Research Output 2009 2017

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2017

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E. , Richards, J. L. , McLeod, K. H. , Stanley, D. , Yap, Y. A. , Knight, J. , McKenzie, C. , Kranich, J. , Oliveira, A. C. , Rossello, F. J. , Krishnamurthy, B. , Nefzger, C. M. , Macia, L. , Thorburn, A. , Baxter, A. G. , Morahan, G. , Wong, L. H. , Polo, J. M. , Moore, R. J. , Lockett, T. J. & 4 others Clarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R. May 2017 In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Research - peer-reviewArticle

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

O'Brien, C. M. , Chy, H. S. , Zhou, Q. , Blumenfeld, S. , Lambshead, J. W. , Liu, X. , Kie, J. , Capaldo, B. D. , Chung, T-L. , Adams, T. E. , Phan, T. , Bentley, J. D. , McKinstry, W. J. , Oliva, K. , McMurrick, P. J. , Wang, Y-C. , Rossello, F. J. , Lindeman, G. J. , Chen, D. , Jarde, T. & 7 others Clark, A. T., Abud, H. E., Visvader, J. E., Nefzger, C. M., Polo, J. M., Loring, J. F. & Laslett, A. L. 1 Mar 2017 In : Stem Cells. 35, 3, p. 626-640 15 p.

Research output: Research - peer-reviewArticle

Open Access
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2016
Open Access
Open Access
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2015

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation

Shu, R., Wong, W. S. F., Ma, Q-H., Yang, Z. Z., Zhu, H., Liu, F. J., Wang, P., Ma, J., Yan, S., Polo, J. M., Bernard, C. C. A., Stanton, L. W., Dawe, G. S. & Xiao, Z. 1 Jan 2015 In : Cell Death and Disease. 6, 2, 12 p., e1651

Research output: Research - peer-reviewArticle

Open Access
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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Horvay, K., Jarde, T., Casagranda, F., Perreau, V. M., Haigh, K., Nefzger, C. M., Akhtar, R., Gridley, T., Berx, G., Haigh, J. J., Barker, N., Polo, J. M., Hime, G. R. & Abud, H. E. 2015 In : EMBO Journal. 34, 10, p. 1319 - 1335 17 p.

Research output: Research - peer-reviewArticle

Transcription factor-mediated reprogramming: epigenetics and therapeutic potential

Firas, J., Liu, E. X., Lim, S. M. & Polo, J. M. 2015 In : Immunology and Cell Biology. 93, 3, p. 284 - 289 6 p.

Research output: Research - peer-reviewArticle

2014

Epigenetic Changes During Reprogramming

Alaei Shehni, S., Knaupp, A. S. & Polo, J. M. 2014 In : Australian Biochemist. 45, 1, p. 17 - 20 4 p.

Research output: OtherArticle

Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: evidence and implications

Firas, J., Liu, E. X. & Polo, J. M. 2014 In : Differentiation. 88, 1, p. 29 - 32 4 p.

Research output: Research - peer-reviewArticle

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

Nguyen, P., Hollway, G. E., Sonntag, C., Miles, L. B., Hall, T. E., Berger, S., Fernandez, K. J., Gurevich, D., Cole, N. J., Alaei Shehni, S., Ramialison, M. S. M., Sutherland, R. L., Polo, J. M., Lieschke, G. & Currie, P. D. 2014 In : Nature. 512, 7514, p. 314 - 318 5 p.

Research output: Research - peer-reviewArticle

Phases of reprogramming

David, L. & Polo, J. M. 2014 In : Stem Cell Research. 12, 3, p. 754 - 761 8 p.

Research output: Research - peer-reviewArticle

Reprogramming can be a transforming experience

Hobbs, R. M. & Polo, J. M. 2014 In : Cell Stem Cell. 14, 3, p. 269 - 271 3 p.

Research output: OtherArticle

2013

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity

De, S., Shaknovich, R., Riester, M., Elemento, O., Geng, H. D. E., Kormaksson, M., Jiang, Y., Woolcock, B., Johnson, N., Polo, J. M., Cerchietti, L., Gascoyne, R. D., Melnick, A. & Michor, F. 2013 In : PLoS Genetics. 9, 1, 14 p., e1003137

Research output: Research - peer-reviewArticle

Open Access
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A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters

Hatzi, K., Jiang, Y., Huang, C., Garrett-Bakelman, F., Gearhart, M. D., Giannopoulou, E. G., Zumbo, P., Kirouac, K., Bhaskara, S., Polo, J. M., Kormaksson, M., MacKerell Jr, A. D., Xue, F., Mason, C. E., Hiebert, S. W., Prive, G. G., Cerchietti, L., Bardwell, V. J., Elemento, O. & Melnick, A. 2013 In : Cell Reports. 4, 3, p. 578 - 588 11 p.

Research output: Research - peer-reviewArticle

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming

Apostolou, E., Ferrari, F., Walsh, R. M., Bar-Nur, O., Stadtfeld, M., Cheloufi, S., Stuart, H. T., Polo, J. M., Ohsumi, T., Borowsky, M. L., Kharchenko, P. V., Park, P. J. & Hochedlinger, K. 2013 In : Cell Stem Cell. 12, 6, p. 699 - 712 14 p.

Research output: Research - peer-reviewArticle

Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells

Kelly, R. D. W., Rodda, A. E., Dickinson, A., Mahmud, A., Nefzger, C., Lee, W., Forsythe, J. S., Polo, J. M., Trounce, I. A., McKenzie, M., Nisbet, D. R. & St John, J. C. 2013 In : Stem Cells. 31, 4, p. 703 - 716 14 p.

Research output: Research - peer-reviewArticle

Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy

Kaur, G., Costa, M., Nefzger, C., Silva, J., Fierro-Gonzalez, J. C., Polo, J. M., Bell, T. D. M. & Plachta, N. 2013 In : Nature Communications. 4, 1637, p. 1 - 13 13 p.

Research output: Research - peer-reviewArticle

Open Access
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2012

A molecular roadmap of reprogramming somatic cells into iPS cells

Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C., Lim, S. M., Borkent, M., Apostolou, E., Alaei Shehni, S., Cloutier, J., Bar-Nur, O., Cheloufi, S., Stadtfeld, M., Figueroa, M. E., Robinton, D., Natesan, S., Melnick, A., Zhu, J., Ramaswamy, S. & Hochedlinger, K. 2012 In : Cell. 151, 7, p. 1617 - 1632 16 p.

Research output: Research - peer-reviewArticle

Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency

Hansson, J., Reza Rafiee, M., Reiland, S., Polo, J. M., Gehring, J., Okawa, S., Huber, W., Hochedlinger, K. & Krijgsveld, J. 2012 In : Cell Reports. 2, 6, p. 1579 - 1592 14 p.

Research output: Research - peer-reviewArticle

2011

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

Ohi, Y., Qin, H., Hong, C., Blouin, L., Polo, J. M., Guo, T., Qi, Z., Downey, S. L., Manos, P. D., Rossi, D. J., Yu, J., Hebrok, M., Hochedlinger, K., Costello, J. F., Song, J. S. & Ramalho-Santos, M. May 2011 In : Nature Cell Biology. 13, 5, p. 541-549 9 p.

Research output: Research - peer-reviewArticle

Sox2+ adult stem and progenitor cells are important for tissue regeneration and survival of mice

Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N. & Hochedlinger, K. 2011 In : Cell Stem Cell. 9, 4, p. 317 - 329 13 p.

Research output: Research - peer-reviewArticle

2010

A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells

Buecker, C., Chen, H. H., Polo, J. M., Daheron, L., Bu, L., Barakat, T. S., Okwieka, P., Porter, A., Gribnau, J., Hochedlinger, K. & Geijsen, N. 4 Jun 2010 In : Cell Stem Cell. 6, 6, p. 535-546 12 p.

Research output: Research - peer-reviewArticle

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

Cerchietti, L. C., Ghetu, A. F., Zhu, X-H., Da Silva, G. F., Zhong, S., Matthews, M., Bunting, K. L., Polo, J. M., Farès, C., Arrowsmith, C. H., Yang, S. N., Garcia, M., Coop, A., MacKerell Jr, A. D., Privé, G. G. & Melnick, A. 13 Apr 2010 In : Cancer Cell. 17, 4, p. 400-411 12 p.

Research output: Research - peer-reviewArticle

BCL6 is critical for the development of a diverse primary B cell repertoire

Duy, C. , Yu, J. J. , Nahar, R. , Swaminathan, S. , Kweon, S. M. , Polo, J. M. , Valls, E. , Klemm, L. , Shojaee, S. , Cerchietti, L. , Schuh, W. , Jäck, H. M. , Hurtz, C. , Ramezani-Rad, P. , Herzog, S. , Jumaa, H. , Koeffler, H. P. , De Alborán, I. M. , Melnick, A. M. , Ye, B. H. & 1 others Müschen, M. 7 Jun 2010 In : Journal of Experimental Medicine. 207, 6, p. 1209-1221 13 p.

Research output: Research - peer-reviewArticle

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

Polo, J. M., Liu, S., Figueroa, M. E., Kulalert, W., Eminli, S., Tan, K. Y., Apostolou, E., Stadtfeld, M., Li, Y., Shioda, T., Natesan, S., Wagers, A. J., Melnick, A., Evans, T. & Hochedlinger, K. Aug 2010 In : Nature Biotechnology. 28, 8, p. 848-855 8 p.

Research output: Research - peer-reviewArticle

SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells

Hammerich-Hille, S., Kaipparettu, B. A., Tsimelzon, A., Creighton, C. J., Jiang, S., Polo, J. M., Melnick, A., Meyer, R. & Oesterreich, S. 5 Feb 2010 In : Journal of Biological Chemistry. 285, 6, p. 3608-3616 9 p.

Research output: Research - peer-reviewArticle

2009

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

Cerchietti, L. C., Yang, S. N., Shaknovich, R., Hatzi, K., Polo, J. M., Chadburn, A., Dowdy, S. F. & Melnick, A. 9 Apr 2009 In : Blood. 113, 15, p. 3397-3405 9 p.

Research output: Research - peer-reviewArticle

BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt

Juszczynski, P., Chen, L., O'Donnell, E., Polo, J. M., Ranuncolo, S. M., Dalla-Favera, R., Melnick, A. & Shipp, M. A. 17 Dec 2009 In : Blood. 114, 26, p. 5315-5321 7 p.

Research output: Research - peer-reviewArticle

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

Utikal, J., Polo, J. M., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J. G. & Hochedlinger, K. 27 Aug 2009 In : Nature. 460, 7259, p. 1145-1148 4 p.

Research output: Research - peer-reviewArticle

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL

Ci, W., Polo, J. M., Cerchietti, L., Shaknovich, R., Wang, L., Shao, N. Y., Ye, K., Farinha, P., Horsman, D. E., Gascoyne, R. D., Elemento, O. & Melnick, A. 2009 In : Blood. 113, 22, p. 5536-5548 13 p.

Research output: Research - peer-reviewArticle