Projects per year
Personal profile
Biography
Position
Associate Professor and Associate Dean, Graduate Research
Faculty of Pharmacy and Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Joseph Nicolazzo graduated with a PhD in 2004 from Monash University (Australia) focusing on buccal mucosal drug delivery. He joined the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University in 2007 as a Lecturer, where he is now an Associate Professor and Associate Dean, Graduate Research. While he has some continuing interest in buccal mucosal drug delivery, his main research focus is on central nervous system (CNS) drug delivery, the role of drug transporters at the blood-brain barrier (BBB) in facilitating and limiting drug access into the CNS, how transport across the BBB alters in neurodegenerative diseases, and how the BBB may be exploited to reverse pathology associated with Alzheimer’s disease. He is the author of 70 peer-reviewed manuscripts and is regularly invited to international conferences in the field of BBB biology, including Gordon Research Conference – Barriers of the CNS and International Conference on Cerebral Vascular Biology. Joseph is President of the Australasian Pharmaceutical Science Association, Editor (Expert Reviews and Theme Issues) of Pharmaceutical Research, and an Editorial Board Member of Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, and Fluids and Barriers of the CNS. He received the Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award (2009), Early Career Research Award (2013) and Excellence in Postgraduate Supervision Award (2018).
Research interests
Using a suite of in vitro, in situ and in vivo models, my research is broadly classified into:
- Understanding the factors affecting BBB transport of drugs and endogenous molecules
- The involvement of intracellular trafficking proteins in facilitating molecular transport across the BBB
- The impact of Alzheimer's disease and motor neurone disease on BBB transport of drugs and endogenous molecules
- Exploring molecular targets at the BBB that can be utilised to reverse cognitive dysfunction associated with Alzheimer's disease
Monash teaching commitment
Unit coordinator, PHR2021 (How Medicines Work III)
Lecturer
- PHR1022 (How Medicines Work II)
- PHR2021 (How Medicines Work III)
- BPS2041 (Drug Delivery and Pharmacokinetics)
Research area keywords
- Alzheimer's Disease
- Blood-Brain Barrier
- CNS Drug Delivery
- Drug Transport
Network
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Developing potent and brain-permeable peptide therapeutics for AD
Wai, D., Norton, R. & Nicolazzo, J.
1/03/22 → 1/12/23
Project: Research
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Optimising dosage regimen design in individuals with motor neuron disease
Nicolazzo, J. & Pan, Y.
1/01/22 → 31/12/22
Project: Research
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Development of blood-brain barrier penetrating peptides as a CNS drug delivery platform
Shabanpoor, F., Turner, B. & Nicolazzo, J.
4/01/21 → 3/01/23
Project: Research
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Developing SMN2 splice-switching antisense oligonucleotide therapy for MND
Turner, B., Shabanpoor, F., Rogers, M. & Nicolazzo, J.
4/01/21 → 3/01/24
Project: Research
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Centre for Research Excellence in Brain Cancer
Scott, A., Gan, H., Janes, P., Nicolazzo, J., Donnelly, P. S., Lakhani, S., Ackermann, U. & Lee, S. T.
Department of Health (DH) (Victoria)
1/07/19 → 30/06/23
Project: Research
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Altered blood–brain barrier and blood–spinal cord barrier dynamics in amyotrophic lateral sclerosis: Impact on medication efficacy and safety
Pan, Y. & Nicolazzo, J. A., Jun 2022, In: British Journal of Pharmacology. 179, 11, p. 2577-2588 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
2 Citations (Scopus) -
Blockade of Microglial Kv1.3 Potassium Channels by the Peptide HsTX1[R14A] Attenuates Lipopolysaccharide-mediated Neuroinflammation
Nicolazzo, J. A., Pan, Y., Di Stefano, I., Choy, K. H. C., Reddiar, S. B., Low, Y. L., Wai, D. C. C., Norton, R. S. & Jin, L., Mar 2022, In: Journal of Pharmaceutical Sciences. 111, 3, p. 638-647 10 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Doctoral Graduate Programs in the Pharmaceutical Sciences: An International Survey
Morris, M. E., Ren, T., Asare-Nkansah, S., Bilensoy, E., Gatwood, J., Giolito, M. V., Nicolazzo, J. A., Zuo, Z. & Pauletti, G. M., 2022, (Accepted/In press) In: Journal of Pharmaceutical Sciences.Research output: Contribution to journal › Article › Research › peer-review
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Master's Graduate Programs in the Pharmaceutical Sciences: An International Survey
Morris, M. E., Ren, T., Asare-Nkansah, S., Bilensoy, E., Gatwood, J., Giolito, M. V., Nicolazzo, J. A., Zuo, Z. & Pauletti, G. M., 14 Jul 2022, (Accepted/In press) In: Journal of Pharmaceutical Sciences. 9 p.Research output: Contribution to journal › Article › Research › peer-review
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Moving Towards FAIR Data Practices in Pharmacy Education
McLaughlin, J. E., Tropsha, A., Nicolazzo, J. A., Crescenzi, A. & Brouwer, K. L. R., 1 Mar 2022, In: American Journal of Pharmaceutical Education. 86, 3, p. 163-166 4 p., 8670.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access
Prizes
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Faculty of Pharmacy and Pharmaceutical Sciences Early Career Researcher Award
Nicolazzo, Joseph (Recipient), 2013
Prize: Prize (including medals and awards)
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Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award
Nicolazzo, Joseph (Recipient), 2009
Prize: Prize (including medals and awards)
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International Pharmaceutical Federation Award of Recognition
Nicolazzo, Joseph (Recipient), 2014
Prize: Prize (including medals and awards)
Activities
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International Conference on the Bioscience of Lipids 2019
Yijun Pan (Organiser), Joseph A. Nicolazzo (Organiser) & Yuji Owada (Organiser)
17 Jun 2019 → 21 Jun 2019Activity: Participating in or organising an event types › Contribution to conference
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Fluids and Barriers of the CNS (Journal)
Joseph Nicolazzo (Editorial board member)
2017Activity: Publication peer-review and editorial work types › Editorial responsibility
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International Journal of Pharmaceutics (Journal)
Joseph Nicolazzo (Editorial board member)
2017Activity: Publication peer-review and editorial work types › Editorial responsibility
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12th International Conference on Cerebral Vascular Biology
Joseph Nicolazzo (Organiser)
28 Nov 2017Activity: Participating in or organising an event types › Contribution to conference
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Globalization of Pharmaceutics Education Net (External organisation)
Joseph Nicolazzo (Executive Member)
2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board