Projects per year
Personal profile
Biography
Dr Josh Bourne is a Postdoctoral Research Fellow in the Monash Neuroinflammation group, investigating novel mechanisms and therapeutic targets to alleviate inflammation in the brain after ischaemic stroke. Dr Bourne completed his PhD in 2022 within the Platelet Group at the University of Birmingham (UK) working with Associate Professor Julie Rayes and Professor Steve Watson. Here, he characterised platelet receptor CLEC-2 in thrombosis and the inflammatory response, and successully published 6 first-author papers. During this time, he found passion in intravital microscopy, so relocated to Melbourne to train with world-leading intravitalist, Associate Professor Connie Wong. Dr Bourne now investigates the complex interplay between thrombosis, associated coagulation factors, and neuroinflammation. Since beginning his Postdoctoral position, he has acquired >$350,000 in competitive funding, and won awards at a national and international level. Dr Bourne received an FMNHS Postdoctoral Fellowship in 2024.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cardiovascular Science, PhD, Characterisation of platelet-receptor, CLEC-2, in thrombosis and inflammation, University of Birmingham
1 Oct 2018 → 30 Jun 2022
Award Date: 5 Dec 2022
Oncology, MSc, University of Nottingham
Award Date: 3 Dec 2018
Medical Physiology and Therapeutics, BSc (Hons), University of Nottingham
Award Date: 1 Jul 2016
Research area keywords
- Innate Immunity
- Thrombosis
- Thromboinflammation
- Inflammation
- Stroke
- Platelet biology
- Macrophages
- Macrophage polarisation
- Microglia
Collaborations and top research areas from the last five years
Projects
- 2 Finished
-
TISN: Tackling ischaemic stroke with nanomedicine
Bourne, J., Wong, C., Veldhuis, N., Whittaker, M. & Lawlor, K.
1/01/23 → 31/03/24
Project: Research
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Delivery of pH-responsive nanoparticles to reduce thrombo-inflammation and neural injury after ischaemic stroke
Wong, C. (Primary Chief Investigator (PCI)), Veldhuis, N. (Chief Investigator (CI)), Whittaker, M. (Chief Investigator (CI)) & Bourne, J. (Chief Investigator (CI))
1/01/23 → 31/12/24
Project: Research
-
Diving head-first into brain intravital microscopy
Suthya, A. R., Wong, C. H. Y. & Bourne, J. H., 2024, In: Frontiers in Immunology. 15, 14 p., 1372996.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice
Bourne, J. H., Perrella, G., El-Awaisi, J., Terry, L. V., Tinkova, V., Hogg, R. L., Gant, P., Grygielska, B., Kalia, N., Kavanagh, D., Brill, A., Dimitrov, J. D., Watson, S. P. & Rayes, J., Jul 2024, In: Journal of Thrombosis and Haemostasis. 22, 7, p. 2018-2026 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice
Bourne, J. H., Campos, J., Hopkin, S. J., Whitworth, K., Palis, J., Senis, Y. A., Rayes, J., Iqbal, A. J. & Brill, A., 2023, In: Frontiers in Immunology. 14, 11 p., 1226196.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
CLEC-2 supports platelet aggregation in mouse but not human blood at arterial shear
Bourne, J., Smith, C. W., Jooss, N. J., Di, Y., Brown, H. C., Montague, S. J., Thomas, M. R., Poulter, N. S., Rayes, J. & Watson, S. P., Dec 2022, In: Thrombosis and Haemostasis. 122, 12, p. 1988-2000 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Citations (Scopus) -
Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature
Khan, A. O., Reyat, J. S., Hill, H., Bourne, J. H., Colicchia, M., Newby, M. L., Allen, J. D., Crispin, M., Youd, E., Murray, P. G., Taylor, G., Stamataki, Z., Richter, A. G., Cunningham, A. F., Pugh, M. & Rayes, J., Nov 2022, In: Cardiovascular Research. 118, 15, p. 3085-3096 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access26 Citations (Scopus)