Projects per year
Personal profile
Biography
Position
Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Joseph Nicolazzo graduated with a PhD in 2004 from Monash University (Australia) focusing on buccal mucosal drug delivery. He joined the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, as a Lecturer (2007), where he is now a Senior Lecturer (2013). While he has some continuing interest in buccal mucosal drug delivery, his main research focus is on central nervous system (CNS) drug delivery, the role of drug transporters at the blood-brain barrier (BBB) in facilitating and limiting drug access into the CNS and how transport across the BBB alters in various disease states, including Alzheimer’s disease. He received the Faculty of Pharmacy and Pharmaceutical Sciences 2009 Young Investigator Award in 2009 and Early Career Research Award in 2013. Joseph is Treasurer of the Australasian Pharmaceutical Science Association, an Editorial Board Member of Journal of Pharmaceutical Sciences, and Editor (Reviews and Theme Issues) of Pharmaceutical Research.
Research interests
My laboratory focusses on the role of the blood-brain barrier (BBB) in governing CNS entry of endogenous and exogenous molecules, the impact of disease state on BBB transport phenomena and the involvement of the BBB in the development of neurodegenerative diseases, particularly Alzheimer's disease. Using a suite of in vitro, in situ and in vivo models, my research is broadly classified into:
- Understanding the factors affecting BBB transport of drugs and endogenous molecules
- The involvement of intracellular trafficking proteins in facilitating molecular transport across the BBB
- The impact of Alzheimer's disease on BBB transport of drugs and endogenous molecules
- Utilising novel approaches to enhance the BBB efflux of amyloid for the treatment of Alzheimer's disease
Monash teaching commitment
Stream leader of Drug Delivery, Bachelor of Pharmacy (Hons)
Unit coordinator, PAC2232 (Drug Delivery and Disposition)
Keywords
- Alzheimer's Disease
- Blood-Brain Barrier
- CNS Drug Delivery
- Drug Transport
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2020
Blood-brain barrier penetrating antisense therapy for spinal muscular atrophy
Shabanpoor, F., Turner, B. J. & Nicolazzo, J.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
Targeting iron at the blood-brain barrier: a novel approach to drain the brain of β-amyloid
28/02/18 → 31/01/19
Project: Research
Altered drug disposition in Alzheimer’s disease: impact on medicine safety
Nicolazzo, J. & Brouwer, K.
1/01/18 → 31/12/18
Project: Research
The role of tau proteins in impairing the blood-brain barrier clearance of beta-amyloid
31/03/15 → 31/03/16
Project: Research
Research Output 2003 2019
Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease
Pan, Y., Omori, K., Ali, I., Tachikawa, M., Terasaki, T., Brouwer, K. L. R. & Nicolazzo, J. A., Jul 2019, In : Journal of Pharmaceutical Sciences. 108, 7, p. 2484-2489 6 p.Research output: Contribution to journal › Article › Research › peer-review
The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature
McInerney, M. P., Pan, Y., Volitakis, I., Bush, A. I., Short, J. L. & Nicolazzo, J. A., Dec 2019, In : Journal of Pharmaceutical Sciences. 108, 7, p. 2247-2255 9 p.Research output: Contribution to journal › Article › Research › peer-review
Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease
Pan, Y., Omori, K., Ali, I., Tachikawa, M., Terasaki, T., Brouwer, K. L. R. & Nicolazzo, J. A., 4 Sep 2018, In : Molecular Pharmaceutics. 15, 9, p. 4073-4083 11 p.Research output: Contribution to journal › Article › Research › peer-review
Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid
Pan, Y., Short, J. L., Newman, S. A., Choy, K. H. C., Tiwari, D., Yap, C., Senyschyn, D., Banks, W. A. & Nicolazzo, J. A., May 2018, In : Brain, Behavior, and Immunity. 70, p. 36-47 12 p.Research output: Contribution to journal › Article › Research › peer-review
Commentary on the 2018 Named Series on blood-brain interfaces: Roles of neuroimmunomodulation in health and disease
Erickson, M. A., Nicolazzo, J. A. & Banks, W. A., Nov 2018, In : Brain, Behavior, and Immunity. 74, p. 3-6 4 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Prizes
Faculty of Pharmacy and Pharmaceutical Sciences Early Career Researcher Award
Joseph Nicolazzo (Recipient), 2013
Prize: Prize (including medals and awards)
Faculty of Pharmacy and Pharmaceutical Sciences Young Investigator Award
Joseph Nicolazzo (Recipient), 2009
Prize: Prize (including medals and awards)
International Pharmaceutical Federation Award of Recognition
Joseph Nicolazzo (Recipient), 2014
Prize: Prize (including medals and awards)
Activities 2002 2017
Fluids and Barriers of the CNS (Journal)
Joseph Nicolazzo (Editorial board member)2017
Activity: Publication peer-review and editorial work types › Editorial responsibility
International Journal of Pharmaceutics (Journal)
Joseph Nicolazzo (Editorial board member)2017
Activity: Publication peer-review and editorial work types › Editorial responsibility
12th International Conference on Cerebral Vascular Biology
Joseph Nicolazzo (Organiser)28 Nov 2017
Activity: Participating in or organising an event types › Contribution to conference
Globalization of Pharmaceutics Education Net (External organisation)
Joseph Nicolazzo (Executive Member)2015
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
Pharmaceutical Research (Journal)
Joseph Nicolazzo (Associate editor)2015
Activity: Publication peer-review and editorial work types › Editorial responsibility