Projects per year
Personal profile
Biography
Rebuilding the brain
The study of the brain is among the most exciting frontiers in modern medical science. As neural tissue engineer Associate Professor John Forsythe is discovering, the brain has potential not previously imagined, perhaps even the potential to regenerate.
John initially joined Monash as part of the CRC Polymers team, researching commodity polymers, such as everyday plastic packaging.
However, he has made a dramatic shift in his research focus, and begun work in what has become his passion: neural tissue engineering.
Within this rapidly developing field John is applying his knowledge of materials engineering, biomaterials and nanotechnology to help develop new therapies to regenerate damaged neural pathways in the brain. The work offers hope for potential new treatments of neurodegenerative diseases such as Parkinson's and Huntington's diseases.
'I made the shift because I saw an interest in this new, interdisciplinary field, and I felt my research could make a difference and help people,' John says.
'That means a lot, at the end of the day.'
John works with leading neurologists and stem cell scientists, creating biomaterial structures to encase stem cells implanted in the brain, helping them survive, differentiate and grow in specific ways to potentially repair nerves and restore function.
This is a complicated business. The brain has evolved over millennia to resist great change in adulthood - it's an innate survival mechanism to prevent critical, hard-wired processes from being erased. So John and his colleagues must trick the brain into accepting the foreign cells, and at the same time create an environment to encourage the growth of stem cells.
Working at the nanoscale, John creates temporary biological or synthetic structures (sometimes a mix of both) to protect and direct the implanted cells. He is also studying the use of different materials at the surfaces of these structures to aid cell growth and survival, delving further into a new branch of science, bionanotechnology.
'We are utilising concepts that are established in nanotechnology and applying them in the biological setting,' John says.
'We need to get down to the nanoscale because the cells interact differently at that level. In fact if you look at the brain, it is itself nanostructured. So we are trying to replicate this nanostructure of the brain in the artificial matrix that we are making, taking cues or signals from what the brain looks like, and building that artificially in these scaffolds.
'This interface between nanotechnology, materials engineering and neurology is really exciting, and they can feed off each other really well.'
Collaboration and cross-disciplinary research is integral to John's work. His nanostructures are being used in a number of projects with partners such as the Australian Regenerative Medicine Institute, the Howard Florey Institute, the Mental Health Institute Victoria, the Monash Immunology and Stem Cell Laboratories, the CSIRO and the Monash Institute of Medical Research.
John is also currently collaborating on the Monash Vision Group's bionic eye project. He will help develop neural prosthetics, electrodes that have increased compatibility with the brain and act as an implanted receiver, passing signals from external cameras directly to the visual cortex. The project has the potential to radically improve the freedom and living standards of people with severe vision impairment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
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Photoreversible hydrogels to study stem cell memory and fate
Frith, J., Forsythe, J. & Tuan, R.
1/01/21 → 31/12/23
Project: Research
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Integrating SANS data with advanced micromechanical models of polymer gels
Brassart, L., Forsythe, J., Truong, V. & Garvey, C. J.
Australian Nuclear Science and Technology Organisation (ANSTO)
9/10/18 → 11/10/18
Project: Research
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Immunospheres: creating an immune system in a microparticle
Jones, S., Forsythe, J., Tarlinton, D. & Morand, E.
5/09/17 → 4/09/18
Project: Research
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Immunospheres: creating an immune system in a microparticle
Jones, S., Tarlinton, D., Morand, E., Forsythe, J. & Hickey, M.
1/09/17 → 31/05/18
Project: Research
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High Resolution Atomic Force Microscopy Facility for Bionanotechnology
Aguilar, M., Ball, A., Boyd, B., Drummond, C., Dunstone, M., Forsythe, J., Fox, K., Greaves, T., Lithgow, T., Ramsland, P. & Separovic, F.
Australian Research Council (ARC), RMIT University, University of Melbourne, Monash University – Internal Faculty Contribution, Monash University – Internal University Contribution
9/06/17 → 11/10/17
Project: Research
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Tissue-mimicking materials for ultrasound-guided needle intervention phantoms: a comprehensive review
Armstrong, S. A., Jafary, R., Forsythe, J. S. & Gregory, S. D., Jan 2023, In: Ultrasound in Medicine and Biology. 49, 1, p. 18-30 13 p.Research output: Contribution to journal › Review Article › Research › peer-review
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Extrusion 3D bioprinting of functional self-supporting neural constructs using a photoclickable gelatin bioink
Yao, Y., Molotnikov, A., Parkington, H. C., Meagher, L. & Forsythe, J. S., 1 Jun 2022, In: Biofabrication. 14, 3, 20 p., 035014.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Micro-hydrogel injectables that deliver effective CAR-T immunotherapy against 3D solid tumor spheroids
Suraiya, A. B., Evtimov, V. J., Truong, V. X., Boyd, R. L., Forsythe, J. S. & Boyd, N. R., Oct 2022, In: Translational Oncology. 24, 10 p., 101477.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Rapid electrophoretic deposition of biocompatible graphene coatings for high-performance recording neural electrodes
Dong, M., Coleman, H. A., Tonta, M. A., Xiong, Z., Li, D., Thomas, S., Liu, M., Fallon, J. B., Parkington, H. C. & Forsythe, J. S., 14 Nov 2022, In: Nanoscale. 14, 42, p. 15845-15858 14 p.Research output: Contribution to journal › Article › Research › peer-review
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Biomaterial Strategies for Restorative Therapies in Parkinson's Disease
Mirzaei, S., Kulkarni, K., Zhou, K., Crack, P. J., Aguilar, M. I., Finkelstein, D. I. & Forsythe, J. S., 17 Nov 2021, In: ACS Chemical Neuroscience. 12, 22, p. 4224-4235 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
3 Citations (Scopus)