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2020

Experimental Antiglomerular Basement Membrane GN Induced by a Peptide from Actinomyces

Gu, Q. H., Huynh, M., Shi, Y., Jia, X. Y., Luo, J. J., Jiang, T. J., Cui, Z., Ooi, J. D., Kitching, A. R. & Zhao, M. H., 1 Jun 2020, In : Journal of the American Society of Nephrology. 31, 6, p. 1282-1295 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Risk factors for treatment resistance and relapse of Chinese patients with MPO-ANCA-associated vasculitis

Huang, L., Shen, C., Zhong, Y., Ooi, J. D., Zhou, Y. O., Chen, J. B., Wu, T., Meng, T., Xiao, Z., Lin, W., Ao, X., Xiao, X., Zhou, Q. & Xiao, P., 1 May 2020, In : Clinical and Experimental Medicine. 20, 2, p. 199-206 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The association of neutrophil-to-lymphocyte ratio with all-cause mortality in Chinese patients with MPO-ANCA associated vasculitis

Huang, L., Shen, C., Zhong, Y., Ooi, J. D., Zhou, Y. O., Chen, J. B., Wu, T., Meng, T., Xiao, Z., Lin, W., Ao, X., Tang, R., Xiao, X., Zhou, Q. & Xiao, P., 21 Apr 2020, (Accepted/In press) In : Clinical and Experimental Medicine. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Ooi, J. D., Jiang, J-H., Eggenhuizen, P. J., Chua, L. L., van Timmeren, M., Loh, K. L., O’Sullivan, K. M., Gan, P. Y., Zhong, Y., Tsyganov, K., Shochet, L. R., Ryan, J., Stegeman, C. A., Fugger, L., Reid, H. H., Rossjohn, J., Heeringa, P., Holdsworth, S. R., Peleg, A. Y. & Kitching, A. R., 29 Jul 2019, In : Nature Communications. 10, 1, 14 p., 3392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Apoptotic Cell-Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN

Gan, P. Y., Godfrey, A. S., Ooi, J. D., O'Sullivan, K. M., Oudin, V., Kitching, A. R. & Holdsworth, S. R., 1 Aug 2019, In : Journal of the American Society of Nephrology. 30, 8, p. 1365-1374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Biologicals targeting T helper cell subset differentiating cytokines are effective in the treatment of murine anti-myeloperoxidase glomerulonephritis

Gan, P. Y., Chan, A., Ooi, J. D., Dick, J., Nagai, K., O'Sullivan, K. M., Oudin, V., Shim, R., Kitching, A. R. & Holdsworth, S. R., Nov 2019, In : Kidney International. 96, 5, p. 1121–1133 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen

Huynh, M., Eggenhuizen, P. J., Olson, G. L., Rao, N. B., Self, C. R., Sun, Y., Holdsworth, S. R., Kitching, A. R. & Ooi, J. D., 1 Sep 2019, In : Journal of Autoimmunity. 103, 7 p., 102276.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

Galea, R., Nel, H. J., Talekar, M., Liu, X., Ooi, J. D., Huynh, M., Hadjigol, S., Robson, K. J., Ting, Y. T., Cole, S., Cochlin, K., Hitchcock, S., Zeng, B., Yekollu, S., Boks, M., Goh, N., Roberts, H., Rossjohn, J., Reid, H. H., Boyd, B. J. & 7 others, Malaviya, R., Shealy, D. J., Baker, D. G., Madakamutil, L., Richard Kitching, A., O’Sullivan, B. J. & Thomas, R., 19 Sep 2019, In : JCI Insight. 4, 18, 21 p., e126025.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

The effect of pulse methylprednisolone induction therapy in Chinese patients with dialysis-dependent MPO-ANCA associated vasculitis

Huang, L., Zhong, Y., Ooi, J. D., Zhou, Y. O., Zuo, X., Luo, H., Chen, J. B., Wu, T., Yang, Y., Meng, T., Xiao, Z., Lin, W., Ao, X., Xiao, X., Zhou, Q. & Xiao, P., Nov 2019, In : International Immunopharmacology. 76, 6 p., 105883.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2018

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Discordance of patient and physician health status concerns in systemic lupus erythematosus

Golder, V., Ooi, JJY., Antony, A. S., Ko, T., Morton, S., Kandane-Rathnayake, R., Morand, EF. & Hoi, A. Y., 1 Mar 2018, In : Lupus. 27, 3, p. 501-506 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2017

CD8+ T cells effect glomerular injury in experimental anti-myeloperoxidase GN

Chang, J., Eggenhuizen, P., O'Sullivan, K. M., Alikhan, M. A., Holdsworth, S. R., Ooi, J. D. & Kitching, A. R., 1 Jan 2017, In : Journal of the American Society of Nephrology. 28, 1, p. 47-55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 others, Holdsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Pathogenic role for γδ T cells in autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P. Y., Fujita, T., Ooi, J. D., Alikhan, M. A., Dick, J., Shim, R., Odobasic, D., O'Sullivan, K. M., Kitching, A. R. & Holdsworth, S. R., 1 Nov 2017, In : Journal of Immunology. 199, 9, p. 3042-3050 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2016

Endogenous toll-like receptor 9 regulates AKI by promoting regulatory T cell recruitment

Alikhan, M., Summers, S. A., Gan, P. Y., Chan, A., Khouri, M., Ooi, J., Ghali, J., Odobasic, D., Hickey, M. J., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 3, p. 706 - 714 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Mast cell stabilization ameliorates autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P-Y., O'Sullivan, K. M., Ooi, J. D., Alikhan, M. A., Odobasic, D., Summers, S. A., Kitching, A. R. & Holdsworth, S. R., 1 May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1321 - 1333 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Myeloperoxidase peptide-based nasal tolerance in experimental ANCA-associated GN

Gan, P. Y., Tan, D. S. Y., Ooi, J., Alikhan, M., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 385 - 391 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The NLRP3 inflammasome in kidney disease and autoimmunity

Hutton, H. L., Ooi, J., Holdsworth, S. R. & Kitching, A. R., 2016, In : Nephrology. 21, 9, p. 736 - 744 9 p.

Research output: Contribution to journalArticleOtherpeer-review

74 Citations (Scopus)
2015

Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis

Gan, P. Y., Ooi, J., Kitching, A. R. & Holdsworth, S. R., 2015, In : Current Pharmaceutical Design. 21, 18, p. 2380 - 2390 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis

Ooi, J., Li, M., Kourkoutzelos, K., Yagita, H., Azuma, M., Holdsworth, S. R. & Kitching, A. R., 2015, In : Nephrology. 20, 12, p. 892 - 898 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2014

Fc(gamma)RIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis

Ooi, J., Gan, P. Y., Chen, T., Eggenhuizen, P. J., Chang, J., Alikhan, M., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2014, In : Kidney International. 86, 6, p. 1140 - 1149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

T cell mediated autoimmune glomerular disease in mice

Ooi, J., Gan, P. Y., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2014, In : Current Protocols in Immunology. 107, p. 1 - 19 19 p.

Research output: Contribution to journalArticleOther

5 Citations (Scopus)
2013

Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation

Yang, Y. H., Song, W., Deane, J. A., Kao, W., Ooi, J., Ngo, D., Kitching, A. R., Morand, E. F. & Hickey, M. J., 2013, In : Journal of Immunology. 190, 3, p. 997 - 1007 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis

Roth, A. J., Ooi, J., Hess, J. J., van Timmeren, M. M., Berg, E. A., Poulton, C. E., McGregor, J., Burkart, M., Hogan, S. L., Hu, Y., Winnik, W., Nachman, P. H., Stegeman, C. A., Niles, J., Heeringa, P., Kitching, A. R., Holdsworth, S. R., Jennette, J. C., Preston, G. A. & Falk, R. J., 2013, In : Journal of Clinical Investigation. 123, 4, p. 1773 - 1783 11 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

Devi, S., Li, A., Westhorpe, C. L., Lo, C. Y-W., Abeynaike, L., Snelgrove, S. L., Hall, P. H., Ooi, J., Sobey, C. G., Kitching, A. R. & Hickey, M. J., 2013, In : Nature Medicine. 19, 1, p. 107 - 112 6 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)
16 Citations (Scopus)

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN

Ooi, J., Chang, J., O'Sullivan, K., Pedchenko, V., Hudson, B. G., Vandenbark, A. A., Fugger, L., Holdsworth, S. R. & Kitching, A. R., 2013, In : Journal of the American Society of Nephrology. 24, 3, p. 419 - 431 13 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN

Tan, D. S. Y., Gan, P. Y., O'Sullivan, K., Hammett, M. V., Summers, S. A., Ooi, J., Lundgren, B. A., Boyd, R. L., Scott, H. S., Kitching, A. R., Chidgey, A. P. & Holdsworth, S. R., 2013, In : Journal of the American Society of Nephrology. 24, 4, p. 573 - 585 13 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2012

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction

Summers, S. A., Gan, P-Y., Dewage, L. T., Ma, F., Ooi, J., O'Sullivan, K., Nikolic-Paterson, D. J., Kitching, A. R. & Holdsworth, S. R., 2012, In : Kidney International. 82, 6, p. 676 - 685 10 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis

Gan, P. Y., Summers, S. A., Ooi, J., O'Sullivan, K., Tan, D. S. Y., Muljadi, R. C. M., Odobasic, D., Kitching, A. R. & Holdsworth, S. R., 2012, In : Journal of the American Society of Nephrology. 23, 12, p. 1955 - 1966 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis

Snelgrove, S., Kausman, J., Lo, C., Lo, C., Ooi, J. D., Coates, P., Hickey, M., Holdsworth, S., Kurts, C., Engel, D. & Kitching, A., 2012, In : American Journal of Pathology. 180, 1, p. 91 - 103 13 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)
61 Citations (Scopus)
2011

Endogenous foxp3{+} T-regulatory cells suppress anti-glomerular basement membrane nephritis

Ooi, J., Snelgrove, S., Engel, D., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O'Sullivan, K., Hickey, M., Holdsworth, S., Kurts, C. & Kitching, A., 2011, In : Kidney International. 79, 9, p. 977 - 986 10 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses

Summers, S. A., Phoon, R., Ooi, J., Holdsworth, S. & Kitching, A., 2011, In : American Journal of Pathology. 178, 2, p. 580 - 590 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis

Summers, S. A., Steinmetz, O., Gan, P-Y., Ooi, J., Odobasic, D., Kitching, A. & Holdsworth, S., 2011, In : Arthritis & Rheumatism. 63, 4, p. 1124 - 1135 12 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2010

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

Summers, S. A., van der Veen, B. S., O'Sullivan, K., Gan, P-Y., Ooi, J., Heeringa, P., Satchell, S. C., Mathieson, P. W., Saleem, M. A., Visvanathan, K., Holdsworth, S. R. & Kitching, A. R., 2010, In : Kidney International. 78, 12, p. 1263 - 1274 12 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Review: T helper 17 cells: their role in glomerulonephritis

Ooi, J., Kitching, A. R. & Holdsworth, S. R., 2010, In : Nephrology. 15, 5, p. 513 - 521 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P-Y., Steinmetz, O., Tan, D. S. Y., O'Sullivan, K., Ooi, J., Iwakura, Y., Kitching, A. R. & Holdsworth, S. R., 2010, In : Journal of the American Society of Nephrology. 21, 6, p. 925 - 931 7 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy

Summers, S. A., Hoi, A., Steinmetz, O., O'Sullivan, K., Ooi, J., Odobasic, D., Akira, S., Kitching, A. R. & Holdsworth, S. R., 2010, In : Journal of Autoimmunity. 35, 4, p. 291 - 298 8 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis

Summers, S. A., Steinmetz, O., Ooi, J., Gan, P-Y., O'Sullivan, K., Visvanathan, K., Akira, S., Kitching, A. R. & Holdsworth, S. R., 2010, In : American Journal of Pathology. 177, 5, p. 2234 - 2244 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2009

Antimyeloperoxidase antibodies rapidly induce alpha4-integrin-dependent glomerular neutrophil adhesion

Kuligowski, M. P., Kwan, R., Lo, C., Wong, C., James, W. G. M., Bourges, D., Ooi, J. D., Abeynaike, L., Hall, P. H., Kitching, A. R. & Hickey, M. J., 2009, In : Blood. 113, 25, p. 6485 - 6494 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen

Ooi, J. D., Phoon, R. K. S., Holdsworth, S. R. & Kitching, A. R., 2009, In : Journal of the American Society of Nephrology. 20, p. 980 - 989 10 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)
2008

Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

Ooi, J., Holdsworth, S. R. & Kitching, A. R., 2008, In : Journal of Autoimmunity. 31, 3, p. 295 - 300 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2006

Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis

Ruth, A-J., Kitching, A. R., Kwan, R. Y. Q., Odobasic, D., Ooi, J. D. K., Timoshanko, J. R., Hickey, M. J. & Holdsworth, S. R., 2006, In : Journal of the American Society of Nephrology. 17, 7, p. 1940 - 1949 10 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease

Apostolopoulos, J., Ooi, J. D. K., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2006, In : Journal of Immunological Methods. 308, 1-2, p. 167 - 178 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)