Jonathan Baell

Professor

19982020

Research output per year

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Personal profile

Biography

Position

Larkins Fellow
NHMRC Principal Research Fellow
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences

Director, Australian Translational Medicinal Chemistry Facility

Research Theme Leader - Fragment library design for the ARC Industrial Transformation Training Centre

President, International Chemical Biology Society

 

 

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Research interests

  • Molecular design
  • Peptidomimetics
  • Small molecule screening libraries and chemoinformatics
  • Hit-to-lead and lead optimisation medicinal chemistry
  • Drug discovery in infectious disease (particularly neglected diseases including malaria) and epigenetic modulation associated with cancer
  • Pre-clinical development of new drug candidates

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Projects

New Treatments for Chagas Disease

Baell, J. & Kelly, J. M.

1/01/1931/12/21

Project: Research

Small molecule Inhibitors of glutathione transferase omega 1-1 (GSTO1-1) for the treatment of inflammatory disease

Baell, J., Board, P., Oakley, A. J., Casarotto, M. & Mujumdar, P.

1/01/1931/12/21

Project: Research

Targeted development of AMPK β2-isoform allosteric activators

Oakhill, J., Baell, J. & Kemp, B. E.

1/01/1831/12/21

Project: Research

Novel Radioligands for PET imaging and phenotyping of multiple sclerosis diagnosis

Baell, J., Kilpatrick, T. J., Binder, M. D., Vivash, L. & Ackermann, U.

1/01/1831/12/20

Project: Research

Research Output

Action plan for hit identification (APHID): KAT6A as a case study

Yi, X., Xue, L., Thomas, T. & Baell, J. B., 1 Mar 2020, In : Future Medicinal Chemistry. 12, 5, p. 423-437 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Copper-catalyzed [4 + 2] annulation reaction of ß-enaminones and aryl diazonium salts without external oxidant: Synthesis of highly functionalized 3: H -1,2,4-triazines via homogeneous or heterogeneous strategy

Ding, Q., Li, M., Sun, Y., Yu, Y., Baell, J. B. & Huang, F., 7 Feb 2020, In : Organic Chemistry Frontiers. 7, 3, p. 457-463 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Xie, Y., Tummala, P., Oakley, A. J., Deora, G. S., Nakano, Y., Rooke, M., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Casarotto, M. G., Board, P. G. & Baell, J. B., 26 Mar 2020, In : Journal of Medicinal Chemistry. 63, 6, p. 2894-2914 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

Varghese, S., Rahmani, R., Russell, S., Deora, G. S., Ferrins, L., Toynton, A., Jones, A., Sykes, M., Kessler, A., Eufrásio, A., Cordeiro, A. T., Sherman, J., Rodriguez, A., Avery, V. M., Piggott, M. J. & Baell, J. B., 2020, In : ACS Medicinal Chemistry Letters. 11, 3, p. 278-285 8 p.

Research output: Contribution to journalArticleResearchpeer-review

HBO1 is required for the maintenance of leukaemia stem cells

MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y. C., Weng, C. F., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K. L., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nguyen, N. & 28 others, Stupple, P. A., Peat, T. S., Zhang, M., de Silva, M., Carrasco-Pozo, C., Avery, V. M., Khoo, P. S., Dolezal, O., Dennis, M. L., Nuttall, S., Surjadi, R., Newman, J., Ren, B., Leaver, D. J., Sun, Y., Baell, J. B., Dovey, O., Vassiliou, G. S., Grebien, F., Dawson, S. J., Street, I. P., Monahan, B. J., Burns, C. J., Choudhary, C., Blewitt, M. E., Voss, A. K., Thomas, T. & Dawson, M. A., 9 Jan 2020, In : Nature. 577, p. 266–270 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Prizes

2004 National Biota Prize for Medicinal Chemistry

Baell, Jonathan (Recipient), 2005

Prize: Prize (including medals and awards)

Adrien Albert Award 2018

Baell, Jonathan (Recipient), 2018

Prize: National/international honour

NHMRC Principal Research Fellow, Medicinal Chemistry

Baell, Jonathan (Recipient), 2017

Prize: Competitive Fellowships

Scientific Achievement Award in Drug Discovery and Development

Baell, Jonathan (Recipient), 2020

Prize: Prize (including medals and awards)