Jonathan Baell

Professor

19982021
If you made any changes in Pure these will be visible here soon.

Research Output 1998 2018

Filter
Article
2018

1,2,4-Oxadiazole antimicrobials act synergistically with daptomycin and display rapid kill kinetics against MDR Enterococcus faecium

Carter, G. P., Harjani, J. R., Li, L., Pitcher, N. P., Nong, Y., Riley, T. V., Williamson, D. A., Stinear, T. P., Baell, J. B. & Howden, B. P., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1562-1569 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Coussens, N. P., Sittampalam, G. S., Guha, R., Brimacombe, K., Grossman, A., Chung, T. D. Y., Weidner, J. R., Riss, T., Trask, O. J., Auld, D., Dahlin, J. L., Devanaryan, V., Foley, T. L., McGee, J., Kahl, S. D., Kales, S. C., Arkin, M., Baell, J., Bejcek, B., Gal-Edd, N. & 25 othersGlicksman, M., Haas, J. V., Iversen, P. W., Hoeppner, M., Lathrop, S., Sayers, E., Liu, H., Trawick, B., McVey, J., Lemmon, V. P., Li, Z., McManus, O., Minor, L., Napper, A., Wildey, M. J., Pacifici, R., Chin, W. W., Xia, M., Xu, X., Lal-Nag, M., Hall, M. D., Michael, S., Inglese, J., Simeonov, A. & Austin, C. P., 1 Sep 2018, In : Clinical and Translational Science. 11, 5, p. 461-470 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

Nguyen, N., Wilson, D. W., Nagalingam, G., Triccas, J. A., Schneider, E. K., Li, J., Velkov, T. & Baell, J., 25 Mar 2018, In : European Journal of Medicinal Chemistry. 148, p. 507-518 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4

Ngoei, K. R. W., Langendorf, C. G., Ling, N. X. Y., Hoque, A., Varghese, S., Camerino, M. A., Walker, S. R., Bozikis, Y. E., Dite, T. A., Ovens, A. J., Smiles, W. J., Jacobs, R., Huang, H., Parker, M. W., Scott, J. W., Rider, M. H., Foitzik, R. C., Kemp, B. E., Baell, J. B. & Oakhill, J. S., 21 Jun 2018, In : Cell Chemical Biology. 25, 6, p. 728-737.e9 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B., 31 May 2017, In : Parasites and Vectors. 10, 1, 272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity

Gilson, P. R., Tan, C., Jarman, K. E., Lowes, K. N., Curtis, J. M., Nguyen, W., Di Rago, A. E., Bullen, H. E., Prinz, B., Duffy, S., Baell, J. B., Hutton, C. A., Jousset Subroux, H., Crabb, B. S., Avery, V. M., Cowman, A. F. & Sleebs, B. E., 9 Feb 2017, In : Journal of Medicinal Chemistry. 60, 3, p. 1171-1188 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes

Preston, S., Jiao, Y., Baell, J. B., Keiser, J., Crawford, S., Koehler, A. V., Wang, T., Simpson, M. M., Kaplan, R. M., Cowley, K. J., Simpson, K. J., Hofmann, A., Jabbar, A. & Gasser, R. B., 1 Dec 2017, In : International Journal for Parasitology: Drugs and Drug Resistance. 7, 3, p. 286-294 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B., 9 Jun 2016, In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner

Sutton, S. K., Carter, D. R., Kim, P., Tan, O., Arndt, G. M., Zhang, X. D., Baell, J., Noll, B. D., Wang, S., Kumar, N., McArthur, G. A., Cheung, B. B. & Marshall, G. M., 1 Aug 2016, In : Oncotarget. 7, 32, p. 52166-52178 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides

Russell, S., Rahmani, R., Jones, A. J., Newson, H. L., Neilde, K., Cotillo, I., Rahmani Khajouei, M., Ferrins, L., Qureishi, S., Nguyen, N., Martinez-Martinez, M. S., Weaver, D. F., Kaiser, M., Riley, J., Thomas, J., De Rycker, M., Read, K. D., Flematti, G. R., Ryan, E., Tanghe, S. & 6 othersRodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M. J., 10 Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Stoessel, D., Nowell, C. J., Jones, A. J., Ferrins, L., Ellis, K. M., Riley, J., Rahmani, R., Read, K. D., McConville, M. J., Avery, V. M., Baell, J. B. & Creek, D. J., 1 Jul 2016, In : Metabolomics. 12, 7, 14 p., 126.

Research output: Contribution to journalArticleResearchpeer-review

New synthetic approaches towards analogues of bedaquiline

Priebbenow, D. L., Barbaro, L. & Baell, J. B., 28 Oct 2016, In : Organic and Biomolecular Chemistry. 14, 40, p. 9622-9628 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open source drug discovery: Highly potent antimalarial compounds derived from the tres cantos arylpyrroles

Williamson, A. E., Ylioja, P. M., Robertson, M. N., Antonova-Koch, Y., Avery, V., Baell, J., Batchu, H., Batra, S., Burrows, J. N., Bhattacharyya, S., Calderon, F., Charman, S., Clark, J., Crespo, B., Dean, M., Debbert, S. L., Delves, M. J., Dennis, A. S. M., Deroose, F., Duffy, S. & 3 othersRyan, E., Wells, T. & White, K., 26 Oct 2016, In : ACS Central Science. 2, 10, p. 687-701 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S., 1 Mar 2016, In : FEBS Letters. 590, 6, p. 696-704 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

Pasaje, C. F. A., Cheung, V., Kennedy, K., Lim, E. E., Baell, J. B., Griffin, M. D. W. & Ralph, S. A., 9 Jun 2016, In : Scientific Reports. 6, 13 p., 27531.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

Preston, S., Luo, J., Zhang, Y., Jabbar, A., Crawford, S., Baell, J., Hofmann, A., Hu, M., Zhou, H-B. & Gasser, R. B., 16 Jun 2016, In : Parasites and Vectors. 9, 1, 11 p., 346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structural basis for the selective binding of inhibitors to 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus and Escherichia coli

Dennis, M. L., Pitcher, N. P., Lee, M. D., Debono, A. J., Wang, Z-C., Harjani, J. R., Rahmani, R., Cleary, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 9 Jun 2016, In : Journal of Medicinal Chemistry. 59, 11, p. 5248-5263 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of 3-(alkylamino)-, 3-(alkoxy)-, 3-(aryloxy)-, 3-(alkylthio)-, and 3-(arylthio)-1,2,4-triazines by using a unified route with 3-(methylsulfonyl)-1,2,4-triazine

Shi, D. H., Harjani, J. R., Gable, R. W. & Baell, J. B., 1 Jun 2016, In : European Journal of Organic Chemistry. 2016, 16, p. 2842-2850 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Truncated latrunculins as actin inhibitors targeting Plasmodium falciparum motility and host cell invasion

Johnson, S., Rahmani, R., Drew, D. R., Williams, M. J., Wilkinson, M. I., Tan, Y. H., Huang, J. X., Tonkin, C. J., Beeson, J., Baum, J., Smith, B. J. & Baell, J., 22 Dec 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 10994-11005 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

6-arylpyrazine-2-carboxamides: a new core for Trypanosoma brucei inhibitors

Rahmani, R., Ban, K., Jones, A. J., Ferrins, L., Ganame, D., Sykes, M. L., Avery, V. M., White, K. L., Ryan, E., Kaiser, M., Charman, S. A. & Baell, J. B., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6753-6765 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A practical Java tool for small-molecule compound appraisal

Amani, P., Sneyd, T., Preston, S., Young, N. D., Mason, L., Bailey, U-M., Baell, J. B., Camp, D. G., Gasser, R. B., Gorse, A-D., Taylor, P. R. & Hofmann, A., 2015, In : Journal of Cheminformatics. 7, 1, 4 p., 28.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

Baker, M. A., Weinberg, A. S., Hetherington, L., Villaverde, A-I., Velkov, T., Baell, J. B. & Gordon, C. P., 2015, In : Biology of Reproduction. 92, 4, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

FAF-Drugs3: a web server for compound property calculation and chemical library design

Lagorce, D., Sperandio, O., Baell, J. B., Miteva, M. A. & Villoutreix, B. O., 1 Jul 2015, In : Nucleic Acids Research. 43, W1, p. W200-W207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Low cost whole-organism screening of compounds for anthelmintic activity

Preston, S., Jabbar, A., Nowell, C. J., Joachim, A., Ruttkowski, B., Baell, J. B., Cardno, T., Korhonen, P. K., Piedrafita, D. M., Ansell, B. R. E., Jex, A. R., Hofmann, A. & Gasser, R. B., 2015, In : International Journal for Parasitology. 45, 5, p. 333 - 343 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Regio- and stereoselective iodoacyloxylations of alkynes

Priebbenow, D., Gable, R. W. & Baell, J. B., 2015, In : Journal of Organic Chemistry. 80, 9, p. 4412 - 4418 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., Avery, V. M. & Payne, R. J., 2015, In : MedChemComm. 6, 3, p. 403 - 406 4 p.

Research output: Contribution to journalArticleOtherpeer-review

2014

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S., 2014, In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B., 2014, In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Contribution to journalArticleResearchpeer-review

De-novo designed library of benzoylureas as inhibitors of BCL-XL: Synthesis, structural and biochemical characterization

Brady, R., Vom, A., Roy, M. J., Toovey, N., Smith, B. J., Moss, R. M., Hatzis, E., Huang, D. CS., Parisot, J. P., Yang, H., Street, I. P., Colman, P. M., Czabotar, P. E., Baell, J. B. & Lessene, G., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1323 - 1343 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei

Rashad, A. A., Jones, A. J., Avery, V. M., Baell, J. B. & Keller, P. A., 2014, In : A C S Medicinal Chemistry Letters. 5, 5, p. 496 - 500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

Callaghan, B., Kosari, S., Pustovit, R. V., Sartor, D. M., Ferens, D. M., Ban, K., Baell, J. B., Nguyen, T. V., Rivera, L. R., Brock, J. A. & Furness, J. B., 2014, In : British Journal of Pharmacology. 171, 5, p. 1275 - 1286 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

Ferrins, L., Gazdik, M., Rahmani, R. S., Varghese, S., Sykes, M. L., Jones, A. J., Avery, V. M., White, K. L., Ryan, E., Charman, S. A., Kaiser, M., Bergstrom, C. A. S. & Baell, J. B., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6393 - 6402 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-guided rescaffolding of selective antagonists of BCL-XL

Koehler, M. F. T., Bergeron, P., Choo, E. F., Lau, K., Ndubaku, C. O., Dudley, D. A., Gibbons, P., Sleebs, B., Rye, C. S., Nikolakopoulos, G., Bui, C. T., Kulasegaram, S., Kersten, W. J. A., Smith, B. J., Czabotar, P. E., Colman, P. M., Huang, D. CS., Baell, J. B., Watson, K. G., Hasvold, L. & 7 othersTao, Z-F., Wang, L., Souers, A. J., Elmore, S. W., Flygare, J. A., Fairbrother, W. J. & Lessene, G., 2014, In : A C S Medicinal Chemistry Letters. 5, 8, p. 662 - 667 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds

Baell, J. B., 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 39 - 55 17 p.

Research output: Contribution to journalArticleResearchpeer-review

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL

Sleebs, B., Kersten, W. J. A., Kulasegaram, S., Nikolakopoulos, G., Hatzis, E., Moss, R. M., Parisot, J. P., Yang, H., Czabotar, P. E., Fairlie, W. D., Lee, E. F., Adams, J. M., Chen, L., van Delft, M. F., Lowes, K. N., Wei, A., Huang, D. CS., Colman, P. M., Street, I. P., Baell, J. B. & 2 othersWatson, K. G. & Lessene, G., 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5514 - 5540 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery and human African trypanosomiasis: A disease less neglected?

Ferrins, L., Rahmani, R. S. & Baell, J. B., 2013, In : Future Medicinal Chemistry. 5, 15, p. 1801 - 1841 41 p.

Research output: Contribution to journalArticleResearchpeer-review

LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice

Li, R., Doherty, J., Antonipillai, J., Chen, S., Devlin, M. G., Visser, K., Baell, J. B., Street, I. P., Anderson, R. & Bernard, O., 2013, In : Clinical and Experimental Metastasis. 30, 4, p. 483 - 495 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Teguh, S., Klonis, N., Duffy, S., Lucantoni, L., Avery, V. M., Hutton, C. A., Baell, J. B. & Tilley, L., 2013, In : Journal of Medicinal Chemistry. 56, 15, p. 6200 - 6215 16 p.

Research output: Contribution to journalArticleResearchpeer-review

PAINS: Relevance to tool compound discovery and fragment-based screening

Baell, J. B., Ferrins, L., Falk, H. & Nikolakopoulos, G., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1483 - 1494 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Strategies for the development of conotoxins as new therapeutic leads

Brady, R., Baell, J. B. & Norton, R. S., 2013, In : Marine Drugs. 11, 7, p. 2293 - 2313 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Dror, R., Green, H. F., Valant, C., Borhani, D. W., Valcourt, J. R., Pan, A. C., Arlow, D. H., Canals, M., Lane, J. R. D., Rahmani, R. S., Baell, J. B., Sexton, P., Christopoulos, A. & Shaw, D. E., 2013, In : Nature. 503, 7475, p. 295 - 299 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-guided design of a selective BCL-XL inhibitor

Lessene, G., Czabotar, P. E., Sleebs, B., Zobel, K., Lowes, K., Adams, J. M., Baell, J. B., Colman, P. M., Deshayes, K., Fairbrother, W. J., Flygare, J. A., Gibbons, P., Kersten, W. J. A., Kulasegaram, S., Moss, R. M., Parisot, J. P., Smith, B. J., Street, I. P., Yang, H., Huang, D. CS. & 1 othersWatson, K. G., 2013, In : Nature Chemical Biology. 9, 6, p. 390 - 400 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Established and emerging trends in computational drug discovery in the structural genomics era

Taboureau, O., Baell, J. B., Fernandez-Recio, J. & Villoutreix, B. O., 2012, In : Chemistry and Biology. 19, 1, p. 29 - 41 13 p.

Research output: Contribution to journalArticleResearchpeer-review