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Jonathan Baell

Professor

19982021
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Personal profile

Biography

Position

Larkins Fellow
NHMRC Principal Research Fellow
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences

 

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Research interests

  • Molecular design
  • Peptidomimetics
  • Small molecule screening libraries and chemoinformatics
  • Hit-to-lead and lead optimisation medicinal chemistry
  • Drug discovery in infectious disease (particularly neglected diseases including malaria) and epigenetic modulation associated with cancer
  • Pre-clinical development of new drug candidates

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Projects 2012 2021

Small molecule Inhibitors of glutathione transferase omega 1-1 (GSTO1-1) for the treatment of inflammatory disease

Baell, J. B., Board, P., Oakley, A. J., Casarotto, M. & Mujumdar, P. P.

1/01/19 → 31/12/21

Project: Research

Prodrug Development of Biased N-Alkylpyridazinones for the Acute Intravenous Treatment of Myocardial Ischaemia-Reperfusion Injury

Baell, J. B., Ritchie, R. H., Kirkpatrick, C. M. J., Figtree, G., Deora, G. S. & Qin, C.

1/01/19 → 31/12/20

Project: Research

New Treatments for Chagas Disease

Baell, J. B. & Kelly, J.

1/01/19 → 31/12/21

Project: Research

Transactivation of RAGE: a novel therapeutic target in type 1 diabetes

Thomas, M. C., Baell, J. B., Rosado, C. J. & Dimitropoulos, A.

1/10/18 → 31/03/20

Project: Research

Male contraception through pharmacological blockade of sperm transport

Ventura, S., Baell, J. B., Charman, S. A. & Sexton, P.

Male Contraceptive Initiative

1/08/18 → 31/05/20

Project: Research

Research Output 1998 2018

1,2,4-Oxadiazole antimicrobials act synergistically with daptomycin and display rapid kill kinetics against MDR Enterococcus faecium

Carter, G. P., Harjani, J. R., Li, L., Pitcher, N. P., Nong, Y., Riley, T. V., Williamson, D. A., Stinear, T. P., Baell, J. B. & Howden, B. P., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1562-1569 8 p.

Research output: Contribution to journal › Article › Research › peer-review

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Coussens, N. P., Sittampalam, G. S., Guha, R., Brimacombe, K., Grossman, A., Chung, T. D. Y., Weidner, J. R., Riss, T., Trask, O. J., Auld, D., Dahlin, J. L., Devanaryan, V., Foley, T. L., McGee, J., Kahl, S. D., Kales, S. C., Arkin, M., Baell, J., Bejcek, B., Gal-Edd, N. & 25 othersGlicksman, M., Haas, J. V., Iversen, P. W., Hoeppner, M., Lathrop, S., Sayers, E., Liu, H., Trawick, B., McVey, J., Lemmon, V. P., Li, Z., McManus, O., Minor, L., Napper, A., Wildey, M. J., Pacifici, R., Chin, W. W., Xia, M., Xu, X., Lal-Nag, M., Hall, M. D., Michael, S., Inglese, J., Simeonov, A. & Austin, C. P., 1 Sep 2018, In : Clinical and Translational Science. 11, 5, p. 461-470 10 p.

Research output: Contribution to journal › Article › Other › peer-review

Open Access
File

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

Nguyen, N., Wilson, D. W., Nagalingam, G., Triccas, J. A., Schneider, E. K., Li, J., Velkov, T. & Baell, J., 25 Mar 2018, In : European Journal of Medicinal Chemistry. 148, p. 507-518 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'

Qin, C. X., May, L. T., Sexton, P. M., DeBono, A. J., Baell, J. B., Christopoulos, A. & Ritchie, R. H., 1 Dec 2018, In : Nature Communications. 9, 1, 4 p., 530.

Research output: Contribution to journal › Letter › Other › peer-review

Open Access
File

Prizes

2004 National Biota Prize for Medicinal Chemistry

Jonathan Bayldon Baell (Recipient), 2005

Prize: Prize (including medals and awards)

Adrien Albert Award 2018

Jonathan Bayldon Baell (Recipient), 2018

Prize: National/international honour