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Research Output 1979 2019

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2019

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 6 Apr 2019, (Accepted/In press) In : Molecular Human Reproduction. 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Oocytes from stem cells

Sarma, U. C., Findlay, J. K. & Hutt, K. J., 1 Feb 2019, In : Best Practice & Research: Clinical Obstetrics & Gynaecology. 55, p. 14-22 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer

Kadife, E., Chan, E., Luwor, R., Kannourakis, G., Findlay, J. K. & Ahmed, N., 19 Feb 2019, In : Cancers. 11, 2, p. 1-24 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Nguyen, Q. N., Zerafa, N., Liew, S. H., Morgan, F. H., Strasser, A., Scott, C. L., Findlay, J. K., Hickey, M. & Hutt, K. J., 1 Jun 2018, In : Cell Death and Disease. 9, 6, 12 p., 633.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer

Chan, E., Luwor, R., Burns, C., Kannourakis, G., Findlay, J. K. & Ahmed, N., 30 Mar 2018, In : Oncotarget. 9, 24, p. 16599-16618 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Samardzija, C., Greening, D. W., Escalona, R., Chen, M., Bilandzic, M., Luwor, R. B., Kannourakis, G., Findlay, J. K. & Ahmed, N., 13 Apr 2017, In : Scientific Reports. 7, 18 p., 46312.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-Apoptotic protein BMF

Liew, S. H., Nguyen, Q. N., Strasser, A., Findlay, J. K. & Hutt, K. J., 3 Aug 2017, In : Cell Death and Disease. 8, 8, e2971.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

BCL2-modifying factor promotes germ cell loss during murine oogenesis

Vaithiyanathan, K., Liew, S. H., Zerafa, N., Gamage, T., Cook, M., O'Reilly, L. A., Bouillet, P., Scott, C. L., Strasser, A., Findlay, J. K. & Hutt, K. J., 1 May 2016, In : Reproduction. 151, 5, p. 553-562 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer

Samardzija, C., Luwor, R. B., Quinn, M. A., Kannourakis, G., Findlay, J. & Ahmed, N., 8 Jul 2016, In : BMC Cancer. 16, 1, 16 p., 432.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling

Wang, Y., Bilandzic, M., Ooi, G. T., Findlay, J. K. & Stenvers, K. L., 15 Nov 2016, In : Molecular and Cellular Endocrinology. 436, p. 68-77 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells

Ahmed, N., Greening, D., Samardzija, C., Escalona, R. M., Chen, M., Findlay, J. K. & Kannourakis, G., 29 Jul 2016, In : Scientific Reports. 6, 13 p., 30061.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer

Samardzija, C., Luwor, R. B., Volchek, M., Quinn, M. A., Findlay, J. J. K. & Ahmed, N., 2015, In : Molecular Cancer. 14, p. 1 - 19 19 p., 152.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Enhanced activation of STAT3 in ascites-derived recurrent ovarian tumors: inhibition of cisplatin-induced STAT3 activation reduced tumorigenicity of ovarian cancer by a loss of cancer stem cell-like characteristics

Abubaker, K., Latifi, A., Chan, E., Luwor, R. B., Burns, C. J., Thompson, E. W., Findlay, J. J. K. & Ahmed, N., 2015, In : Journal of Cancer Stem Cell Research. 3, 17 p., e1001.

Research output: Contribution to journalArticleResearchpeer-review

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How Is the number of primordial follicles in the ovarian reserve established?

Findlay, J. J. K., Hutt, K. J., Hickey, M. & Anderson, R. A., 2015, In : Biology of Reproduction. 93, 5 (Art. ID : 111), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NF?B-mediated induction of MMP2

Bilandzic, M., Wang, Y., Ahmed, N., Luwor, R. B., Zhu, H-J., Findlay, J. J. K. & Stenvers, K. L., 2014, In : Cancer Letters. 354, 1, p. 107 - 114 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

Abubaker, K., Luwor, R. B., Zhu, H-J., McNally, O. M., Quinn, M. A., Burns, C. J., Thompson, E. W., Findlay, J. K. & Ahmed, N., 2014, In : BMC Cancer. p. 1 - 22 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

Liew, S. H., Vaithiyanathan, K., Cook, M., Bouillet, P., Scott, C. L., Kerr, J. B., Strasser, A., Findlay, J. J. K. & Hutt, K. J., 2014, In : Biology of Reproduction. 90, 4 (Art. ID: 77), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

PUMA regulates germ cell loss and primordial follicle endowment in mice

Myers, M., Morgan, F. H., Liew, S. H., Zerafa, N., Gamage, T. U., Sarraj, M., Cook, M., Kuyznierewicz, I., Sutherland, A., Scott, C. L., Strasser, A., Findlay, J. J. K., Kerr, J. B. & Hutt, K. J., 2014, In : Reproduction. 148, 2, p. 211 - 219 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted disruption of the JAK2/STAT3 pathway in combination with systemic administration of paclitaxel inhibits the priming of ovarian cancer stem cells leading to a reduced tumor burden

Abubaker, K., Luwor, R. B., Escalona, R., McNally, O., Quinn, M. A., Thompson, E. W., Findlay, J. K. & Ahmed, N., 2014, In : Frontiers in Oncology. 4 APR, 12 p., Article 75.

Research output: Contribution to journalArticleResearchpeer-review

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2013

Betaglycan alters NF{kappa}B-TGF{beta}2 cross talk to reduce survival of human granulosa tumor cells

Bilandzic, M., Chu, S., Wang, Y., Tan, H. L., Fuller, P. J., Findlay, J. K. & Stenvers, K. L., 2013, In : Molecular Endocrinology. 27, 3, p. 466 - 479 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of TGFbeta2 on wild-type and Tgfbr3 knockout mouse fetal testis

Sarraj, M., Escalona, R. M., Western, P. S., Findlay, J. K. & Stenvers, K. L., 2013, In : Biology of Reproduction. 88, 3 (Art. No.: 66), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden

Abubaker, K., Latifi, A., Luwor, R., Nazaretian, S., Zhu, H., Quinn, M. A., Thompson, E. W., Findlay, J. K. & Ahmed, N., 27 Mar 2013, In : Molecular Cancer. 12, 1, 24.

Research output: Contribution to journalArticleResearchpeer-review

2012

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

Kerr, J. B., Hutt, K. J., Cook, M., Speed, T. P., Strasser, A., Findlay, J. K. & Scott, C. L., 2012, In : Nature Medicine. 18, 8, p. 1170 - 1172 3 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

Kerr, J. B., Hutt, K. J., Michalak, E. M., Cook, M., Vandenberg, C., Liew, S. H., Bouillet, P., Mills, A. A., Scott, C. L., Findlay, J. K. & Strasser, A., 2012, In : Molecular Cell. 48, 3, p. 343 - 352 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors

Latifi, A., Luwor, R. B., Bilandzic, M., Nazaretian, S., Stenvers, K., Pyman, J. M., Zhu, H., Thompson, E. W., Quinn, M. A., Findlay, J. K. & Ahmed, N., 8 Oct 2012, In : PLoS ONE. 7, 10, e46858.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The effects of FSH and activin A on follicle development in vitro

Cossigny, D. A., Findlay, J. K. & Drummond, A. E., Feb 2012, In : Reproduction. 143, 2, p. 221-229 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The primordial follicle reserve is not renewed after chemical or gamma-irradiation mediated depletion

Kerr, J. B., Brogan, L., Myers, M., Hutt, K. J., Mladenovska, T., Ricardo, S. D., Hamza, K., Scott, C. L., Strasser, A. & Findlay, J. K., 2012, In : Reproduction. 143, 4, p. 469 - 476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Apoptosis in the germ line

Aitken, R. J., Findlay, J. K., Hutt, K. J. & Kerr, J. B., 2011, In : Reproduction. 141, 2, p. 139 - 150 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile

Latifi, A., Abubaker, K., Castrechini, N., Ward, A. C., Liongue, C., Dobill, F., Kumar, J., Thompson, E. W., Quinn, M. A., Findlay, J. K. & Ahmed, N., Oct 2011, In : Journal of Cellular Biochemistry. 112, 10, p. 2850-2864 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Estrogen-dependent gene expression in the mouse ovary

Liew, S., Sarraj, M., Drummond, A. & Findlay, J., 2011, In : PLoS ONE. 6, 2 (Art. No: e14672), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer

Ahmed, N., Abubaker, K., Findlay, J. & Quinn, M., 2010, In : Current Cancer Drug Targets. 10, 3, p. 268-278 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fetal testis dysgenesis and compromised leydig cell function in Tgfbr3 (betaglycan) knockout mice

Sarraj, M., Escalona, R. M., Umbers, A., Chua, H. K., Small, C., Griswold, M., Loveland, K. A. L., Findlay, J. K. & Stenvers, K. L., 2010, In : Biology of Reproduction. 82, 1, p. 153 - 162 10 p.

Research output: Contribution to journalArticleResearchpeer-review

High-temperature requirement factor A3 (Htra3): A novel serine protease and its potential role in ovarian function and ovarian cancers

Bowden, M., Drummond, A., Fuller, P., Salamonsen, L., Findlay, J. & Nie, G., 2010, In : Molecular and Cellular Endocrinology. 327, 1-2, p. 13 - 18 6 p.

Research output: Contribution to journalArticleResearchpeer-review

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The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype

Liew, S. H., Drummond, A. E., Jones, M. E. & Findlay, J. K., 2010, In : Molecular and Cellular Endocrinology. 327, 1-2, p. 56 - 64 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

A randomized controlled trial of treatment options for troublesome uterine bleeding in Implanon users

Weisberg, E., Hickey, M., Palmer, D. C., O'Connor, V., Salamonsen, L. A., Findlay, J. K. & Fraser, I. S., Aug 2009, In : Human Reproduction. 24, 8, p. 1852-1861 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas

Magee, M., Ward, A. C., Riley, C. B., Trenerry, M. K., Cameron-Smith, D., Findlay, J. J. K., Ackland, M. L. & Ahmed, N., 2009, In : British Journal of Cancer. 100, 1, p. 134 - 144 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Evolutionary conservation of mammalian HTRA3 and its developmental regulation in the rat ovary

Bowden, M., Drummond, A. E., Salamonsen, L. A., Findlay, J. K. & Nie, G., 2009, In : Journal of Experimental Zoology Part B-Molecular and Developmental Evolution. 312, 7, p. 701 - 713 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Extra-ovarian expression and activity of growth differentiation factor 9

Wang, Y., Nicholls, P. K., Stanton, P. G., Harrison, C. A., Sarraj, M., Gilchrist, R. B., Findlay, J. K. & Farnworth, P. G., 2009, In : Journal of Endocrinology. 202, 3, p. 419 - 430 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells

Bilandzic, M., Chu, S., Farnworth, P. G., Harrison, C., Nicholls, P., Wang, Y., Escalona, R. M., Fuller, P. J., Findlay, J. K. & Stenvers, K. L., Apr 2009, In : Molecular Endocrinology. 23, 4, p. 539-548 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Reducing betaglycan expression by RNA interference (RNAi) attenuates inhibin bioactivity in LβT2 gonadotropes

Escalona, R. M., Stenvers, K. L., Farnworth, P. G., Findlay, J. K. & Ooi, G. T., 13 Aug 2009, In : Molecular and Cellular Endocrinology. 307, 1-2, p. 149-156 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Gene expression profiling of human oocytes following in vivo or in vitro maturation

Jones, G. M., Cram, D. S., Song, B., Magli, C., Gianaroli, L., Lacham, O., Findlay, J. K., Jenkin, G. & Trounson, A. O., 2008, In : Human Reproduction. 23, 5, p. 1138 - 1144 7 p.

Research output: Contribution to journalArticleResearchpeer-review

HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium, and at the maternal-fetal interface during early pregnancy

Bowden, M. A., Li, Y., Liu, Y-X., Findlay, J. K., Salamonsen, L. A. & Nie, G., 2008, In : Reproductive Biology and Endocrinology. 6, 22, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Transforming growth factor-β: Its role in ovarian follicle development

Rosairo, D., Kuyznierewicz, I., Findlay, J. & Drummond, A., Dec 2008, In : Reproduction. 136, 6, p. 799-809 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Differential expression of TGFBR3 (betaglycan) in mouse ovary and testis during gonadogenesis

Sarraj, M., Chua, H. K., Umbers, A., Loveland, K. A. L., Findlay, J. K. & Stenvers, K. L., 2007, In : Growth Factors. 25, 5, p. 334 - 345 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fibroblast growth factor-9, a local regulator of ovarian function

Drummond, A. E., Tellbach, M., Dyson, M. & Findlay, J. K., Aug 2007, In : Endocrinology. 148, 8, p. 3711-3721 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Transforming growth factor-β blocks inhibin binding to different target cell types in a context-dependent manner through dual mechanisms involving betaglycan

Farnworth, P. G., Wang, Y., Escalona, R., Leembruggen, P., Ooi, G. T. & Findlay, J. K., Nov 2007, In : Endocrinology. 148, 11, p. 5355-5368 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Activin A and Inhibin a differentially regulate human uterine matrix metalloproteinases: potential interactions during decidualization and trophoblast invasion

Jones, R. L., Findlay, J. K., Farnworth, P. G., Robertson, D., Wallace, E. M. & Salamonsen, L. A., 2006, In : Endocrinology. 147, 2, p. 724 - 732 9 p.

Research output: Contribution to journalArticleResearchpeer-review