Projects per year
Personal profile
Biography
Position
Professor and Associate Dean, Graduate Research
Faculty of Pharmacy and Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Joseph Nicolazzo graduated with a PhD in 2004 from Monash University (Australia) focusing on buccal mucosal drug delivery. He joined the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University in 2007 as a Lecturer, where he is now a Professor and Associate Dean, Graduate Research. His research focuses on central nervous system (CNS) drug delivery, the role of drug transporters at the blood-brain barrier (BBB) in facilitating and limiting drug access into the CNS, how transport across the BBB alters in neurodegenerative diseases, and how the BBB may be exploited to reverse pathology associated with Alzheimer’s disease and amyotrophic lateral sclerosis. He is the author of 110 peer-reviewed manuscripts and is regularly invited to international conferences in the field of BBB biology, including Gordon Research Conference – Barriers of the CNS and International Conference on Cerebral Vascular Biology. Joseph is Immediate Past President of the Australasian Pharmaceutical Science Association, Editor of Pharmaceutical Research, and an Editorial Board Member of Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, Journal of Pharmacy and Pharmacology, and Fluids and Barriers of the CNS. He is a Steering Council Member of International Brain Barriers Society, Executive Committee Member of the Board of Pharmaceutical Sciences of International Pharmaceutical Federation (FIP), and has been induced as a Fellow of FIP.
Research interests
Using a suite of in vitro, in situ and in vivo models, my research is broadly classified into:
- Understanding the factors affecting BBB transport of drugs and endogenous molecules
- The involvement of intracellular trafficking proteins in facilitating molecular transport across the BBB
- The impact of Alzheimer's disease and amyotrophic lateral sclerosis on BBB transport of drugs and endogenous molecules
- Exploring molecular targets at the BBB that can be utilised to reverse cognitive dysfunction associated with Alzheimer's disease
Monash teaching commitment
Unit coordinator, PHR2021 (How Medicines Work III)
Lecturer
- PHR1022 (How Medicines Work II)
- PHR2021 (How Medicines Work III)
- BPS2041 (Drug Delivery and Pharmacokinetics)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Alzheimer's Disease
- Blood-Brain Barrier
- CNS Drug Delivery
- Drug Transport
Collaborations and top research areas from the last five years
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Exploring the impact of altered blood-brain barrier dynamics in brain cancer on therapeutic drug delivery
1/07/23 → 30/06/27
Project: Research
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Developing potent and brain-permeable peptide therapeutics for AD
Wai, D., Norton, R. & Nicolazzo, J.
1/03/22 → 1/12/23
Project: Research
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Optimising dosage regimen design in individuals with motor neuron disease
Nicolazzo, J. & Pan, Y.
1/01/22 → 31/12/22
Project: Research
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In relation to In vitro/in vivo Validation of Blood Brain Barrier Microfluidic Chip Model
Department of Defence (Australia)
1/07/21 → 1/07/22
Project: Research
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Brain-penetrating antisense oligonucleotide to down-regulate alpha-synuclein
Shabanpoor, F., Maljevic, S., Nicolazzo, J., Petrou, S. & Finkelstein, D. I.
Michael J Fox Foundation for Parkinson's Research
15/02/21 → 14/03/22
Project: Research
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Acute Neuroinflammation Alters the Transport of a Model Therapeutic Protein from the Brain into Lymph and Blood
Hoang, T. A., Jin, L., Nicolazzo, J. A. & Trevaskis, N. L., 26 Aug 2024, In: Molecular Pharmaceutics. 21, 10, p. 5138–5149 12 p.Research output: Contribution to journal › Article › Research › peer-review
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Folic Acid-Conjugated Brush Polymers Show Enhanced Blood-Brain Barrier Crossing in Static and Dynamic In Vitro Models Toward Brain Cancer Targeting Therapy
Mazrad, Z. A. I., Refaat, A., Morrow, J. P., Voelcker, N. H., Nicolazzo, J. A., Leiske, M. N. & Kempe, K., 31 Mar 2024, In: ACS Biomaterials Science & Engineering. 10, 5, p. 2894–2910 17 p.Research output: Contribution to journal › Article › Research › peer-review
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Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
Hoang, T. A., Gracia, G., Cao, E., Nicolazzo, J. A. & Trevaskis, N. L., 5 Apr 2024, In: Molecular Pharmaceutics. 21, 5, p. 2473–2483 11 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Sex-Dependent Changes to the Intestinal and Hepatic Abundance of Drug Transporters and Metabolizing Enzymes in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Koehn, L. M., Steele, J. R., Schittenhelm, R. B., Turner, B. J. & Nicolazzo, J. A., Apr 2024, In: Molecular Pharmaceutics. 21, 4, p. 1756-1767 12 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Comparison of the Anti-inflammatory Activity and Cellular Interaction of Brush Polymer-N-Acetyl Cysteine Conjugates in Human and Murine Microglial Cell Lines
Mazrad, Z. A. I., Leiske, M. N., Tabor, R. F., Nicolazzo, J. A. & Kempe, K., 17 Apr 2023, In: Molecular Pharmaceutics. 20, 5, p. 2686–2701 16 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)
Prizes
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Education Excellence: Teaching Excellence
Galbraith, Kirsten (Recipient), Malone, Daniel (Recipient), Lyons, Kayley (Recipient), Brock, Tina (Recipient), Larson, Ian (Recipient), White, Paul (Recipient), Mak, Vivienne (Recipient), Nicolazzo, Joseph (Recipient), Exintaris, Betty (Recipient), Fradinho Bruno, Andreia (Recipient), Khera, Harjit (Recipient) & Costelloe, Marian (Recipient), 2022
Prize: Prize (including medals and awards)
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Faculty of Pharmacy and Pharmaceutical Sciences Early Career Researcher Award
Nicolazzo, Joseph (Recipient), 2013
Prize: Prize (including medals and awards)
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Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award
Nicolazzo, Joseph (Recipient), 2009
Prize: Prize (including medals and awards)
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International Pharmaceutical Federation Award of Recognition
Nicolazzo, Joseph (Recipient), 2014
Prize: Prize (including medals and awards)
Activities
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International Conference on the Bioscience of Lipids 2019
Yijun Pan (Organiser), Joseph A. Nicolazzo (Organiser) & Yuji Owada (Organiser)
17 Jun 2019 → 21 Jun 2019Activity: Participating in or organising an event types › Contribution to conference
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12th International Conference on Cerebral Vascular Biology
Joseph Nicolazzo (Organiser)
28 Nov 2017Activity: Participating in or organising an event types › Contribution to conference
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Fluids and Barriers of the CNS (Journal)
Joseph Nicolazzo (Editorial board member)
2017Activity: Publication peer-review and editorial work types › Editorial responsibility
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International Journal of Pharmaceutics (Journal)
Joseph Nicolazzo (Editorial board member)
2017Activity: Publication peer-review and editorial work types › Editorial responsibility
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Globalization of Pharmaceutics Education Net (External organisation)
Joseph Nicolazzo (Executive Member)
2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board