Jonathan Baell

Professor

19982021
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Research Output 1998 2019

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2013

Structure-guided design of a selective BCL-XL inhibitor

Lessene, G., Czabotar, P. E., Sleebs, B., Zobel, K., Lowes, K., Adams, J. M., Baell, J. B., Colman, P. M., Deshayes, K., Fairbrother, W. J., Flygare, J. A., Gibbons, P., Kersten, W. J. A., Kulasegaram, S., Moss, R. M., Parisot, J. P., Smith, B. J., Street, I. P., Yang, H., Huang, D. CS. & 1 othersWatson, K. G., 2013, In : Nature Chemical Biology. 9, 6, p. 390 - 400 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Established and emerging trends in computational drug discovery in the structural genomics era

Taboureau, O., Baell, J. B., Fernandez-Recio, J. & Villoutreix, B. O., 2012, In : Chemistry and Biology. 19, 1, p. 29 - 41 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign

Sykes, M. L., Baell, J. B., Kaiser, M., Chatelain, E., Moawad, S. R., Ganame, D., Ioset, J. R. & Avery, V. M., 2012, In : PLoS Neglected Tropical Diseases. 6, 11, 14 p., e1896.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

IP issues facing researchers by Gino D'Oca

Almarsson, O., Angiolini, M., Baell, J., Giardina, G., Ingham, A., Hughes, A., Pevarello, P. & Sindelar, R., 1 May 2012, In : Pharmaceutical Patent Analyst. 1, 2, p. 129-135 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Omega-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca v2.2 ion channels

Tranberg, C. E., Yang, A., Vetter, I., McArthur, J. R., Baell, J. B., Lewis, R. J., Tuck, K. L. & Duggan, P., 2012, In : Marine Drugs. 10, 10, p. 2349 - 2368 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sites of action of ghrelin receptor ligands in cardiovascular control

Callaghan, B., Hunne, B., Hirayama, H., Sartor, D. M., Nguyen, T. V., Abogadie, F. C., Ferens, D. M., McIntyre, P. B., Ban, K., Baell, J. B., Furness, J. B. & Brock, J. A., 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 8, p. 1011 - 1021 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of conformationally constrained benzoylureas as BH3-mimetics

Brady, R., Hatzis, E., Connor, T., Street, I. P., Baell, J. B. & Lessene, G., 2012, In : Organic and Biomolecular Chemistry. 10, 27, p. 5230 - 5237 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets

Falk, H., Connor, T., Yang, H., Loft, K. J., Alcindor, J. L., Nikolakopoulos, G., Surjadi, R. N., Bentley, J. D., Hattarki, M., Dolezal, O., Murphy, J. M., Monahan, B., Peat, T., Thomas, T., Baell, J. B., Parisot, J. P. & Street, I. P., 2011, In : Journal of Biomolecular Screening. 16, 10, p. 1196 - 1205 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Benzoylureas as removable cis amide inducers: Synthesis of cyclic amides via ring closing metathesis (RCM)

Brady, R., Khakham, Y., Lessene, G. & Baell, J. B., 2011, In : Organic and Biomolecular Chemistry. 9, 3, p. 656 - 658 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

Sleebs, B., Ganame, D., Levit, A., Street, I., Gregg, A., Falk, H. & Baell, J., 2011, In : MedChemComm. 2, p. 982 - 986 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

Sleebs, B., Levit, A., Street, I. P., Falk, H., Hammonds, T. R., Wong, A. C., Charles, M. D., Olson, M. F. & Baell, J. B., 2011, In : MedChemComm. 2, 10, p. 977 - 981 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

Sleebs, B., Nikolakopoulos, G., Street, I. P., Falk, H. & Baell, J. B., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 19, p. 5992 - 5994 3 p.

Research output: Contribution to journalArticleResearchpeer-review

KNIME workflow to assess PAINS filters in SMARTS format. Comparison of RDKit and indigo cheminformatics libraries

Saubern, S., Guha, R. & Baell, J. B., 2011, In : Molecular Informatics. 30, 10, p. 847 - 850 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Sleebs, B., Czabotar, P. E., Fairbrother, W. J., Fairlie, W. D., Flygare, J. A., Huang, D. CS., Kersten, W. J. A., Koehler, M. F. T., Lessene, G., Lowes, K. N., Parisot, J. P., Smith, B. J., Smith, M. L., Souers, A. J., Street, I. P., Yang, H. & Baell, J. B., 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1914 - 1926 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Redox-active nuisance screening compounds and their classification

Baell, J. B., 2011, In : Drug Discovery Today. 16, 17, p. 840 - 841 2 p.

Research output: Contribution to journalArticleResearchpeer-review

The FAF-Drugs2 server: A multistep engine to prepare electronic chemical compound collections

Lagorce, D., Maupetit, J., Baell, J. B., Sperandio, O., Tuffery, P., Miteva, M. A., Galons, H. & Villoutreix, B. O., 2011, In : Bioinformatics. 27, 14, p. 2018 - 2020 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

Ban, K., Duffy, S., Khakham, Y., Avery, V., Hughes, A., Montagnat, O., Katneni, K., Ryan, E. & Baell, J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6024 - 6029 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

Nhu, D. Q., Duffy, S., Avery, V. M., Hughes, A. B. & Baell, J. B., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 15, p. 4496 - 4498 3 p.

Research output: Contribution to journalArticleResearchpeer-review

De novo synthesis of a potent LIMK1 inhibitor

Sleebs, B., Street, I. P., Bu, X. & Baell, J. B., 2010, In : Synthesis-Stuttgart. 7, p. 1091 - 1096 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi

Holloway, G. A., Parisot, J. P., Novello, P. M., Watson, K. G., Armstrong, T., Thompson, R. C. A., Street, I. P. & Baell, J. B., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 1816 - 1818 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library

Lackovic, K. P., Parisot, J. P., Sleebs, N., Baell, J. B., Debien, L., Watson, K. G., Curtis, J., Handman, E., Street, I. P. & Kedzierski, L., 2010, In : Antimicrobial Agents and Chemotherapy. 54, 5, p. 1712 - 1719 8 p.

Research output: Contribution to journalArticleResearchpeer-review

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

Baell, J. B. & Holloway, G. A., 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2719 - 2740 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Observations on screening-based research and some concerning trends in the literature

Baell, J. B., 2010, In : Future Medicinal Chemistry. 2, 10, p. 1529 - 1546 18 p.

Research output: Contribution to journalArticleResearchpeer-review

The cooperative research centre for cancer therapeutics: Bridging the gap between leading cancer research at Australias universities and developing novel cancer drugs

Baell, J. B., Heathers, G. & Sage, C., Jun 2010, In : Future Medicinal Chemistry. 2, 6, p. 941-947 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

Lessene, G., Smith, B. J., Gable, R. W. & Baell, J. B., 2009, In : Journal of Organic Chemistry. 74, 17, p. 6511 - 6525 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of destructive autoimmune arthritis in FcgRIIa transgenic mice by small chemical entities

Pietersz, G. A., Mottram, P. L., van de Velde, N. C., Sardjono, C. T., Esparon, S. E., Ramsland, P. A., Moloney, G., Baell, J. B., McCarthy, T. D., Matthews, B. R., Powell, M. & Hogarth, P. M., 2009, In : Immunology and Cell Biology. 87, 1, p. 3 - 12 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Omega-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine

Andersson, A., Baell, J. B., Duggan, P., Graham, J. E., Lewis, R. J., Lumsden, N. G., Tranberg, C. E., Tuck, K. L. & Yang, A., 2009, In : Bioorganic & Medicinal Chemistry. 17, p. 6659 - 6670 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

Holloway, G. A., Charman, W. N., Fairlamb, A. H., Brun, R., Kaiser, M., Kostewicz, E. S., Novello, P. M., Parisot, J. P., Richardson, J., Street, I. P., Watson, K. G. & Baell, J. B., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2824 - 2833 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Synthesis and Biological Evaluation of Chalcones as Inhibitors of the Voltage-Gated Potassium Channel Kv1.3

Cianci, J., Baell, J. B., Flynn, B. L., Gable, R. W., Mould, J., Paul, D. & Harvey, A. J., 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 6, p. 2055 - 2061 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

Holloway, G. A., Baell, J. B., Fairlamb, A. H., Novello, P. M., Parisot, J. P., Richardson, J., Watson, K. G. & Street, I. P., 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1422 - 1427 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of compounds that influence I K (KCNN4) channels on afterhyperpolarizing potentials, and determination of I K channel sequence, in guinea pig enteric neurons

Nguyen, T. V., Matsuyama, H., Baell, J. B., Hunne, B. L., Fowler, C. J., Smith, J. E., Nurgali, K. & Furness, J. B., 2007, In : Journal of Neurophysiology. 97, 3, p. 2024 - 2031 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of modulators of Ca 2+-activated, intermediate- conductance potassium channels on motility of the rat small intestine, in vivo

Ferens, D. M., Baell, J. B., Lessene, G., Smith, J. E. & Furness, J. B., 2007, In : Neurogastroenterology and Motility. 19, 5, p. 383 - 389 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids

Cianci, J., Baell, J. B. & Harvey, A. J., 2007, In : Tetrahedron Letters. 48, 34, p. 5973 - 5975 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

Hirokawa, Y., Levitzki, A., Lessene, G., Baell, J. B., Xiao, Y., Zhu, H-J. & Maruta, H., 2007, In : Cancer Letters. 245, 1, p. 242 - 251 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases

Rye, C. S., Baell, J. B. & Street, I. P., 2007, In : Tetrahedron. 63, 16, p. 3306 - 3311 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone

Harvey, A. J., Baell, J. B., Toovey, N., Homerick, D. & Wulff, H., 2006, In : Journal of Medicinal Chemistry. 49, 4, p. 1433 - 1441 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of -conotoxin GVIA

Baell, J. B., Duggan, P. J., Forsyth, S. A., Lewis, R. J., Lok, Y. P., Schroeder, C. I. & Shepherd, N. E., 2006, In : Tetrahedron. 62, 31, p. 7284 - 7292 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor

Harvey, A. J., Gable, R. W. & Baell, J. B., 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 13, p. 3193 - 3196 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

1,6-Bis(5-acetyl-4,7-dimethoxybenzofuran-6-yloxy)hexane

Baell, J. B., Gable, R. W. & Harvey, A. J., 1 Jun 2004, In : Acta Crystallographica Section E: Structure Reports Online. 60, 6

Research output: Contribution to journalArticleResearchpeer-review

Khellinone Derivatives as Blockers of the Voltage-Gated Potassium Channel Kv1.3: Synthesis and Immunosuppressive Activity

Baell, J. B., Gable, R. W., Harvey, A. J., Toovey, N., Herzog, T., Hänsel, W. & Wulff, H., 22 Apr 2004, In : Journal of Medicinal Chemistry. 47, 9, p. 2326-2336 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of nonpeptide mimetics of w-conotoxin GVIA

Baell, J. B., Duggan, P. J., Forsyth, S. A., Lewis, R. J., Lok, Y. P. & Schroeder, C. I., 2004, In : Bioorganic & Medicinal Chemistry. 12, p. 4025 - 4037 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation

He, H., Hirokawa, Y., Gazit, A., Yamashita, Y., Mano, H., Kawakami, Y., Kawakami, Hsieh, C. Y., Kung, H. J., Lessene, G., Baell, J., Levitzki, A. & Maruta, H., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 1, p. 96-101 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Inhibition studies of sulfonamide-containing folate analogs in yeast

Patel, O., Satchell, J., Baell, J. B., Fernley, R., Coloe, P. & Macreadie, I., 2003, In : Microbial Drug Resistance. 9, 2, p. 139 - 145 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Methyl (RS)-[1-hydroxy-1-(3-nitrophenyl)-3-oxo-1,3-dihydroisoindol-2-yl]acetate

Baell, J. B., Duggan, P. J., Fallon, G. D. & Lok, Y. P., 2003, In : Acta Crystallographica Section E: Structure Reports Online. 59, p. 1958 - 1959 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Design and synthesis of type-III mimetics of ShK toxin

Baell, J. B., Harvey, A. J. & Norton, R. S., 1 Apr 2002, In : Journal of Computer-Aided Molecular Design. 16, 4, p. 245-262 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

Baell, J. B. & Huang, D. C. S., 1 Sep 2002, In : Biochemical Pharmacology. 64, 5-6, p. 851-863 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Design and synthesis of type-III mimetics of ω-conotoxin GVIA

Baell, J. B., Forsyth, S. A., Gable, R. W., Norton, R. S. & Mulder, R. J., 2001, In : Journal of Computer-Aided Molecular Design. 15, 12, p. 1119-1136 18 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Polypeptide ω-conotoxin GVIA as a basis for new analgesic and neuroprotective agents

Norton, R. S., Pallaghy, P. K., Baell, J. B., Wright, C. E., Lew, M. J. & Angus, J. A., 1999, In : Drug Development Research. 46, 3-4, p. 206-218 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Design and assay of inhibitors of HIV-1 Vpr cell killing and growth arrest activity using microbial assay systems

Sankovich, S. E., Koleski, D., Baell, J., Matthews, B., Azad, A. A. & Macreadie, I. G., 1 Jan 1998, In : Journal of Biomolecular Screening. 3, 4, p. 299-304 6 p.

Research output: Contribution to journalArticleResearchpeer-review