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Personal profile

Biography

Position

Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

 

Joseph Nicolazzo graduated with a PhD in 2004 from Monash University (Australia) focusing on buccal mucosal drug delivery. He joined the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, as a Lecturer (2007), where he is now a Senior Lecturer (2013). While he has some continuing interest in buccal mucosal drug delivery, his main research focus is on central nervous system (CNS) drug delivery, the role of drug transporters at the blood-brain barrier (BBB) in facilitating and limiting drug access into the CNS and how transport across the BBB alters in various disease states, including Alzheimer’s disease. He received the Faculty of Pharmacy and Pharmaceutical Sciences 2009 Young Investigator Award in 2009 and Early Career Research Award in 2013. Joseph is Treasurer of the Australasian Pharmaceutical Science Association, an Editorial Board Member of Journal of Pharmaceutical Sciences, and Editor (Reviews and Theme Issues) of Pharmaceutical Research.

 

Research interests

My laboratory focusses on the role of the blood-brain barrier (BBB) in governing CNS entry of endogenous and exogenous molecules, the impact of disease state on BBB transport phenomena and the involvement of the BBB in the development of neurodegenerative diseases, particularly Alzheimer's disease. Using a suite of in vitro, in situ and in vivo models, my research is broadly classified into:

  • Understanding the factors affecting BBB transport of drugs and endogenous molecules
  • The involvement of intracellular trafficking proteins in facilitating molecular transport across the BBB
  • The impact of Alzheimer's disease on BBB transport of drugs and endogenous molecules
  • Utilising novel approaches to enhance the BBB efflux of amyloid for the treatment of Alzheimer's disease

Monash teaching commitment

Stream leader of Drug Delivery, Bachelor of Pharmacy (Hons)

Unit coordinator, PAC2232 (Drug Delivery and Disposition)

 

 

Keywords

  • Alzheimer's Disease
  • Blood-Brain Barrier
  • CNS Drug Delivery
  • Drug Transport

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Projects 2007 2020

Research Output 2003 2018

Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid

Pan, Y., Short, J. L., Newman, S. A., Choy, K. H. C., Tiwari, D., Yap, C., Senyschyn, D., Banks, W. A. & Nicolazzo, J. A., 2018, (Accepted/In press) In : Brain, Behavior, and Immunity. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A., 1 Mar 2018, In : Pharmaceutical Research. 35, 3, 12 p., 70.

Research output: Contribution to journalArticleResearchpeer-review

Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells

Lee, G. S., Pan, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., 2018, (Accepted/In press) In : Journal of Pharmaceutical Sciences. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics

Pan, Y. & Nicolazzo, J. A., 2018, (Accepted/In press) In : Advanced Drug Delivery Reviews. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award

Joseph Nicolazzo (Recipient), 2009

Prize: Prize (including medals and awards)

International Pharmaceutical Federation Award of Recognition

Joseph Nicolazzo (Recipient), 2014

Prize: Prize (including medals and awards)

Activities 2002 2017

  • 4 Editorial responsibility
  • 4 Membership of an advisory panel/policy group/ board
  • 3 Contribution to conference
  • 1 Submissions to industry or govt committees, commissions and inquiries

International Journal of Pharmaceutics (Journal)

Joseph Nicolazzo (Editorial board member)
2017

Activity: Publication peer-review and editorial work typesEditorial responsibility

12th International Conference on Cerebral Vascular Biology

Joseph Nicolazzo (Organiser)
28 Nov 2017

Activity: Participating in or organising an event typesContribution to conference

Fluids and Barriers of the CNS (Journal)

Joseph Nicolazzo (Editorial board member)
2017

Activity: Publication peer-review and editorial work typesEditorial responsibility

Globalization of Pharmaceutics Education Net (External organisation)

Joseph Nicolazzo (Executive Member)
2015

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Pharmaceutical Research (Journal)

Joseph Nicolazzo (Associate editor)
2015

Activity: Publication peer-review and editorial work typesEditorial responsibility