Research Output 1999 2018

2018
Open Access
File
2017

8-Mercaptoguanine derivatives as inhibitors of dihydropteroate synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 2017 (Accepted/In press) In : Chemistry-A European Journal. 10 p.

Research output: Research - peer-reviewArticle

Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity

Gilson, P. R., Tan, C., Jarman, K. E., Lowes, K. N., Curtis, J. M., Nguyen, W., Di Rago, A. E., Bullen, H. E., Prinz, B., Duffy, S., Baell, J. B., Hutton, C. A., Jousset Subroux, H., Crabb, B. S., Avery, V. M., Cowman, A. F. & Sleebs, B. E. 9 Feb 2017 In : Journal of Medicinal Chemistry. 60, 3, p. 1171-1188 18 p.

Research output: Research - peer-reviewArticle

2016

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B. 9 Jun 2016 In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Research - peer-reviewArticle

A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner

Sutton, S. K., Carter, D. R., Kim, P., Tan, O., Arndt, G. M., Zhang, X. D., Baell, J., Noll, B. D., Wang, S., Kumar, N., McArthur, G. A., Cheung, B. B. & Marshall, G. M. 1 Aug 2016 In : OncoTarget. 7, 32, p. 52166-52178 13 p.

Research output: Research - peer-reviewArticle

Open Access

Feeling nature's PAINS: natural products, natural product drugs, and Pan Assay Interference Compounds (PAINS)

Baell, J. B. 25 Mar 2016 In : Journal of Natural Products. 79, 3, p. 616-628 13 p.

Research output: Research - peer-reviewReview Article

Histone acetyltransferase inhibitors: Where art thou?

Baell, J. B. & Miao, W. 1 Sep 2016 In : Future Medicinal Chemistry. 8, 13, p. 1525-1528 4 p.

Research output: Other - peer-reviewEditorial

Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides

Russell, S. , Rahmani, R. , Jones, A. J. , Newson, H. L. , Neilde, K. , Cotillo, I. , Rahmani Khajouei, M. , Ferrins, L. , Qureishi, S. , Nguyen, N. , Martinez-Martinez, M. S. , Weaver, D. F. , Kaiser, M. , Riley, J. , Thomas, J. , De Rycker, M. , Read, K. D. , Flematti, G. R. , Ryan, E. , Tanghe, S. & 6 others Rodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M. J. 10 Nov 2016 In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

Research output: Research - peer-reviewArticle

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Stoessel, D., Nowell, C. J., Jones, A. J., Ferrins, L., Ellis, K. M., Riley, J., Rahmani, R., Read, K. D., McConville, M. J., Avery, V. M., Baell, J. B. & Creek, D. J. 1 Jul 2016 In : Metabolomics. 12, 7, 14 p., 126

Research output: Research - peer-reviewArticle

New synthetic approaches towards analogues of bedaquiline

Priebbenow, D. L., Barbaro, L. & Baell, J. B. 28 Oct 2016 In : Organic and Biomolecular Chemistry. 14, 40, p. 9622-9628 7 p.

Research output: Research - peer-reviewArticle

Open source drug discovery: Highly potent antimalarial compounds derived from the tres cantos arylpyrroles

Williamson, A. E. , Ylioja, P. M. , Robertson, M. N. , Antonova-Koch, Y. , Avery, V. , Baell, J. , Batchu, H. , Batra, S. , Burrows, J. N. , Bhattacharyya, S. , Calderon, F. , Charman, S. , Clark, J. , Crespo, B. , Dean, M. , Debbert, S. L. , Delves, M. J. , Dennis, A. S. M. , Deroose, F. , Duffy, S. & 3 others Ryan, E., Wells, T. & White, K. 26 Oct 2016 In : ACS Central Science. 2, 10, p. 687-701 15 p.

Research output: Research - peer-reviewArticle

Open Access

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S. 1 Mar 2016 In : FEBS Letters. 590, 6, p. 696-704 9 p.

Research output: Research - peer-reviewArticle

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

Pasaje, C. F. A., Cheung, V., Kennedy, K., Lim, E. E., Baell, J. B., Griffin, M. D. W. & Ralph, S. A. 9 Jun 2016 In : Scientific Reports. 6, 13 p., 27531

Research output: Research - peer-reviewArticle

Open Access
File

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

Preston, S., Luo, J., Zhang, Y., Jabbar, A., Crawford, S., Baell, J., Hofmann, A., Hu, M., Zhou, H-B. & Gasser, R. B. 16 Jun 2016 In : Parasites and Vectors. 9, 1, 11 p., 346

Research output: Research - peer-reviewArticle

Open Access
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Structural basis for the selective binding of inhibitors to 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus and Escherichia coli

Dennis, M. L., Pitcher, N. P., Lee, M. D., Debono, A. J., Wang, Z-C., Harjani, J. R., Rahmani, R., Cleary, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 9 Jun 2016 In : Journal of Medicinal Chemistry. 59, 11, p. 5248-5263 16 p.

Research output: Research - peer-reviewArticle

Truncated latrunculins as actin inhibitors targeting Plasmodium falciparum motility and host cell invasion

Johnson, S., Rahmani, R., Drew, D. R., Williams, M. J., Wilkinson, M. I., Tan, Y. H., Huang, J. X., Tonkin, C. J., Beeson, J., Baum, J., Smith, B. J. & Baell, J. 22 Dec 2016 In : Journal of Medicinal Chemistry. 59, 24, p. 10994-11005 12 p.

Research output: Research - peer-reviewArticle

2015

6-arylpyrazine-2-carboxamides: a new core for Trypanosoma brucei inhibitors

Rahmani, R., Ban, K., Jones, A. J., Ferrins, L., Ganame, D., Sykes, M. L., Avery, V. M., White, K. L., Ryan, E., Kaiser, M., Charman, S. A. & Baell, J. B. 2015 In : Journal of Medicinal Chemistry. 58, 17, p. 6753-6765 13 p.

Research output: Research - peer-reviewArticle

A practical Java tool for small-molecule compound appraisal

Amani, P., Sneyd, T., Preston, S., Young, N. D., Mason, L., Bailey, U-M., Baell, J. B., Camp, D. G., Gasser, R. B., Gorse, A-D., Taylor, P. R. & Hofmann, A. 2015 In : Journal of Cheminformatics. 7, 1, 4 p., 28

Research output: Research - peer-reviewArticle

Open Access
File

Corrigendum: The promise and peril of chemical probes

Arrowsmith, C. H. , Audia, J. E. , Austin, C. , Baell, J. , Bennett, J. , Blagg, J. , Bountra, C. , Brennan, P. E. , Brown, P. J. , Bunnage, M. E. , Buser-Doepner, C. , Campbell, R. M. , Carter, A. J. , Cohen, P. , Copeland, R. A. , Cravatt, B. , Dahlin, J. L. , Dhanak, D. , Edwards, A. M. , Frederiksen, M. & 34 others Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Ross, R., Roth, B., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J. 20 Oct 2015 In : Nature Chemical Biology. 11, 11, p. 887 1 p.

Research output: Other - peer-reviewComment / Debate

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

Baker, M. A., Weinberg, A. S., Hetherington, L., Villaverde, A-I., Velkov, T., Baell, J. B. & Gordon, C. P. 2015 In : Biology of Reproduction. 92, 4, p. 1 - 10 10 p.

Research output: Research - peer-reviewArticle

FAF-Drugs3: a web server for compound property calculation and chemical library design

Lagorce, D., Sperandio, O., Baell, J. B., Miteva, M. A. & Villoutreix, B. O. 1 Jul 2015 In : Nucleic Acids Research. 43, W1, p. W200-W207 8 p.

Research output: Research - peer-reviewArticle

Open Access
File

Low cost whole-organism screening of compounds for anthelmintic activity

Preston, S., Jabbar, A., Nowell, C. J., Joachim, A., Ruttkowski, B., Baell, J. B., Cardno, T., Korhonen, P. K., Piedrafita, D. M., Ansell, B. R. E., Jex, A. R., Hofmann, A. & Gasser, R. B. 2015 In : International Journal for Parasitology. 45, 5, p. 333 - 343 11 p.

Research output: Research - peer-reviewArticle

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M. 2015 In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Research - peer-reviewArticle

Regio- and stereoselective iodoacyloxylations of alkynes

Priebbenow, D., Gable, R. W. & Baell, J. B. 2015 In : Journal of Organic Chemistry. 80, 9, p. 4412 - 4418 7 p.

Research output: Research - peer-reviewArticle

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., Avery, V. M. & Payne, R. J. 2015 In : MedChemComm. 6, 3, p. 403 - 406 4 p.

Research output: Other - peer-reviewArticle

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., Buser-Doepner, C., Campbell, R. M., Carter, A. J., Cohen, P., Copeland, R. A., Cravatt, B., Dahlin, J. L., Dhanak, D., Edwards, A. M. & Frye, S. V. 21 Jul 2015 In : Nature Chemical Biology. 11, 8, p. 536-541 6 p.

Research output: Research - peer-reviewComment / Debate

2014

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S. 2014 In : Chemical Biology and Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Research - peer-reviewArticle

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B. 2014 In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Research - peer-reviewArticle

A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research-eighteen million assays and counting

Lackovic, K. P., Lessene, G., Falk, H., Leuchowius, K-J., Baell, J. B. & Street, I. P. 2014 In : Combinatorial Chemistry and High Throughput Screening. 17, 3, p. 241 - 252 12 p.

Research output: OtherLetter

Chemical con artists foil drug discovery

Baell, J. B. & Walters, M. A. 2014 In : Nature. 513, 7519, p. 481-483 3 p.

Research output: Research - peer-reviewComment / Debate

De-novo designed library of benzoylureas as inhibitors of BCL-XL: Synthesis, structural and biochemical characterization

Brady, R., Vom, A., Roy, M. J., Toovey, N., Smith, B. J., Moss, R. M., Hatzis, E., Huang, D. C. S., Parisot, J. P., Yang, H., Street, I. P., Colman, P. M., Czabotar, P. E., Baell, J. B. & Lessene, G. 2014 In : Journal of Medicinal Chemistry. 57, 4, p. 1323 - 1343 21 p.

Research output: Research - peer-reviewArticle

Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei

Rashad, A. A., Jones, A. J., Avery, V. M., Baell, J. B. & Keller, P. A. 2014 In : A C S Medicinal Chemistry Letters. 5, 5, p. 496 - 500 5 p.

Research output: Research - peer-reviewArticle

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

Callaghan, B., Kosari, S., Pustovit, R. V., Sartor, D. M., Ferens, D. M., Ban, K., Baell, J. B., Nguyen, T. V., Rivera, L. R., Brock, J. A. & Furness, J. B. 2014 In : British Journal of Pharmacology. 171, 5, p. 1275 - 1286 12 p.

Research output: Research - peer-reviewArticle

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

Ferrins, L., Gazdik, M., Rahmani, R. S., Varghese, S., Sykes, M. L., Jones, A. J., Avery, V. M., White, K. L., Ryan, E., Charman, S. A., Kaiser, M., Bergstrom, C. A. S. & Baell, J. B. 2014 In : Journal of Medicinal Chemistry. 57, 15, p. 6393 - 6402 10 p.

Research output: Research - peer-reviewArticle

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 2014 In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Research - peer-reviewArticle

Structure-guided rescaffolding of selective antagonists of BCL-XL

Koehler, M. F. T. , Bergeron, P. , Choo, E. F. , Lau, K. , Ndubaku, C. O. , Dudley, D. A. , Gibbons, P. , Sleebs, B. , Rye, C. S. , Nikolakopoulos, G. , Bui, C. T. , Kulasegaram, S. , Kersten, W. J. A. , Smith, B. J. , Czabotar, P. E. , Colman, P. M. , Huang, D. C. S. , Baell, J. B. , Watson, K. G. , Hasvold, L. & 7 others Tao, Z-F., Wang, L., Souers, A. J., Elmore, S. W., Flygare, J. A., Fairbrother, W. J. & Lessene, G. 2014 In : A C S Medicinal Chemistry Letters. 5, 8, p. 662 - 667 6 p.

Research output: Research - peer-reviewArticle

2013

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B. 2013 In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Research - peer-reviewArticle

Ask the experts: Past, present and future of the rule of five

Baell, J. B., Congreve, M., Leeson, P. & Abad-Zapatero, C. 2013 In : Future Medicinal Chemistry. 5, 7, p. 745 - 752 8 p.

Research output: OtherLetter

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B. 2013 In : Bioorganic & Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Other - peer-reviewArticle

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL

Sleebs, B. , Kersten, W. J. A. , Kulasegaram, S. , Nikolakopoulos, G. , Hatzis, E. , Moss, R. M. , Parisot, J. P. , Yang, H. , Czabotar, P. E. , Fairlie, W. D. , Lee, E. F. , Adams, J. M. , Chen, L. , van Delft, M. F. , Lowes, K. N. , Wei, A. , Huang, D. C. S. , Colman, P. M. , Street, I. P. , Baell, J. B. & 2 others Watson, K. G. & Lessene, G. 2013 In : Journal of Medicinal Chemistry. 56, 13, p. 5514 - 5540 27 p.

Research output: Research - peer-reviewArticle

Drug discovery and human African trypanosomiasis: A disease less neglected?

Ferrins, L., Rahmani, R. S. & Baell, J. B. 2013 In : Future Medicinal Chemistry. 5, 15, p. 1801 - 1841 41 p.

Research output: Research - peer-reviewArticle

Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

Avery, V. M., Buckner, F. S., Baell, J. B., Fairlamb, A. H., Michels, P. & Tarleton, R. L. 2013 In : Future Medicinal Chemistry. 5, 15, p. 1709 - 1718 10 p.

Research output: OtherLetter

LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice

Li, R., Doherty, J., Antonipillai, J., Chen, S., Devlin, M. G., Visser, K., Baell, J. B., Street, I. P., Anderson, R. & Bernard, O. 2013 In : Clinical and Experimental Metastasis. 30, 4, p. 483 - 495 13 p.

Research output: Research - peer-reviewArticle

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Teguh, S., Klonis, N., Duffy, S., Lucantoni, L., Avery, V. M., Hutton, C. A., Baell, J. B. & Tilley, L. 2013 In : Journal of Medicinal Chemistry. 56, 15, p. 6200 - 6215 16 p.

Research output: Research - peer-reviewArticle

PAINS: Relevance to tool compound discovery and fragment-based screening

Baell, J. B., Ferrins, L., Falk, H. & Nikolakopoulos, G. 2013 In : Australian Journal of Chemistry. 66, 12, p. 1483 - 1494 12 p.

Research output: Research - peer-reviewArticle

Strategies for the development of conotoxins as new therapeutic leads

Brady, R., Baell, J. B. & Norton, R. S. 2013 In : Marine Drugs. 11, 7, p. 2293 - 2313 21 p.

Research output: Research - peer-reviewArticle

Open Access