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Research Output 2004 2018

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2018

Fine tuning of canonical Wnt stimulation enhances differentiation of pluripotent stem cells independent of β-catenin-mediated T-cell factor signalling

Chen, J., Nefzger, C. M., Rossello, F., Sun, Y. B. Y., Lim, S. M., Liu, X., De Boer, S., Knaupp, A. S., Li, J., Davidson, K. C., Polo, J. M. & Barberi, T., Jun 2018, In : Stem Cells. 36, 6, p. 822-833 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an attention deficit hyperactivity disorder (ADHD) individual and a health sibling in an Australia-Caucasian family

Tong, J., Lee, K., Liu, X., Nefzger, C. M., Vijayakumar, P., Hawi, Z., Pang, K. C., Parish, C. L., Polo, J. M. & Bellgrove, M. A., 27 Nov 2018, (Accepted/In press) In : Stem Cell Research.

Research output: Contribution to journalArticleResearchpeer-review

Identification of dynamic undifferentiated cell states within the male germline

La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In : Nature Communications. 9, 1, 18 p., 2819.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

Ratnadiwakara, M., Archer, S. K., Dent, C. I., Ruiz De Los Mozos, I., Beilharz, T. H., Knaupp, A. S., Nefzger, C. M., Polo, J. M. & Anko, M-L., 2018, (Accepted/In press) In : eLife.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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TFAP2C regulates transcription in human naive pluripotency by opening enhancers

Pastor, W. A., Liu, W., Chen, D., Ho, J., Kim, R., Hunt, T. J., Lukianchikov, A., Liu, X., Polo, J. M., Jacobsen, S. E. & Clark, A. T., 1 May 2018, In : Nature Cell Biology. 20, 5, p. 553-564 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Cell Type of Origin Dictates the Route to Pluripotency

Nefzger, C. M., Rossello, F. J., Chen, J., Liu, X., Knaupp, A. S., Firas, J., Paynter, J. M., Pflueger, J., Buckberry, S., Lim, S. M., Williams, B., Alaei, S., Faye-Chauhan, K., Petretto, E., Nilsson, S. K., Lister, R., Ramialison, M., Powell, D. R., Rackham, O. J. L. & Polo, J. M., 5 Dec 2017, In : Cell Reports. 21, 10, p. 2649-2660 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Liu, X., Nefzger, C. M., Rossello, F. J., Chen, J., Knaupp, A. S., Firas, J., Ford, E., Pflueger, J., Paynter, J. M., Chy, H. S., O'Brien, C. M., Huang, C., Mishra, K., Hodgson-Garms, M., Jansz, N., Williams, S. M., Blewitt, M. E., Nilsson, S. K., Schittenhelm, R. B., Laslett, A. L. & 2 othersLister, R. & Polo, J. M., 31 Oct 2017, In : Nature Methods. 14, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., Krishnamurthy, B., Nefzger, C. M., Macia, L., Thorburn, A., Baxter, A. G., Morahan, G., Wong, L. H., Polo, J. M., Moore, R. J., Lockett, T. J. & 4 othersClarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R., May 2017, In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest

Nguyen, P. D., Gurevich, D. B., Sonntag, C., Hersey, L., Alaei, S., Nim, H. T., Siegel, A., Hall, T. E., Rossello, F. J., Boyd, S. E., Polo, J. M. & Currie, P. D., 6 Jul 2017, In : Cell Stem Cell. 21, 1, p. 107-119.e6 19 p.

Research output: Contribution to journalArticleResearchpeer-review

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

O'Brien, C. M., Chy, H. S., Zhou, Q., Blumenfeld, S., Lambshead, J. W., Liu, X., Kie, J., Capaldo, B. D., Chung, T-L., Adams, T. E., Phan, T., Bentley, J. D., McKinstry, W. J., Oliva, K., McMurrick, P. J., Wang, Y-C., Rossello, F. J., Lindeman, G. J., Chen, D., Jarde, T. & 7 othersClark, A. T., Abud, H. E., Visvader, J. E., Nefzger, C. M., Polo, J. M., Loring, J. F. & Laslett, A. L., 1 Mar 2017, In : Stem Cells. 35, 3, p. 626-640 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming

Knaupp, A. S., Buckberry, S., Pflueger, J., Lim, S. M., Ford, E., Larcombe, M. R., Rossello, F. J., de Mendoza, A., Alaei, S., Firas, J., Holmes, M. L., Nair, S. S., Clark, S. J., Nefzger, C. M., Lister, R. & Polo, J. M., 7 Dec 2017, In : Cell Stem Cell. 21, 6, p. 834-845.e6 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

An improved reprogrammable mouse model harbouring the reverse tetracycline-controlled transcriptional transactivator 3

Alaei, S., Knaupp, A. S., Lim, S. M., Chen, J., Holmes, M. L., Ankö, M-L., Nefzger, C. M. & Polo, J. M., 1 Jul 2016, In : Stem Cell Research. 17, 1, p. 49-53 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells

Nefzger, C. M., Jarde, T., Rossello, F. J., Horvay, K., Knaupp, A. S., Powell, D. R., Chen, J. Y., Abud, H. E. & Polo, J. M., 2016, In : Stem Cell Reports. 6, 3, p. 321 - 329 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation

Shu, R., Wong, W. S. F., Ma, Q-H., Yang, Z. Z., Zhu, H., Liu, F. J., Wang, P., Ma, J., Yan, S., Polo, J. M., Bernard, C. C. A., Stanton, L. W., Dawe, G. S. & Xiao, Z., 1 Jan 2015, In : Cell Death and Disease. 6, 2, 12 p., e1651.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Horvay, K., Jarde, T., Casagranda, F., Perreau, V. M., Haigh, K., Nefzger, C. M., Akhtar, R., Gridley, T., Berx, G., Haigh, J. J., Barker, N., Polo, J. M., Hime, G. R. & Abud, H. E., 2015, In : EMBO Journal. 34, 10, p. 1319 - 1335 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transcription factor-mediated reprogramming: epigenetics and therapeutic potential

Firas, J., Liu, E. X., Lim, S. M. & Polo, J. M., 2015, In : Immunology and Cell Biology. 93, 3, p. 284 - 289 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Cell surface marker mediated purification of iPS cell intermediates from a reprogrammable mouse model

Nefzger, C. M., Alaei Shehni, S., Knaupp, A. S., Holmes, M. L. & Polo, J. M., 2014, In : Journal of Visualized Experiments. 91, (Art. No.: e51728), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic Changes During Reprogramming

Alaei Shehni, S., Knaupp, A. S. & Polo, J. M., 2014, In : Australian Biochemist. 45, 1, p. 17 - 20 4 p.

Research output: Contribution to journalArticleOther

Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: evidence and implications

Firas, J., Liu, E. X. & Polo, J. M., 2014, In : Differentiation. 88, 1, p. 29 - 32 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

Nguyen, P., Hollway, G. E., Sonntag, C., Miles, L. B., Hall, T. E., Berger, S., Fernandez, K. J., Gurevich, D., Cole, N. J., Alaei Shehni, S., Ramialison, M. S. M., Sutherland, R. L., Polo, J. M., Lieschke, G. & Currie, P. D., 2014, In : Nature. 512, 7514, p. 314 - 318 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Phases of reprogramming

David, L. & Polo, J. M., 2014, In : Stem Cell Research. 12, 3, p. 754 - 761 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Reprogramming can be a transforming experience

Hobbs, R. M. & Polo, J. M., 2014, In : Cell Stem Cell. 14, 3, p. 269 - 271 3 p.

Research output: Contribution to journalArticleOther

2013

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity

De, S., Shaknovich, R., Riester, M., Elemento, O., Geng, H. DE., Kormaksson, M., Jiang, Y., Woolcock, B., Johnson, N., Polo, J. M., Cerchietti, L., Gascoyne, R. D., Melnick, A. & Michor, F., 2013, In : PLoS Genetics. 9, 1, 14 p., e1003137.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters

Hatzi, K., Jiang, Y., Huang, C., Garrett-Bakelman, F., Gearhart, M. D., Giannopoulou, E. G., Zumbo, P., Kirouac, K., Bhaskara, S., Polo, J. M., Kormaksson, M., MacKerell Jr, A. D., Xue, F., Mason, C. E., Hiebert, S. W., Prive, G. G., Cerchietti, L., Bardwell, V. J., Elemento, O. & Melnick, A., 2013, In : Cell Reports. 4, 3, p. 578 - 588 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming

Apostolou, E., Ferrari, F., Walsh, R. M., Bar-Nur, O., Stadtfeld, M., Cheloufi, S., Stuart, H. T., Polo, J. M., Ohsumi, T., Borowsky, M. L., Kharchenko, P. V., Park, P. J. & Hochedlinger, K., 2013, In : Cell Stem Cell. 12, 6, p. 699 - 712 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells

Kelly, R. D. W., Rodda, A. E., Dickinson, A., Mahmud, A., Nefzger, C., Lee, W., Forsythe, J. S., Polo, J. M., Trounce, I. A., McKenzie, M., Nisbet, D. R. & St John, J. C., 2013, In : Stem Cells. 31, 4, p. 703 - 716 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy

Kaur, G., Costa, M., Nefzger, C., Silva, J., Fierro-Gonzalez, J. C., Polo, J. M., Bell, T. D. M. & Plachta, N., 2013, In : Nature Communications. 4, 1637, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2012

A molecular roadmap of reprogramming somatic cells into iPS cells

Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C., Lim, S. M., Borkent, M., Apostolou, E., Alaei Shehni, S., Cloutier, J., Bar-Nur, O., Cheloufi, S., Stadtfeld, M., Figueroa, M. E., Robinton, D., Natesan, S., Melnick, A., Zhu, J., Ramaswamy, S. & Hochedlinger, K., 2012, In : Cell. 151, 7, p. 1617 - 1632 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency

Hansson, J., Reza Rafiee, M., Reiland, S., Polo, J. M., Gehring, J., Okawa, S., Huber, W., Hochedlinger, K. & Krijgsveld, J., 2012, In : Cell Reports. 2, 6, p. 1579 - 1592 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

Ohi, Y., Qin, H., Hong, C., Blouin, L., Polo, J. M., Guo, T., Qi, Z., Downey, S. L., Manos, P. D., Rossi, D. J., Yu, J., Hebrok, M., Hochedlinger, K., Costello, J. F., Song, J. S. & Ramalho-Santos, M., May 2011, In : Nature Cell Biology. 13, 5, p. 541-549 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice

Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N. & Hochedlinger, K., 2011, In : Cell Stem Cell. 9, 4, p. 317 - 329 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells

Buecker, C., Chen, H. H., Polo, J. M., Daheron, L., Bu, L., Barakat, T. S., Okwieka, P., Porter, A., Gribnau, J., Hochedlinger, K. & Geijsen, N., 4 Jun 2010, In : Cell Stem Cell. 6, 6, p. 535-546 12 p.

Research output: Contribution to journalArticleResearchpeer-review

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

Cerchietti, L. C., Ghetu, A. F., Zhu, X-H., Da Silva, G. F., Zhong, S., Matthews, M., Bunting, K. L., Polo, J. M., Farès, C., Arrowsmith, C. H., Yang, S. N., Garcia, M., Coop, A., MacKerell Jr, A. D., Privé, G. G. & Melnick, A., 13 Apr 2010, In : Cancer Cell. 17, 4, p. 400-411 12 p.

Research output: Contribution to journalArticleResearchpeer-review

BCL6 is critical for the development of a diverse primary B cell repertoire

Duy, C., Yu, J. J., Nahar, R., Swaminathan, S., Kweon, S. M., Polo, J. M., Valls, E., Klemm, L., Shojaee, S., Cerchietti, L., Schuh, W., Jäck, H. M., Hurtz, C., Ramezani-Rad, P., Herzog, S., Jumaa, H., Koeffler, H. P., De Alborán, I. M., Melnick, A. M., Ye, B. H. & 1 othersMüschen, M., 7 Jun 2010, In : Journal of Experimental Medicine. 207, 6, p. 1209-1221 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

Polo, J. M., Liu, S., Figueroa, M. E., Kulalert, W., Eminli, S., Tan, K. Y., Apostolou, E., Stadtfeld, M., Li, Y., Shioda, T., Natesan, S., Wagers, A. J., Melnick, A., Evans, T. & Hochedlinger, K., Aug 2010, In : Nature Biotechnology. 28, 8, p. 848-855 8 p.

Research output: Contribution to journalArticleResearchpeer-review

SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells

Hammerich-Hille, S., Kaipparettu, B. A., Tsimelzon, A., Creighton, C. J., Jiang, S., Polo, J. M., Melnick, A., Meyer, R. & Oesterreich, S., 5 Feb 2010, In : Journal of Biological Chemistry. 285, 6, p. 3608-3616 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

Cerchietti, L. C., Yang, S. N., Shaknovich, R., Hatzi, K., Polo, J. M., Chadburn, A., Dowdy, S. F. & Melnick, A., 9 Apr 2009, In : Blood. 113, 15, p. 3397-3405 9 p.

Research output: Contribution to journalArticleResearchpeer-review

BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt

Juszczynski, P., Chen, L., O'Donnell, E., Polo, J. M., Ranuncolo, S. M., Dalla-Favera, R., Melnick, A. & Shipp, M. A., 17 Dec 2009, In : Blood. 114, 26, p. 5315-5321 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

Utikal, J., Polo, J. M., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J. G. & Hochedlinger, K., 27 Aug 2009, In : Nature. 460, 7259, p. 1145-1148 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL

Ci, W., Polo, J. M., Cerchietti, L., Shaknovich, R., Wang, L., Shao, N. Y., Ye, K., Farinha, P., Horsman, D. E., Gascoyne, R. D., Elemento, O. & Melnick, A., 2009, In : Blood. 113, 22, p. 5536-5548 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner

Ranuncolo, S. M., Wang, L., Polo, J. M., Dell'Oso, T., Dierov, J., Gaymes, T. J., Rassool, F., Carroll, M. & Melnick, A., 15 Aug 2008, In : Journal of Biological Chemistry. 283, 33, p. 22565-22572 8 p.

Research output: Contribution to journalArticleResearchpeer-review

BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

Ranuncolo, S. M., Polo, J. M. & Melnick, A., Jul 2008, In : Blood Cells, Molecules, and Diseases. 41, 1, p. 95-99 5 p.

Research output: Contribution to journalArticleResearchpeer-review

CtBP is an essential corepressor for BCL6 autoregulation

Mendez, L. M., Polo, J. M., Yu, J. J., Krupski, M., Ding, B. B., Melnick, A. & Ye, B. H., Apr 2008, In : Molecular and Cellular Biology. 28, 7, p. 2175-2186 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells

Polo, J. M., Ci, W., Licht, J. D. & Melnick, A., 1 Aug 2008, In : Blood. 112, 3, p. 644-651 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Sequential transcription factor targeting for diffuse large B-cell lymphomas

Cerchietti, L. C., Polo, J. M., Da Silva, G. F., Farinha, P., Shaknovich, R., Gascoyne, R. D., Dowdy, S. F. & Melnick, A., 1 May 2008, In : Cancer Research. 68, 9, p. 3361-3369 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR

Ranuncolo, S. M., Polo, J. M., Dierov, J., Singer, M., Kuo, T., Greally, J., Green, R., Carroll, M. & Melnick, A., Jul 2007, In : Nature Immunology. 8, 7, p. 705-714 10 p.

Research output: Contribution to journalArticleResearchpeer-review

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

Parekh, S., Polo, J. M., Shaknovich, R., Juszczynski, P., Lev, P., Ranuncolo, S. M., Yin, G., Klein, U., Cattoretti, G., Dalla Favera, R., Shipp, M. A. & Melnick, A., 15 Sep 2007, In : Blood. 110, 6, p. 2067-2074 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas

Polo, J. M., Juszczynski, P., Monti, S., Cerchietti, L., Ye, K., Greally, J. M., Shipp, M. & Melnick, A., 27 Feb 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 9, p. 3207-3212 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells

Polo, J. M., Dell'Oso, T., Ranuncolo, S. M., Cerchietti, L., Beck, D., Da Silva, G. F., Prive, G. G., Licht, J. D. & Melnick, A., Dec 2004, In : Nature Medicine. 10, 12, p. 1329-1335 7 p.

Research output: Contribution to journalArticleResearchpeer-review