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Personal profile

Biography

Josie works in the Faculty of Engineering at Monash University as a Lecturer.

Research interests

My research focuses on the way in which fluid forces in blood flow affect cardiovascular function. One aspect is to generate controlled in-vitro flow environments that accurately mimic the complex blood flow conditions found the human body facilitating highly detailed measurements which are not otherwise possible. Such tools are aimed at investigations of disease mechanisms, development of implantable devices and drug evaluation. Recent examples include: 

Targeted lab-on-a-chip devices: a microfluidic devices which mimic flow in a vessel wall 

Flow control: development of devices to replicate patient specific blood pressure and flow waves 

New algorithms: combining computer simulation and experimental measurements to obtain data sets that could previously only be measured in separate independent experiments. For example to simultaneously measure time resolved blood flow (pressure, flow shear) and biological activity (cell adhesion, thrombus stability, fluorescent receptor markers). Key publications: Pinar et al, PLoS ONE 2015, Nesbitt et al, Nature Med 2009. NHMRC Project grant APP1126536 2017-2019

Research Output 1997 2016

A-disintegrin-and-metalloproteinase (ADAM) 10 activity on resting and activated platelets

Facey, A. D., Pinar, I., Arthur, J. F., Qiao, J. L., Jing, J., Mado, B., Carberry, J. J., Andrews, R. K. & Gardiner, E. E., 2016, In : Biochemistry. 55, 8, p. 1187 - 1194 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Methods for understanding shear induced thrombus growth

Pinar, I. P., Arthur, J., Andrews, R., Gardiner, E. E., Ryan, K. & Carberry, J. J., 2015, Ninth International Symposium on Turbulence and Shear Flow Phenomena (TSFP-9). Tavoularis, S. & Marusic, I. (eds.). Melbourne Australia: University of Melbourne, p. 1 - 5 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Methods to determine the lagrangian shear experienced by platelets during thrombus growth

Pinar, I., Arthur, J. F., Andrews, R. K., Gardiner, E. E., Ryan, K. & Carberry, J. J., 2015, In : PLoS ONE. 10, 12, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Techniques towards understanding shear dependent thrombus formation

Pinar, I., Arthur, J., Andrews, R., Gardiner, E., Ryan, K. & Carberry, J., 2014, Proceedings of the 19th Australasian Fluid Mechanics Conference (AFMC). Chowdhury, H. & Alam, F. (eds.). Melbourne Vic Australia: RMIT University, p. 1 - 4 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Medicine Meets Mathematics: Measuring ADAM10 Activity Directly On a Forming Thrombus

Arthur, J. F., Pinar, I., Facey, A., Fouras, A., Ryan, K., Andrews, R. K., Carberry, J. & Gardiner, E. E. (ed.), 15 Nov 2013, In : Blood. 122, 21, p. 196-196 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review