Jonathan Baell

Professor

19982021
If you made any changes in Pure these will be visible here soon.

Research Output 1998 2019

2013

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Ask the experts: Past, present and future of the rule of five

Baell, J. B., Congreve, M., Leeson, P. & Abad-Zapatero, C., 2013, In : Future Medicinal Chemistry. 5, 7, p. 745 - 752 8 p.

Research output: Contribution to journalLetterOther

Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds

Baell, J. B., 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 39 - 55 17 p.

Research output: Contribution to journalArticleResearchpeer-review

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL

Sleebs, B., Kersten, W. J. A., Kulasegaram, S., Nikolakopoulos, G., Hatzis, E., Moss, R. M., Parisot, J. P., Yang, H., Czabotar, P. E., Fairlie, W. D., Lee, E. F., Adams, J. M., Chen, L., van Delft, M. F., Lowes, K. N., Wei, A., Huang, D. CS., Colman, P. M., Street, I. P., Baell, J. B. & 2 othersWatson, K. G. & Lessene, G., 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5514 - 5540 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery and human African trypanosomiasis: A disease less neglected?

Ferrins, L., Rahmani, R. S. & Baell, J. B., 2013, In : Future Medicinal Chemistry. 5, 15, p. 1801 - 1841 41 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

Avery, V. M., Buckner, F. S., Baell, J. B., Fairlamb, A. H., Michels, P. & Tarleton, R. L., 2013, In : Future Medicinal Chemistry. 5, 15, p. 1709 - 1718 10 p.

Research output: Contribution to journalLetterOther

LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice

Li, R., Doherty, J., Antonipillai, J., Chen, S., Devlin, M. G., Visser, K., Baell, J. B., Street, I. P., Anderson, R. & Bernard, O., 2013, In : Clinical and Experimental Metastasis. 30, 4, p. 483 - 495 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Teguh, S., Klonis, N., Duffy, S., Lucantoni, L., Avery, V. M., Hutton, C. A., Baell, J. B. & Tilley, L., 2013, In : Journal of Medicinal Chemistry. 56, 15, p. 6200 - 6215 16 p.

Research output: Contribution to journalArticleResearchpeer-review

PAINS: Relevance to tool compound discovery and fragment-based screening

Baell, J. B., Ferrins, L., Falk, H. & Nikolakopoulos, G., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1483 - 1494 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Strategies for the development of conotoxins as new therapeutic leads

Brady, R., Baell, J. B. & Norton, R. S., 2013, In : Marine Drugs. 11, 7, p. 2293 - 2313 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Dror, R., Green, H. F., Valant, C., Borhani, D. W., Valcourt, J. R., Pan, A. C., Arlow, D. H., Canals, M., Lane, J. R. D., Rahmani, R. S., Baell, J. B., Sexton, P., Christopoulos, A. & Shaw, D. E., 2013, In : Nature. 503, 7475, p. 295 - 299 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-guided design of a selective BCL-XL inhibitor

Lessene, G., Czabotar, P. E., Sleebs, B., Zobel, K., Lowes, K., Adams, J. M., Baell, J. B., Colman, P. M., Deshayes, K., Fairbrother, W. J., Flygare, J. A., Gibbons, P., Kersten, W. J. A., Kulasegaram, S., Moss, R. M., Parisot, J. P., Smith, B. J., Street, I. P., Yang, H., Huang, D. CS. & 1 othersWatson, K. G., 2013, In : Nature Chemical Biology. 9, 6, p. 390 - 400 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Erratum: Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors (Bioorganic and Medicinal Chemistry Letters (2011) 21 (5992-5994))

Sleebs, B. E., Nikolakopoulos, G., Street, I. P., Falk, H. & Baell, J. B., 1 Jan 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 755-757 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Established and emerging trends in computational drug discovery in the structural genomics era

Taboureau, O., Baell, J. B., Fernandez-Recio, J. & Villoutreix, B. O., 2012, In : Chemistry and Biology. 19, 1, p. 29 - 41 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign

Sykes, M. L., Baell, J. B., Kaiser, M., Chatelain, E., Moawad, S. R., Ganame, D., Ioset, J. R. & Avery, V. M., 2012, In : PLoS Neglected Tropical Diseases. 6, 11, 14 p., e1896.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

IP issues facing researchers by Gino D'Oca

Almarsson, O., Angiolini, M., Baell, J., Giardina, G., Ingham, A., Hughes, A., Pevarello, P. & Sindelar, R., 1 May 2012, In : Pharmaceutical Patent Analyst. 1, 2, p. 129-135 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Omega-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca v2.2 ion channels

Tranberg, C. E., Yang, A., Vetter, I., McArthur, J. R., Baell, J. B., Lewis, R. J., Tuck, K. L. & Duggan, P., 2012, In : Marine Drugs. 10, 10, p. 2349 - 2368 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sites of action of ghrelin receptor ligands in cardiovascular control

Callaghan, B., Hunne, B., Hirayama, H., Sartor, D. M., Nguyen, T. V., Abogadie, F. C., Ferens, D. M., McIntyre, P. B., Ban, K., Baell, J. B., Furness, J. B. & Brock, J. A., 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 8, p. 1011 - 1021 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of conformationally constrained benzoylureas as BH3-mimetics

Brady, R., Hatzis, E., Connor, T., Street, I. P., Baell, J. B. & Lessene, G., 2012, In : Organic and Biomolecular Chemistry. 10, 27, p. 5230 - 5237 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets

Falk, H., Connor, T., Yang, H., Loft, K. J., Alcindor, J. L., Nikolakopoulos, G., Surjadi, R. N., Bentley, J. D., Hattarki, M., Dolezal, O., Murphy, J. M., Monahan, B., Peat, T., Thomas, T., Baell, J. B., Parisot, J. P. & Street, I. P., 2011, In : Journal of Biomolecular Screening. 16, 10, p. 1196 - 1205 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Benzoylureas as removable cis amide inducers: Synthesis of cyclic amides via ring closing metathesis (RCM)

Brady, R., Khakham, Y., Lessene, G. & Baell, J. B., 2011, In : Organic and Biomolecular Chemistry. 9, 3, p. 656 - 658 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

Sleebs, B., Ganame, D., Levit, A., Street, I., Gregg, A., Falk, H. & Baell, J., 2011, In : MedChemComm. 2, p. 982 - 986 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

Sleebs, B., Levit, A., Street, I. P., Falk, H., Hammonds, T. R., Wong, A. C., Charles, M. D., Olson, M. F. & Baell, J. B., 2011, In : MedChemComm. 2, 10, p. 977 - 981 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

Sleebs, B., Nikolakopoulos, G., Street, I. P., Falk, H. & Baell, J. B., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 19, p. 5992 - 5994 3 p.

Research output: Contribution to journalArticleResearchpeer-review

KNIME workflow to assess PAINS filters in SMARTS format. Comparison of RDKit and indigo cheminformatics libraries

Saubern, S., Guha, R. & Baell, J. B., 2011, In : Molecular Informatics. 30, 10, p. 847 - 850 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Sleebs, B., Czabotar, P. E., Fairbrother, W. J., Fairlie, W. D., Flygare, J. A., Huang, D. CS., Kersten, W. J. A., Koehler, M. F. T., Lessene, G., Lowes, K. N., Parisot, J. P., Smith, B. J., Smith, M. L., Souers, A. J., Street, I. P., Yang, H. & Baell, J. B., 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1914 - 1926 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Redox-active nuisance screening compounds and their classification

Baell, J. B., 2011, In : Drug Discovery Today. 16, 17, p. 840 - 841 2 p.

Research output: Contribution to journalArticleResearchpeer-review

The FAF-Drugs2 server: A multistep engine to prepare electronic chemical compound collections

Lagorce, D., Maupetit, J., Baell, J. B., Sperandio, O., Tuffery, P., Miteva, M. A., Galons, H. & Villoutreix, B. O., 2011, In : Bioinformatics. 27, 14, p. 2018 - 2020 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

Ban, K., Duffy, S., Khakham, Y., Avery, V., Hughes, A., Montagnat, O., Katneni, K., Ryan, E. & Baell, J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6024 - 6029 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

Nhu, D. Q., Duffy, S., Avery, V. M., Hughes, A. B. & Baell, J. B., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 15, p. 4496 - 4498 3 p.

Research output: Contribution to journalArticleResearchpeer-review

De novo synthesis of a potent LIMK1 inhibitor

Sleebs, B., Street, I. P., Bu, X. & Baell, J. B., 2010, In : Synthesis-Stuttgart. 7, p. 1091 - 1096 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi

Holloway, G. A., Parisot, J. P., Novello, P. M., Watson, K. G., Armstrong, T., Thompson, R. C. A., Street, I. P. & Baell, J. B., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 1816 - 1818 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library

Lackovic, K. P., Parisot, J. P., Sleebs, N., Baell, J. B., Debien, L., Watson, K. G., Curtis, J., Handman, E., Street, I. P. & Kedzierski, L., 2010, In : Antimicrobial Agents and Chemotherapy. 54, 5, p. 1712 - 1719 8 p.

Research output: Contribution to journalArticleResearchpeer-review

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

Baell, J. B. & Holloway, G. A., 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2719 - 2740 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Observations on screening-based research and some concerning trends in the literature

Baell, J. B., 2010, In : Future Medicinal Chemistry. 2, 10, p. 1529 - 1546 18 p.

Research output: Contribution to journalArticleResearchpeer-review

The cooperative research centre for cancer therapeutics: Bridging the gap between leading cancer research at Australias universities and developing novel cancer drugs

Baell, J. B., Heathers, G. & Sage, C., Jun 2010, In : Future Medicinal Chemistry. 2, 6, p. 941-947 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

Lessene, G., Smith, B. J., Gable, R. W. & Baell, J. B., 2009, In : Journal of Organic Chemistry. 74, 17, p. 6511 - 6525 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of destructive autoimmune arthritis in FcgRIIa transgenic mice by small chemical entities

Pietersz, G. A., Mottram, P. L., van de Velde, N. C., Sardjono, C. T., Esparon, S. E., Ramsland, P. A., Moloney, G., Baell, J. B., McCarthy, T. D., Matthews, B. R., Powell, M. & Hogarth, P. M., 2009, In : Immunology and Cell Biology. 87, 1, p. 3 - 12 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Omega-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine

Andersson, A., Baell, J. B., Duggan, P., Graham, J. E., Lewis, R. J., Lumsden, N. G., Tranberg, C. E., Tuck, K. L. & Yang, A., 2009, In : Bioorganic & Medicinal Chemistry. 17, p. 6659 - 6670 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

Holloway, G. A., Charman, W. N., Fairlamb, A. H., Brun, R., Kaiser, M., Kostewicz, E. S., Novello, P. M., Parisot, J. P., Richardson, J., Street, I. P., Watson, K. G. & Baell, J. B., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2824 - 2833 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Synthesis and Biological Evaluation of Chalcones as Inhibitors of the Voltage-Gated Potassium Channel Kv1.3

Cianci, J., Baell, J. B., Flynn, B. L., Gable, R. W., Mould, J., Paul, D. & Harvey, A. J., 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 6, p. 2055 - 2061 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

Holloway, G. A., Baell, J. B., Fairlamb, A. H., Novello, P. M., Parisot, J. P., Richardson, J., Watson, K. G. & Street, I. P., 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1422 - 1427 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of compounds that influence I K (KCNN4) channels on afterhyperpolarizing potentials, and determination of I K channel sequence, in guinea pig enteric neurons

Nguyen, T. V., Matsuyama, H., Baell, J. B., Hunne, B. L., Fowler, C. J., Smith, J. E., Nurgali, K. & Furness, J. B., 2007, In : Journal of Neurophysiology. 97, 3, p. 2024 - 2031 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of modulators of Ca 2+-activated, intermediate- conductance potassium channels on motility of the rat small intestine, in vivo

Ferens, D. M., Baell, J. B., Lessene, G., Smith, J. E. & Furness, J. B., 2007, In : Neurogastroenterology and Motility. 19, 5, p. 383 - 389 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids

Cianci, J., Baell, J. B. & Harvey, A. J., 2007, In : Tetrahedron Letters. 48, 34, p. 5973 - 5975 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

Hirokawa, Y., Levitzki, A., Lessene, G., Baell, J. B., Xiao, Y., Zhu, H-J. & Maruta, H., 2007, In : Cancer Letters. 245, 1, p. 242 - 251 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases

Rye, C. S., Baell, J. B. & Street, I. P., 2007, In : Tetrahedron. 63, 16, p. 3306 - 3311 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone

Harvey, A. J., Baell, J. B., Toovey, N., Homerick, D. & Wulff, H., 2006, In : Journal of Medicinal Chemistry. 49, 4, p. 1433 - 1441 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of -conotoxin GVIA

Baell, J. B., Duggan, P. J., Forsyth, S. A., Lewis, R. J., Lok, Y. P., Schroeder, C. I. & Shepherd, N. E., 2006, In : Tetrahedron. 62, 31, p. 7284 - 7292 9 p.

Research output: Contribution to journalArticleResearchpeer-review