Jonathan Baell

Professor

19992021
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Research Output 1999 2018

2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 6 Feb 2018 In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

Nguyen, N., Wilson, D. W., Nagalingam, G., Triccas, J. A., Schneider, E. K., Li, J., Velkov, T. & Baell, J. 25 Mar 2018 In : European Journal of Medicinal Chemistry. 148, p. 507-518 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A. 1 Mar 2018 In : Antiviral Research. 151, p. 8-19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B. 31 May 2017 In : Parasites and Vectors. 10, 1, 272

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity

Gilson, P. R., Tan, C., Jarman, K. E., Lowes, K. N., Curtis, J. M., Nguyen, W., Di Rago, A. E., Bullen, H. E., Prinz, B., Duffy, S., Baell, J. B., Hutton, C. A., Jousset Subroux, H., Crabb, B. S., Avery, V. M., Cowman, A. F. & Sleebs, B. E. 9 Feb 2017 In : Journal of Medicinal Chemistry. 60, 3, p. 1171-1188 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes

Preston, S., Jiao, Y., Baell, J. B., Keiser, J., Crawford, S., Koehler, A. V., Wang, T., Simpson, M. M., Kaplan, R. M., Cowley, K. J., Simpson, K. J., Hofmann, A., Jabbar, A. & Gasser, R. B. 1 Dec 2017 In : International Journal for Parasitology: Drugs and Drug Resistance. 7, 3, p. 286-294 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B. 9 Jun 2016 In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner

Sutton, S. K., Carter, D. R., Kim, P., Tan, O., Arndt, G. M., Zhang, X. D., Baell, J., Noll, B. D., Wang, S., Kumar, N., McArthur, G. A., Cheung, B. B. & Marshall, G. M. 1 Aug 2016 In : Oncotarget. 7, 32, p. 52166-52178 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Feeling nature's PAINS: natural products, natural product drugs, and Pan Assay Interference Compounds (PAINS)

Baell, J. B. 25 Mar 2016 In : Journal of Natural Products. 79, 3, p. 616-628 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Histone acetyltransferase inhibitors: Where art thou?

Baell, J. B. & Miao, W. 1 Sep 2016 In : Future Medicinal Chemistry. 8, 13, p. 1525-1528 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides

Russell, S. , Rahmani, R. , Jones, A. J. , Newson, H. L. , Neilde, K. , Cotillo, I. , Rahmani Khajouei, M. , Ferrins, L. , Qureishi, S. , Nguyen, N. , Martinez-Martinez, M. S. , Weaver, D. F. , Kaiser, M. , Riley, J. , Thomas, J. , De Rycker, M. , Read, K. D. , Flematti, G. R. , Ryan, E. , Tanghe, S. & 6 others Rodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M. J. 10 Nov 2016 In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Stoessel, D., Nowell, C. J., Jones, A. J., Ferrins, L., Ellis, K. M., Riley, J., Rahmani, R., Read, K. D., McConville, M. J., Avery, V. M., Baell, J. B. & Creek, D. J. 1 Jul 2016 In : Metabolomics. 12, 7, 14 p., 126

Research output: Contribution to journalArticleResearchpeer-review

New synthetic approaches towards analogues of bedaquiline

Priebbenow, D. L., Barbaro, L. & Baell, J. B. 28 Oct 2016 In : Organic and Biomolecular Chemistry. 14, 40, p. 9622-9628 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open source drug discovery: Highly potent antimalarial compounds derived from the tres cantos arylpyrroles

Williamson, A. E. , Ylioja, P. M. , Robertson, M. N. , Antonova-Koch, Y. , Avery, V. , Baell, J. , Batchu, H. , Batra, S. , Burrows, J. N. , Bhattacharyya, S. , Calderon, F. , Charman, S. , Clark, J. , Crespo, B. , Dean, M. , Debbert, S. L. , Delves, M. J. , Dennis, A. S. M. , Deroose, F. , Duffy, S. & 3 others Ryan, E., Wells, T. & White, K. 26 Oct 2016 In : ACS Central Science. 2, 10, p. 687-701 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S. 1 Mar 2016 In : FEBS Letters. 590, 6, p. 696-704 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

Pasaje, C. F. A., Cheung, V., Kennedy, K., Lim, E. E., Baell, J. B., Griffin, M. D. W. & Ralph, S. A. 9 Jun 2016 In : Scientific Reports. 6, 13 p., 27531

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

Preston, S., Luo, J., Zhang, Y., Jabbar, A., Crawford, S., Baell, J., Hofmann, A., Hu, M., Zhou, H-B. & Gasser, R. B. 16 Jun 2016 In : Parasites and Vectors. 9, 1, 11 p., 346

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural basis for the selective binding of inhibitors to 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus and Escherichia coli

Dennis, M. L., Pitcher, N. P., Lee, M. D., Debono, A. J., Wang, Z-C., Harjani, J. R., Rahmani, R., Cleary, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 9 Jun 2016 In : Journal of Medicinal Chemistry. 59, 11, p. 5248-5263 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of 3-(alkylamino)-, 3-(alkoxy)-, 3-(aryloxy)-, 3-(alkylthio)-, and 3-(arylthio)-1,2,4-triazines by using a unified route with 3-(methylsulfonyl)-1,2,4-triazine

Shi, D. H., Harjani, J. R., Gable, R. W. & Baell, J. B. 1 Jun 2016 In : European Journal of Organic Chemistry. 2016, 16, p. 2842-2850 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Truncated latrunculins as actin inhibitors targeting Plasmodium falciparum motility and host cell invasion

Johnson, S., Rahmani, R., Drew, D. R., Williams, M. J., Wilkinson, M. I., Tan, Y. H., Huang, J. X., Tonkin, C. J., Beeson, J., Baum, J., Smith, B. J. & Baell, J. 22 Dec 2016 In : Journal of Medicinal Chemistry. 59, 24, p. 10994-11005 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

6-arylpyrazine-2-carboxamides: a new core for Trypanosoma brucei inhibitors

Rahmani, R., Ban, K., Jones, A. J., Ferrins, L., Ganame, D., Sykes, M. L., Avery, V. M., White, K. L., Ryan, E., Kaiser, M., Charman, S. A. & Baell, J. B. 2015 In : Journal of Medicinal Chemistry. 58, 17, p. 6753-6765 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A practical Java tool for small-molecule compound appraisal

Amani, P., Sneyd, T., Preston, S., Young, N. D., Mason, L., Bailey, U-M., Baell, J. B., Camp, D. G., Gasser, R. B., Gorse, A-D., Taylor, P. R. & Hofmann, A. 2015 In : Journal of Cheminformatics. 7, 1, 4 p., 28

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Corrigendum: The promise and peril of chemical probes

Arrowsmith, C. H. , Audia, J. E. , Austin, C. , Baell, J. , Bennett, J. , Blagg, J. , Bountra, C. , Brennan, P. E. , Brown, P. J. , Bunnage, M. E. , Buser-Doepner, C. , Campbell, R. M. , Carter, A. J. , Cohen, P. , Copeland, R. A. , Cravatt, B. , Dahlin, J. L. , Dhanak, D. , Edwards, A. M. , Frederiksen, M. & 34 others Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Ross, R., Roth, B., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J. 20 Oct 2015 In : Nature Chemical Biology. 11, 11, p. 887 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

Baker, M. A., Weinberg, A. S., Hetherington, L., Villaverde, A-I., Velkov, T., Baell, J. B. & Gordon, C. P. 2015 In : Biology of Reproduction. 92, 4, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

FAF-Drugs3: a web server for compound property calculation and chemical library design

Lagorce, D., Sperandio, O., Baell, J. B., Miteva, M. A. & Villoutreix, B. O. 1 Jul 2015 In : Nucleic Acids Research. 43, W1, p. W200-W207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Low cost whole-organism screening of compounds for anthelmintic activity

Preston, S., Jabbar, A., Nowell, C. J., Joachim, A., Ruttkowski, B., Baell, J. B., Cardno, T., Korhonen, P. K., Piedrafita, D. M., Ansell, B. R. E., Jex, A. R., Hofmann, A. & Gasser, R. B. 2015 In : International Journal for Parasitology. 45, 5, p. 333 - 343 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M. 2015 In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Regio- and stereoselective iodoacyloxylations of alkynes

Priebbenow, D., Gable, R. W. & Baell, J. B. 2015 In : Journal of Organic Chemistry. 80, 9, p. 4412 - 4418 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Screening-based translation of public research encounters painful problems

Baell, J. B. 2015 In : A C S Medicinal Chemistry Letters. 6, 3, p. 229 - 234 6 p.

Research output: Contribution to journalLetterOther

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., Avery, V. M. & Payne, R. J. 2015 In : MedChemComm. 6, 3, p. 403 - 406 4 p.

Research output: Contribution to journalArticleOtherpeer-review

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., Buser-Doepner, C., Campbell, R. M., Carter, A. J., Cohen, P., Copeland, R. A., Cravatt, B., Dahlin, J. L., Dhanak, D., Edwards, A. M. & Frye, S. V. 21 Jul 2015 In : Nature Chemical Biology. 11, 8, p. 536-541 6 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

2014

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S. 2014 In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B. 2014 In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research-eighteen million assays and counting

Lackovic, K. P., Lessene, G., Falk, H., Leuchowius, K-J., Baell, J. B. & Street, I. P. 2014 In : Combinatorial Chemistry and High Throughput Screening. 17, 3, p. 241 - 252 12 p.

Research output: Contribution to journalLetterOther

Chemical con artists foil drug discovery

Baell, J. B. & Walters, M. A. 2014 In : Nature. 513, 7519, p. 481-483 3 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

De-novo designed library of benzoylureas as inhibitors of BCL-XL: Synthesis, structural and biochemical characterization

Brady, R., Vom, A., Roy, M. J., Toovey, N., Smith, B. J., Moss, R. M., Hatzis, E., Huang, D. CS., Parisot, J. P., Yang, H., Street, I. P., Colman, P. M., Czabotar, P. E., Baell, J. B. & Lessene, G. 2014 In : Journal of Medicinal Chemistry. 57, 4, p. 1323 - 1343 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei

Rashad, A. A., Jones, A. J., Avery, V. M., Baell, J. B. & Keller, P. A. 2014 In : A C S Medicinal Chemistry Letters. 5, 5, p. 496 - 500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

Callaghan, B., Kosari, S., Pustovit, R. V., Sartor, D. M., Ferens, D. M., Ban, K., Baell, J. B., Nguyen, T. V., Rivera, L. R., Brock, J. A. & Furness, J. B. 2014 In : British Journal of Pharmacology. 171, 5, p. 1275 - 1286 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

Ferrins, L., Gazdik, M., Rahmani, R. S., Varghese, S., Sykes, M. L., Jones, A. J., Avery, V. M., White, K. L., Ryan, E., Charman, S. A., Kaiser, M., Bergstrom, C. A. S. & Baell, J. B. 2014 In : Journal of Medicinal Chemistry. 57, 15, p. 6393 - 6402 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 2014 In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-guided rescaffolding of selective antagonists of BCL-XL

Koehler, M. F. T. , Bergeron, P. , Choo, E. F. , Lau, K. , Ndubaku, C. O. , Dudley, D. A. , Gibbons, P. , Sleebs, B. , Rye, C. S. , Nikolakopoulos, G. , Bui, C. T. , Kulasegaram, S. , Kersten, W. J. A. , Smith, B. J. , Czabotar, P. E. , Colman, P. M. , Huang, D. CS. , Baell, J. B. , Watson, K. G. , Hasvold, L. & 7 others Tao, Z-F., Wang, L., Souers, A. J., Elmore, S. W., Flygare, J. A., Fairbrother, W. J. & Lessene, G. 2014 In : A C S Medicinal Chemistry Letters. 5, 8, p. 662 - 667 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B. 2013 In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Ask the experts: Past, present and future of the rule of five

Baell, J. B., Congreve, M., Leeson, P. & Abad-Zapatero, C. 2013 In : Future Medicinal Chemistry. 5, 7, p. 745 - 752 8 p.

Research output: Contribution to journalLetterOther

Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds

Baell, J. B. 2013 In : Journal of Chemical Information and Modeling. 53, 1, p. 39 - 55 17 p.

Research output: Contribution to journalArticleResearchpeer-review

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B. 2013 In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL

Sleebs, B. , Kersten, W. J. A. , Kulasegaram, S. , Nikolakopoulos, G. , Hatzis, E. , Moss, R. M. , Parisot, J. P. , Yang, H. , Czabotar, P. E. , Fairlie, W. D. , Lee, E. F. , Adams, J. M. , Chen, L. , van Delft, M. F. , Lowes, K. N. , Wei, A. , Huang, D. CS. , Colman, P. M. , Street, I. P. , Baell, J. B. & 2 others Watson, K. G. & Lessene, G. 2013 In : Journal of Medicinal Chemistry. 56, 13, p. 5514 - 5540 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery and human African trypanosomiasis: A disease less neglected?

Ferrins, L., Rahmani, R. S. & Baell, J. B. 2013 In : Future Medicinal Chemistry. 5, 15, p. 1801 - 1841 41 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

Avery, V. M., Buckner, F. S., Baell, J. B., Fairlamb, A. H., Michels, P. & Tarleton, R. L. 2013 In : Future Medicinal Chemistry. 5, 15, p. 1709 - 1718 10 p.

Research output: Contribution to journalLetterOther