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Research Output 1997 2019

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Article
2019

Characterising an Alternative Murine Model of Diabetic Cardiomyopathy

Tate, M., Prakoso, D., Willis, A. M., Peng, C., Deo, M., Qin, C. X., Walsh, J. L., Nash, D. M., Cohen, C. D., Rofe, A. K., Sharma, A., Kiriazis, H., Donner, D. G., De Haan, J. B., Watson, A. M. D., De Blasio, M. J. & Ritchie, R. H., 14 Nov 2019, In : Frontiers in Physiology. 10, 15 p., 1395.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018
1 Citation (Scopus)

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation

Mathew, G., Sharma, A., Pickering, R. J., Rosado, C. J., Lemarie, J., Mudgal, J., Thambi, M., Sebastian, S., Jandeleit-Dahm, K. A., de Haan, J. B. & Unnikrishnan, M. K., 3 Oct 2018, In : Free Radical Research. 52, 10, p. 1140-1157 18 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Nrf2 activation is a potential therapeutic approach to attenuate diabetic retinopathy

Deliyanti, D., Alrashdi, S. F., Tan, S. M., Meyer, C., Ward, K. W., de Haan, J. B. & Wilkinson-Berka, J. L., 1 Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 815-825 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
4 Citations (Scopus)

Does lack of glutathione peroxidase 1 gene expression exacerbate lung injury induced by neonatal hyperoxia in mice?

Bouch, S., O'Reilly, M., de Haan, J. B., Harding, R. & Sozo, F., 1 Jul 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 1, p. L115-L125 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

JNK activation of BIM promotes hepatic oxidative stress, steatosis, and insulin resistance in obesity

Litwak, S. A., Pang, L., Galic, S., Igoillo-Esteve, M., Stanley, W. J., Turatsinze, J. V., Loh, K., Thomas, H. E., Sharma, A., Trepo, E., Moreno, C., Gough, D. J., Eizirik, D. L., De Haan, J. B. & Gurzov, E. N., 1 Dec 2017, In : Diabetes. 66, 12, p. 2973-2986 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Protective effect of inflammasome activation by hydrogen peroxide in a mouse model of septic shock

Huet, O., Pickering, R. J., Tikellis, C., Latouche, C., Long, F., Kingwell, B., Dickinson, B., Chang, C. J., Masters, S., Mackay, F., Cooper, M. E. & De Haan, J. B., 1 Feb 2017, In : Critical Care Medicine. 45, 2, p. e184-e194 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

Sharma, A., Rizky, L., Stefanovic, N., Tate, M., Ritchie, R. H., Ward, K. W. & de Haan, J. B., 3 Mar 2017, In : Cardiovascular Diabetology. 16, 1, 13 p., 33.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)
2016
15 Citations (Scopus)

A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy

Deliyanti, D., Lee, J. Y., Petratos, S., Meyer, C. J., Ward, K., Wilkinson-Berka, J. & De Haan-Klein, J. B., 1 Aug 2016, In : Clinical Science. 130, 15, p. 1375-1387 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium

Sharma, A., Yuen, D., Huet, O., Pickering, R., Stefanovic, N., Bernatchez, P. & de Haan, J. B., 1 Apr 2016, In : Vascular Pharmacology. 79, p. 32-42 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
25 Citations (Scopus)

Direct endothelial nitric oxide synthase activation provides atheroprotection in diabetes-accelerated atherosclerosis

Sharma, A., Sellers, S., Stefanovic, N., Leung, C., Tan, S., Huet, O., Granville, D. J., Cooper, M. E., De Haan-Klein, J. B. & Bernatchez, P., 2015, In : Diabetes. 64, 11, p. 3937-3950 14 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Ebselen by modulating oxidative stress improves hypoxia-induced macroglial Müller cell and vascular injury in the retina

Tan, S. M., Deliyanti, D., Figgett, W. A., Talia, D. M., De Haan, J. B. & Wilkinson-Berka, J. L., 1 Jul 2015, In : Experimental Eye Research. 136, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

Stanley, W. J., Litwak, S. A., Quah, H. S., Tan, S. M., Kay, T. W. H., Tiganis, T., De Haan-Klein, J. B., Thomas, H. E. & Gurzov, E., 2015, In : Diabetes. 64, 7, p. 2489 - 2496 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy

Tan, S. M., Sharma, A., Stefanovic, N. & de Haan, J. B., Mar 2015, In : Free Radical Research. 49, 3, p. 219-227 9 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide

Guo, J., Wang, X., Henstridge, D. C., Richardson, J. J., Cui, J., Sharma, A., Febbraio, M. A., Peter, K., De Haan-Klein, J. B., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Healthcare Materials. 4, 14, p. 2170 - 2175 6 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice

Rasmiena, A. A., Barlow, C. K., Stefanovic, N., Huynh, K., Tan, R., Sharma, A., Tull, D., de Haan, J. B. & Meikle, P. J., 1 Dec 2015, In : Atherosclerosis. 243, 2, p. 598-608 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
58 Citations (Scopus)

Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-Associated atherosclerosis and improves diabetic kidney disease

Tan, S. M., Sharma, A., Stefanovic, N., Yuen, D. Y. C., Karagiannis, T. C., Meyer, C., Ward, K. W., Cooper, M. E. & De Haan, J. B., Sep 2014, In : Diabetes. 63, 9, p. 3091-3103 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013
24 Citations (Scopus)

An Apolipoprotein A-I Mimetic Peptide Designed with a Reductionist Approach Stimulates Reverse Cholesterol Transport and Reduces Atherosclerosis in Mice

Ditiatkovski, M., D'Souza, W., Kesani, R., Chin-Dusting, J., de Haan, J. B., Remaley, A. & Sviridov, D., 9 Jul 2013, In : PLoS ONE. 8, 7, e68802.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Ensuring animal welfare while meeting scientific aims using a murine pneumonia model of septic shock

Huet, O., Ramsey, D., Miljavec, S., Jenney, A., Aubron, C., Aprico, A., Stefanovic, N., Balkau, B., Head, G. A., de Haan, J. B. & Chin-Dusting, J. P. F., Jun 2013, In : Shock. 39, 6, p. 488-494 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Lack of the antioxidant glutathione peroxidase-1 (GPx1) exacerbates retinopathy of prematurity in mice

Tan, S., Stefanovic, N., Tan, G. M. L., Wilkinson-Berka, J. & de Haan, J. B., 1 Jan 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 555 - 562 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
204 Citations (Scopus)

NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., De Haan-Klein, J. B., Koulis, C., El-Osta, A., Andrews, K. L., Chin-Dusting, J. PF., Touyz, R. M., Wingler, K., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2013, In : Circulation. 127, 18, p. 1888 - 1902 15 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Oxidative stress in surgery in an ageing population: pathophysiology and therapy

Rosenfeldt, F. L., Wilson, M. D., Lee, G. A., Kure, C., Ou, R., Braun, L. A. & de Haan, J., 2013, In : Experimental Gerontology. 48, 1, p. 45 - 54 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The Modified Selenenyl Amide, M-hydroxy Ebselen, Attenuates Diabetic Nephropathy and Diabetes-Associated Atherosclerosis in ApoE/GPx1 Double Knockout Mice

Tan, S. M., Sharma, A., Yuen, D. Y. C., Stefanovic, N., Krippner, G., Mugesh, G., Chai, Z. & de Haan, J. B., 16 Jul 2013, In : PLoS ONE. 8, 7, e69193.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2011
15 Citations (Scopus)

Cell division autoantigen 1 enhances signaling and the profibrotic effects of transforming growth factor-beta in diabetic nephropathy

Tu, Y., Wu, T., Dai, A., Pham, Y., Chew, P., de Haan, J., Wang, Y., Toh, B-H., Zhu, H., Cao, Z., Cooper, M. & Chai, Z., 2011, In : Kidney International. 79, 2, p. 199 - 209 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
61 Citations (Scopus)

Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse

Chew, P., Yuen, D., Stefanovic, N., Pete, J., Coughlan, M. T., Jandeleit-Dahm, K., Thomas, M., Rosenfeldt, F., Cooper, M. & De Haan, J. B., 2010, In : Diabetes. 59, 12, p. 3198-3207 10 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

Ballinger, M. L., Osman, N., Hashimura, K., De Haan, J. B., Jandeleit-Dahm, K. A., Ilen, T. A., Tannock, L., Rutledge, J. C. & Little, P. J., 2010, In : Journal of Cellular and Molecular Medicine. 14, 6B, p. 1408 - 1418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
62 Citations (Scopus)

Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse

Chew, P., Yuen, D. Y. C., Koh, P., Stefanovic, N., Febbraio, M. A., Kola, I., Cooper, M. E. & de Haan, J. B., Jun 2009, In : Arteriosclerosis, Thrombosis and Vascular Biology. 29, 6, p. 823-830 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
186 Citations (Scopus)

Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice

Lewis, P., Stefanovic, N., Pete, J., Calkin, A. C., Giunti, S., Thallas-Bonke, V., Jandeleit-Dahm, K. A., Allen, T. J., Kola, I., Cooper, M. E. & De Haan, J. B., 1 Apr 2007, In : Circulation. 115, 16, p. 2178-2187 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2006
43 Citations (Scopus)

Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet

De Haan, J. B., Witting, P. K., Stefanovic, N., Pete, J., Daskalakis, M., Kola, I., Stocker, R. & Smolich, J. J., 2006, In : Journal of Lipid Research. 47, 6, p. 1157 - 1167 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1

Gosbell, A. D., Stefanovic, N., Scurr, L. L., Pete, J., Kola, I., Favilla, I. & De Haan, J. B., 2006, In : Investigative Ophthalmology and Visual Science. 47, 6, p. 2613 - 2622 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
46 Citations (Scopus)

Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy

De Haan-Klein, J. B., Stefanovic, N., Nikolic-Paterson, D. J., Scurr, L. L., Croft, K. D., Mori, T. A., Hertzog, P. J., Kola, I., Atkins, R. C. & Tesch, G. H., 2005, In : American Journal of Physiology - Renal Physiology. 289, 3, p. F544 - F551 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
55 Citations (Scopus)

Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death

De Haan, J. B., Bladier, C., Lotfi-Miri, M., Taylor, J., Hutchinson, P., Crack, P. J., Hertzog, P. & Kola, I., 1 Jan 2004, In : Free Radical Biology and Medicine. 36, 1, p. 53-64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
37 Citations (Scopus)

An altered antioxidant balance occurs in Down syndrome fetal organs: implications for the "gene dosage effect" hypothesis

De Haan-Klein, J. B., Susil, B., Pritchard, M. A. & Kola, I., 2003, In : Journal of Neural Transmission. 67, Suppl, p. 67 - 83 17 p.

Research output: Contribution to journalArticleResearchpeer-review

An imbalance in antioxidant defense affects cellular function: The pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse

De Haan, J. B., Crack, P. J., Flentjar, N. J., Iannello, R. C., Hertzog, P. J. & Kola, I., 2003, In : Redox Report. 8, 2, p. 69 - 79 11 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Glutathione peroxidase-1 contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic mouse in response to ischemia/reperfusion injury

Crack, P. J., Taylor, J. M., De Haan, J. B., Kola, I., Hertzog, P. & Iannello, R. C., 1 Jan 2003, In : Journal of Cerebral Blood Flow and Metabolism. 23, 1, p. 19-22 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
36 Citations (Scopus)

Mice lacking glutathione peroxidase-1 activity show increased tunel staining and an accelerated inflammatory response in brain following a cold induced injury

Flentjar, N. J., Crack, P. J., Boyd, R., Malin, M. A., De Haan, J. B., Hertzog, P. J., Kola, I. & Iannello, R. C., 2002, In : Experimental Neurology. 177, p. 9 - 20 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
148 Citations (Scopus)

Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury

Crack, P. J., Taylor, J. M., Flentjar, N. J., De Haan-Klein, J. B., Hertzog, P. J., Iannello, R. C. & Kola, I., 2001, In : Journal of Neurochemistry. 78, p. 1389 - 1399 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1999
72 Citations (Scopus)

Oxidative stress and neural dysfunction in Down Syndrome

Iannello, R., Crack, P. J., De Haan, J. B. & Kola, I., 1999, In : Journal of Neural Transmission. p. 257 - 267 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptability to the oxidative stress-inducing agents parquat and hydrogen peroxide

De Haan, J. B., Bladier, C., Griffiths, P., Kelner, M. J., O'Shea, R. D., Cheung, N. S., Bronson, R. T., Silvestro, M. J., Wild, S., Zheng, S. S., Beart, P. M., Hertzog, P. J. & Kola, I., 1998, In : Journal of Biological Chemistry. p. 22528 - 22536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

358 Citations (Scopus)

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

De Haan, J. B., Bladier, C., Griffiths, P., Kelner, M. J., Bronson, R. T., Silvestro, M. J., Wild, S., Zheng, S. S., Hertzog, P. J., Kola, I., O'Shea, R. D., Cheung, N. S. & Beart, P. M., 1998, In : Journal of Biological Chemistry. p. 22528 - 22536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1997
151 Citations (Scopus)

Response of a primary human fibroblast cell line to H2O2: senescence like growth arrest or apoptosis?

Bladier, C., Wolvetang, E. J., Hutchinson, P., De Haan, J. B. & Kola, I., 1997, In : Cell Growth and Differentiation. p. 589 - 598 10 p.

Research output: Contribution to journalArticleResearchpeer-review