Projects per year
Personal profile
Biography
Position
Associate Professor and Associate Dean, Graduate Research
Faculty of Pharmacy and Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Joseph Nicolazzo graduated with a PhD in 2004 from Monash University (Australia) focusing on buccal mucosal drug delivery. He joined the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University in 2007 as a Lecturer, where he is now an Associate Professor and Associate Dean, Graduate Research. While he has some continuing interest in buccal mucosal drug delivery, his main research focus is on central nervous system (CNS) drug delivery, the role of drug transporters at the blood-brain barrier (BBB) in facilitating and limiting drug access into the CNS, how transport across the BBB alters in neurodegenerative diseases, and how the BBB may be exploited to reverse pathology associated with Alzheimer’s disease. He is the author of 70 peer-reviewed manuscripts and is regularly invited to international conferences in the field of BBB biology, including Gordon Research Conference – Barriers of the CNS and International Conference on Cerebral Vascular Biology. Joseph is President of the Australasian Pharmaceutical Science Association, Editor (Expert Reviews and Theme Issues) of Pharmaceutical Research, and an Editorial Board Member of Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, and Fluids and Barriers of the CNS. He received the Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award (2009), Early Career Research Award (2013) and Excellence in Postgraduate Supervision Award (2018).
Research interests
Using a suite of in vitro, in situ and in vivo models, my research is broadly classified into:
- Understanding the factors affecting BBB transport of drugs and endogenous molecules
- The involvement of intracellular trafficking proteins in facilitating molecular transport across the BBB
- The impact of Alzheimer's disease and motor neurone disease on BBB transport of drugs and endogenous molecules
- Exploring molecular targets at the BBB that can be utilised to reverse cognitive dysfunction associated with Alzheimer's disease
Monash teaching commitment
Unit coordinator, PHR2021 (How Medicines Work III)
Lecturer
- PHR1022 (How Medicines Work II)
- PHR2021 (How Medicines Work III)
- BPS2041 (Drug Delivery and Pharmacokinetics)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Alzheimer's Disease
- Blood-Brain Barrier
- CNS Drug Delivery
- Drug Transport
Collaborations and top research areas from the last five years
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Exploring the impact of altered blood-brain barrier dynamics in brain cancer on therapeutic drug delivery
1/07/23 → 30/06/27
Project: Research
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Developing potent and brain-permeable peptide therapeutics for AD
Wai, D., Norton, R. & Nicolazzo, J.
1/03/22 → 1/12/23
Project: Research
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Developing SMN2 splice-switching antisense oligonucleotide therapy for MND
Turner, B. J., Shabanpoor, F., Rogers, M. & Nicolazzo, J.
4/01/21 → 3/01/24
Project: Research
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Optimising dosage regimen design in individuals with motor neuron disease
Nicolazzo, J. & Pan, Y.
1/01/22 → 31/12/22
Project: Research
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In relation to In vitro/in vivo Validation of Blood Brain Barrier Microfluidic Chip Model
Department of Defence (Australia)
1/07/21 → 1/07/22
Project: Research
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Comparison of the Anti-inflammatory Activity and Cellular Interaction of Brush Polymer-N-Acetyl Cysteine Conjugates in Human and Murine Microglial Cell Lines
Mazrad, Z. A. I., Leiske, M. N., Tabor, R. F., Nicolazzo, J. A. & Kempe, K., 17 Apr 2023, In: Molecular Pharmaceutics. 20, 5, p. 2686–2701 16 p.Research output: Contribution to journal › Article › Research › peer-review
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Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice
Pyun, J., Koay, H. J., Runwal, P., Mawal, C., Bush, A. I., Pan, Y., Donnelly, P. S., Short, J. L. & Nicolazzo, J. A., 3 Aug 2023, In: Pharmaceutics. 15, 8, 21 p., 2084.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Development and application of a novel cervical lymph collection method to assess lymphatic transport in rats
Hoang, T. A., Cao, E., Gracia, G., Nicolazzo, J. A. & Trevaskis, N. L., 20 Jan 2023, In: Frontiers in Pharmacology. 14, 10 p., 1111617.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Fatty Acid-Binding Protein 4 is Essential for the Inflammatory and Metabolic Response of Microglia to Lipopolysaccharide
Kagawa, Y., Low, Y. L., Pyun, J., Doglione, U., Short, J. L., Pan, Y. & Nicolazzo, J. A., Aug 2023, (Accepted/In press) In: Journal of Neuroimmune Pharmacology. 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
From the gut to the blood–brain barrier: Novel approaches for the treatment and targeted delivery of therapeutics in Alzheimer's disease
Nicolazzo, J. A. & Abasszade, J. H., 31 Mar 2023, (Accepted/In press) In: Advanced Drug Delivery Reviews. 2 p., 114818.Research output: Contribution to journal › Editorial › Other › peer-review
Prizes
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Education Excellence: Teaching Excellence
Galbraith, Kirsten (Recipient), Malone, Daniel (Recipient), Lyons, Kayley (Recipient), Brock, Tina (Recipient), Larson, Ian (Recipient), White, Paul (Recipient), Mak, Vivienne (Recipient), Nicolazzo, Joseph (Recipient), Exintaris, Betty (Recipient), Fradinho Bruno, Andreia (Recipient), Khera, Harjit (Recipient) & Costelloe, Marian (Recipient), 2022
Prize: Prize (including medals and awards)
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Faculty of Pharmacy and Pharmaceutical Sciences Early Career Researcher Award
Nicolazzo, Joseph (Recipient), 2013
Prize: Prize (including medals and awards)
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Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award
Nicolazzo, Joseph (Recipient), 2009
Prize: Prize (including medals and awards)
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International Pharmaceutical Federation Award of Recognition
Nicolazzo, Joseph (Recipient), 2014
Prize: Prize (including medals and awards)
Activities
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International Conference on the Bioscience of Lipids 2019
Yijun Pan (Organiser), Joseph A. Nicolazzo (Organiser) & Yuji Owada (Organiser)
17 Jun 2019 → 21 Jun 2019Activity: Participating in or organising an event types › Contribution to conference
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International Journal of Pharmaceutics (Journal)
Joseph Nicolazzo (Editorial board member)
2017Activity: Publication peer-review and editorial work types › Editorial responsibility
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12th International Conference on Cerebral Vascular Biology
Joseph Nicolazzo (Organiser)
28 Nov 2017Activity: Participating in or organising an event types › Contribution to conference
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Fluids and Barriers of the CNS (Journal)
Joseph Nicolazzo (Editorial board member)
2017Activity: Publication peer-review and editorial work types › Editorial responsibility
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Pharmaceutical Research (Journal)
Joseph Nicolazzo (Associate editor)
2015Activity: Publication peer-review and editorial work types › Editorial responsibility