Projects per year
Personal profile
Biography
Position
Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Joseph Nicolazzo graduated with a PhD in 2004 from Monash University (Australia) focusing on buccal mucosal drug delivery. He joined the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, as a Lecturer (2007), where he is now a Senior Lecturer (2013). While he has some continuing interest in buccal mucosal drug delivery, his main research focus is on central nervous system (CNS) drug delivery, the role of drug transporters at the blood-brain barrier (BBB) in facilitating and limiting drug access into the CNS and how transport across the BBB alters in various disease states, including Alzheimer’s disease. He received the Faculty of Pharmacy and Pharmaceutical Sciences 2009 Young Investigator Award in 2009 and Early Career Research Award in 2013. Joseph is Treasurer of the Australasian Pharmaceutical Science Association, an Editorial Board Member of Journal of Pharmaceutical Sciences, and Editor (Reviews and Theme Issues) of Pharmaceutical Research.
Research interests
My laboratory focusses on the role of the blood-brain barrier (BBB) in governing CNS entry of endogenous and exogenous molecules, the impact of disease state on BBB transport phenomena and the involvement of the BBB in the development of neurodegenerative diseases, particularly Alzheimer's disease. Using a suite of in vitro, in situ and in vivo models, my research is broadly classified into:
- Understanding the factors affecting BBB transport of drugs and endogenous molecules
- The involvement of intracellular trafficking proteins in facilitating molecular transport across the BBB
- The impact of Alzheimer's disease on BBB transport of drugs and endogenous molecules
- Utilising novel approaches to enhance the BBB efflux of amyloid for the treatment of Alzheimer's disease
Monash teaching commitment
Stream leader of Drug Delivery, Bachelor of Pharmacy (Hons)
Unit coordinator, PAC2232 (Drug Delivery and Disposition)
Keywords
- Alzheimer's Disease
- Blood-Brain Barrier
- CNS Drug Delivery
- Drug Transport
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2020
Targeting iron at the blood-brain barrier: a novel approach to drain the brain of β-amyloid
28/02/18 → 31/01/19
Project: Research
Blood-brain barrier penetrating antisense therapy for spinal muscular atrophy
Shabanpoor, F., Turner, B. J. & Nicolazzo, J.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
Altered drug disposition in Alzheimer’s disease: impact on medicine safety
Nicolazzo, J. & Brouwer, K.
1/01/18 → 31/12/18
Project: Research
Delta-containing GABAA receptors as targets for neuroprotection
National Health & Medical Research Council (NHMRC)
1/01/15 → 31/12/18
Project: Research
The role of tau proteins in impairing the blood-brain barrier clearance of beta-amyloid
31/03/15 → 31/03/16
Project: Research
Research Output 2003 2018
Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid
Pan, Y., Short, J. L., Newman, S. A., Choy, K. H. C., Tiwari, D., Yap, C., Senyschyn, D., Banks, W. A. & Nicolazzo, J. A. 2018 (Accepted/In press) In : Brain, Behavior, and Immunity. 12 p.Research output: Contribution to journal › Article
Dietary docosahexaenoic acid supplementation enhances expression of fatty acid-binding protein 5 at the blood–brain barrier and brain docosahexaenoic acid levels
Pan, Y., Morris, E. R., Scanlon, M. J., Marriott, P. J., Porter, C. J. H. & Nicolazzo, J. A. 2018 (Accepted/In press) In : Journal of Neurochemistry. 12 p.Research output: Contribution to journal › Article
Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging
Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A. 1 Mar 2018 In : Pharmaceutical Research. 35, 3, 12 p., 70Research output: Contribution to journal › Article
Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells
Lee, G. S., Pan, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A. 2018 (Accepted/In press) In : Journal of Pharmaceutical Sciences. 9 p.Research output: Contribution to journal › Article
Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics
Pan, Y. & Nicolazzo, J. A. 2018 (Accepted/In press) In : Advanced Drug Delivery Reviews. 13 p.Research output: Contribution to journal › Article
Prizes
Faculty of Pharmacy and Pharmaceutical Sciences Early Career Researcher Award
Joseph Nicolazzo (Recipient), 2013
Prize: Prize (including medals and awards)
Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award
Joseph Nicolazzo (Recipient), 2009
Prize: Prize (including medals and awards)
International Pharmaceutical Federation Award of Recognition
Joseph Nicolazzo (Recipient), 2014
Prize: Prize (including medals and awards)
Activities 2002 2017
12th International Conference on Cerebral Vascular Biology
Nicolazzo, J. (Organiser)28 Nov 2017
Activity: Contribution to conference
Fluids and Barriers of the CNS (Journal)
Nicolazzo, J. (Editorial board member)2017
Activity: Editorial responsibility
International Journal of Pharmaceutics (Journal)
Nicolazzo, J. (Editorial board member)2017
Activity: Editorial responsibility
Pharmaceutical Research (Journal)
Nicolazzo, J. (Associate editor)2015
Activity: Editorial responsibility
Globalization of Pharmaceutics Education Net (External organisation)
Nicolazzo, J. (Executive Member)2015
Activity: Membership of an advisory panel/policy group/ board