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Personal profile

Biography

Position

Associate Professor and Associate Dean, Graduate Research
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

 

Joseph Nicolazzo graduated with a PhD in 2004 from Monash University (Australia) focusing on buccal mucosal drug delivery. He joined the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University in 2007 as a Lecturer, where he is now an Associate Professor and Associate Dean, Graduate Research. While he has some continuing interest in buccal mucosal drug delivery, his main research focus is on central nervous system (CNS) drug delivery, the role of drug transporters at the blood-brain barrier (BBB) in facilitating and limiting drug access into the CNS, how transport across the BBB alters in neurodegenerative diseases, and how the BBB may be exploited to reverse pathology associated with Alzheimer’s disease. He is the author of 70 peer-reviewed manuscripts and is regularly invited to international conferences in the field of BBB biology, including Gordon Research Conference – Barriers of the CNS and International Conference on Cerebral Vascular Biology. Joseph is Treasurer of the Australasian Pharmaceutical Science Association, Editor (Expert Reviews and Theme Issues) of Pharmaceutical Research, and an Editorial Board Member of Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, and Fluids and Barriers of the CNS. He received the Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award (2009), Early Career Research Award (2013) and Excellence in Postgraduate Supervision Award (2018).

Research interests

Using a suite of in vitro, in situ and in vivo models, my research is broadly classified into:

  • Understanding the factors affecting BBB transport of drugs and endogenous molecules
  • The involvement of intracellular trafficking proteins in facilitating molecular transport across the BBB
  • The impact of Alzheimer's disease and motor neurone disease on BBB transport of drugs and endogenous molecules
  • Exploring molecular targets at the BBB that can be utilised to reverse cognitive dysfunction associated with Alzheimer's disease

Monash teaching commitment

Unit coordinator, PHR2021 (How Medicines Work III)

Lecturer

- PHR1022 (How Medicines Work II)

- PHR2021 (How Medicines Work III)

- BPS2041 (Drug Delivery and Pharmacokinetics)

 

 

Research area keywords

  • Alzheimer's Disease
  • Blood-Brain Barrier
  • CNS Drug Delivery
  • Drug Transport

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2007 2022

Research Output 2003 2019

Impact of reduced P-glycoprotein function on digoxin concentrations in patients with dementia

Ali, I., Guidone, D., Nicolazzo, J. A. & Brouwer, K. L. R., 1 Jan 2019, In : British Journal of Clinical Pharmacology. 85, 10, p. 2351-2359 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease

Pan, Y., Omori, K., Ali, I., Tachikawa, M., Terasaki, T., Brouwer, K. L. R. & Nicolazzo, J. A., Jul 2019, In : Journal of Pharmaceutical Sciences. 108, 7, p. 2484-2489 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature

McInerney, M. P., Pan, Y., Volitakis, I., Bush, A. I., Short, J. L. & Nicolazzo, J. A., Dec 2019, In : Journal of Pharmaceutical Sciences. 108, 7, p. 2247-2255 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease

Pan, Y., Omori, K., Ali, I., Tachikawa, M., Terasaki, T., Brouwer, K. L. R. & Nicolazzo, J. A., 4 Sep 2018, In : Molecular Pharmaceutics. 15, 9, p. 4073-4083 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid

Pan, Y., Short, J. L., Newman, S. A., Choy, K. H. C., Tiwari, D., Yap, C., Senyschyn, D., Banks, W. A. & Nicolazzo, J. A., May 2018, In : Brain, Behavior, and Immunity. 70, p. 36-47 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award

Joseph Nicolazzo (Recipient), 2009

Prize: Prize (including medals and awards)

International Pharmaceutical Federation Award of Recognition

Joseph Nicolazzo (Recipient), 2014

Prize: Prize (including medals and awards)

Activities 2002 2017

  • 4 Editorial responsibility
  • 4 Membership of an advisory panel/policy group/ board
  • 3 Contribution to conference
  • 1 Submissions to industry or govt committees, commissions and inquiries

International Journal of Pharmaceutics (Journal)

Joseph Nicolazzo (Editorial board member)
2017

Activity: Publication peer-review and editorial work typesEditorial responsibility

12th International Conference on Cerebral Vascular Biology

Joseph Nicolazzo (Organiser)
28 Nov 2017

Activity: Participating in or organising an event typesContribution to conference

Fluids and Barriers of the CNS (Journal)

Joseph Nicolazzo (Editorial board member)
2017

Activity: Publication peer-review and editorial work typesEditorial responsibility

Pharmaceutical Research (Journal)

Joseph Nicolazzo (Associate editor)
2015

Activity: Publication peer-review and editorial work typesEditorial responsibility

Globalization of Pharmaceutics Education Net (External organisation)

Joseph Nicolazzo (Executive Member)
2015

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board