M., Hiscox, T. J., Chakravorty, A., Smith, A. I., Gell, D. A., Rood, J. I. & Awad, M. M., 16 Sep 2016, In : PLoS ONE. 11, 9, 26 p., 0162981.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)
2015

Animal models to study the pathogenesis of human and animal clostridium perfringens infections

Uzal, F. A., McClane, B. A., Cheung, J. K. T., Theoret, J. R., Garcia, J. P., Moore, R. J. & Rood, J. I., 2015, In : Veterinary Microbiology. 179, 1-2, p. 23 - 33 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

A two-component regulatory system modulates twitching motility in Dichelobacter nodosus

Kennan, R. M., Lovitt, C. J., Han, X. Y., Parker, D., Turnbull, L., Whitchurch, C. B. & Rood, J. I., 2015, In : Veterinary Microbiology. 179, 1-2, p. 34 - 41 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Binding of Clostridium perfringens to collagen correlates with the ability to cause necrotic enteritis in chickens

Wade, B., Keyburn, A. L., Seemann, T., Rood, J. I. & Moore, R. J., 2015, In : Veterinary Microbiology. 180, 3-4, p. 299 - 303 5 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Clostridium perfringens extracellular toxins and enzymes: 20 and counting

Revitt-Mills, S. A., Rood, J. I. & Adams, V., 2015, In : Microbiology Australia. 36, 3, p. 114-117 4 p.

Research output: Contribution to journalArticleOther

Clostridium perfringens type A-E toxin plasmids

Freedman, J. C., Theoret, J. R., Wisniewski, J. A., Uzal, F. A., Rood, J. I. & McClane, B. A., 2015, In : Research in Microbiology. 166, 5, p. 264 - 279 16 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Comparative neuropathology of ovine enterotoxemia produced by clostridium perfringens type D wild-type strain CN1020 and its genetically modified derivatives

Garcia, J. P., Giannitti, F., Finnie, J. W., Manavis, J., Beingesser, J., Adams, V. M., Rood, J. I. & Uzal, F. A., 2015, In : Veterinary Pathology. 52, 3, p. 465 - 475 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)

Correction for Chen et al., Epsilon-Toxin Production by Clostridium perfringens Type D Strain CN3718 Is Dependent upon the agr Operon but Not the VirS/VirR Two-Component Regulatory System

Chen, J., Rood, J. I. & McClane, B. A., 2015, In : mBio. 6, 1, 1 p., e02491-14.

Research output: Contribution to journalArticleOtherpeer-review

Defining the roles of TcdA and TcdB in localized gastrointestinal disease, systemic organ damage, and the host response during clostridium difficile Infections

Carter, G. P., Chakravorty, A., Nguyen, T. A. P., Mileto, S., Schreiber, F., Li, L., Howarth, P., Clare, S., Cunningham, B., Sambol, S. P., Cheknis, A. K., Figueroa, I., Johnson, S., Gerding, D., Rood, J. I., Dougan, G., Lawley, T. D. & Lyras, D., 2015, In : mBio. 6, 3, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
104 Citations (Scopus)

Functional analysis of a bacitracin resistance determinant located on ICECp1, a novel Tn916-like element from a conjugative plasmid in Clostridium perfringens

Han, X. Y., Du, X-D., Southey, L. C., Bulach, D. M., Seemann, T., Yan, X., Bannam, T. L. & Rood, J. I., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6855 - 6865 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Genomic analyses of Clostridium perfringens isolates from five toxinotypes

Hassan, K. A., Elbourne, L. D. H., Tetu, S. G., Melville, S. B., Rood, J. I. & Paulsen, I. T., 2015, In : Research in Microbiology. 166, 4, p. 255 - 263 9 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

International Society for Plasmid Biology

Rood, J., Jensen, S. O., Lyras, D. & Top, E. M., 1 Jul 2015, In : Plasmid. 80, p. iv

Research output: Contribution to journalArticleOtherpeer-review

Molecular characterization and antimicrobial susceptibilities of Clostridium difficile clinical isolates from Victoria, Australia

Mackin, K. E., Elliott, B., Kotsanas, D., Howden, B. P., Carter, G. P., Korman, T. M., Riley, T. V., Rood, J. I., Jenkin, G. A. & Lyras, D., 2015, In : Anaerobe. 34, p. 80 - 83 4 p.

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

NanR, a transcriptional regulator that binds to the promoters of genes involved in sialic acid metabolism in the anaerobic pathogen clostridium perfringens

Therit, B. H., Cheung, J. K. L., Rood, J. I. & Melville, S. B., 2015, In : PLoS ONE. 10, 7 , 17 p., e0133217.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Plasmid partitioning systems of conjugative plasmids from Clostridium perfringens

Adams, V., Watts, T. D., Bulach, D. M., Lyras, D. & Rood, J. I., 2015, In : Plasmid. 80, p. 90-96 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX

Headey, S. J., Sivakumaran, A., Adams, V., Lyras, D., Rood, J. I., Scanlon, M. & Wilce, M. C. J., 2015, In : Journal of Molecular Recognition. 28, 5, p. 316-324 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The pore-forming alpha-toxin from clostridium septicum activates the MAPK pathway in a Ras-c-Raf-dependent and independent manner

Chakravorty, A., Awad, M. M., Cheung, J. K. T., Hiscox, T. J., Lyras, D. & Rood, J. I., 2015, In : Toxins. 7, 2, p. 516 - 534 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Two novel membrane proteins, TcpD and TcpE, are essential for conjugative transfer of pCW3 in clostridium perfringens

Wisniewski, J. A., Teng, S. W. L., Bannam, T. L. & Rood, J. I., 2015, In : Journal of Bacteriology. 197, 4, p. 774 - 781 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)
2014

Detection of an en masse and reversible B- to A-DNA conformational transition in prokaryotes in response to desiccation

Whelan, D. R., Hiscox, T. J., Rood, J. I., Bambery, K. R., McNaughton, D. & Wood, B. R., 2014, In : Journal of the Royal Society Interface. 11, 97, p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Genomic evidence for a Globally distributed, Bimodal population in the Ovine footrot pathogen dichelobacter nodosus

Kennan, R. M., Gilhuus, M., Frosth, S., Seemann, T., Dhungyel, O. P., Whittington, R. J., Boyce, J. D., Powell, D. R., Aspan, A., Jorgensen, H. J., Bulach, D. M. & Rood, J. I., 2014, In : mBio. 5, 5, p. 1 - 11 11 p., e01821-14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Identification of a two-component signal transduction system that regulates maltose genes in Clostridium perfringens

Hiscox, T. J., Ohtani, K., Shimizu, T., Cheung, K-L. J. & Rood, J. I., 2014, In : Anaerobe. 30, p. 199 - 204 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Opioid analgesics stop the development of clostridial gas gangrene

Chakravorty, A., Awad, M. M., Hiscox, T. J., Cheung, K-L. J., Choo, J. M. F., Lyras, D. & Rood, J. I., 2014, In : Journal of Infectious Diseases. 210, 3, p. 483 - 492 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease

Uzal, F. A., Freedman, J. C., Shrestha, A., Theoret, J. R., Garcia, J. P., Awad, M. M., Adams, V. M., Moore, R. J., Rood, J. I. & McClane, B. A., 2014, In : Future Microbiology. 9, 3, p. 361 - 377 17 p.

Research output: Contribution to journalArticleResearchpeer-review

146 Citations (Scopus)

Utility of the clostridial site-specific recombinase TnpX to clone toxic-product-encoding genes and selectively remove genomic DNA fragments

Adams, V., Bantwal, R., Stevenson, L., Cheung, K-L. J., Awad, M. M., Nicholson, A. J., Carter, G. P., Mackin, K. E., Rood, J. I. & Lyras, D., 2014, In : Applied and Environmental Microbiology. 80, 12, p. 3597-3603 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Virulence plasmids of spore-forming bacteria

Adams, V., Li, J., Wisniewski, J. A., Uzal, F. A., Moore, R. J., McClane, B. & Rood, J. I., 1 Dec 2014, In : Microbiology spectrum. 2, 6, 24 p., PLAS-0024-2014.

Research output: Contribution to journalArticleOtherpeer-review

16 Citations (Scopus)
2013

Epsilon toxin is essential for the virulence of Clostridium perfringens type D infection in sheep, goats, and mice

Garcia, J. P., Adams, V. M., Beingesser, J., Hughes, M. L., Poon, R., Lyras, D., Hill, A., McClane, B. A., Rood, J. I. & Uzal, F. A., 2013, In : Infection and Immunity. 81, 7, p. 2405 - 2414 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis

Keyburn, A., Portela, R. W., Ford, M. E., Bannam, T. L., Yan, X., Rood, J. I. & Moore, R. J., 2013, In : Veterinary Research. 44, 1, p. 1 - 7 7 p., 108.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Regulation of sialidase production in Clostridium perfringens by the orphan sensor histidine kinase ReeS

Hiscox, T. J., Harrison, P. F., Chakravorty, A., Choo, J. M. F., Ohtani, K., Shimizu, T., Cheung, K-L. J. & Rood, J. I., 2013, In : PLoS ONE. 8, 9, 8 p., e73525.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)