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Research Output 2004 2018

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2018

Identification of dynamic undifferentiated cell states within the male germline

La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M. 19 Jul 2018 In : Nature Communications. 9, 1, 18 p., 2819

Research output: Contribution to journalArticle

Open Access
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SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

Ratnadiwakara, M., Archer, S. K., Dent, C. I., Ruiz De Los Mozos, I., Beilharz, T. H., Knaupp, A. S., Nefzger, C. M., Polo, J. M. & Anko, M-L. 2018 (Accepted/In press) In : eLife.

Research output: Contribution to journalArticle

Open Access
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TFAP2C regulates transcription in human naive pluripotency by opening enhancers

Pastor, W. A., Liu, W., Chen, D., Ho, J., Kim, R., Hunt, T. J., Lukianchikov, A., Liu, X., Polo, J. M., Jacobsen, S. E. & Clark, A. T. 1 May 2018 In : Nature Cell Biology. 20, 5, p. 553-564 12 p.

Research output: Contribution to journalArticle

2017

Cell Type of Origin Dictates the Route to Pluripotency

Nefzger, C. M., Rossello, F. J., Chen, J., Liu, X., Knaupp, A. S., Firas, J., Paynter, J. M., Pflueger, J., Buckberry, S., Lim, S. M., Williams, B., Alaei, S., Faye-Chauhan, K., Petretto, E., Nilsson, S. K., Lister, R., Ramialison, M., Powell, D. R., Rackham, O. J. L. & Polo, J. M. 5 Dec 2017 In : Cell Reports. 21, 10, p. 2649-2660 12 p.

Research output: Contribution to journalArticle

Open Access
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Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Liu, X. , Nefzger, C. M. , Rossello, F. J. , Chen, J. , Knaupp, A. S. , Firas, J. , Ford, E. , Pflueger, J. , Paynter, J. M. , Chy, H. S. , O'Brien, C. M. , Huang, C. , Mishra, K. , Hodgson-Garms, M. , Jansz, N. , Williams, S. M. , Blewitt, M. E. , Nilsson, S. K. , Schittenhelm, R. B. , Laslett, A. L. & 2 others Lister, R. & Polo, J. M. 31 Oct 2017 In : Nature Methods. 14, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

Open Access
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Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E. , Richards, J. L. , McLeod, K. H. , Stanley, D. , Yap, Y. A. , Knight, J. , McKenzie, C. , Kranich, J. , Oliveira, A. C. , Rossello, F. J. , Krishnamurthy, B. , Nefzger, C. M. , Macia, L. , Thorburn, A. , Baxter, A. G. , Morahan, G. , Wong, L. H. , Polo, J. M. , Moore, R. J. , Lockett, T. J. & 4 others Clarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R. May 2017 In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Contribution to journalArticle

Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest

Nguyen, P. D., Gurevich, D. B., Sonntag, C., Hersey, L., Alaei , S., Nim, H. T., Siegel, A., Hall, T. E., Rossello, F. J., Boyd, S. E., Polo, J. M. & Currie, P. D. 6 Jul 2017 In : Cell Stem Cell. 21, 1, p. 107-119.e6 19 p.

Research output: Contribution to journalArticle

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

O'Brien, C. M. , Chy, H. S. , Zhou, Q. , Blumenfeld, S. , Lambshead, J. W. , Liu, X. , Kie, J. , Capaldo, B. D. , Chung, T-L. , Adams, T. E. , Phan, T. , Bentley, J. D. , McKinstry, W. J. , Oliva, K. , McMurrick, P. J. , Wang, Y-C. , Rossello, F. J. , Lindeman, G. J. , Chen, D. , Jarde, T. & 7 others Clark, A. T., Abud, H. E., Visvader, J. E., Nefzger, C. M., Polo, J. M., Loring, J. F. & Laslett, A. L. 1 Mar 2017 In : Stem Cells. 35, 3, p. 626-640 15 p.

Research output: Contribution to journalArticle

Open Access
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Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming

Knaupp, A. S., Buckberry, S., Pflueger, J., Lim, S. M., Ford, E., Larcombe, M. R., Rossello, F. J., de Mendoza, A., Alaei, S., Firas, J., Holmes, M. L., Nair, S. S., Clark, S. J., Nefzger, C. M., Lister, R. & Polo, J. M. 7 Dec 2017 In : Cell Stem Cell. 21, 6, p. 834-845.e6 18 p.

Research output: Contribution to journalArticle

2016
Open Access
Open Access
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2015

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation

Shu, R., Wong, W. S. F., Ma, Q-H., Yang, Z. Z., Zhu, H., Liu, F. J., Wang, P., Ma, J., Yan, S., Polo, J. M., Bernard, C. C. A., Stanton, L. W., Dawe, G. S. & Xiao, Z. 1 Jan 2015 In : Cell Death and Disease. 6, 2, 12 p., e1651

Research output: Contribution to journalArticle

Open Access
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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Horvay, K., Jarde, T., Casagranda, F., Perreau, V. M., Haigh, K., Nefzger, C. M., Akhtar, R., Gridley, T., Berx, G., Haigh, J. J., Barker, N., Polo, J. M., Hime, G. R. & Abud, H. E. 2015 In : EMBO Journal. 34, 10, p. 1319 - 1335 17 p.

Research output: Contribution to journalArticle

Open Access
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Transcription factor-mediated reprogramming: epigenetics and therapeutic potential

Firas, J., Liu, E. X., Lim, S. M. & Polo, J. M. 2015 In : Immunology and Cell Biology. 93, 3, p. 284 - 289 6 p.

Research output: Contribution to journalArticle

2014

Epigenetic Changes During Reprogramming

Alaei Shehni, S., Knaupp, A. S. & Polo, J. M. 2014 In : Australian Biochemist. 45, 1, p. 17 - 20 4 p.

Research output: Contribution to journalArticle

Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: evidence and implications

Firas, J., Liu, E. X. & Polo, J. M. 2014 In : Differentiation. 88, 1, p. 29 - 32 4 p.

Research output: Contribution to journalArticle

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

Nguyen, P., Hollway, G. E., Sonntag, C., Miles, L. B., Hall, T. E., Berger, S., Fernandez, K. J., Gurevich, D., Cole, N. J., Alaei Shehni, S., Ramialison, M. S. M., Sutherland, R. L., Polo, J. M., Lieschke, G. & Currie, P. D. 2014 In : Nature. 512, 7514, p. 314 - 318 5 p.

Research output: Contribution to journalArticle

Phases of reprogramming

David, L. & Polo, J. M. 2014 In : Stem Cell Research. 12, 3, p. 754 - 761 8 p.

Research output: Contribution to journalArticle

Open Access

Reprogramming can be a transforming experience

Hobbs, R. M. & Polo, J. M. 2014 In : Cell Stem Cell. 14, 3, p. 269 - 271 3 p.

Research output: Contribution to journalArticle

2013

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity

De, S., Shaknovich, R., Riester, M., Elemento, O., Geng, H. D. E., Kormaksson, M., Jiang, Y., Woolcock, B., Johnson, N., Polo, J. M., Cerchietti, L., Gascoyne, R. D., Melnick, A. & Michor, F. 2013 In : PLoS Genetics. 9, 1, 14 p., e1003137

Research output: Contribution to journalArticle

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A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters

Hatzi, K., Jiang, Y., Huang, C., Garrett-Bakelman, F., Gearhart, M. D., Giannopoulou, E. G., Zumbo, P., Kirouac, K., Bhaskara, S., Polo, J. M., Kormaksson, M., MacKerell Jr, A. D., Xue, F., Mason, C. E., Hiebert, S. W., Prive, G. G., Cerchietti, L., Bardwell, V. J., Elemento, O. & Melnick, A. 2013 In : Cell Reports. 4, 3, p. 578 - 588 11 p.

Research output: Contribution to journalArticle

Open Access

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming

Apostolou, E., Ferrari, F., Walsh, R. M., Bar-Nur, O., Stadtfeld, M., Cheloufi, S., Stuart, H. T., Polo, J. M., Ohsumi, T., Borowsky, M. L., Kharchenko, P. V., Park, P. J. & Hochedlinger, K. 2013 In : Cell Stem Cell. 12, 6, p. 699 - 712 14 p.

Research output: Contribution to journalArticle

Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells

Kelly, R. D. W., Rodda, A. E., Dickinson, A., Mahmud, A., Nefzger, C., Lee, W., Forsythe, J. S., Polo, J. M., Trounce, I. A., McKenzie, M., Nisbet, D. R. & St John, J. C. 2013 In : Stem Cells. 31, 4, p. 703 - 716 14 p.

Research output: Contribution to journalArticle

Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy

Kaur, G., Costa, M., Nefzger, C., Silva, J., Fierro-Gonzalez, J. C., Polo, J. M., Bell, T. D. M. & Plachta, N. 2013 In : Nature Communications. 4, 1637, p. 1 - 13 13 p.

Research output: Contribution to journalArticle

Open Access
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2012

A molecular roadmap of reprogramming somatic cells into iPS cells

Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C., Lim, S. M., Borkent, M., Apostolou, E., Alaei Shehni, S., Cloutier, J., Bar-Nur, O., Cheloufi, S., Stadtfeld, M., Figueroa, M. E., Robinton, D., Natesan, S., Melnick, A., Zhu, J., Ramaswamy, S. & Hochedlinger, K. 2012 In : Cell. 151, 7, p. 1617 - 1632 16 p.

Research output: Contribution to journalArticle

Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency

Hansson, J., Reza Rafiee, M., Reiland, S., Polo, J. M., Gehring, J., Okawa, S., Huber, W., Hochedlinger, K. & Krijgsveld, J. 2012 In : Cell Reports. 2, 6, p. 1579 - 1592 14 p.

Research output: Contribution to journalArticle

Open Access
2011

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

Ohi, Y., Qin, H., Hong, C., Blouin, L., Polo, J. M., Guo, T., Qi, Z., Downey, S. L., Manos, P. D., Rossi, D. J., Yu, J., Hebrok, M., Hochedlinger, K., Costello, J. F., Song, J. S. & Ramalho-Santos, M. May 2011 In : Nature Cell Biology. 13, 5, p. 541-549 9 p.

Research output: Contribution to journalArticle

Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice

Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N. & Hochedlinger, K. 2011 In : Cell Stem Cell. 9, 4, p. 317 - 329 13 p.

Research output: Contribution to journalArticle

2010

A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells

Buecker, C., Chen, H. H., Polo, J. M., Daheron, L., Bu, L., Barakat, T. S., Okwieka, P., Porter, A., Gribnau, J., Hochedlinger, K. & Geijsen, N. 4 Jun 2010 In : Cell Stem Cell. 6, 6, p. 535-546 12 p.

Research output: Contribution to journalArticle

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

Cerchietti, L. C., Ghetu, A. F., Zhu, X-H., Da Silva, G. F., Zhong, S., Matthews, M., Bunting, K. L., Polo, J. M., Farès, C., Arrowsmith, C. H., Yang, S. N., Garcia, M., Coop, A., MacKerell Jr, A. D., Privé, G. G. & Melnick, A. 13 Apr 2010 In : Cancer Cell. 17, 4, p. 400-411 12 p.

Research output: Contribution to journalArticle

BCL6 is critical for the development of a diverse primary B cell repertoire

Duy, C. , Yu, J. J. , Nahar, R. , Swaminathan, S. , Kweon, S. M. , Polo, J. M. , Valls, E. , Klemm, L. , Shojaee, S. , Cerchietti, L. , Schuh, W. , Jäck, H. M. , Hurtz, C. , Ramezani-Rad, P. , Herzog, S. , Jumaa, H. , Koeffler, H. P. , De Alborán, I. M. , Melnick, A. M. , Ye, B. H. & 1 others Müschen, M. 7 Jun 2010 In : Journal of Experimental Medicine. 207, 6, p. 1209-1221 13 p.

Research output: Contribution to journalArticle

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

Polo, J. M., Liu, S., Figueroa, M. E., Kulalert, W., Eminli, S., Tan, K. Y., Apostolou, E., Stadtfeld, M., Li, Y., Shioda, T., Natesan, S., Wagers, A. J., Melnick, A., Evans, T. & Hochedlinger, K. Aug 2010 In : Nature Biotechnology. 28, 8, p. 848-855 8 p.

Research output: Contribution to journalArticle

SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells

Hammerich-Hille, S., Kaipparettu, B. A., Tsimelzon, A., Creighton, C. J., Jiang, S., Polo, J. M., Melnick, A., Meyer, R. & Oesterreich, S. 5 Feb 2010 In : Journal of Biological Chemistry. 285, 6, p. 3608-3616 9 p.

Research output: Contribution to journalArticle

2009

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

Cerchietti, L. C., Yang, S. N., Shaknovich, R., Hatzi, K., Polo, J. M., Chadburn, A., Dowdy, S. F. & Melnick, A. 9 Apr 2009 In : Blood. 113, 15, p. 3397-3405 9 p.

Research output: Contribution to journalArticle

BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt

Juszczynski, P., Chen, L., O'Donnell, E., Polo, J. M., Ranuncolo, S. M., Dalla-Favera, R., Melnick, A. & Shipp, M. A. 17 Dec 2009 In : Blood. 114, 26, p. 5315-5321 7 p.

Research output: Contribution to journalArticle

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

Utikal, J., Polo, J. M., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J. G. & Hochedlinger, K. 27 Aug 2009 In : Nature. 460, 7259, p. 1145-1148 4 p.

Research output: Contribution to journalArticle

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL

Ci, W., Polo, J. M., Cerchietti, L., Shaknovich, R., Wang, L., Shao, N. Y., Ye, K., Farinha, P., Horsman, D. E., Gascoyne, R. D., Elemento, O. & Melnick, A. 2009 In : Blood. 113, 22, p. 5536-5548 13 p.

Research output: Contribution to journalArticle

2008

BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner

Ranuncolo, S. M., Wang, L., Polo, J. M., Dell'Oso, T., Dierov, J., Gaymes, T. J., Rassool, F., Carroll, M. & Melnick, A. 15 Aug 2008 In : Journal of Biological Chemistry. 283, 33, p. 22565-22572 8 p.

Research output: Contribution to journalArticle

BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

Ranuncolo, S. M., Polo, J. M. & Melnick, A. Jul 2008 In : Blood Cells, Molecules, and Diseases. 41, 1, p. 95-99 5 p.

Research output: Contribution to journalArticle

CtBP is an essential corepressor for BCL6 autoregulation

Mendez, L. M., Polo, J. M., Yu, J. J., Krupski, M., Ding, B. B., Melnick, A. & Ye, B. H. Apr 2008 In : Molecular and Cellular Biology. 28, 7, p. 2175-2186 12 p.

Research output: Contribution to journalArticle

Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells

Polo, J. M., Ci, W., Licht, J. D. & Melnick, A. 1 Aug 2008 In : Blood. 112, 3, p. 644-651 8 p.

Research output: Contribution to journalArticle

Sequential transcription factor targeting for diffuse large B-cell lymphomas

Cerchietti, L. C., Polo, J. M., Da Silva, G. F., Farinha, P., Shaknovich, R., Gascoyne, R. D., Dowdy, S. F. & Melnick, A. 1 May 2008 In : Cancer Research. 68, 9, p. 3361-3369 9 p.

Research output: Contribution to journalArticle

2007

Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR

Ranuncolo, S. M., Polo, J. M., Dierov, J., Singer, M., Kuo, T., Greally, J., Green, R., Carroll, M. & Melnick, A. Jul 2007 In : Nature Immunology. 8, 7, p. 705-714 10 p.

Research output: Contribution to journalArticle

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

Parekh, S., Polo, J. M., Shaknovich, R., Juszczynski, P., Lev, P., Ranuncolo, S. M., Yin, G., Klein, U., Cattoretti, G., Dalla Favera, R., Shipp, M. A. & Melnick, A. 15 Sep 2007 In : Blood. 110, 6, p. 2067-2074 8 p.

Research output: Contribution to journalArticle

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas

Polo, J. M., Juszczynski, P., Monti, S., Cerchietti, L., Ye, K., Greally, J. M., Shipp, M. & Melnick, A. 27 Feb 2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 9, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

2004

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells

Polo, J. M., Dell'Oso, T., Ranuncolo, S. M., Cerchietti, L., Beck, D., Da Silva, G. F., Prive, G. G., Licht, J. D. & Melnick, A. Dec 2004 In : Nature Medicine. 10, 12, p. 1329-1335 7 p.

Research output: Contribution to journalArticle