Projects per year
Personal profile
Biography
Our research is focused on understanding the mechanisms of oocyte development, maturation and fertilization in mammals. Early embryo development in mammals is driven and underpinned by a healthy fertile oocyte. How the oocyte acquires this developmental potential is not understood and problems in oocyte quality are largely responsible for the high rates of infertility and miscarriage in the population.
Our work focuses on understanding how the oocyte undergoes the meiotic cell divisions and why the rate of chromosome abnormalities is so high in women in their late 30s and early 40s. A major factor in determining oocyte quality is the ability of mitochondria to generate ATP. We are studying mitochondrial dynamics and function in oocytes with the aim of modulating mitochondrial activity in order to improve oocyte quality. We have established a new collaboration with Monash IVF in order to translate our findings to the clinic. Our research has been funded by long term MRC Programme Grants and the ARC and the results are published in leading journal including Nature Cell Biology, Science, Developmental Cell, Development and Journal of Cell Biology.
Career Summary:
John obtained his PhD in 1991 from the University of Adelaide before moving to the MRC Experimental Embryology Unit in London. John moved to University College London (UCL) in 1996 where he held an MRC Fellowship and an academic position. In 2004 John was appointed Professor and Head of Department of Physiology, becoming the Associate Dean and Director of the UCL Division of Biosciences in 2007.
Prof John Carroll joined Monash University in September 2012 to take up the position of Head of School of Biomedical Sciences.
Supervision interests
Research area keywords
- fertility
- oocyte
- meiosis
- aneuploidy
- cell cycle
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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'Smart light-sheet with metabolic imaging for extremely delicate samples'
Carroll, J. (Primary Chief Investigator (PCI)), Arumugam, S. (Chief Investigator (CI)), Rajagopal, V. (Chief Investigator (CI)), McArthur, K. (Chief Investigator (CI)), Hutt, K. (Chief Investigator (CI)), Fan, D. (Chief Investigator (CI)), Robker, R. (Chief Investigator (CI)) & Polo, J. (Chief Investigator (CI))
ARC - Australian Research Council
31/08/26 → 30/08/27
Project: Research
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Do mitochondria transfer horizontally into the mammalian female germ line?
Adhikari, D. (Primary Chief Investigator (PCI)) & Carroll, J. (Chief Investigator (CI))
1/01/26 → 31/12/28
Project: Research
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MitoHOPE: Introducing Mitochondrial Donation in Australia: The MitoHOPE (Healthy Outcomes Pilot and Evaluation) Program
Carroll, J. (Primary Chief Investigator (PCI)), Herbert, M. (Chief Investigator (CI)), Christodoulou, J. (Chief Investigator (CI)), Thorburn, D. R. (Chief Investigator (CI)), Mills, C. (Chief Investigator (CI)), Zander-Fox, D. L. (Chief Investigator (CI)), Robker, R. (Chief Investigator (CI)), Rombauts, L. (Chief Investigator (CI)), Sallevelt, S. (Chief Investigator (CI)), Ludlow, K. (Chief Investigator (CI)), Coman, D. J. (Chief Investigator (CI)), Ellaway, C. (Chief Investigator (CI)), Mackey, D. A. (Chief Investigator (CI)), Delatycki, M. (Chief Investigator (CI)), Yau, W. Y. (Chief Investigator (CI)), Tchan, M. C. (Chief Investigator (CI)), Long, J. C. (Chief Investigator (CI)), Hardy, T. (Chief Investigator (CI)), Adhikari, D. (Chief Investigator (CI)), Choudhary, M. (Chief Investigator (CI)), Hyslop, L. A. (Chief Investigator (CI)), Mann, J. (Chief Investigator (CI)), Ryan, M. (Chief Investigator (CI)), Hodges, R. (Chief Investigator (CI)), Hui, L. (Chief Investigator (CI)), Kamien, B. A. (Chief Investigator (CI)), Mallett, A. J. (Chief Investigator (CI)), Wallis, M. (Chief Investigator (CI)), Wall, M. (Chief Investigator (CI)), Zoungas, S. (Chief Investigator (CI)), Goranitis, I. (Chief Investigator (CI)), Gyngell, C. (Chief Investigator (CI)), Hammarberg, K. (Chief Investigator (CI)), Sparrow, R. (Chief Investigator (CI)), Warren, N. (Chief Investigator (CI)), Fahey, M. (Chief Investigator (CI)), Stutterd, C. A. (Associate Investigator (AI)), Schweitzer, D. R. (Associate Investigator (AI)), McGillivray, G. (Associate Investigator (AI)), Savulescu, J. (Associate Investigator (AI)), Panetta, J. (Associate Investigator (AI)), Kava, M. P. (Associate Investigator (AI)), Freckmann, M.-L. (Associate Investigator (AI)), Lynch, M. (Associate Investigator (AI)), Lamont, P. J. (Associate Investigator (AI)), Scott, R. (Associate Investigator (AI)), Ware, T. (Associate Investigator (AI)), Mowat, D. (Associate Investigator (AI)), Jones, K. J. (Associate Investigator (AI)), Green, S. (Associate Investigator (AI)), Wolfe, R. (Associate Investigator (AI)), Hackett, A. (Associate Investigator (AI)), Bratkovic, D. (Associate Investigator (AI)), Horton, A. (Associate Investigator (AI)) & Blok, R. (Project Manager)
Monash University – Internal Faculty Contribution, Australian Genomics, James Cook University, Lyons Eye Institute Limited, Macquarie University, Murdoch Children's Research Institute, Australian Mitochondrial Disease Foundation Limited (trading as Mito Foundation), Monash IVF Group Limited, Perron Institute for Neurological and Translational Science Limited, Queensland Children's Hosptial , Tasmanian Clinical Genetics Service, Adelaide University, Victorian Assisted Reproductive Treatment Authority (VARTA) (Victoria), Women's and Children's Health Care Network Incorporated, Western Sydney Local Health District (WSLHD)
1/06/23 → 31/05/29
Project: Research
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Development of novel mRNA products for clinical trials
Pouton, C. (Primary Chief Investigator (PCI)), Beilharz, T. (Chief Investigator (CI)), Carroll, J. (Chief Investigator (CI)), Porter, C. (Chief Investigator (CI)), Al-Wassiti, H. (Chief Investigator (CI)), Davidovich, C. (Chief Investigator (CI)), Johnston, A. (Chief Investigator (CI)) & Trevaskis, N. (Chief Investigator (CI))
10/05/23 → 2/10/28
Project: Research
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Mitigating the risks of mitochondrial donation
Stocker, R. (Primary Chief Investigator (PCI)) & Carroll, J. (Supervisor)
15/08/23 → 15/02/25
Project: Research
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Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
Nabti, I., Grimes, R., Sarna, H., Marangos, P. & Carroll, J., 18 May 2017, In: Nature Communications. 8, 9 p., 15346.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile58 Link opens in a new tab Citations (Scopus) -
DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age
Marangos, P., Stevense, M., Niaka, K., Lagoudaki, M., Nabti, I., Jessberger, R. & Carroll, J. G., 2015, In: Nature Communications. 6, 10 p., 8706.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile123 Link opens in a new tab Citations (Scopus) -
Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity
Nabti, I., Marangos, P., Bormann, J., Kudo, N. R. & Carroll, J. G., 2014, In: Journal of Cell Biology. 204, 6, p. 891 - 900 10 p.Research output: Contribution to journal › Article › Research › peer-review
33 Link opens in a new tab Citations (Scopus) -
Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte
Dalton, C. & Carroll, J. G., 2013, In: Journal of Cell Science. 126, 13, p. 2955 - 2964 10 p.Research output: Contribution to journal › Article › Research › peer-review
163 Link opens in a new tab Citations (Scopus) -
A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression
Homer, H., Gui, L. & Carroll, J. G., 2009, In: Science. 326, 5955, p. 991 - 994 4 p.Research output: Contribution to journal › Article › Research › peer-review
137 Link opens in a new tab Citations (Scopus)
Prizes
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Vice-Chancellor's Diversity and Inclusion Award
Carroll, J. (Recipient), Brown, M. (Recipient), Edgington-Mitchell, D. (Recipient), Garcia De La Banda, M. (Recipient), Gurvich, C. (Recipient), Ho, S. (Recipient), Joschko, L. (Recipient), Maher, J. (Recipient), McDonald, M. (Recipient), McGlinn, E. (Recipient), McGuigan, N. (Recipient), Morgan, M. (Recipient), Murray-Zaia, J. (Recipient) & Strengers, Y. (Recipient), 10 Dec 2020
Prize: Prize (including medals and awards)
Activities
- 1 Public event
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National Science Week 2017 - Discussion of the future of biomedical research in Australia
Carroll, J. (Contributor)
Aug 2017Activity: Community Talks, Presentations, Exhibitions and Events › Public event