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Jonathan Baell

Professor

19982021
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Personal profile

Biography

Position

Larkins Fellow
NHMRC Principal Research Fellow
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences

 

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Research interests

  • Molecular design
  • Peptidomimetics
  • Small molecule screening libraries and chemoinformatics
  • Hit-to-lead and lead optimisation medicinal chemistry
  • Drug discovery in infectious disease (particularly neglected diseases including malaria) and epigenetic modulation associated with cancer
  • Pre-clinical development of new drug candidates

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Projects 2012 2021

Small molecule Inhibitors of glutathione transferase omega 1-1 (GSTO1-1) for the treatment of inflammatory disease

Baell, J., Board, P., Oakley, A. J., Casarotto, M. & Mujumdar, P.

1/01/19 → 31/12/21

Project: Research

New Treatments for Chagas Disease

Baell, J. & Kelly, J. M.

1/01/19 → 31/12/21

Project: Research

Prodrug Development of Biased N-Alkylpyridazinones for the Acute Intravenous Treatment of Myocardial Ischaemia-Reperfusion Injury

Baell, J., Ritchie, R. H., Kirkpatrick, C., Figtree, G., Deora, G. & Qin, H.

1/01/19 → 31/12/20

Project: Research

Transactivation of RAGE: a novel therapeutic target in type 1 diabetes

Thomas, M., Baell, J., Rosado, C. & Dimitropoulos, A.

1/10/18 → 31/03/20

Project: Research

Male contraception through pharmacological blockade of sperm transport

Ventura, S., Baell, J., Charman, S. & Sexton, P.

Male Contraceptive Initiative

1/08/18 → 31/05/20

Project: Research

Research Output 1998 2019

1 Citation (Scopus)

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Schneider-Futschik, E. K., Hoyer, D., Khromykh, A. A., Baell, J. B., Marsh, G. A., Baker, M. A., Li, J. & Velkov, T., 1 Nov 2019, In : ACS Infectious Diseases. 5, 1, p. 35-48 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A

Leaver, D. J., Cleary, B., Nguyen, N., Priebbenow, D., Lagiakos, H. R., Sanchez, J., Xue, L., Huang, F., Sun, Y., Mujumdar, P., Mudududdla, R., Varghese, S., Teguh, S., Charman, S. A., White, K. L., Katneni, K., Cuellar, M., Strasser, J. M., Dahlin, J. L., Walters, M. A. & 10 others, Street, I. P., Monahan, B. J., Jarman, K. E., Sabroux, H. J., Falk, H., Chung, M. C., Hermans, S. J., Parker, M. W., Thomas, T. & Baell, J. B., 8 Aug 2019, In : Journal of Medicinal Chemistry. 62, 15, p. 7146-7159 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

Varghese, S., Rahmani, R., Russell, S., Deora, G. S., Ferrins, L., Toynton, A., Jones, A., Sykes, M., Kessler, A., Eufrásio, A., Cordeiro, A. T., Sherman, J., Rodriguez, A., Avery, V. M., Piggott, M. J. & Baell, J. B., 2019, (Accepted/In press) In : ACS Medicinal Chemistry Letters. 8 p.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

Hughes, M. M., Hooftman, A., Angiari, S., Tummala, P., Zaslona, Z., Runtsch, M. C., McGettrick, A. F., Sutton, C. E., Diskin, C., Rooke, M., Takahashi, S., Sundararaj, S., Casarotto, M. G., Dahlstrom, J. E., Palsson-McDermott, E. M., Corr, S. C., Mills, K. H. G., Preston, R. J. S., Neamati, N., Xie, Y. & 3 others, Baell, J. B., Board, P. G. & O'Neill, L. A. J., 1 Oct 2019, In : Cell Reports. 29, 1, p. 151-161.e5 11 p.

Research output: Contribution to journal › Article › Research › peer-review

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Prizes

2004 National Biota Prize for Medicinal Chemistry

Jonathan Baell (Recipient), 2005

Prize: Prize (including medals and awards)

Adrien Albert Award 2018

Jonathan Baell (Recipient), 2018

Prize: National/international honour