Projects per year
Personal profile
Biography
Professor Judy de Haan is a Baker Institute Fellow and Head of the Oxidative Stress laboratory at the Baker Heart and Diabetes Institute. She holds an adjunct Professorship through Swinburne University and Assoc. Professorship appointments through La Trobe University and Torrens University, Adelaide, and senior lectureships in the Departments of Immunology and Diabetes, at Monash University.
Prof de Haan’s research focuses on improving the lives of diabetic patients by reducing the burden of cardiovascular complications. A focus has been on the pathogenesis of oxidant stress, where free radicals build up in the body and elicit damage, in particular, their contribution to diabetic macrovascular complications, such as diabetes-associated atherosclerosis and diabetes-linked endothelial dysfunction. This has led to significant discoveries on the role of endogenous antioxidant enzyme defences to limit disease. Her work has identified several key antioxidant enzyme mimetics, as well as activators of the transcriptional regulator of oxidant stress, Nrf2, as novel therapeutic strategies to lessen diabetic cardiovascular complications. Her research now focuses on the interplay between antioxidant defence and inflammation, with a particular focus on the Nrf2/NLRP3-inflammasome axis. Her preclinical investigations hold tremendous potential for translation into humans, and this next phase of her research is anticipated to yield far better cardiovascular outcomes than previous non-selective antioxidants such as vitamins C and E.
In addition, a recent approach, together with the University of Swinburne, has been the development of an interdisciplinary molecular, cell biology and surface engineering strategy to limit regrowth and obstruction of heart vessels after stent surgery.
Professor de Haan has more than 80 career publications with more than 3700 career citations, and an H-index of 35, many published in highly ranked scientific journals such as Circulation, Diabetes, Human Mol. Genet., ATVB, Kidney Int and JBC.
Professor de Haan's work has been supported by grants from the NHMRC, National Heart Foundation, Diabetes Australia Research Program, as well as numerous industry awards.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Oxidant stress
- Diabetes
- Antioxidant defence
- Inflammation
Network
-
The Role of the Antioxidant Enzyme Glutathione Peroxidase-1 (gpx1) in Atheroscerosis
De Haan-Klein, J. & Kola, I.
1/01/00 → 31/12/01
Project: Research
-
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease
Østergaard, J. A., Jha, J. C., Sharma, A., Dai, A., Choi, J. S. Y., de Haan, J. B., Cooper, M. E. & Jandeleit-Dahm, K., Jan 2022, In: Clinical science (London, England : 1979). 136, 2, p. 167-180 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Animal models of diabetes-associated vascular diseases: an update on available models and experimental analysis
Choi, J. S. Y., de Haan, J. B. & Sharma, A., Mar 2022, In: British Journal of Pharmacology. 179, 5, p. 748-769 22 p.Research output: Contribution to journal › Review Article › Research › peer-review
6 Citations (Scopus) -
The Mechanisms of Restenosis and Relevance to Next Generation Stent Design
Clare, J., Ganly, J., Bursill, C. A., Sumer, H., Kingshott, P. & de Haan, J. B., Mar 2022, In: Biomolecules. 12, 3, 20 p., 430.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access5 Citations (Scopus) -
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery
May, L. T., Bartolo, B. A., Harrison, D. G., Guzik, T., Drummond, G. R., Figtree, G. A., Ritchie, R. H., Rye, K. A. & de Haan, J. B., 9 Dec 2022, In: Clinical Science. 136, 23, p. 1731-1758 28 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Author Correction: Selenium–GPX4 axis protects follicular helper T cells from ferroptosis (Nature Immunology, (2021), 22, 9, (1127-1139), 10.1038/s41590-021-00996-0)
Yao, Y., Chen, Z., Zhang, H., Chen, C., Zeng, M., Yunis, J., Wei, Y., Wan, Y., Wang, N., Zhou, M., Qiu, C., Zeng, Q., Ong, H. S., Wang, H., Makota, F. V., Yang, Y., Yang, Z., Wang, N., Deng, J., Shen, C., & 19 others , 4 Oct 2021, In: Nature Immunology. 22, 1 p., 1599.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open AccessFile3 Citations (Scopus)