If you made any changes in Pure these will be visible here soon.

Personal profile


Dr Lee received his PhD from The University of Melbourne and the Florey Neuroscience Institutes, in the area of neuroscience and pharmacology. He then worked as a Parkinson’s Society Canada Research Fellow at the Toronto Western Hospital in Canada, to investigate the role of abnormal synaptic plasticity in Parkinson’s disease. In 2006 he returned to the Florey Neurosciences Institute to investigate the neural mechanisms underlying Parkinson’s disease and drug addiction, before joining the Hudson Institute in 2008.

Dr Lee’s research focuses on sex differences in brain function in normal and diseased states. In particular the research laboratory is focusing on the potential role of the male sex-determining gene SRY in the sex differences in neurological diseases, such as Parkinson’s disease, attention-deficit hyperactive disorder (ADHD) and autism. He has a strong interest in understanding the role of the Y-chromosome gene SRY and the male brain and how abnormal regulation of SRY may increase the susceptibility of males to neurological disorders such as Parkinson’s disease and ADHD.

Research area keywords

  • Parkinson's Disease
  • Autism Spectrum Disorders
  • ADHD
  • Dopamine
  • Schizophrenia
  • Neurodegenerative Diseases/Disorders
  • Neurodevelopmental Disorders
  • Sexual Dimorphism
  • Genetics
  • Animal Disease Models

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2016

Research Output 1998 2019

3 Citations (Scopus)

Human umbilical cord therapy improves long-term behavioral outcomes following neonatal hypoxic ischemic brain injury

Penny, T. R., Sutherland, A. E., Mihelakis, J. G., Paton, M. C. B., Pham, Y., Lee, J., Jones, N. M., Jenkin, G., Fahey, M. C., Miller, S. L. & McDonald, C. A., 1 Jan 2019, In : Frontiers in Physiology. 10, MAR, 11 p., 283.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson's disease

Lee, J., Pinares-Garcia, P., Loke, H., Ham, S., Vilain, E. & Harley, V., 13 Aug 2019, In : Proceedings of the National Academy of Sciences. 116, 33, p. 16577-16582 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Sex: A significant risk factor for neurodevelopmental and neurodegenerative disorders

Pinares-Garcia, P., Stratikopoulos, M., Zagato, A., Loke, H. & Lee, J., 13 Aug 2018, In : Brain Sciences. 8, 8, 27 p., 154.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access

Dysregulation of SRY in the male brain: a genetic basis for sex-biased neurological disorders

Loke, H., Pinares-Garcia, P., Czech, D., Harley, V. & Lee, J., 2016, p. 114 - 115. 2 p.

Research output: Contribution to conferencePoster

43 Citations (Scopus)

Biological factors underlying sex differences in neurological disorders

Loke, H. P. Y., Harley, V. R. & Lee, J., 2015, In : International Journal of Biochemistry and Cell Biology. 65, p. 139 - 150 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2010 2010

  • 1 Editorial responsibility

PLoS ONE (Journal)

Joohyung Lee (Editorial board member)

Activity: Publication peer-review and editorial work typesEditorial responsibility